Methicillin-resistant Staphylococcus aureus nasal colonization among HIV-infected patients in Taiwan: prevalence, molecular characteristics and associated factors with nasal carriage

Methicillin-resistant Staphylococcus aureus nasal colonization among HIV-infected patients in Taiwan: prevalence, molecular characteristics and associated factors with nasal carriage | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research article Methicillin-resistant Staphylococcus aureus nasal colonization among HIV-infected patients in Taiwan: prevalence, molecular characteristics and associated factors with nasal carriage Yi-Yu Hsu, David Wu, Chien-Ching Hung, Shie-Shian Huang, Fang-Hsueh Yuan, and 9 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.2.18964/v3 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 30 Mar, 2020 Read the published version in BMC Infectious Diseases → Version 3 posted 2 You are reading this latest preprint version Show more versions Abstract Background : To evaluate nasal carriage, antibiotic susceptibility and molecular characteristics of methicillin-resistant Staphylococcus aureus (MRSA), as well as the risk factors of MRSA colonization, in human immunodeficiency virus (HIV)-infected patients in northern Taiwan. Methods: From September 2014 to November 2015, HIV-infected patients seeking outpatient care at four hospitals were eligible for this study. A nasal specimen was obtained from each subject for the detection of S. aureus and a questionnaire was completed by each subject. MRSA isolates once identified were characterized. Results: Of 553 patients surveyed, methicillin-susceptible S. aureus (MSSA) was detected in 119 subjects (21.5%) and MRSA in 19 subjects (3.4%). Female gender, injection drug use, smoking, hepatitis C virus carrier, cancer and antibiotic use within one year were positively associated with MRSA colonization. By multivariate analysis, only cancer (adjust odds ratio (aOR) 7.78, [95% confidence interval (CI), 1.909-31.731]) and antibiotic use within one year (aOR 3.89, [95% CI, 1.219-12.433]) were significantly associated with MRSA colonization. Ten isolates were characterized as sequence type (ST) 59/staphylococcal chromosome cassette (SCC) IV or V T , endemic community strains in Taiwan, four isolates as ST 8/SCC mec IV (USA 300) and one isolate as ST 239/SCC mec IIIA, a hospital strain. All the community-associated MRSA isolates were susceptible to trimethoprim-sulfamethoxazole (TMP-SMX). Conclusions: Nasal MRSA carriage in HIV-infected patients seeking outpatient care was low (3.4%) in northern Taiwan. Most of the colonizing isolates were genetically endemic community strains and exhibited high susceptibility to TMP-SMX and fluoroquinolones. Cancer and antibiotic use within one year were associated with MRSA colonization. Infectious Diseases nasal carriage antibiotic use injection drug use injection drug user molecular typing Figures Figure 1 Background Methicillin-resistant Staphylococcus aureus (MRSA) was first reported in the 1960s [1] and the infections due to MRSA rapidly increased in the 1980s [2-4], most of which were health care-acquired infections. In the late 1990s, MRSA began to be recognized as a major cause of community-onset infections, which was termed as community-associated MRSA (CA-MRSA) later [2-4]. The epidemic of CA-MRSA has spread rapidly both in the community [2-4] and in healthcare settings over the past decade. Carriage of S. aureus , including MRSA, has been identified as a predisposing factor for subsequent invasive infections [5, 6], and the anterior nares are the most common site of colonization. Among human immunodeficiency virus (HIV)-infected patients, S. aureus infection is considered to be a major cause of significant morbidity and mortality [7-9]. Previous studies suggest that prevalence of nasal colonization with MRSA is higher in HIV-infected individuals than in the general population [10-12]. HIV infection is also related to persistent colonization [13]. The higher colonization burden may be associated with a higher incidence of subsequent infections [10, 11, 14]. However, risk factors for S. aureus colonization appear to be different among different populations, including patients infected with HIV [11, 15-17]. MRSA colonization in HIV-infected patients may vary widely in different geographical regions [15, 18-21], the time point of survey [14], and the coverage of antiretroviral therapy in the population [22]. MRSA has been a prevalent etiology of infections in Asian countries, including Taiwan, either in healthcare settings or in the community, for decades, but the reports regarding MRSA colonization in HIV-infected population have been scarce [12,15, 23]. Hence, we conducted this study to evaluate the prevalence of and associated factors for MRSA colonization in HIV-infected population in Taiwan. All collected MRSA isolates were further characterized by molecular methods and antibiotic susceptibility. Methods The study was approved by the institutional review board (IRB) of Chang Gung Memorial Hospital (protocol number:103-2418A3) and the Research Ethics Committee of National Taiwan University Hospital. A written informed consent was obtained from each subject. Subject Enrollment The study was conducted in hospital-based infectious diseases outpatient clinics at Chang Gung Memorial Hospital (CGMH) and National Taiwan University Hospital (NTUH) from September 2014 to November 2015. Both CGMH and NTUH are university-affiliated medical centers situated in northern Taiwan. Data were obtained in multiple CGMH branches, including Linkou branch, Taipei branch and Keelung branch. We also recruited patients from prison and correctional facilities in Keelung, where inmates were regularly followed by infectious diseases specialists in CGMH Keelung branch. All the HIV-infected patients who visited and treated at CGMH and NTUH were eligible and invited to participate in this study. Study subjects were enrolled when they sought HIV care at the infectious diseases outpatient departments. Data collection To identify the associated factors with MRSA acquisition, a self-administered questionnaire interview was performed to inquire into the factors for colonization with MRSA in HIV-infected patients. The following information was also collected from medical records of the participants: age, gender, drinking habits and smoking habits, underlying diseases, clinical characteristics, latest hospitalization, community exposure (eg, drug use, and incarceration), previous S. aureus infection, antibiotic use, skin disease, plasma HIV RNA load and CD4＋T lymphocytes, and antiretroviral therapy. Clinical information regarding hospitalization, residence in a long-term care facility, outpatient department visit, surgery, dialysis, and usage of tubes (nasogastric tube, urine catheter, tracheostomy tube, drainage tube, port-A, and dialysis tube) were also obtained. Substance abuse was defined as current or former use if illicit drugs. Microbiologic study Nasal specimens were obtained by swabbing the anterior 1 cm of the nasal vestibule of both anterior nares of the participants. The swabs were preserved in the transport medium (Venturi Transystem, Copan Innovation Ltd.) immediately. S. aureus was identified by colony morphology, Gram stain, positive coagulase tests, and presence of β-hemolysis after subculture to tryptic soy agar plates containing 5% sheep’s blood. Methicillin resistance was confirmed by cefoxitin disk-diffusion method according to the recommendation of Clinical and Laboratory Standard Institutes [24]. Antimicrobial susceptibility study The antimicrobial susceptibility of all MRSA isolates to ten antibiotics, including ciprofloxacin, trimethoprim/sulfamethoxazole (SXT), penicillin, teicoplanin, linezolid, clindamycin, doxycyclin, fusidic acid, vancomycin, and erythromycin, was tested in accordance with the guideline of Clinical and Laboratory Standard Institutes by using the disk-diffusion method [24]. Molecular characterization All the MRSA isolates, once identified, were characterized by molecular methods. By pulsed-field gel electrophoresis (PFGE) with Sma I digestion [25-27], the genotypes were designated in alphabetical order, as in our previous studies [25-27]; any new genotype, if identified, was designated consecutively. PFGE patterns with fewer than four band differences from an existing genotype were defined as subtypes of that genotype. Staphylococcal chromosome cassette mec (SCC mec ) type, and the presence of Panton-Valentine leukocidin (PVL) genes were determined by a multiplex PCR strategy [28]. Some isolates of representative PFGE patterns were selected and underwent multilocus sequence typing (MLST) [29] and spa typing [27]. The allelic profiles were assigned through comparison of the sequences at each locus with those of the known alleles in the S. aureus MLST database and were defined as sequence types accordingly. The details of the procedures were described elsewhere previously [25-29]. Statistical Analysis Statistical analyses were performed with the Statistical Package for the Social Sciences (SPSS software for Windows, version 17.0). The definition of statistical significance was p <0.05. Chi-square analysis or Fisher’s exact test was used for examination of categorical variables. Continuous variables were compared between patients with MRSA colonization versus patients without MRSA colonization using two-sample t-test, in which Levene's test was used to determine equality of variances between the two groups. Results During the 14-month study period, a total of 810 HIV-infected patients sought outpatient care at CGMH and NTUH (446 from CGMH and 364 from NTUH). Of the 810 eligible patients, 586 patients (275 from CGMH and 311 from NTUH) were interviewed and invited to participate in this study. 553 patients (259 from CGMH and 294 from NTUH) were enrolled in total and were surveyed for nasal carriage of MRSA after giving their written informed consent. Detailed demographic data are shown in Table 1. 531 were male (96%) and 22 female (4%). The majority of the participants were aged 20-60 years (with 47.6% between 20-39 years, and 45.6% between 40-60 years). The main route of HIV acquisition was male-to-male sex contact (68.0%), followed by injection drug use (16.3%). Table 1 shows the comparison among different hospitals and no statistically significant difference was found among different hospitals in terms of nasal MRSA carriage rate among the HIV-infected patients. The overall MSSA and MRSA nasal colonization rate was 21.5% and 3.4%, respectively. The comparison of underlying diseases and other medical history between patients with and without MRSA colonization are shown in Tables 2 and 3. In univariate analysis, we found that female gender (p=0.005), injection drug use (p=0.001), smoking (p=0.02), hepatitis C virus (HCV) carrier (p=0.003), cancer (p=0.001) and antibiotic use within one year (p=0.02) were significant factors associated with MRSA colonization. CD4 + T lymphocytes or plasma HIV RNA load was not significantly associated with MRSA colonization. By multivariate analysis, cancer (adjust odds ratio (aOR) 7.78, [95% confidence interval (CI), 1.909-31.731]) and antibiotic use within one year (aOR 3.89, [95% CI, 1.219-12.433]) were significantly associated with MRSA colonization. All 19 MRSA isolates were available for molecular characterization and the distribution of PFGE patterns, SCC mec types, SPA typing, and the presence of PVL genes among the 19 MRSA isolates are shown in Figure1. MLST was selectively done in eleven isolates, and five sequence types were identified. Totally six PFGE patterns were identified. One isolate carried SCC mec type IIIA and the remaining isolates carried either SCC m ec type IV or VT. PFGE pattern D/ sequence type (ST) 59 was the relatively common clone, followed by PFGE pattern C/ST 59 and PFGE pattern AI/ST 8. PVL is one of the most important virulence factors of S. aureus and PVL genes were present in 9 isolates (47%). PVL genes were present in all isolates with PFGE pattern AI/ST 8 and most isolates with PFGE pattern D/ST 59/SCC mec V T , but absent in isolates with PFGE pattern AG4/ST 30 and C/ST 59/SCC mec IV. All the MRSA strains were resistant to penicillin and susceptible to linezolid, teicoplanin, doxycycline, and vancomycin. The susceptibility rates to erythromycin, clindamycin, ciprofloxacin, trimethoprim-sulfamethoxazole (TMP-SMX), and fusidic acid were 15.8%, 42.1%, 84.20%, 94.7%, and 89.5%, respectively. Discussion To our knowledge, this is the largest study on this issue in Asian countries [15]. In this cross-section survey among 553 HIV-infected patients seeking care at the outpatient clinics in four hospitals in northern Taiwan, we found that the overall prevalence of MRSA nasal carriage among the HIV-infected individual was 3.4% while the prevalence of MSSA nasal carriage was 21.5%. The nasal carriage of MRSA was associated with cancer and antibiotic exposure within the past 12 months. The nasal carriage rate of MRSA in this study is slightly lower than that previously reported in Taiwan in 2003 (5.6% of 296 HIV-infected patients) [12] and in 2009-2010 (4.4% of 457 HIV-infected patients) [23]. Compared with other populations in Taiwan, the nasal MRSA carriage rate among HIV-infected patients was significantly lower than that for patients hospitalized in the intensive care units (ICU) (32% of 177 patients) [30], but similar to that for adult patients receiving hemodialysis (3.8% of 296 patients) [31], adult patients visiting emergency room (3.8% of 502 patients) [32] and otherwise healthy adults for health examination (3.8% of 3098 adults) [33]. It could be explained that in the era of highly active antiretroviral therapy (HAART), the majority of the HIV-infected patients recruited in this study came from community settings, outpatient visiting and these patients were not frequently exposed to the high-risk populations for MRSA acquisition, such as patients admitted to the ICUs. For patients infected with HIV, the nasal MRSA carriage rate was different, with a huge discrepancy, in different countries and regions. A latest meta-analysis on this issue [15] showed that the estimated pooled worldwide prevalence of MRSA in HIV-infected people is around 7% (5%-9%), with the prevalence of 7%-13% in the region of the Americas and 0-1% in the European region. Compared with other Asian countries, the prevalence rate (3.4%) in this study was lower than that in India (6%-26%), as well as in Singapore (3%-10%) but higher than that in Malaysia (<1%). This variation may be attributable to different prevailing MRSA clones, study population, the intermittent nature of colonization [10] and different culture of antibiotic use between countries [34]. We observed that MRSA colonization was associated with antibiotic use within 12 months among HIV-infected individuals. This finding supported previous observations that recent receipt of antibiotics was strongly associated with MRSA colonization [12]. Wang et al found that smoking was a protective factor against MRSA colonization in the community setting [33], which was not confirmed in this study. The potential reasons for the disparity might be the difference in questionnaire design. A latest meta-analysis on this issue [15] indicated that the risk factors for MRSA colonization included having a previous MRSA infection, hospitalization in the past year and use of antibiotics in the past six months. Molecular characterization of MRSA isolates in the present study showed that 10 (52.6%) of the 19 isolates belonged to ST59 linage, the predominant community-associated MRSA strain in Taiwan. One isolate was characterized by ST239-SCC mec IIIA which had been known as the most dominant healthcare-associated MRSA clone in Taiwan [4]. The patient with the isolate of ST239 did have a medical history of recent hospitalization within the past year and had been admitted four times after being diagnosed with HIV. The remaining eight isolates carried type IV SCC mec . Among these eight isolates, four of them were identified and confirmed as USA 300 later [35], the predominant community-associated MRSA strain in the United States, on the basis of their being sequence type 8 by multilocus sequence typing (MLST), detection of arginine catabolic metabolic element (ACME) gene and harboring SCC mec type IV and genes for PVL. Three of them were characterized by ST30-SCC mec IV strains, known as the Southwest Pacific clone [2,4]. One isolate characterized as sequence type 45 which had been identified as the predominate strain in nursing homes in Taiwan [36]. In this study, USA300 (ST8) accounted for four isolates and was a second most common clone. All four isolates were from NTUH. This is an emergent issue in Taiwan [35], which needs further surveillance and observation. There were several limitations to the current study. First, less than 70% of the HIV-infected patients visiting CGMH and NTUH participated in this study which reduced the sample size and indirectly affected the analysis of statistical significance. It may be the reason for the lack of statistically significant association between MRSA colonization and the common risk factors reported in previous studies such as low CD4 T-cell count and hospitalization within the past year [37]. Second, the presence of other unrecognized sites of colonization should be considered. In this study, nasal specimens for MRSA detection were obtained by swabbing both anterior nares. Patients might be colonized in the inguinal, genital or peri-rectal areas but not in the nasopharynx [11,37]. Other potential reasons for the disparity between the studies included the intermittent nature of colonization [10] and the difference in questionnaire design. Conclusions The prevalence of nasal MRSA colonization in HIV-infected patients seeking outpatient care was low (3.4%) in northern Taiwan. Most of the colonizing isolates were genetically endemic community strains and exhibited high susceptible to TMP-SMX and fluoroqinolones. Cancer and antibiotic use within one year were associated with MRSA colonization. Nasal MRSA carriage in HIV-infected patients seeking outpatient care was low (3.4%) in northern Taiwan. Declarations Ethics approval and consent to participate The study was approved by the institutional review board of Chang Gung Memorial Hospital and the Research Ethics Committee of National Taiwan University Hospital. A written informed consent was obtained from each subject. Consent to publish Not applicable. Availability of data and materials The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.". Competing interests The authors have no conflicts of interest relevant to this article to disclose. Funding The study was supported by a grant from the Ministry of Science and Technology, Executive Yuan, Taiwan (MOST 104-2815-C-182A-003B) and a grant from Medical Foundation in Memory of Dr. Deh-Lin Cheng. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Authors’ contribution YYH and DW: laboratory performance, acquisition of data, analysis and interpretation of data, drafting the manuscript CCH: acquisition of data, analysis and interpretation of data SSH, FHY, MHL, CTH, PYH, SSS, CCY, CWC, HSL, TSW: acquisition of data and interpretation of data, YCH: conception and design, analysis and interpretation of data, modifying and revising the manuscript All the authors read and approved the final manuscript. Acknowledgement The authors thank the research assistants, Ya-Lin Huang and Yu-Chiao Huang for excellent technical assistance. Abbreviations MRSA, methicillin-resistant Staphylococcus aureus ; MSSA, methicillin-sensitive Staphylococcus aureus ; CA, community-associated; PFGE, pulsed-field gel electrophoresis; MLST, multilocus sequence typing; ST, sequence type; PVL, Panton-Valentine leucocidin; ACME, arginine catabolic metabolic element; HIV, human immunodeficiency virus; HCV, hepatitis C virus; ICU, intensive care units References Jevons MP. “Celbenin”-resistant staphylococci. BMJ 1961; 1 :124-5. Chuang YY, Huang YC: Molecular epidemiology of community-associated meticillin-resistant Staphylococcus aureus in Asia. Lancet Infect Dis 2013; 13 : 698-708. David MZ, Daum RS. Community-associated methicillin-resistant Staphylococcus aureus: epidemiology and clinical consequences of an emerging epidemic. Clin Microbiol Rev 2010; 23 :616-87. 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Tables Table 1: Comparison of demographics and transmission vehicles between HIV-infected patients with and without methicillin-resistant Staphylococcus aureus (MRSA) nasal colonization Characteristic No. (%) of subjects P value Total (n=553) MRSA carriers (n=19) Non-MRSA carriers (n=534) Age in years, mean (SD) 41.2 (11.4) 43.8 (13.0) 41.1 (11.3) 0.296 Gender Male 531(96) 15(79) 516(97) 0.005* Female 22(4) 4(21) 18(3) Route of HIV transmission Injection drug use 90(16) 9(47) 81(15) 0.001* Heterosexual activity 62(11) 2(11) 61(11) 1.000 Male-to-male sex 375(68) 6(32) 369(69) 0.002* Blood transfusion 3(0.5) 0(0) 3(0.6) 1.000 Vertical transmission 1(0.2) 0(0) 1(0.2) 1.000 Unknown 36(6.5) 2(11) 34(6.4) 0.380 Facility 0.203 CGMH, Linko branch 111 (20.1) 3 (15.8) 108 (20.2) CGMH, Taipei branch 13 (2.4) 0 (0) 13 (2.4) CGMH, Keelung branch 117 (21.2) 8 (42.1) 109 (20.4) Keelung jail and prison 18 (3.3) 1 (5.3) 17 (3.2) NTUH 294 (53.2) 7 (36.8) 287 (53.8) Abbreviations: CGMH, Chang Gung Memorial Hospital; NTUH, National Taiwan University Hospital Table 2: Analysis of risk factors for nasal colonization with methicillin-resistant Staphylococcus aureus (MRSA) among HIV-infected Outpatients Characteristic No. (%) of subjects P value Total (n=553) MRSA carriers (n=19) Non-MRSA carriers (n=534) Personal history Smoking 290(52) 15(79) 275(51) 0.020* Alcohol Drinking 139(25) 6(32) 133(25) 0.590 Hospitalization after HIV diagnosis 269(49) 7(37) 262(49) 0.354 Recent hospitalization within one year 80(14) 5(26) 75(14) 0.174 Operation history 16(3) 0(0) 16(3) 1.000 Nurse home 3(0.6) 0(0) 3(0.6) 1.000 Underlying diseases Hypertension 59(11) 3(16) 56(10) 0.443 DM 21(4) 1(5) 20(4) 0.527 Arrhythmia history 10(2) 1(5) 9(2) 0.297 Angina history 7(1) 0(0) 7(1) 1.000 Pneumonia history 26(5) 1(5) 25(5) 0.606 COPD 6(1) 0(0) 6(1) 1.000 Asthma 12(2) 0(0) 12(2) 1.000 Tuberculosis 20(4) 1(5) 19(4) 0.509 HBV carrier 62(11) 2(11) 60(11) 1.000 HCV carrier 123(22) 10(53) 113(21) 0.003* Cirrhosis 3(0.5) 1(5) 2(0.4) 0.100 CKD 10(2) 1(5) 9(2) 0.297 Cancer 27(5) 5(26) 22(4) 0.001* Recent infectious diseases (within 3 months) Recent URI 62(11) 2(11) 60(11) 1.000 Skin infection 29(5) 1(5) 28(5) 1.000 Unhealed wound 16(3) 1(5) 15(3) 0.433 UTI 6(1) 0(0) 6(1) 1.000 Recent treatment (in 3 months) On all catheters 10(2) 1(5) 9(2) 0.297 Hemodialysis 2(0.3) 1(5) 1(0.2) 0.068 Antibiotic use in 1 year 88(16) 7(37) 81(15) 0.020* Laboratory data CD4 count (cells/uL), mean + SD 469.16 + 214.8 540.61+292.3 0.292 Plasma HIV RNA load (Log 10 of copies/ml), mean + SD 1.341 + 2.055 0.929 + 1.660 0.293 Abbreviations: DM, diabetes mellitus; COPD, chronic obstructive pulmonary disease; HBV, hepatitis B virus; HCV, hepatitis C virus; CKD, chronic kidney disease; URI, upper respiratory infection; SD, standard deviation Table 3. Multivariate analysis of factors associated with nasal colonization of MRSA in HIV carriers in Taiwan. Factor Adjust odds ratio 95% confidence interval P value Female Gender 2.910 0.690 – 12.276 0.1459 Injection drug user 1.189 0.207 – 6.837 0.8464 Male-to-male sex 0.241 0.055 – 1.050 0.0581 Smoking 2.004 0.581 – 6.911 0.2713 HCV carrier 2.233 0.504 – 9.885 0.2899 Cancer 7.782 1.909 – 31.731 0.0042 Antibiotic use within the past one year 3.892 1.219 – 12.433 0.0218 Abbreviations: HCV, hepatitis C virus Cite Share Download PDF Status: Published Journal Publication published 30 Mar, 2020 Read the published version in BMC Infectious Diseases → Version 3 posted Submission checks completed at journal 16 Mar, 2020 Editorial decision: Accept 16 Mar, 2020 You are reading this latest preprint version Show more versions Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-9582","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research article","associatedPublications":[],"authors":[{"id":415868,"identity":"cdae4af9-b1f5-44ef-93d2-d9189ce4f1dd","order_by":1,"name":"Yi-Yu Hsu","email":"","orcid":"","institution":"Mackay Memorial Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Yi-Yu","middleName":"","lastName":"Hsu","suffix":""},{"id":415869,"identity":"eba77cb0-3c58-4407-a42f-5284d2434470","order_by":2,"name":"David Wu","email":"","orcid":"","institution":"Cathay General 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Huang","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA2klEQVRIiWNgGAWjYFACHjApB8RspGkxRmghrBOiJbGBaC0Gx88ek/i5oza9v3912gOGint2DfI9Bvi1nMlLk+w9czx3xo232w0YzhQnN7DxENByg8dMgrftWO4GibPbJBjbEpIZ2Hg3ENQi+bftWLoBSVqkedtqEgz4e8Fa7AhqkTyTY2wt23bAcMYN3m0SCWcSEtjY8j/g1cJ3/IzhzbdtdfL8/UCHfahIsOdnPpaAV4vCATB1mIFBAqgQiBLb8KoHAvkGMFXHwMAP0WxPSMcoGAWjYBSMPAAAeTtFbh66bpUAAAAASUVORK5CYII=","orcid":"","institution":"Taoyuan Chang Gung Memorial Hospital","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Yhu-Chering","middleName":"","lastName":"Huang","suffix":""}],"badges":[],"createdAt":"2019-12-12 14:23:18","currentVersionCode":3,"declarations":"","doi":"10.21203/rs.2.18964/v3","doiUrl":"https://doi.org/10.21203/rs.2.18964/v3","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1186/s12879-020-04979-8","type":"published","date":"2020-03-30T18:25:40+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":674413,"identity":"db89a9e1-575c-4a1c-971c-46209ec95f9b","added_by":"auto","created_at":"2020-03-19 18:27:06","extension":"jpg","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":329826,"visible":true,"origin":"","legend":"Molecular characteristics of methicillin-resistant Staphylococcus aureus isolates from 19 HIV-infected patients. All 19 isolates were resistant to penicillin, and susceptible to vancomycin, teicoplanin, linezolid, and doxycycline. Antimicrobial susceptibility tests (AST): black indicates resistance, and grey indicates susceptibility. Abbreviations are as follows: ciprofloxacin (CIP), erythromycin (E), fusidic acid (FA), clindamycin (CC), trimethoprim-sulfamethoxazole (SXT). PFGE, pulsed-field gel electrophoresis. PVL: black indicates that Pantone-Valentine leucocidin genes were detected. SCCmec, staphylococcal cassette chromosome mec; MLST, multilocus sequence typing. Spa types t2365, t3385 and t3485 are variants of t437, while t2849 is the variant of t008.","description":"","filename":"figure1.jpg","url":"https://assets-eu.researchsquare.com/files/rs-9582/v3/figure 1.jpg"},{"id":15666456,"identity":"b735fad6-8f9c-4593-b80d-c8d133c949c2","added_by":"auto","created_at":"2021-11-18 13:36:58","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":471334,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-9582/v3/45474ff8-b38d-43ae-bdf1-88841b43420c.pdf"}],"financialInterests":"","formattedTitle":"\u003cp\u003eMethicillin-resistant \u003cem\u003eStaphylococcus aureus\u003c/em\u003e nasal colonization among HIV-infected patients in Taiwan: prevalence, molecular characteristics and associated factors with nasal carriage\u003c/p\u003e","fulltext":[{"header":"Background","content":"\u003cp\u003eMethicillin-resistant \u003cem\u003eStaphylococcus aureus\u003c/em\u003e (MRSA) was first reported in the 1960s [1] and the infections due to MRSA rapidly increased in the 1980s [2-4], most of which were health care-acquired infections. In the late 1990s, MRSA began to be recognized as a major cause of community-onset infections, which was termed as community-associated MRSA (CA-MRSA) later [2-4]. The epidemic of CA-MRSA has spread rapidly both in the community [2-4] and in healthcare settings over the past decade. Carriage of\u0026nbsp;\u003cem\u003eS. aureus\u003c/em\u003e, including MRSA, has been identified as a predisposing factor for subsequent invasive infections [5, 6], and the anterior nares are the most common site of colonization.\u003c/p\u003e\n\u003cp\u003eAmong human immunodeficiency virus (HIV)-infected patients, \u003cem\u003eS. aureus \u003c/em\u003einfection is considered to be a major cause of significant morbidity and mortality [7-9]. Previous studies suggest that prevalence of nasal colonization with MRSA is higher in HIV-infected individuals than in the general population [10-12]. HIV infection is also related to persistent colonization [13]. The higher colonization burden may be associated with a higher incidence of subsequent infections [10, 11, 14]. However, risk factors for \u003cem\u003eS. aureus \u003c/em\u003ecolonization appear to be different among different populations, including patients infected with HIV [11, 15-17]. MRSA colonization in HIV-infected patients may vary widely in different geographical regions [15, 18-21], the time point of survey [14], and the coverage of antiretroviral therapy in the population [22].\u003c/p\u003e\n\u003cp\u003eMRSA has been a prevalent etiology of infections in Asian countries, including Taiwan, either in healthcare settings or in the community, for decades, but the reports regarding MRSA colonization in HIV-infected population have been scarce [12,15, 23]. Hence, we conducted this study to evaluate the prevalence of and associated factors for MRSA colonization in HIV-infected population in Taiwan. All collected MRSA isolates were further characterized by molecular methods and antibiotic susceptibility.\u003c/p\u003e"},{"header":"Methods","content":"\u003cp\u003eThe study was approved by the institutional review board (IRB) of Chang Gung Memorial Hospital (protocol number:103-2418A3) and the Research Ethics Committee of National Taiwan University Hospital. A written informed consent was obtained from each subject.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eSubject Enrollment\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe study was conducted in hospital-based infectious diseases outpatient clinics at Chang Gung Memorial Hospital (CGMH) and National Taiwan University Hospital (NTUH) from September 2014 to November 2015. Both CGMH and NTUH are university-affiliated medical centers situated in northern Taiwan. Data were obtained in multiple CGMH branches, including Linkou branch,\u0026nbsp;Taipei branch and Keelung branch. We also recruited patients from prison and correctional facilities in Keelung, where inmates were regularly followed by infectious diseases specialists in CGMH Keelung branch. All the HIV-infected patients who visited and treated at CGMH and NTUH were eligible and invited to participate in this study. Study subjects were enrolled when they sought HIV care at the infectious diseases outpatient departments.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eData collection\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eTo identify the associated factors with MRSA acquisition, a self-administered questionnaire interview was performed to inquire into the factors for colonization with MRSA in HIV-infected patients. The following information was also collected from medical records of the participants: age, gender, drinking habits and smoking habits, underlying diseases, clinical characteristics, latest hospitalization, community exposure (eg, drug use, and incarceration), previous \u003cem\u003eS. aureus\u003c/em\u003e infection, antibiotic use, skin disease, plasma HIV RNA load and CD4＋T lymphocytes, and antiretroviral therapy. Clinical information regarding hospitalization, residence in a long-term care facility, outpatient department visit, surgery, dialysis, and usage of tubes (nasogastric tube, urine catheter, tracheostomy tube, drainage tube, port-A, and dialysis tube) were also obtained. Substance abuse was defined as current or former use if illicit drugs.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMicrobiologic \u003c/strong\u003e\u003cstrong\u003estudy\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNasal specimens were obtained by swabbing the anterior 1 cm of the nasal vestibule of both anterior nares of the participants. The swabs were preserved in the transport medium (Venturi Transystem, Copan Innovation Ltd.) immediately. \u003cem\u003eS. aureus\u003c/em\u003e was identified by colony morphology, Gram stain, positive coagulase tests, and presence of \u0026beta;-hemolysis after subculture to tryptic soy agar plates containing 5% sheep\u0026rsquo;s blood. Methicillin resistance was confirmed by cefoxitin disk-diffusion method according to the recommendation of Clinical and Laboratory Standard Institutes [24].\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAntimicrobial susceptibility study\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe antimicrobial susceptibility of all MRSA isolates to ten antibiotics, including ciprofloxacin, trimethoprim/sulfamethoxazole (SXT), penicillin, teicoplanin, linezolid, clindamycin, doxycyclin, fusidic acid, vancomycin, and erythromycin, was tested in accordance with the guideline of Clinical and Laboratory Standard Institutes by using the disk-diffusion method [24].\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMolecular characterization\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAll the MRSA isolates, once identified, were characterized by molecular methods. By pulsed-field gel electrophoresis (PFGE) with \u003cem\u003eSma\u003c/em\u003eI digestion [25-27], the genotypes were designated in alphabetical order, as in our previous studies [25-27]; any new genotype, if identified, was designated consecutively. PFGE patterns with fewer than four band differences from an existing genotype were defined as subtypes of that genotype. Staphylococcal chromosome cassette mec (SCC\u003cem\u003emec\u003c/em\u003e) type, and the presence of Panton-Valentine leukocidin (PVL) genes were determined by a multiplex PCR strategy [28]. Some isolates of representative PFGE patterns were selected and underwent multilocus sequence typing (MLST) [29] and \u003cem\u003espa\u003c/em\u003e typing [27]. The allelic profiles were assigned through comparison of the sequences at each locus with those of the known alleles in the\u0026nbsp;\u003cem\u003eS. aureus\u003c/em\u003e\u0026nbsp;MLST database and were defined as sequence types accordingly. The details of the procedures were described elsewhere previously [25-29].\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eStatistical Analysis\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eStatistical analyses were performed with the Statistical Package for the Social Sciences (SPSS software for Windows, version 17.0). The definition of statistical significance was p \u0026lt;0.05. Chi-square analysis or Fisher\u0026rsquo;s exact test was used for examination of categorical variables. Continuous variables were compared between patients with MRSA colonization versus patients without MRSA colonization using two-sample t-test, in which Levene's test was used to determine equality of variances between the two groups.\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003eDuring the 14-month study period, a total of 810 HIV-infected patients sought outpatient care at CGMH and NTUH (446 from CGMH and 364 from NTUH). Of the 810 eligible patients, 586 patients (275 from CGMH and 311 from NTUH) were interviewed and invited to participate in this study. 553 patients (259 from CGMH and 294 from NTUH) were enrolled in total and were surveyed for nasal carriage of MRSA after giving their written informed consent.\u003c/p\u003e\n\u003cp\u003eDetailed demographic data are shown in Table 1. 531 were male (96%) and 22 female (4%). The majority of the participants were aged 20-60 years (with 47.6% between 20-39 years, and 45.6% between 40-60 years). The main route of HIV acquisition was male-to-male sex contact (68.0%), followed by injection drug use (16.3%). Table 1 shows the comparison among different hospitals and no statistically significant difference was found among different hospitals in terms of nasal MRSA carriage rate among the HIV-infected patients.\u003c/p\u003e\n\u003cp\u003eThe overall MSSA and MRSA nasal colonization rate was 21.5% and 3.4%, respectively. The comparison of underlying diseases and other medical history between patients with and without MRSA colonization are shown in Tables 2 and 3. In univariate analysis, we found that female gender (p=0.005), injection drug use (p=0.001), smoking (p=0.02), hepatitis C virus (HCV) carrier (p=0.003),\u0026nbsp;cancer (p=0.001)\u0026nbsp;and antibiotic use\u0026nbsp;within one year (p=0.02) were significant factors associated with MRSA colonization. CD4 + T lymphocytes or plasma HIV RNA load was not significantly associated with MRSA colonization. By multivariate analysis, cancer (adjust odds ratio (aOR) 7.78, [95% confidence interval (CI), 1.909-31.731])\u0026nbsp;and antibiotic use within one year (aOR 3.89, [95% CI, 1.219-12.433]) were significantly associated with MRSA colonization.\u003c/p\u003e\n\u003cp\u003eAll 19 MRSA isolates were available for molecular characterization and the distribution of PFGE patterns, SCC\u003cem\u003emec\u003c/em\u003e\u0026nbsp;types, SPA typing, and the presence of PVL genes among the 19 MRSA isolates are shown in\u0026nbsp;Figure1. MLST was selectively done in eleven isolates, and five sequence types were identified. Totally six PFGE patterns were identified. One isolate carried SCC\u003cem\u003emec\u003c/em\u003e type IIIA and the remaining isolates carried either SCC\u003cem\u003em\u003c/em\u003e\u003cem\u003eec\u003c/em\u003e type IV or VT. PFGE pattern D/ sequence type (ST) 59 was the relatively common clone, followed by PFGE pattern C/ST 59 and PFGE pattern AI/ST 8. PVL is one of the most important\u0026nbsp;virulence factors\u0026nbsp;of S. \u003cem\u003eaureus\u003c/em\u003e and PVL genes were present in 9 isolates (47%). PVL genes were present in all isolates with PFGE pattern AI/ST 8 and most isolates with PFGE pattern D/ST 59/SCC\u003cem\u003emec\u003c/em\u003e V\u003csub\u003eT\u003c/sub\u003e, but absent in isolates with PFGE pattern AG4/ST 30 and C/ST 59/SCC\u003cem\u003emec\u003c/em\u003e IV.\u003c/p\u003e\n\u003cp\u003eAll the MRSA strains were resistant to penicillin and susceptible to linezolid, teicoplanin, doxycycline, and vancomycin. The susceptibility rates to erythromycin, clindamycin, ciprofloxacin, trimethoprim-sulfamethoxazole (TMP-SMX), and fusidic acid were 15.8%, 42.1%, 84.20%, 94.7%, and 89.5%, respectively.\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eTo our knowledge, this is the largest study on this issue in Asian countries [15]. In this cross-section survey among 553 HIV-infected patients seeking care at the outpatient clinics in four hospitals in northern Taiwan, we found that the overall prevalence of MRSA nasal carriage among the HIV-infected individual was 3.4% while the prevalence of MSSA nasal carriage was 21.5%. The nasal carriage of MRSA was associated with cancer and antibiotic exposure within the past 12 months.\u003c/p\u003e\n\u003cp\u003eThe nasal carriage rate of MRSA in this study is slightly lower than that previously reported in Taiwan in 2003 (5.6% of 296 HIV-infected patients) [12] and in 2009-2010 (4.4% of 457 HIV-infected patients) [23]. Compared with other populations in Taiwan, the nasal MRSA carriage rate among HIV-infected patients was significantly lower than that for patients hospitalized in the intensive care units (ICU) (32% of 177 patients) [30], but similar to that for adult patients receiving hemodialysis (3.8% of 296 patients) [31], adult patients visiting emergency room (3.8% of 502 patients) [32] and otherwise healthy adults for health examination (3.8% of 3098 adults) [33]. It could be explained that in the era of highly active antiretroviral therapy (HAART), the majority of the HIV-infected patients recruited in this study came from community settings, outpatient visiting and these patients were not frequently exposed to the high-risk populations for MRSA acquisition, such as patients admitted to the ICUs.\u003c/p\u003e\n\u003cp\u003eFor patients infected with HIV, the nasal MRSA carriage rate was different, with a huge discrepancy, in different countries and regions. A latest meta-analysis on this issue [15] showed that the estimated pooled worldwide prevalence of MRSA in HIV-infected people is around 7% (5%-9%), with the prevalence of 7%-13% in the region of the Americas and 0-1% in the European region. Compared with other Asian countries, the prevalence rate (3.4%) in this study was lower than that in India (6%-26%), as well as in Singapore (3%-10%) but higher than that in Malaysia (\u0026lt;1%). This variation may be attributable to different prevailing MRSA clones, study population, the intermittent nature of colonization [10] and different culture of antibiotic use between countries [34].\u003c/p\u003e\n\u003cp\u003eWe observed that MRSA colonization was associated with antibiotic use within 12 months among HIV-infected individuals. This finding supported previous observations that recent receipt of antibiotics was strongly associated with MRSA colonization [12]. Wang et al found that smoking was a protective factor against MRSA colonization in the community setting [33], which was not confirmed in this study. The potential reasons for the disparity might be the difference in questionnaire design. A latest meta-analysis on this issue [15] indicated that the risk factors for MRSA colonization included having a previous MRSA infection, hospitalization in the past year and use of antibiotics in the past six months.\u003c/p\u003e\n\u003cp\u003eMolecular characterization of MRSA isolates in the present study showed that 10 (52.6%) of the 19 isolates belonged to ST59 linage, the predominant community-associated MRSA strain in Taiwan. One isolate was characterized by ST239-SCC\u003cem\u003emec\u003c/em\u003e IIIA which had been known as the most dominant healthcare-associated MRSA clone in Taiwan [4]. The patient with the isolate of ST239 did have a medical history of recent hospitalization within the past year and had been admitted four times after being diagnosed with HIV. The remaining eight isolates carried type IV SCC\u003cem\u003emec\u003c/em\u003e. Among these eight isolates, four of them were identified and confirmed as USA 300 later [35], the predominant community-associated MRSA strain in the United States, on the basis of their being sequence type 8 by multilocus sequence typing (MLST), detection of arginine catabolic metabolic element (ACME) gene and harboring SCC\u003cem\u003emec\u003c/em\u003e type IV and genes for PVL. Three of them were characterized by ST30-SCC\u003cem\u003emec\u003c/em\u003e IV strains, known as the Southwest Pacific clone [2,4]. One isolate characterized as sequence type 45 which had been identified as the predominate strain in nursing homes in Taiwan [36]. In this study, USA300 (ST8) accounted for four isolates and was a second most common clone. All four isolates were from NTUH. This is an emergent issue in Taiwan [35], which needs further surveillance and observation.\u003c/p\u003e\n\u003cp\u003eThere were several limitations to the current study. First, less than 70% of the HIV-infected patients visiting CGMH and NTUH participated in this study which reduced the sample size and indirectly affected the analysis of statistical significance. It may be the reason for the lack of statistically significant association between MRSA colonization and the common risk factors reported in previous studies such as low CD4 T-cell count and hospitalization within the past year [37]. Second, the presence of other unrecognized sites of colonization should be considered. In this study, nasal specimens for MRSA detection were obtained by swabbing both anterior nares. Patients might be colonized in the inguinal, genital or peri-rectal areas but not in the nasopharynx [11,37]. Other potential reasons for the disparity between the studies included the intermittent nature of colonization [10] and the difference in questionnaire design.\u003c/p\u003e"},{"header":"Conclusions","content":"\u003cp\u003eThe prevalence of nasal MRSA colonization in HIV-infected patients seeking outpatient care was low (3.4%) in northern Taiwan. Most of the colonizing isolates were genetically endemic\u0026nbsp;community strains and exhibited high susceptible to TMP-SMX and fluoroqinolones. Cancer and antibiotic use within one year were associated with MRSA colonization. Nasal MRSA carriage in HIV-infected patients seeking outpatient care was low (3.4%) in northern Taiwan.\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eEthics approval and consent to participate\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe study was approved by the institutional review board of Chang Gung Memorial Hospital and the Research Ethics Committee of National Taiwan University Hospital. A written informed consent was obtained from each subject.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent to publish\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAvailability of data and materials\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.\".\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting interests\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;The authors have no conflicts of interest relevant to this article to disclose.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe study was supported by a grant from the Ministry of Science and Technology, Executive Yuan, Taiwan (MOST 104-2815-C-182A-003B) and a grant from Medical Foundation in Memory of Dr. Deh-Lin Cheng. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthors\u0026rsquo; contribution\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eYYH and DW: laboratory performance, acquisition of data, analysis and interpretation of data, drafting the manuscript\u003c/p\u003e\n\u003cp\u003eCCH: acquisition of data, analysis and interpretation of data\u003c/p\u003e\n\u003cp\u003eSSH, FHY, MHL, CTH, PYH, SSS, CCY, CWC, HSL, TSW: acquisition of data and interpretation of data,\u003c/p\u003e\n\u003cp\u003eYCH: conception and design, analysis and interpretation of data, modifying and revising the manuscript\u003c/p\u003e\n\u003cp\u003eAll the authors read and approved the final manuscript.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAcknowledgement\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors thank the research assistants, Ya-Lin Huang and Yu-Chiao Huang for excellent technical assistance.\u003c/p\u003e"},{"header":"Abbreviations","content":"\u003cp\u003eMRSA, methicillin-resistant \u003cem\u003eStaphylococcus aureus\u003c/em\u003e; MSSA, methicillin-sensitive \u003cem\u003eStaphylococcus aureus\u003c/em\u003e; CA, community-associated; PFGE, pulsed-field gel electrophoresis; MLST, multilocus sequence typing; ST, sequence type; PVL, Panton-Valentine leucocidin; ACME, arginine catabolic metabolic element; HIV, human immunodeficiency virus; HCV, hepatitis C virus; ICU, intensive care units\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eJevons MP. \u0026ldquo;Celbenin\u0026rdquo;-resistant staphylococci. \u003cem\u003eBMJ\u003c/em\u003e 1961; \u003cstrong\u003e1\u003c/strong\u003e:124-5.\u003c/li\u003e\n\u003cli\u003eChuang YY, Huang YC: Molecular epidemiology of community-associated meticillin-resistant \u003cem\u003eStaphylococcus aureus \u003c/em\u003ein Asia. \u003cem\u003eLancet Infect Dis\u003c/em\u003e 2013; \u003cstrong\u003e13\u003c/strong\u003e: 698-708.\u003c/li\u003e\n\u003cli\u003eDavid MZ, Daum RS. 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Prevalence of and risk factors for methicillin-resistant \u003cem\u003eStaphylococcus aureus\u003c/em\u003e colonization in HIV infection: a meta-analysis. Clin Infect Dis 2014; \u003cstrong\u003e59\u003c/strong\u003e: 1302-11.\u003c/li\u003e\n\u003c/ol\u003e"},{"header":"Tables","content":"\u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:200%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"line-height: 200%; font-family: \u0026quot;Times New Roman\u0026quot;, serif; color: rgb(0, 0, 0);\"\u003eTable 1: Comparison of demographics and transmission vehicles between HIV-infected patients with and without methicillin-resistant\u0026nbsp;\u003c/span\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"line-height: 200%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003eStaphylococcus aureus\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"line-height: 200%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e\u0026nbsp;(MRSA)\u0026nbsp;nasal\u0026nbsp;colonization\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cdiv align=\"center\" style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:justify;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\n \u003ctable border=\"0\" cellpadding=\"0\" cellspacing=\"0\" style=\"width:410.75pt;border-collapse:collapse;border:none;\" width=\"548\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 141.75pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"34.48905109489051%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eCharacteristic\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 212.65pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"51.824817518248175%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eNo. (%) of subjects\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 56.35pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.686131386861314%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eP value\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 63.8pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"30.035335689045937%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eTotal (n=553)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"30.035335689045937%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eMRSA carriers (n=19)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"39.92932862190813%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eNon-MRSA carriers (n=534)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 141.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"34.552102376599635%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eAge in years, mean (SD)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"15.539305301645339%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e41.2 (11.4)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"15.539305301645339%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e43.8 (13.0)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"20.6581352833638%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e41.1 (11.3)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.35pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.711151736745887%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.296\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 141.75pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"34.48905109489051%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eGender\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width: 269pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"65.51094890510949%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:141.75pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"34.552102376599635%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;text-indent:11.35pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eMale\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"15.539305301645339%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e531(96)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"15.539305301645339%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e15(79)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:85.05pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"20.6581352833638%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e516(97)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:56.35pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"13.711151736745887%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.005*\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:141.75pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"40.04237288135593%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;text-indent:11.35pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eFemale\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"18.008474576271187%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e22(4)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"18.008474576271187%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e4(21)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:85.05pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"23.940677966101696%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e18(3)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"5\" style=\"width:410.75pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"100%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eRoute of HIV transmission\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:141.75pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"34.552102376599635%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;text-indent:11.35pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eInjection drug use\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"15.539305301645339%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e90(16)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"15.539305301645339%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e9(47)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:85.05pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"20.6581352833638%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e81(15)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.35pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"13.711151736745887%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.001*\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:141.75pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"34.552102376599635%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;text-indent:11.35pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eHeterosexual activity\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"15.539305301645339%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e62(11)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"15.539305301645339%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e2(11)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:85.05pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"20.6581352833638%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e61(11)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.35pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"13.711151736745887%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e1.000\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:141.75pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"34.552102376599635%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;text-indent:11.35pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eMale-to-male sex\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"15.539305301645339%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e375(68)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"15.539305301645339%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e6(32)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:85.05pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"20.6581352833638%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e369(69)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.35pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"13.711151736745887%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.002*\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:141.75pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"34.552102376599635%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;text-indent:11.35pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eBlood transfusion\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"15.539305301645339%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e3(0.5)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"15.539305301645339%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e0(0)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:85.05pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"20.6581352833638%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e3(0.6)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.35pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"13.711151736745887%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e1.000\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:141.75pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"34.552102376599635%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;text-indent:11.35pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eVertical transmission\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"15.539305301645339%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e1(0.2)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"15.539305301645339%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e0(0)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:85.05pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"20.6581352833638%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e1(0.2)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.35pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"13.711151736745887%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e1.000\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:141.75pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"34.552102376599635%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;text-indent:11.35pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eUnknown\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"15.539305301645339%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e36(6.5)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"15.539305301645339%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e2(11)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:85.05pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"20.6581352833638%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e34(6.4)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.35pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"13.711151736745887%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.380\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:141.75pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"34.552102376599635%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eFacility\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"15.539305301645339%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"15.539305301645339%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:85.05pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"20.6581352833638%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.35pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"13.711151736745887%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.203\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:141.75pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"34.552102376599635%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;text-indent:11.35pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eCGMH, Linko branch\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"15.539305301645339%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e111 (20.1)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"15.539305301645339%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e3 (15.8)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:85.05pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"20.6581352833638%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e108 (20.2)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.35pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"13.711151736745887%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:141.75pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"34.552102376599635%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;text-indent:11.35pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eCGMH, Taipei branch\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"15.539305301645339%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e13 (2.4)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"15.539305301645339%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0 (0)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:85.05pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"20.6581352833638%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e13 (2.4)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.35pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"13.711151736745887%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:141.75pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"34.552102376599635%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;text-indent:11.35pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eCGMH, Keelung branch\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"15.539305301645339%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e117 (21.2)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"15.539305301645339%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e8 (42.1)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:85.05pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"20.6581352833638%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e109 (20.4)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.35pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"13.711151736745887%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:141.75pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"34.552102376599635%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;text-indent:11.35pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eKeelung jail and prison\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"15.539305301645339%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e18 (3.3)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"15.539305301645339%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e1 (5.3)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:85.05pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"20.6581352833638%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e17 (3.2)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.35pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"13.711151736745887%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:141.75pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"34.552102376599635%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;text-indent:11.35pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eNTUH\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"15.539305301645339%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e294 (53.2)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"15.539305301645339%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e7 (36.8)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:85.05pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"20.6581352833638%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e287 (53.8)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.35pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"13.711151736745887%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003c/table\u003e\n\u003c/div\u003e\n\u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003eAbbreviations:\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;CGMH, Chang Gung Memorial Hospital; NTUH, National Taiwan University Hospital\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\n \u003cbr\u003e\n\u003c/p\u003e\n\u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\n \u003cbr\u003e\u0026nbsp;\n \u003c/span\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003eTable 2: Analysis of risk factors for nasal colonization with methicillin-resistant Staphylococcus aureus (MRSA) among HIV-infected Outpatients\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable border=\"0\" cellpadding=\"0\" cellspacing=\"0\" style=\"width:426.1pt;border-collapse:collapse;border:none;\" width=\"568\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 127.45pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"29.876977152899823%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:12.0pt;margin-left:0in;text-align:left;line-height:13.0pt;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eCharacteristic\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 251.7pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"59.05096660808436%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eNo. (%) of subjects\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 46.95pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"11.072056239015817%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eP value\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 93.15pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"37.014925373134325%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eTotal (n=553)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.6pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"30.746268656716417%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eMRSA carriers (n=19)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 80.95pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"32.23880597014925%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eNon-MRSA \u0026nbsp;carriers (n=534)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"5\" style=\"width: 426.1pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"100%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003ePersonal history\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:127.45pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"29.929577464788732%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eSmoking\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:93.15pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"21.830985915492956%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e290(52)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.6pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"18.133802816901408%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e15(79)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"19.014084507042252%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e275(51)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"11.091549295774648%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.020*\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:127.45pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"29.929577464788732%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eAlcohol Drinking\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:93.15pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"21.830985915492956%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e139(25)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.6pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.133802816901408%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e6(32)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"19.014084507042252%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e133(25)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"11.091549295774648%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.590\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:127.45pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"29.929577464788732%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eHospitalization \n \u003cbr\u003e\u0026nbsp;after HIV diagnosis\n \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:93.15pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"21.830985915492956%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e269(49)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.6pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"18.133802816901408%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e7(37)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"19.014084507042252%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e262(49)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"11.091549295774648%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.354\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:127.45pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"29.929577464788732%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eRecent hospitalization within one year\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:93.15pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"21.830985915492956%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e80(14)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.6pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"18.133802816901408%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e5(26)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"19.014084507042252%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e75(14)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"11.091549295774648%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.174\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:127.45pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"29.929577464788732%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eOperation history\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:93.15pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"21.830985915492956%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e16(3)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.6pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.133802816901408%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e0(0)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"19.014084507042252%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e16(3)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"11.091549295774648%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e1.000\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:127.45pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"29.929577464788732%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eNurse home\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:93.15pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"21.830985915492956%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e3(0.6)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.6pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.133802816901408%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e0(0)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"19.014084507042252%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e3(0.6)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"11.091549295774648%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e1.000\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"5\" style=\"width:426.1pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"100%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003eUnderlying diseases\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:127.45pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"29.929577464788732%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eHypertension\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:93.15pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"21.830985915492956%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e59(11)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.6pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.133802816901408%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e3(16)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"19.014084507042252%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e56(10)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"11.091549295774648%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.443\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:127.45pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"29.929577464788732%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eDM\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:93.15pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"21.830985915492956%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e21(4)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.6pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.133802816901408%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e1(5)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"19.014084507042252%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e20(4)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"11.091549295774648%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.527\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:127.45pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"29.929577464788732%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003eArrhythmia history\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:93.15pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"21.830985915492956%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e10(2)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.6pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.133802816901408%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e1(5)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"19.014084507042252%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e9(2)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"11.091549295774648%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e0.297\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:127.45pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"29.929577464788732%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003eAngina history\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:93.15pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"21.830985915492956%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e7(1)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.6pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.133802816901408%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e0(0)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"19.014084507042252%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e7(1)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"11.091549295774648%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e1.000\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:127.45pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"29.929577464788732%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003ePneumonia history\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:93.15pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"21.830985915492956%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e26(5)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.6pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"18.133802816901408%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e1(5)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"19.014084507042252%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e25(5)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"11.091549295774648%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e0.606\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:127.45pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"29.929577464788732%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003eCOPD\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:93.15pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"21.830985915492956%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e6(1)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.6pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.133802816901408%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e0(0)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"19.014084507042252%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e6(1)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"11.091549295774648%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: 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rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e12(2)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.6pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.133802816901408%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e0(0)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"19.014084507042252%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e12(2)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"11.091549295774648%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e1.000\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:127.45pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"29.929577464788732%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003eTuberculosis\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:93.15pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"21.830985915492956%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e20(4)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.6pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.133802816901408%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e1(5)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"19.014084507042252%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e19(4)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"11.091549295774648%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e0.509\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:127.45pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"29.929577464788732%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003eHBV carrier\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:93.15pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"21.830985915492956%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e62(11)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.6pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.133802816901408%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e2(11)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"19.014084507042252%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e60(11)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"11.091549295774648%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e1.000\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:127.45pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"29.929577464788732%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003eHCV carrier\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n 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serif;\"\u003e10(53)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"19.014084507042252%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e113(21)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"11.091549295774648%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e0.003*\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:127.45pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"29.929577464788732%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003eCirrhosis\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:93.15pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"21.830985915492956%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e3(0.5)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.6pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.133802816901408%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e1(5)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"19.014084507042252%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e2(0.4)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"11.091549295774648%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e0.100\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:127.45pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"29.929577464788732%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003eCKD\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:93.15pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"21.830985915492956%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e10(2)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.6pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"18.133802816901408%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e1(5)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"19.014084507042252%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e9(2)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"11.091549295774648%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e0.297\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:127.45pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"29.929577464788732%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003eCancer\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:93.15pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"21.830985915492956%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e27(5)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.6pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"18.133802816901408%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e5(26)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"19.014084507042252%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e22(4)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"11.091549295774648%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e0.001*\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"5\" style=\"width:426.1pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"100%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003eRecent infectious diseases (within 3 months)\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:127.45pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"29.929577464788732%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eRecent URI\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:93.15pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"21.830985915492956%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e62(11)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.6pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"18.133802816901408%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e2(11)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"19.014084507042252%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e60(11)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"11.091549295774648%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e1.000\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:127.45pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"29.929577464788732%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eSkin infection\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:93.15pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"21.830985915492956%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e29(5)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.6pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"18.133802816901408%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e1(5)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"19.014084507042252%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e28(5)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"11.091549295774648%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e1.000\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:127.45pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"29.929577464788732%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eUnhealed wound\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:93.15pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"21.830985915492956%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e16(3)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.6pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"18.133802816901408%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e1(5)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"19.014084507042252%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e15(3)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"11.091549295774648%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.433\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:127.45pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"29.929577464788732%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003eUTI\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:93.15pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"21.830985915492956%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e6(1)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.6pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.133802816901408%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e0(0)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"19.014084507042252%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e6(1)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"11.091549295774648%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e1.000\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"5\" style=\"width:426.1pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"100%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003eRecent treatment (in 3 months)\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:127.45pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"29.929577464788732%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eOn all catheters\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:93.15pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"21.830985915492956%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e10(2)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.6pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.133802816901408%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e1(5)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"19.014084507042252%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e9(2)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"11.091549295774648%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.297\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:127.45pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"29.929577464788732%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eHemodialysis\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:93.15pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"21.830985915492956%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e2(0.3)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.6pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"18.133802816901408%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e1(5)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"19.014084507042252%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003e1(0.2)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"11.091549295774648%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.068\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:127.45pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"29.929577464788732%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eAntibiotic use in 1 year\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:93.15pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"21.830985915492956%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e88(16)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.6pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"18.133802816901408%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e7(37)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"19.014084507042252%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e81(15)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"11.091549295774648%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.020*\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"5\" style=\"width: 426.1pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"100%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height:105%;font-family: \u0026quot;Times New Roman\u0026quot;,serif;\"\u003eLaboratory data\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 127.45pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"29.929577464788732%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eCD4 count (cells/uL), mean \u003cu\u003e+\u003c/u\u003e SD\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:93.15pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"21.830985915492956%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height:105%;font-family: \u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.6pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"18.133802816901408%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e469.16\u003cu\u003e+\u003c/u\u003e214.8\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"19.014084507042252%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e540.61+292.3\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.95pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"11.091549295774648%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.292\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 127.45pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 28.7pt;vertical-align: top;\" valign=\"top\" width=\"29.929577464788732%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003ePlasma HIV RNA load (Log\u003csub\u003e10\u0026nbsp;\u003c/sub\u003eof copies/ml), mean \u003cu\u003e+\u003c/u\u003e SD\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:93.15pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:28.7pt;\" width=\"21.830985915492956%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height:105%;font-family: \u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.6pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:28.7pt;\" width=\"18.133802816901408%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e1.341\u003cu\u003e+\u003c/u\u003e2.055\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.95pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:28.7pt;\" width=\"19.014084507042252%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.929\u003cu\u003e+\u003c/u\u003e1.660\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.95pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 28.7pt;vertical-align: top;\" valign=\"top\" width=\"11.091549295774648%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.293\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif;\"\u003eAbbreviations:\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;DM, diabetes mellitus; COPD, chronic obstructive pulmonary disease; HBV, hepatitis B virus; HCV, hepatitis C virus; CKD, chronic kidney disease; URI, upper respiratory infection; SD, standard deviation\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:16px;line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\n \u003cbr\u003e\u0026nbsp;\n \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:justify;line-height:200%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eTable 3. Multivariate analysis of factors associated with nasal colonization of MRSA in HIV carriers in Taiwan.\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable border=\"0\" cellpadding=\"0\" cellspacing=\"0\" style=\"border-collapse:collapse;border:none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 85.15pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"25%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: \u0026quot;Times New Roman\u0026quot;,serif;\"\u003eFactor\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.15pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"25%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eAdjust odds ratio\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.15pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"25%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e95% confidence interval\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.15pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"25%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eP value\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 85.15pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"25%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: \u0026quot;Times New Roman\u0026quot;,serif;\"\u003eFemale Gender\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.15pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"25%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e2.910\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.15pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"25%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.690 – 12.276\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.15pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"25%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.1459\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 85.15pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"25%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: \u0026quot;Times New Roman\u0026quot;,serif;\"\u003eInjection drug user\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.15pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"25%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e1.189\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.15pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"25%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.207 – 6.837\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.15pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"25%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.8464\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 85.15pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"25%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: \u0026quot;Times New Roman\u0026quot;,serif;\"\u003eMale-to-male sex\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.15pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"25%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.241\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.15pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"25%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.055 – 1.050\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.15pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"25%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.0581\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 85.15pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"25%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: \u0026quot;Times New Roman\u0026quot;,serif;\"\u003eSmoking\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.15pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"25%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e2.004\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.15pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"25%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.581 – 6.911\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.15pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"25%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.2713\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 85.15pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"25%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: \u0026quot;Times New Roman\u0026quot;,serif;\"\u003eHCV carrier\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.15pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"25%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e2.233\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.15pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"25%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.504 – 9.885\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.15pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"25%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.2899\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 85.15pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"25%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: \u0026quot;Times New Roman\u0026quot;,serif;\"\u003eCancer\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.15pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"25%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e7.782\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.15pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"25%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e1.909 – 31.731\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.15pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"25%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.0042\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 85.15pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"25%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: \u0026quot;Times New Roman\u0026quot;,serif;\"\u003eAntibiotic use within the past one year\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.15pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"25%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e3.892\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.15pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"25%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e1.219 – 12.433\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.15pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"25%\"\u003e\n \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:center;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.0218\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:justify;line-height:105%;font-size:16px;font-family:\u0026quot;Cambria\u0026quot;,serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height:105%;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eAbbreviations:\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003cspan style=\"line-height: 105%; font-family: \u0026quot;Times New Roman\u0026quot;, serif; color: rgb(0, 0, 0);\"\u003eHCV, hepatitis C virus\u003c/span\u003e\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"bmc-infectious-diseases","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"infd","sideBox":"Learn more about [BMC Infectious Diseases](http://bmcinfectdis.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/infd","title":"BMC Infectious Diseases","twitterHandle":"#bmcinfectdis","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"nasal carriage, antibiotic use, injection drug use, injection drug user, molecular typing","lastPublishedDoi":"10.21203/rs.2.18964/v3","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.2.18964/v3","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground\u003c/strong\u003e: To evaluate nasal carriage, antibiotic susceptibility and molecular characteristics of methicillin-resistant \u003cem\u003eStaphylococcus aureus\u003c/em\u003e (MRSA), as well as the risk factors of MRSA colonization, in human immunodeficiency virus (HIV)-infected patients in northern Taiwan.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eMethods: \u003c/strong\u003e\u0026nbsp;From September\u0026nbsp;2014\u0026nbsp;to\u0026nbsp;November\u0026nbsp;2015,\u0026nbsp;HIV-infected patients seeking outpatient care at four hospitals were eligible for this study.\u0026nbsp;A nasal specimen was obtained from each subject for the detection of\u0026nbsp;\u003cem\u003eS. aureus\u003c/em\u003e and a questionnaire was completed by each subject. MRSA isolates once identified\u0026nbsp;were characterized.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eResults: \u003c/strong\u003eOf\u0026nbsp;553\u0026nbsp;patients\u0026nbsp;surveyed, methicillin-susceptible \u003cem\u003eS. aureus\u003c/em\u003e (MSSA) was detected in 119 subjects (21.5%) and MRSA in 19 subjects (3.4%). Female gender, injection drug use, smoking, hepatitis C virus carrier,\u0026nbsp;cancer\u0026nbsp;and antibiotic use within one year\u0026nbsp;were positively associated with MRSA colonization.\u0026nbsp;By multivariate analysis, only cancer (adjust odds ratio (aOR) 7.78, [95% confidence interval (CI), 1.909-31.731])\u0026nbsp;and antibiotic use within one year (aOR 3.89, [95% CI, 1.219-12.433])\u0026nbsp;were significantly associated with MRSA colonization. Ten isolates were characterized as sequence type (ST) 59/staphylococcal chromosome cassette (SCC) IV or V\u003csub\u003eT\u003c/sub\u003e, endemic community strains in Taiwan, four isolates as ST 8/SCC\u003cem\u003emec\u003c/em\u003e IV (USA 300) and one isolate as ST 239/SCC\u003cem\u003emec\u003c/em\u003e\u0026nbsp;IIIA, a hospital strain. All the community-associated MRSA isolates were susceptible to trimethoprim-sulfamethoxazole (TMP-SMX). \u003c/p\u003e\u003cp\u003e\u003cstrong\u003eConclusions: \u003c/strong\u003eNasal MRSA carriage in HIV-infected patients seeking outpatient care was low (3.4%) in northern Taiwan. Most of the colonizing isolates were genetically endemic\u0026nbsp;community strains and exhibited high susceptibility to TMP-SMX and fluoroquinolones. Cancer and antibiotic use within one year were associated with MRSA colonization.\u0026nbsp;\u003c/p\u003e","manuscriptTitle":"Methicillin-resistant Staphylococcus aureus nasal colonization among HIV-infected patients in Taiwan: prevalence, molecular characteristics and associated factors with nasal carriage","msid":"","msnumber":"","nonDraftVersions":[{"code":3,"date":"2020-03-19 18:27:05","doi":"10.21203/rs.2.18964/v3","editorialEvents":[{"type":"communityComments","content":0},{"type":"checksComplete","content":"","date":"2020-03-16T12:00:00+00:00","index":"","fulltext":""},{"type":"decision","content":"Accept","date":"2020-03-16T12:00:00+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-infectious-diseases","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"infd","sideBox":"Learn more about [BMC Infectious Diseases](http://bmcinfectdis.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/infd","title":"BMC Infectious Diseases","twitterHandle":"#bmcinfectdis","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}},{"code":2,"date":"2020-02-24 17:08:47","doi":"10.21203/rs.2.18964/v2","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Minor revision","date":"2020-03-13T12:00:00+00:00","index":"","fulltext":""},{"type":"reviewerAgreed","content":"","date":"2020-03-08T12:00:00+00:00","index":2,"fulltext":""},{"type":"editorInvitedReview","content":"","date":"2020-03-08T12:00:00+00:00","index":2,"fulltext":"Recommendation: Accept without revision\nForm responses:\n---\n\nComments to Author:\n---\nThe authors made all suggested corrections.* Are the methods appropriate and well described?: **Yes**\n* Does the work include the necessary controls?: **Yes**\n* Are the conclusions drawn adequately supported by the data shown?: **Yes**\n* Are you able to assess any statistics in the manuscript or would you recommend an additional statistical review?: **I am able to assess the statistics**\n* Quality of written English: **Acceptable**\n* Declaration of competing interests: **I declare that I have no competing interests**\n* I agree to the open peer review policy of the journal. I understand that my name will be included on my report to the authors and, if the manuscript is accepted for publication, my named report including any attachments I upload will be posted on the website along with the authors' responses. I agree for my report to be made available under an Open Access Creative Commons CC-BY license (http://creativecommons.org/licenses/by/4.0/). I understand that any comments which I do not wish to be included in my named report can be included as confidential comments to the editors, which will not be published.: ** I agree to the open peer review policy of the journal**\n"},{"type":"reviewerAgreed","content":"","date":"2020-03-07T12:00:00+00:00","index":1,"fulltext":""},{"type":"editorInvitedReview","content":"","date":"2020-03-07T12:00:00+00:00","index":1,"fulltext":"Recommendation: Accept without revision\nForm responses:\n---\n\nComments to Author:\n---\n* Are the methods appropriate and well described?: **Yes**\n* Does the work include the necessary controls?: **Yes**\n* Are the conclusions drawn adequately supported by the data shown?: **Yes**\n* Are you able to assess any statistics in the manuscript or would you recommend an additional statistical review?: **I am able to assess the statistics**\n* Quality of written English: **Acceptable**\n* Declaration of competing interests: **I declare that i dont have any conflict of interest.**\n* I agree to the open peer review policy of the journal. I understand that my name will be included on my report to the authors and, if the manuscript is accepted for publication, my named report including any attachments I upload will be posted on the website along with the authors' responses. I agree for my report to be made available under an Open Access Creative Commons CC-BY license (http://creativecommons.org/licenses/by/4.0/). I understand that any comments which I do not wish to be included in my named report can be included as confidential comments to the editors, which will not be published.: ** I agree to the open peer review policy of the journal**\n"},{"type":"reviewersInvited","content":"","date":"2020-03-05T12:00:00+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2020-02-23T12:00:00+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2020-02-22T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2020-02-22T12:00:00+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-infectious-diseases","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"infd","sideBox":"Learn more about [BMC Infectious Diseases](http://bmcinfectdis.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/infd","title":"BMC Infectious Diseases","twitterHandle":"#bmcinfectdis","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}},{"code":1,"date":"2019-12-15 23:46:54","doi":"10.21203/rs.2.18964/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Major revision","date":"2020-01-30T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2020-01-21T12:00:00+00:00","index":2,"fulltext":"Recommendation: Accept after minor essential revisions\nForm responses:\n---\n* Are the methods appropriate and well described?: **Yes**\n* Does the work include the necessary controls?: **Yes**\n* Are the conclusions drawn adequately supported by the data shown?: **Yes**\n* Are you able to assess any statistics in the manuscript or would you recommend an additional statistical review?: **I am able to assess the statistics**\n* Quality of written English: **Acceptable**\n* Declaration of competing interests: **I declare that I have no competing interests**\n\nComments to Author:\n---\nThe article assesses the prevalence, molecular characterization and risk factors for colonization by methicillin-resistant Staphylococcus aureus (MRSA) in human immunodeficiency virus (HIV) -infected patients in northern\nTaiwan.\nThe work is well written and the objectives are clear and concise. However, information on the susceptibility of MRSA strains was missing from the abstract and conclusions. The methodology is adequate to the objectives and the results were presented in a satisfactory manner. The discussion and conclusions are adequate.\n\nThe following minor modifications must be made:\n\nIn abstract:\n1. remove \"in\" before human immunodeficiency virus in the objectives;\n\nIn Background:\n1. Line 72: change \"patients infected with HIV\" to \"HIV-infected patients\"\n2. Lines 80-81: in the objectives presented at the end of the background, the authors say that susceptibility to antibiotics would also be described, which is not included in the objectives of the abstract. In addition, this information was not reported in the results of the abstract.\n\nMethods:\n1. put the approval protocol number of the ethics committee in the first paragraph.\n2. What information was contained in the questionnaire used in the study? Only data from patients' medical records were cited.\n3. Line 105: Change CD4 count to CD4 + T-cell.\n\nResults\n1. Line 155: Put the percentage of men and women after the absolute number\n2. Line 168: Change CD4 count to CD4 + T lymphocytes.\n3. It would be interesting to add the time of knowledge of HIV infection and the time of knowledge of cancer\n4. Were all study participants asymptomatic for symptoms of respiratory disease? Was everyone asymptomatic? It is not clear in the description of the participants.\n5. It would be interesting to add a table with the epidemiological characteristics of all 19 individuals who had MRSA\n6. Table 1: Remove a parenthesis in Injection drug use \"81 ((15)\". Mention the statistical test used in the tables.\n7. Table 2: Remove a parenthesis in Alcohol Drinking in MRSA \"6 ((32)\".\n\n\nIn Conclusions\n1. Add information about the susceptibility profile of isolated MRSA strains to antibiotics.\n\n\n\nIn List of abbreviations used:\n1. Add HCV\n2. Add ACME\n3. Add MLST\n4. Add ICUs"},{"type":"reviewerAgreed","content":"","date":"2020-01-12T12:00:00+00:00","index":3,"fulltext":""},{"type":"editorInvitedReview","content":"","date":"2019-12-19T12:00:00+00:00","index":1,"fulltext":"Recommendation: Major revisions required\nForm responses:\n---\n* Are the methods appropriate and well described?: **No**\n* Does the work include the necessary controls?: **Yes**\n* Are the conclusions drawn adequately supported by the data shown?: **No**\n* Are you able to assess any statistics in the manuscript or would you recommend an additional statistical review?: **I recommend additional statistical review**\n* Quality of written English: **Needs some language corrections before being published**\n* Declaration of competing interests: **I declare that I have no competing interests**\n\nComments to Author:\n---\nThanks for your manuscript. I think is very interesting subject. The review of the aforementioned manuscript has been finished and there are some points which must be response to clarify. You could find the attached file about the reviewer comments.\nBest Regards"},{"type":"reviewerAgreed","content":"","date":"2019-12-17T12:00:00+00:00","index":1,"fulltext":""},{"type":"reviewerAgreed","content":"","date":"2019-12-17T12:00:00+00:00","index":2,"fulltext":""},{"type":"reviewersInvited","content":"","date":"2019-12-16T12:00:00+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2019-12-09T12:00:00+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2019-12-08T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2019-12-08T12:00:00+00:00","index":"","fulltext":""},{"type":"submitted","content":"","date":"2019-12-05T12:00:00+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-infectious-diseases","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"infd","sideBox":"Learn more about [BMC Infectious Diseases](http://bmcinfectdis.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/infd","title":"BMC Infectious Diseases","twitterHandle":"#bmcinfectdis","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"c80887b1-87a5-455f-9fbb-5801aaa1a66f","owner":[],"postedDate":"March 19th, 2020","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[{"id":61740,"name":"Infectious Diseases"}],"tags":[],"updatedAt":"2021-09-27T18:29:38+00:00","versionOfRecord":{"articleIdentity":"rs-9582","link":"https://doi.org/10.1186/s12879-020-04979-8","journal":{"identity":"bmc-infectious-diseases","isVorOnly":false,"title":"BMC Infectious Diseases"},"publishedOn":"2020-03-30 18:25:40","publishedOnDateReadable":"March 30th, 2020"},"versionCreatedAt":"2020-03-19 18:27:05","video":"","vorDoi":"10.1186/s12879-020-04979-8","vorDoiUrl":"https://doi.org/10.1186/s12879-020-04979-8","workflowStages":[]},"version":"v3","identity":"rs-9582","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"identity":"rs-9582","version":["v3"]},"buildId":"7rjqhiLT3MXkJMwkYKINL","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}