Livin、survivin、caspase-3在子宫内膜异位症中的表达及其意义

In: 武警医学 · 2011 · vol. 22(7) , pp. 602–605 · W122858867
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This study found that Livin and survivin were upregulated while caspase-3 was downregulated in eutopic and ectopic endometrium of endometriosis patients compared to normal controls, suggesting these proteins play a role in the disease pathogenesis.

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Abstract

目的研究Livin、survivin、caspase-3在子宫内膜异位症(endometriosis,EMs)中的表达,探讨其在EMs发病中的作用。方法采用原位杂交方法检测Livin在40例EMs在位内膜、异位内膜及25例正常子宫内膜中的含量,同时用二步法免疫组化的方法检测survivin、caspase-3在上述三组中的表达。结果Livin、survivin在EMs异位内膜与EMs在位内膜的表达强于正常子宫内膜,其差异有统计学意义(P〈0.05);caspase-3在EMs在位内膜与异位内膜的表达弱于正常子宫内膜,其差异有统计学意义(P〈0.05);无论是EMs组还是正常对照组,Livin、sunivin、caspase-3在月经增生期和分泌期表达强度差异无统计学意义(P〉0.05)。结论子宫内膜异位症的发病可能与Livin、survivin、caspase-3的异常表达有关。

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endometriosis

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