Prognostic value of estimated plasma volume status in patients with sepsis

Abstract Background: Sepsis is associated with endothelial dysfunction and alteration of capillary permeability. The objective of this study was to evaluate the prognostic value of estimated plasma volume status (ePVS) in patients with sepsis or septic shock who were admitted to intensive care unit (ICU).Methods: In this single-center, prospective observational study, 100 patients with sepsis or septic shock who were admitted ICU were enrolled. The primary outcome was in-hospital mortality and multivariable logistic regression analysis was used to adjust for confounding factors.Results: The in-hospital mortality was 47%. The mean ePVS in patients who died was higher than in those who survived (7.7 ± 2.1 dL/g vs. 6.6 ± 1.6 dL/g, P = 0.003). To evaluate the utility of ePVS in predicting in-hospital mortality, a receiver operating characteristic curve was produced. Sensitivity and specificity were optimal at a cut-off point of 7.09 dL/g, with an area under the curve of 0.655. In the multivariate analysis, higher ePVS was significantly associated with higher in-hospital mortality (adjusted odds ratio, 1.39; 95% confidence interval, 1.04 – 1.85, P = 0.028). The Kaplan-Meier curve showed that an ePVS value above 7.09 is associated with an increased risk of in-hospital mortality compared to the rest of the population (P = 0.004).Conclusions: The ePVS provided additional prognostic value in patients with sepsis or septic shock who were admitted in the ICU.