Epidemiological Shifts in Ovarian Cancer Burden: Regional Differences and the Influence of Socioeconomic Factors

Epidemiological Shifts in Ovarian Cancer Burden: Regional Differences and the Influence of Socioeconomic Factors | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Epidemiological Shifts in Ovarian Cancer Burden: Regional Differences and the Influence of Socioeconomic Factors Cheng Liu, Xianglin Luo, Jinfeng Zhao, Mingmei Liao This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7031267/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Ovarian cancer remains a critical global health challenge, ranking eighth in incidence and accounting for 3.4% of new cancer cases and 4.8% of cancer deaths in 2022. Using GBD 2021 data (204 countries, 1990–2021), we assessed age-standardized incidence, prevalence, and DALYs against SDI. Incident cases nearly doubled (159 096→298 876), yet ASRs declined by 0.38% (incidence), 0.07% (prevalence) and 0.59% (DALYs) per year. Regional trends diverged—Andean Latin America saw the largest ASR increase; Australia experienced the steepest decline. High-SDI regions maintained the highest burden but showed sustained declines, whereas low- and middle-SDI regions saw rising rates. Population growth (86.7%) and aging (38.5%) drove DALY increases. Despite narrowing inequalities, the absolute burden persists, highlighting the need for precision detection in high-SDI settings and strengthened care in lower-SDI regions. Ovarian cancer Global burden disease Incidence Prevalence Trends DALYs SDI Full Text Additional Declarations No competing interests reported. Supplementary Files DocumentS1.docx DocumentS2.docx Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-7031267","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":497362411,"identity":"f894152f-dc4a-4fae-a8b4-f33c338dad99","order_by":0,"name":"Cheng Liu","email":"","orcid":"","institution":"Xiangya Hospital Central South University","correspondingAuthor":false,"prefix":"","firstName":"Cheng","middleName":"","lastName":"Liu","suffix":""},{"id":497362413,"identity":"73fccdcc-429d-4f90-b4b4-2851e60d5177","order_by":1,"name":"Xianglin Luo","email":"","orcid":"","institution":"Xiangya Hospital Central South 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