Prevalence of Lymphopenia in the American Population: Insights from Demographic, BMI, and Lifestyle Factors

Objective: Understanding the prevalence of lymphopenia in the American population according to different variables. Methods A total of 33,365 participants were included in the 2009–2018 National Health and Nutrition Survey (NHANES). All analyses used weighted samples and considered the layering and clustering of the design. Results The prevalence of lymphopenia in Mexican-American participants was significantly lower than that of white participants ( P  = 0.018). The prevalence of lymphopenia increases with age, reaching a peak of 6.84% among elderly participants aged 75 and above. In terms of the gender difference, the prevalence of lymphopenia in men is significantly higher than that in women ( P  < 0.001). The prevalence of lymphopenia in participants with sleep disorders is significantly higher than those without sleep disorders ( P  = 0.014). Conclusion We propose a novel perspective that the diagnosis and treatment of lymphopenia should be tailored to the lymphocyte levels of specific subpopulations, rather than applying a generalized approach.