DMRT2 gene polymorphisms is associated with the coronary artery disease in Han population in Xinjiang, China

Background: DMRT2 gene plays a significant role in human gonad and skeletal muscle, as well as affecting human immune, inflammatory and metabolic pathways. The main purpose of this study was to explore the relationship between single-nucleotide polymorphisms (SNPs) of DMRT2 gene and coronary artery disease (CAD) in Xinjiang Han population. Methods We designed a case–control study including 1092 participants (male: 533; female: 559); Among them, 542 patients with CAD and 550 normal coronary angiographies. We used the improved multiplex ligation detection reaction(iMLDR) method, we genotyped two SNPs (rs12350001 and rs7856817) of DMRT2 gene in all subjects. Results We found that the dominant model (A/A vs A/G + G/G) and over-dominant model (G/G + A/A vs A/G) of rs12350001 were significantly different between CAD patients and the controls (P = 0.003, P = 0.002 and P = 0.007, respectively). The dominant model (G/G vs G/A + A/A) of rs7856817 were significantly different between CAD and controls (P = 0.031 and P = 0.029, respectively). The rs12350001 G allele was associated with a significantly elevated CAD risk [AG/GG vs AA: odds ratio (OR) = 1.870, 95% confidence interval (CI) = 1.237–2.824, P = 0.003], and the rs7856817 A allele was associated with a significantly elevated CAD risk [GA/AA vs GG: odds ratio (OR) = 2.062, 95% confidence interval (CI) = 1.353–3.142, P < 0.001]. After adjustment for confounders, the TG and LDL-C levels were significantly higher in rs12350001 AG/GG genotypes than that in AA genotypes (P < 0.05). The TG levels were significantly higher in rs7856817 GA/AA genotypes than that in GG genotypes (P < 0.05). Conclusions Rs12350001 and rs7856817 of DMRT2 gene are associated with CAD in Han subjects. Subjects with G allele of rs12350001 or A allele of rs7856817 were associated with an increased risk of CAD.