Effect of estradiol and steroid analogues on the clearance of immunoglobulin G-coated erythrocytes.

D.E Friedman, F Netti, Alan D. Schreiber
In: Journal of Clinical Investigation · 1985 · vol. 75(1) , pp. 162–167 · doi:10.1172/jci111669 · PMID:3880770 · W2031855040
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Estradiol significantly enhanced the clearance of IgG-coated erythrocytes in an animal model by increasing macrophage Fc(IgG) receptor affinity, whereas corticosteroids impaired clearance.

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The study used an animal model to test how estradiol and related steroid agents influence the immune clearance of IgG-coated erythrocytes, compared with corticosteroids and other steroid analogues. Corticosteroids impaired clearance, whereas estradiol at pregnancy-relevant doses significantly enhanced clearance; this enhancement was not seen for splenic clearance of heat-altered erythrocytes. Estradiol-treated animals had splenic macrophages with increased Fc(IgG) receptor affinity, while no consistent changes were observed in C3 receptors; danazol, deoxycorticosterone, and tetrahydrocortisone did not affect clearance after 7 days, and tamoxifen enhanced clearance less than estradiol. This paper is not centrally about endometriosis or adenomyosis, but it relates tangentially because it addresses how estrogen-state changes can modulate immune clearance relevant to sex-steroid–linked inflammatory conditions, including endometriosis and adenomyosis.

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Abstract

Although the disproportionate frequency of several immunologic disorders among women is well recognized, the effect of sex steroids on immunologic processes is unclear. We used an animal model, which has helped to elucidate the effect of corticosteroids in vivo, to quantitatively assess the effect of estradiol and steroid analogues on the immune clearance of IgG-coated erythrocytes. While corticosteroids impaired the clearance of IgG-coated erythrocytes, estradiol, in doses comparable to those achieved during pregnancy, significantly enhanced the clearance. Estradiol, however, did not enhance the splenic clearance of heat-altered erythrocytes. Splenic macrophages isolated from estradiol-treated animals expressed enhanced receptor affinity for the Fc portion of immunoglobulin G [Fc(IgG)], an effect probably responsible for the enhanced in vivo clearance. No consistent effect of estradiol on the splenic macrophage C3 receptors was observed. The synthetic androgen danazol, the mineralocorticoid deoxycorticosterone, and the cortisol metabolite tetrahydrocortisone did not alter the clearance of IgG-coated cells after 7 d of therapy. The estrogen antagonist/agonist tamoxifen enhanced the clearance of IgG-coated cells, but to a lesser extent than estradiol. An effect of estrogens on macrophage Fc (IgG) receptor-mediated clearance may explain in part the variation in clinical expression of several autoimmune disorders during changes in hormonal state, such as pregnancy.
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Advertisement Research Article Free access | 10.1172/JCI111669 Find articles by Friedman, D. in: PubMed | Google Scholar Find articles by Netti, F. in: PubMed | Google Scholar Find articles by Schreiber, A. in: PubMed | Google Scholar Published January 1, 1985 - More info Published in Volume 75, Issue 1 on January 1, 1985 J Clin Invest. 1985;75(1):162–167. https://doi.org/10.1172/JCI111669. © 1985 The American Society for Clinical Investigation J Clin Invest. 1985;75(1):162–167. https://doi.org/10.1172/JCI111669. © 1985 The American Society for Clinical Investigation Published January 1, 1985 - Version history - Abstract Although the disproportionate frequency of several immunologic disorders among women is well recognized, the effect of sex steroids on immunologic processes is unclear. We used an animal model, which has helped to elucidate the effect of corticosteroids in vivo, to quantitatively assess the effect of estradiol and steroid analogues on the immune clearance of IgG-coated erythrocytes. While corticosteroids impaired the clearance of IgG-coated erythrocytes, estradiol, in doses comparable to those achieved during pregnancy, significantly enhanced the clearance. Estradiol, however, did not enhance the splenic clearance of heat-altered erythrocytes. Splenic macrophages isolated from estradiol-treated animals expressed enhanced receptor affinity for the Fc portion of immunoglobulin G [Fc(IgG)], an effect probably responsible for the enhanced in vivo clearance. No consistent effect of estradiol on the splenic macrophage C3 receptors was observed. The synthetic androgen danazol, the mineralocorticoid deoxycorticosterone, and the cortisol metabolite tetrahydrocortisone did not alter the clearance of IgG-coated cells after 7 d of therapy. The estrogen antagonist/agonist tamoxifen enhanced the clearance of IgG-coated cells, but to a lesser extent than estradiol. An effect of estrogens on macrophage Fc (IgG) receptor-mediated clearance may explain in part the variation in clinical expression of several autoimmune disorders during changes in hormonal state, such as pregnancy. - Version history - Version 1 (January 1, 1985): No description Advertisement Advertisement Copyright © 2026 American Society for Clinical Investigation ISSN: 0021-9738 (print), 1558-8238 (online)

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