Inflammation Markers at the Beginning and After the Manic Episode in Bipolar Disorder Patients

Inflammation Markers at the Beginning and After the Manic Episode in Bipolar Disorder Patients | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 8 March 2025 V1 Latest version Share on Inflammation Markers at the Beginning and After the Manic Episode in Bipolar Disorder Patients https://doi.org/10.22541/au.174142806.69717361/v1 163 views 55 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Backround: This study aimed to compare blood-based inflammatory marker levels during manic episodes and early remission in patients with bipolar disorder (BD) and their relationship with the Young Mania Rating Scale (YMRS). Materials and Methods: This retrospective clinical study included 61 patients diagnosed with BD manic episodes who were treated between January 1, 2016, and June 1, 2024, along with 64 healthy control subjects. The control group consisted of individuals aged 18 to 65 years who had undergone a general health check-up at the family medicine outpatient clinic. BD diagnosis was made based on DSM-V criteria. Hemogram values, CRP, and albumin levels were measured within 24 hours of hospital admission and again at discharge. Results: BD patients showed higher levels of CRP, CAR, NEU, and MPV compared to healthy controls (p<0.05), while albumin levels were lower (p<0.000). The monocyte and SIRI values significantly increased after treatment in female but not in male patients. A negative correlation was identified between the YMRS scores and inflammatory markers in females for albumin and monocytes, while in males, a negative correlation was identified for CRP and CAR. Conclusions: These findings highlight the role of systemic inflammation in BD and suggest gender-specific differences in disease characteristics and treatment responses, warranting further investigation. Title: Inflammation Markers at the Beginning and After the Manic Episode in Bipolar Disorder Patients Running title: İnflammation İn Bipolar Disorder Sıdıka BAZİKİ ÇETİN, Harran University Faculty of Medicine, Department of Psychiatry, Sanlıurfa, Turkey, 0000-0002-4686-8214 Ülker ATILAN FEDAİ, Harran University Faculty of Medicine, Department of Psychiatry, Sanlıurfa, Turkey, 0000-0001-5428-3868 Conceptualization: SBÇ, ÜAF Data curation: SBÇ Formal Analysis: SBÇ Methodology: SBÇ, ÜAF Writing – review & editing: SBÇ, ÜAF Corresponding Author*: Sıdıka BAZİKİ ÇETİN. Tel: 04143183031, [email protected] , Harran University Faculty of Medicine, Department of Psychiatry, Osmanbey Campus, Şanlıurfa, Turkey, ORCİD: 0000-0002-4686-8214 Acknowledgment The authors report no conflicts of interest The data can be shared upon request. All authors have read and approved the final version submitted and take public responsibility for all aspects of the work. Supplementary Material File (aparefrens.docx) Download 81.68 KB Information & Authors Information Version history V1 Version 1 08 March 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords affectıve dısorders albumin bipolar disorders i̇nflammation Authors Metrics & Citations Metrics Article Usage 163 views 55 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Inflammation Markers at the Beginning and After the Manic Episode in Bipolar Disorder Patients. Authorea . 08 March 2025. DOI: https://doi.org/10.22541/au.174142806.69717361/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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