WITHDRAWN: Efficacy and safety of bronchial arterial chemoembolization in combination with tislelizumab for non-small cell lung cancer: a phase II study

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Abstract This study was designed to assess the efficacy and safety of bronchial arterial chemoembolization (BACE) combined with tislelizumab for stage III-IV non-small cell lung cancer (NSCLC). In a single-arm, phase II study (NCT05058560), stage III-IV NSCLC patients who refused or were ineligible to receive standard treatments were enrolled. Patients received BACE followed by 200 mg tislelizumab every 3 weeks until disease progression, intolerable toxicities, or discontinuation determined by the investigators. The primary endpoint was progression-free survival (PFS), and the secondary endpoints were overall survival (OS), objective response rate (ORR), disease control rate (DCR), safety, and quality of life (QoL). Thirty patients (median age, 67 years, 24 male) were enrolled in this study between December 2021 and August 2022. The median follow-up was 23 (95% confidence interval [CI], 21.5-24.5) months. At the data cutoff (March 1, 2024), the median PFS was 10.5 (95%CI, 7.8-13.2) months and the median OS was 15.0 (95%CI, 8.2-21.8) months. Of the 30 patients, 1 patient (3.3%) achieved complete response (CR).17 patients (56.7%) showed partial response (PR), 6 (20.0%) had stable disease (SD), and 6 patients (20.0%) had progressive disease (PD). The ORR was 60.0% (18 of 30 patients) and the DCR was 80.0% (24 of 30patients). The expression rate of PD-L1, tumor feeding arteries and previous treatment history were prognostic factors for PFS and OS. No grade 3 or higher treatment-related adverse events (TRAEs) occurred. Common grade 2 TRAEs were nausea, fever, and cough. QoL improved significantly after 1 cycle of treatment compared with baseline, including global quality of life, physical functioning, and emotional functioning. In conclusion, BACE with tislelizumab is a safe, feasible and efective palliative treatment option for stage III-IV NSCLC patients.
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WITHDRAWN: Efficacy and safety of bronchial arterial chemoembolization in combination with tislelizumab for non-small cell lung cancer: a phase II study | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article WITHDRAWN: Efficacy and safety of bronchial arterial chemoembolization in combination with tislelizumab for non-small cell lung cancer: a phase II study Chao Liang, Daqian Han, Hao Li, Manzhou Wang, Donglin Kuang, Pengfei Chen, and 6 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-5026061/v2 This work is licensed under a CC BY 4.0 License Status: Posted Version 2 posted You are reading this latest preprint version Show more versions Editorial Note The full text of this preprint has been withdrawn, as it was submitted in error. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author. Editorial notes are used to provide important context regarding the topic of a preprint or to alert readers to potential issues concerning that preprint or a downstream publication associated with it. For more information on editorial notes, see our Editorial Policies . Abstract The full text of this preprint has been withdrawn, as it was submitted in error. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author. Biological sciences/Cancer Biological sciences/Cancer/Lung cancer Full Text The authors have withdrawn this preprint from Research Square. Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 2 posted You are reading this latest preprint version Show more versions Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. 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