Age-Specific Trend and Birth Cohort Effect on Different Histologic Types of Uterine Corpus Cancers

To evaluate the uterine corpus cancer incidence rates, age-specific trends and birth cohort patterns by different histologic types. From the Taiwan Cancer Registry, we identified women with a primary diagnosis of uterine corpus cancer ( n =28 769) from1998 to 2017. We analyzed the incidences, stages of disease at diagnosis and prognostic factors in endometrioid and non-endometrioid carcinoma. During the study period, uterine corpus cancer incidence rates increased over time from 5.3 to 15.21 per 100 000 woman-years. Incidence trends for endometrioid carcinoma increased in all age groups and the rise was steeper in women age 40 years and younger. For non-endometrioid carcinomas, incidence rates increased in women over 50 years. Women diagnosed after 2013 had significantly better cancer-specific survival (CSS) (hazard ratio [HR] =0.81, 95% confidence interval [CI] 0.73-0.89) compared with those at the period of 2009-2012. CSS also improved in stage I (HR=0.81, 95% CI 0.49-0.63) and stage III (HR 0.90, 95% CI 0.58-0.72) endometrioid carcinomas after 2013. Whereas CSS remained unchanged for non-endometrioid carcinomas. We found the incidences of both endometrioid and non-endometrioid carcinomas continued to increase among contemporary birth cohorts. Etiologic research is mandatory to explain the causes for these trends.