An Orally Bioavailable (Mice) Prodrug of Glutathione

2021 · doi:10.20944/preprints202104.0368.v1
preprint OA: closed CC-BY-4.0
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Abstract

Cysteine-glutathione mixed disulfide (CySSG), a prodrug of glutathione (GSH) --the “Master Antioxidant”, was found to be orally bioavailable in mice, and protected against a toxic dose of acetaminophen. If oral bioavailability can also be demonstrated in humans, this suggests a wide range of applicability for CySSG.

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License: CC-BY-4.0