Predicting COVID-19 case status from self-reported symptoms and behaviors using data from a massive online survey

A bstract With the varying availability of RT-PCR testing for COVID-19 across time and location, there is a need for alternative methods of predicting COVID-19 case status. In this study, multiple machine learning (ML) models were trained and assessed for their ability to accurately predict the COVID-19 case status using US COVID-19 Trends and Impact Survey (CTIS) data. The CTIS includes information on testing, symptoms, demographics, behaviors, and vaccination status. The best performing model was XGBoost, which achieved an F1 score of ≈ 94% in predicting whether an individual was COVID-19 positive or negative. This is a notable improvement on existing models for predicting COVID-19 case status and demonstrates the potential for ML methods to provide policy-relevant estimates.