Expression and clinical significance of VEGF、ENS and MVD in adenomyosis

Objective To detect the expression of vascular endothelial growth factor (VEGF),endostatin (ENS) and microvessel density(MVD)in eutopic and ectopic endometrium in adenomyosis(AM) and their relationship with clinical significance.Methods Immunohistochemical staining was used to determine the expression of VEGF,ENS and MVD in eutopic and ectopic endometrium tissue specimens obtained from 51 patients with adenomysis who underwent hysterectomy and 40 normal endometrium tissue samples as control group.Results Expression of VEGF,ENS and MVD in ectopic endometrium tissue was significantly higher than that in eutopic endometrium and normal endometrium (P0.05). In normal endometrium,expression of VEGF,ENS,MVD in secretory phase were significantly higher than that in proliferative phase (P0.05). However,no significant difference between proliferative phase and secretory phase was found in ectopic endometrium in adenomyosis (P0.05). The expression of VEGF and VEGF/ENS was correlated with MVD positively (r=0.36、r=0.43,P0.05),while the expression of ENS was correlated with MVD negatively (r=-0.22,P0.05).Conclusions The high expression of VEGF、MVD and VEGF/ENS in AM patients indicates that angiogenesis may related to the pathogenesis of adenomyosis.