Epigenetic Regulation of Autophagy in Breast Cancer: Implications for Biomarker Discovery and Personalized Therapy.

Epigenetic Regulation of Autophagy in Breast Cancer: Implications for Biomarker Discovery and Personalized Therapy. | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 15 May 2025 V1 Latest version Share on Epigenetic Regulation of Autophagy in Breast Cancer: Implications for Biomarker Discovery and Personalized Therapy. Author : Bushra Faryal 0009-0005-6813-9249 [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.174731243.30192719/v1 Published Cancer Reports Version of record Peer review timeline 380 views 160 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Breast cancer is a heterogeneous disease and a prevalent form of aggressive tumors in females. It remains a leading cause of mortality among adult and older women worldwide, with therapeutic resistance leading to a barrier for reliable clinical outcomes. Many studies are exploring the relationship between epigenetic dysregulation and autophagy, driving therapy resistance, tumor progression, and metabolic changes. Sudden modifications in histone tails, non-coding RNAs, and DNA methylation patterns directly modify autophagic genes, while dysregulated autophagy conversely alters the epigenetic landscape under therapeutic stress. Recent studies have shown that molecular mechanisms link epigenetic alterations with autophagy regulation in breast cancer. This literature review systematically selected studies highlighting the molecular mechanism of autophagy dysregulation and its role in chemotherapy, endocrine, and targeted therapy resistance in breast cancer. This article briefly discusses the clinical implications of epigenetic biomarkers for early detection and treatment response prediction. Furthermore, we discussed new therapeutic methods combining autophagy inhibitors and epigenetic modulators, emphasizing the role of advanced medicine approaches powered by AI-driven drug discovery. The main idea of this literature review is to provide an in-depth insight into the epigenetic autophagy link in breast cancer and shed light on promising therapeutic outcomes overcoming chemotherapeutic resistance. Supplementary Material File (manuscript.docx) Download 552.13 KB File (table 1.docx) Download 29.49 KB File (table 2.docx) Download 28.23 KB File (table 3.docx) Download 15.66 KB File (table 4.docx) Download 15.41 KB Information & Authors Information Version history V1 Version 1 15 May 2025 Peer review timeline Published Cancer Reports Version of Record 2 Dec 2025 Published Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords artificial-intelligence autophagy cancerepigenetics hdacs personalized-medicine therapyresistance Authors Affiliations Bushra Faryal 0009-0005-6813-9249 [email protected] Universita degli Studi della Campania Luigi Vanvitelli Dipartimento di Medicina Sperimentale View all articles by this author Metrics & Citations Metrics Article Usage 380 views 160 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Bushra Faryal. Epigenetic Regulation of Autophagy in Breast Cancer: Implications for Biomarker Discovery and Personalized Therapy.. Authorea . 15 May 2025. DOI: https://doi.org/10.22541/au.174731243.30192719/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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