Granulosa cell tumor in 8 African pygmy hedgehogs (Atelerix albiventris).

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A retrospective study of eight African pygmy hedgehogs with granulosa cell tumors found that carboplatin treatment eliminated tumor mass in one recurrent case, suggesting its potential as an antineoplastic drug.

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This retrospective study examined eight African pygmy hedgehogs diagnosed with granulosa cell tumors, noting a median age of onset at 3.6 years. Clinical signs included hematuria and abdominal distension in over half the cases, with survival outcomes differing significantly between patients presenting only with hematuria versus those with ascites. While exploratory surgery was performed on all subjects, intraperitoneal carboplatin injection showed potential efficacy in one recurrent case where the tumor mass disappeared. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

A retrospective study involving eight African pygmy hedgehogs histopathologically diagnosed with granulosa cell tumors was conducted. The age at onset was 2.2-4.5 years, with a median age of 3.6 years. The most common clinical signs were hematuria and abdominal distension, which were observed in >50% cases. Exploratory laparotomy was performed in all cases, and ovariohysterectomy or excision of the abdominal mass was performed. Patients with only hematuria survived for >250 days after surgery, whereas those with initial ascites showed recurrence of ascites or tumor growth and survived for approximately 130 days after surgery. Intraperitoneal injection of carboplatin was performed in three recurrent cases. In one of these three cases, the tumor mass disappeared. Hence, carboplatin can be considered a potential antineoplastic drug for the treatment of granulosa cell tumors.
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Wildlife Science Granulosa cell tumor in 8 African pygmy hedgehogs (Atelerix albiventris) 2021 Volume 83 Issue 4 Pages 685-688 Details Abstract A retrospective study involving eight African pygmy hedgehogs histopathologically diagnosed with granulosa cell tumors was conducted. The age at onset was 2.2–4.5 years, with a median age of 3.6 years. The most common clinical signs were hematuria and abdominal distension, which were observed in >50% cases. Exploratory laparotomy was performed in all cases, and ovariohysterectomy or excision of the abdominal mass was performed. Patients with only hematuria survived for >250 days after surgery, whereas those with initial ascites showed recurrence of ascites or tumor growth and survived for approximately 130 days after surgery. Intraperitoneal injection of carboplatin was performed in three recurrent cases. In one of these three cases, the tumor mass disappeared. Hence, carboplatin can be considered a potential antineoplastic drug for the treatment of granulosa cell tumors. © 2021 by the Japanese Society of Veterinary Science This article is licensed under a Creative Commons [Attribution-NonCommercial-NoDerivatives 4.0 International] license. https://creativecommons.org/licenses/by-nc-nd/4.0/ Favorites & Alerts Recently viewed articles

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