Pipelle Endometrial Sampling and Morphological Findings in Women with Abnormal Uterine Bleeding

Sahar Salahuddin Amir, Aman-ur- Rehman
In: Pakistan Journal of Medical and Health Sciences · 2022 · vol. 16(11) , pp. 299–301 · doi:10.53350/pjmhs20221611299 · W4313299816
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⚙ AI-generated summary by claude@2026-06, 2026-06-13 ⓘ

This study assessed Pipelle endometrial sampling in women with abnormal uterine bleeding, finding it adequately sampled tissue in 80% of cases, with secondary endometrium being the most common finding.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-13 · read from full text ⓘ

This cross-sectional descriptive study evaluated the adequacy of pipelle endometrial sampling and associated histopathologic morphological findings in 237 adult women with abnormal uterine bleeding who were otherwise recommended for D&C. Samples were collected in gynecology outpatient settings and analyzed in histopathology, with exclusions including endometrial thickness <4 mm, fibroids, pelvic inflammatory disease, and clotting factor disorders; the paper reports 80.0% adequate sampling. The most common findings were secondary endometrium (39.9%), proliferative endometrium (36.2%), and chronic endometritis (12.2%), with 6 cases of carcinoma total (4 adenocarcinoma and 2 squamous cell carcinoma). The study concludes pipelle sampling can be considered effective, and it does not specifically address endometriosis or adenomyosis in its design or results, so relevance to these conditions is limited. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Background: The abnormal uterine bleeding has many causes and consequences in women. The exact causes are described by histology of sample through D&C. Pipple biopsy samples is considered one of the least invasive, OPD setting technique, comparable to D&C. Objective: To see the adequacy of Pipelle endometrial sampling and morphological findings among women with abnormal uterine bleeding. Study Design: Cross-sectional descriptive study Place and Duration of Study: Department of Gynaecology & Histopathology, Shaikh Zayed Hospital Lahore from 1st May to 31st December 2021. Methodology: Two hundred and thirty seven adult women with AUB recommended for D&C were included. Those with endometrial thickness less than 4mm, having fibroids, with pelvic inflammatory disease, or clotting factor disorders were excluded. Pipelle endometrial sample was taken in Gyne OPD and were examined at Histopathology Department. Results: 80.0% were sampled adequately through Pipelle. Secondary endometrium was most common in 39.9% followed by proliferative endometrium in 36.2% and chronic endometritis 12.2%. There were 6 cases with carcinoma, 4 (2.1%) with adenocarcinoma and 2(1.1%) squamous cell carcinoma. Conclusion: Pipelle Endometrial sampling can be considered an effective methods for endometrial sampling. Keywords: Abnormal uterine bleeding, Pipelle endometrial biopsy, Sample adequacy, Endometrial pathology
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Background

The abnormal uterine bleeding has many causes and consequences in women. The exact causes are described by histology of sample through D&C. Pipple biopsy samples is considered one of the least invasive, OPD setting technique, comparable to D&C.

Objective

To see the adequacy of Pipelle endometrial sampling and morphological findings among women with abnormal uterine bleeding. Study Design: Cross-sectional descriptive study Place and Duration of Study: Department of Gynaecology & Histopathology, Shaikh Zayed Hospital Lahore from 1st May to 31st December 2021. Methodology: Two hundred and thirty seven adult women with AUB recommended for D&C were included. Those with endometrial thickness less than 4mm, having fibroids, with pelvic inflammatory disease, or clotting factor disorders were excluded. Pipelle endometrial sample was taken in Gyne OPD and were examined at Histopathology Department.

Results

80.0% were sampled adequately through Pipelle. Secondary endometrium was most common in 39.9% followed by proliferative endometrium in 36.2% and chronic endometritis 12.2%. There were 6 cases with carcinoma, 4 (2.1%) with adenocarcinoma and 2(1.1%) squamous cell carcinoma.

Conclusion

Pipelle Endometrial sampling can be considered an effective methods for endometrial sampling.

Keywords

Abnormal uterine bleeding, Pipelle endometrial biopsy, Sample adequacy, Endometrial pathology

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disambig:endometritis

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