Advance in new generation of progestin and anti-progestin

The development of new generation of progestin and anti-progestin compounds was reviewed in this paper.Based on R D achievements of new generation progestin and anti-progestin in recent years,we summarized the pharmacological effects and the applications of drospirenone,dienogest,nestorone,nomegestrol acetate,trimegestone and ulipristal acetate.The ability of the new generation of progestin and anti-progestin binding to progesterone receptor has been greatly improved.The natures of the new progestin are closer to native steroid hormones.They have no androgen,estrogen or glucocorticoid activities,which greatly improved the safety of oral contraceptives and HRT,and the tolerance.Some of progestin also has potential adverse reaction.China should speed up the development of the new generation of progestin/anti-progestin,while some new side-effects should be considered in advance.