Maternal cardiovascular and haematological diseases alter the risk associations between environmental exposure and adverse pregnancy outcomes

Maternal cardiovascular and haematological diseases alter the risk associations between environmental exposure and adverse pregnancy outcomes | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Maternal cardiovascular and haematological diseases alter the risk associations between environmental exposure and adverse pregnancy outcomes Haitong Sun, Yuming Guo, Haiyang Tang, Huan Zhao, Qingyi Xiang, and 8 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-3672609/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract China’s “three-child policy” in response to population ageing has cast safeguarding perinatal health an urgent priority, whereas previous research seldom explored the pregnancy-related cardiovascular and haematological diseases. Here we conducted comprehensive epidemiological analyses on 121,090 pregnant women and their 124,025 neonates from the ZEBRA Chinese prospective maternity cohort. We find that unit incremental exposure in PM 2.5 , O 3 , and green space can change the risks of maternal pregnancy-induced cardiovascular diseases (CVDs) by 7.3% (95% confidence interval 6.4–8.2%), 2.7% (2.2–3.3%), and –3.6% (1.8–5.2%), respectively. Maternal cardiovascular and haematological diseases significantly aggravate the risk of adverse pregnancy outcomes (APOs, including congenital heart disease) by 69.3% (61.5–77.5%), and also modify the environment-APO risk associations by amplifying the hazards of air pollution and weakening the protective effect of greenness accessibility. Our research supports several Sustainable Development Goals by providing first-hand epidemiological evidence and clinical guidance for maternal and neonatal health protection. Health sciences/Diseases/Cardiovascular diseases Health sciences/Diseases/Haematological diseases Health sciences/Risk factors Health sciences/Health care/Public health/Epidemiology Earth and environmental sciences/Environmental social sciences/Environmental impact Full Text Additional Declarations There is NO Competing Interest. Supplementary Files SupplementaryMaterials.pdf Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-3672609","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":255140370,"identity":"4aaf5b6e-958e-45d3-9675-77369effe302","order_by":0,"name":"Haitong 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