Development of ploidy and cell proliferation in serial samples of ascites from patients with ovarian carcinoma

K Sahni, Sahni K, B Tribukait, Tribukait B, Einhorn N, N Einhorn
Acta oncologica (Stockholm, Sweden) · 1990 · vol. 29(2) , pp. 193–7 · doi:10.3109/02841869009126544 · PMID:2334572
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Analysis of serial ascites samples from 14 ovarian carcinoma patients revealed that while ploidy remained stable, S-phase proportions increased significantly over time, suggesting a shift toward more aggressive tumor cell lines and chemoresistance.

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This study analyzed serial ascites samples from 14 ovarian carcinoma patients to track changes in tumor cell ploidy and proliferation over periods ranging from 10 to 360 days. Using flow cytometry and monoclonal antibodies for bromodeoxyuridine labeling, the researchers found that while ploidy remained largely stable, the proportion of cells in the S-phase increased significantly over time. The authors suggest this rise in proliferation reflects selective pressures favoring more aggressive tumor cell lines and the development of chemoresistance. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Repeated samples of ascites were obtained from 14 ovarian carcinoma patients over a period of 10 to 360 days. The samples were studied by means of flow-cytometry and monoclonal antibodies specific for bromodeoxyuridine. Ploidy and proliferation of tumor cell populations were measured to establish the significance of these properties in the development of the tumors. Ploidy was mostly a stable feature while the proportion of S-phase values increased significantly over the passage of time. This increase is discussed in relation to the expression of selective processes towards more aggressive tumor cell lines and to the development of chemoresistance.
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Development of Ploidy and Cell Proliferation in Serial Samples of Ascites from Patients with Ovarian Carcinoma DOI: https://doi.org/10.3109/02841869009126544Keywords: Ovarian carcinoma, ascites, flow-cytometry, Brd-Urd labelling index, ploidy, proliferation, chemotherapyAbstract Repeated samples of ascites were obtained from 14 ovarian carcinoma patients over a period of 10 to 360 days. The samples were studied by means of flow-cytometry and monoclonal antibodies specific for bromodeoxyuridine. Ploidy and proliferation of tumor cell populations were measured to establish the significance of these properties in the development of the tumors. Ploidy was mostly a stable feature while the proportion of S-phase values increased significantly over the passage of time. This increase is discussed in relation to the expression of selective processes towards more aggressive tumor cell lines and to the development of chemoresistance.

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Condition tags

endometriosis

MeSH descriptors

Adenocarcinoma Endometriosis Ovarian Neoplasms Ploidies Ploidies Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenocarcinoma Adult Adult Aged Aged Ascites Ascites Ascites Bromodeoxyuridine Bromodeoxyuridine Bromodeoxyuridine Cell Division

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