Advances in surface plasmon resonance–based biosensor technologies for Cancer Cell detection

Abstract Efforts have been made to enhance the sensitivity of the conventional surface plasmon resonance biosensor. Two-dimensional heterostructure layer of titanium disilicide and black phosphorus has been deposited over the metal surface to improve the sensitivity. The titanium dis-ilicide (TiSi2) nanosheet is placed in between silver (Ag) and black phosphorus (BP) films in the Kretschmann arrangement. This biosen-sor executes better over a wide range of refractive index variations, including biological cell distribution in individual blood. It may become a fast method of detecting cancerous cells and the several variants of corona and other viruses that turn into a pandemic. Using finite element method based simulation technique, sensitivity obtained as are 195.4 deg/RIU, 167.6 deg/RIU, 212.4 deg/RIU, 168.4 deg/RIU, 212.4 deg/RIU, 186.6 deg/RIU, 218.6 deg/RIU, 195.4 deg/RIU, 203.6 deg/RIU, 202.6 deg/RIU 203.6 deg/RIU and 202.6 for sensing Basal (Skin Cancer), Basal (Normal Cell), Hela (Cervical Cancer) MCF-7 1 Springer Nature 2021 L A T E X template Article Title (Breast cancer), Hela (Normal Cell), Jurkat (Blood Cancer), Jurkat (Normal Cell), PCI-2 (Adrenal Gland Cancer), PCI-2 (Normal Cell), MDA-MB-231 (Breast Cancer), MDA-MB-231 (Normal Cell), MCF-7 (Breast Cancer) and MCF-7 (Normal Cell) respectively, and other performance parameters such as detection accuracy, quality factor and full width and half maximum (FWHM) are also evaluated.