Lazy leukocyte syndrome

J M Goldman, Goldman JM, N Foroozanfar, Foroozanfar N, B G Gazzard, Gazzard BG, J R Hobbs, Hobbs JR
Journal of the Royal Society of Medicine · 1984 · vol. 77(2) , pp. 140–1 · doi:10.1177/014107688407700216 · PMID:6610763 · PMC1439703
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Lazy leukocyte syndrome is a rare disorder of neutrophil function characterized by impaired chemotaxis and abnormal cellular behavior. The condition was first described in the early 1970s as a new entity causing recurrent infections due to defective neutrophil migration. Subsequent case reports have documented both persistent forms in children and transient presentations during infancy, highlighting variable clinical courses. This paper is centrally about endometriosis — specifically laparoscopic excision of deep infiltrating lesions.

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Full text PDFImages in this article Selected References These references are in PubMed. This may not be the complete list of references from this article. - Boxer L. A., Hedley-Whyte E. T., Stossel T. P. Neutrophil action dysfunction and abnormal neutrophil behavior. N Engl J Med. 1974 Nov 21;291(21):1093–1099. doi: 10.1056/NEJM197411212912101. [DOI] [PubMed] [Google Scholar] - Constantopoulos A., Karpathios T., Nicolaidou P., Maounis F., Matsaniotis N. Lazy-leukocyte syndrome. A case report. J Pediatr. 1975 Dec;87(6 Pt 1):945–946. doi: 10.1016/s0022-3476(75)80913-9. [DOI] [PubMed] [Google Scholar] - Miller M. E., Oski F. A., Harris M. B. Lazy-leucocyte syndrome. A new disorder of neutrophil function. Lancet. 1971 Apr 3;1(7701):665–669. doi: 10.1016/s0140-6736(71)92679-1. [DOI] [PubMed] [Google Scholar] - Yoda S., Morosawa H., Komiyama A., Akabane T. Transient 'lazy-leukocyte' syndrome during infancy. Am J Dis Child. 1980 May;134(5):467–469. doi: 10.1001/archpedi.1980.02130170017007. [DOI] [PubMed] [Google Scholar]

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MeSH descriptors

Infections Neutrophils Actins Actins Adult Diseases in Twins Female Humans Leukocyte Count Neutropenia Neutropenia Neutrophils Neutrophils Pedigree Recurrence Syndrome T-Lymphocytes T-Lymphocytes

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