Sister Mary Joseph Nodule: A Rare Presentation of Squamous Cell Carcinoma of the Cervix
Case report
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This case report describes an 88-year-old woman whose Sister Mary Joseph nodule was the presenting sign of metastatic squamous cell carcinoma of the cervix.
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Abstract
BACKGROUND: Sister Mary Joseph nodule refers to metastatic malignancy of the periumbilical region. Umbilical metastasis is an indicator of advanced malignant disease.
CASE REPORT: We present the case of an 88-year-old patient presenting with postmenopausal vaginal bleeding, inguinal lymphadenopathy, and physical findings of a palpable umbilical nodule (Sister Mary Joseph nodule). Further workup was consistent with metastatic squamous cell carcinoma of the cervix.
CONCLUSION: Because Sister Mary Joseph nodule may be the only manifestation of underlying malignancy, thorough physical examination plays an important role in diagnosing the malignancy in a more confined state that may have a positive impact on the patient's length of survival.
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Source provenance
- europepmc
- last seen: 2026-11-08T09:52:27.483963+00:00
- pubmed
- last seen: 2026-10-08T21:16:31.290043+00:00