What is the Efficacy of Beta-tricalcium Phosphate as Graft Material in Periodontal Infra-bony Defects? Systematic Review and Meta-Analysis

Background: β-TCP is a synthetic grafting material (alloplasts)that can be used as allografts and xenografts in peridontal periodontal infra-bony defect. However, it is important to compare this material outcomes in such treatments when comparted to others Therefore, the aim of this review is to evaluate the effectiveness of β-TCP in the regeneration of periodontal infra-bony defect. Methods: : Three electronic databases (Cochrane, Pubmed, Embase) were searched up to March 2020. The inclusion criteria consist of regeneration of periodontal infra-bony defect via implementation of β-TCP in combination with other bone graft materials. Outcomes consisted of pocket depth reduction, clinical attachment level gain and bone fill. Results: : Five studies were included according to inclusion criteria. β-TCP found to be superior than debridement alone while it shown comparable result to other bone grafts materials in term of pocket depth reduction, clinical attachment level gain and bone fill. the outcomes of the regenerative procedures of periodontal infra-bony defect with the use of β-TCP in combination with other growth factors seems to be superior than alone. Conclusion: β-TCP seems to be a promising material to be used in periodontal infra-bony defect regeneration. However, randomized clinical trials with larger sample size and more controlled study design are needed to support the findings