Retinoic Acid Biosynthesis Is Impaired in Human and Murine Endometriosis1
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Human and murine endometriosis lesions exhibit reduced all-trans retinoic acid levels and elevated retinol and retinyl ester concentrations compared to healthy endometrium.
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Abstract
Endometriosis is characterized by the presence of endome-trial glands and stroma in extrauterine sites. Our objective was to determine whether endometriotic lesions (ELs) from women with endometriosis have altered retinoid levels compared with their eutopic endometrium, and to test the hypothesis that defects in all-trans retinoic acid (ATRA) biosynthesis in EL is related to reduced expression of cellular retinol-binding protein type 1 (RBP1). Retinoids were evaluated by liquid chromatography-tandem mass spectrometry and high-perfor-mance liquid chromatography in eutopic endometrial biopsies (EBs) and ELs from 42 patients with pathologically confirmed endometriosis. The ATRA levels were reduced, whereas the retinol and retinyl ester concentrations were elevated in EL compared with EB tissue. Similar results were found in a mouse
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- last seen: 2026-05-10T11:04:21.402092+00:00
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