Alzheimer’s Amyloid-Beta Intermediates Generated by Polymer-Nanodiscs
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Abstract
Polymethacrylate-copolymer (PMA) encased lipid-nanodiscs (~10 nm) and macro-nanodiscs (>15 nm) are used to study Aβ 1-40 aggregation. We demonstrate that PMA-nanodiscs form a ternary association with Aβ and regulate its aggregation kinetics by trapping intermediates. Results demonstrating reduced neurotoxicity of nanodisc-bound Aβ oligomers are also reported.
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- europepmc
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- unpaywall
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