iPS-derived exosomes alleviated pancreatic ischemia reperfusion injury through activating the AMPK/mTOR/NF-κB pathway

iPS-derived exosomes alleviated pancreatic ischemia reperfusion injury through activating the AMPK/mTOR/NF-κB pathway | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article iPS-derived exosomes alleviated pancreatic ischemia reperfusion injury through activating the AMPK/mTOR/NF-κB pathway Bowen Yu, Xiaofeng Shen, Jiahui Lin, Yihao Wang, Ke Chen, Wanying Wu, and 7 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8586494/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Pancreatic ischemia-reperfusion (IR) injury is a key factor contributing to post-transplantation rejection and graft dysfunction. This study investigated the therapeutic potential of exosomes derived from induced pluripotent stem cells (iPS-EXOs), a novel, cell-free therapeutic strategy, in a rat model of pancreatic IR injury induced by splenic artery occlusion. Administration of iPS-EXOs significantly improved survival, attenuated pancreatic edema, and ameliorated histopathological damage. The protective effects were mediated through multi-faceted actions that iPS-EXOs restored microcirculatory perfusion through promoting VEGF-A/VEGFR2 signaling, mitigated oxidative stress via normalizing levels of ROS, MDA, MPO, GPx, and SOD, and suppressed the inflammatory cascade by reducing serum levels of IL-1β, IL-6, and TNF-α. Furthermore, iPS-EXOs exerted anti-apoptotic effects, as evidenced by decreased TUNEL-positive cells and modulation of BCL-2/BAX and Caspase-3/9 pathways. We identified that hsa-miR-1976 in iPS-EXOs could target HRH4, leading to AMPK activation and subsequent inhibition of the mTOR/NF-κB signaling pathway. Collectively, our reuslts demonstrated that iPS-EXOs exerted protection against pancreatic IR injury of rat by coordinating microvascular repair, anti-oxidant, anti-inflammatory, and anti-apoptosis through endogenous hsa-miR-1976 binding to HRH4 to activate AMPK/mTOR/NF-κB pathway. These findings indicated that iPS-EXOs could be a promising therapeutic agent for pancreatic IR injury. Pancreatic ischemia-reperfusion Exosomes derived from induced pluripotent stem cells miR-1976 Anti-inflammatory Anti-apoptosis Figures Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 1. Introduction Blood flow obstruction or tissue ischemia is a common and pivotal pathological event in clinical surgical procedures, pharmacotherapy implementation, and pathophysiological processes[ 1 ]. It not only directly compromises treatment efficacy but also often induces subsequent tissue damage and functional impairment[ 2 , 3 ]. Pancreatic transplantation is an important therapeutic option for patients with end-stage pancreatic diseases, such as severe chronic pancreatitis or post-resection advanced pancreatic cancer. Although it offers the potential to improve quality of life and prolong survival, its clinical outcomes remain inferior to those of other solid organ transplants, such as liver and kidney transplantation[ 4 ]. This is primarily due to its relatively low long-term survival rates and unfavorable graft prognosis[ 5 ]. According to clinical data, the incidence of acute rejection post-pancreatic transplantation is approximately 15%, while chronic rejection occurs at an even higher rate of 21%. Moreover, the graft failure rate within five years after transplantation can climb to 40%[ 6 , 7 ]. Previous studies have shown that these adverse clinical outcomes are directly or indirectly linked to the unavoidable ischemia-reperfusion (IR) injury during the transplantation process[ 5 ]. IR injury refers to the pathophysiological process in transplantation characterized by an initial interruption of blood supply followed by subsequent restoration of perfusion[ 8 ]. The core pathological mechanism underlying IR injury-induced pancreatic cell apoptosis begins with ischemic insult during organ procurement and implantation. After reperfusion, a series of pathological responses are triggered, including oxidative stress caused by excessive production of reactive oxygen species (ROS), toxic damage to cell membranes and organelles by oxygen free radicals, aberrant release and amplification of inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), as well as calcium overload resulting from loss of intracellular calcium homeostasis[ 9 – 12 ]. These mechanisms collectively exacerbate necrosis of pancreatic parenchymal cells and interstitial injury. Although the negative impact of IR injury on pancreatic transplant outcomes is well recognized, the progress of clinical treatment research for pancreatic IR injury remains slow. Therefore, developing novel therapeutic strategies against pancreatic IR injury is a critical and urgent clinical need. Induced pluripotent stem cells (iPSCs) are obtained through somatic cell reprogramming and possess all kinds of cell differentiation potential equivalent to that of embryonic stem cells (ESCs), while avoiding ethical controversies and immune rejection[ 13 ]. They are regarded as cell sources that are closer to clinical application[ 11 ]. Their secreted exosomes (iPS-EXOs), with a diameter of 30–150 nm, are rich in proteins, nucleic acids, and metabolites. These exosomes can stably exist in body fluids such as blood and urine, and remotely regulate the functions of target cells[ 14 , 15 ]. Previous studies have confirmed that iPS-EXOs significantly alleviate various inflammatory injuries by suppressing key pro-inflammatory factors such as IL-1β, IL-6, and TNF-α[ 16 ]. Similarly, umbilical cord mesenchymal stem cell-derived exosomes (MSC-EXOs) have been shown to reduce inflammatory infiltration and apoptosis in traumatic pancreatitis models[ 17 ]. Furthermore, iPS-EXOs can scavenge ROS, repair DNA damage, and stabilize mitochondrial function, demonstrating a broad-spectrum protective activity against oxidative stress-related injuries[ 18 ]. However, whether iPS-EXOs have protective effects on pancreatic IR injury remains unreported. In this study, we will utilize a surgically induced pancreatic IR injury model in rats to investigate the protective effects of iPS-EXOs and attempt to elucidate the potential mechanism. This research aims to provide a novel cell-free therapeutic strategy for the treatment of IR injury. 2. Materials and methods 2.1. Isolation and purification of exosomes Human-induced pluripotent stem cells (hiPSCs) were purchased from CELLAPY Biotechnology Co., Ltd. (hiPSC-U1, Beijing, China). The cells were cultured in PSCeasy ® II human pluripotent stem cell medium (CA1014500, CELLAPY) at 37°C, 5% CO2 incubator. Next, the supernatant of cells in the logarithmic growth phase (~ 80% confluency) was collected for exosome purification. The collected supernatant was stored at -80°C. Exosomes were isolated using a combination of differential centrifugation and ultracentrifugation[ 19 , 20 ]. Briefly, the collected conditioned medium was subjected to gradient centrifugation (300 × g for 10 min, 2000 × g for 10 min, 10,000 × g for 1 h) at 4°C to remove cellular debris. The supernatant was filtered through a 0.22 µm sterile membrane filter (Millipore, MA, USA) into ultracentrifuge tubes. Exosomes were pelleted by ultracentrifugation at 120,000 × g for 1.5 h at 4°C using a SW32Ti rotor (Beckman, CA, USA). The final exosome pellet (iPS-EXOs) was resuspended in PBS buffer for the following analysis. 2.2. Construction of hsa-miR-1976-knockout iPS-EXOs siRNA targeting hsa-miR-1976 was synthesized by GenScript Biotech (Nanjing, China) and transfected into hiPSCs via electroporation. Subsequently, iPS-EXOs were isolated and purified from the collected conditioned medium of the transfected cells. These exosomes are named as hsa-miR-1976-knockout iPS-EXOs (hsa-miR-1976-KO iPS-EXOs), and used for the next experiments. 2.3. Characterization of exosomes The protein concentration of iPS-EXOs was first quantified using the BCA assay (Beyotime, Shanghai, China), and the expressions of exosomal markers such as CD9, CD63, and CD81 were confirmed by western blot. Exosomes were fixed with 2.5% glutaraldehyde, followed by agitation and storage at 4°C. After fixation, the samples were washed three times with PBS for 15 min each time. Subsequently, post-fixation was performed using 0.5 mL of 2% osmium tetroxide for 2 h, followed by another three PBS washes. Dehydration was carried out using a series of graded ethanol (50%, 70%, 80%, and 90%, 15 min per step), followed by two additional treatments with absolute ethanol (20 min each). The samples were then treated with acetone twice (15 min each) for solvent replacement. Following infiltration, the specimens were embedded in pure embedding resin and polymerized at 65°C for 48 h. Ultrathin sections were stained with uranyl acetate and lead citrate, each for 10 min, and finally observed under a transmission electron microscope (FEI, OR, USA). Furthermore, the isolated exosomes were resuspended and diluted 20-fold in sterile PBS. Following the manufacturer's protocol for the DynaPro system (Malvern Britain), the cuvette was first rinsed twice with pure water to ensure cleanliness. An appropriate amount of pure water was then applied to confirm the absence of particulate contamination. Subsequently, the diluted iPS-EXOs suspension was loaded into the cuvette, and the hydrodynamic diameter distribution of the particles was measured, recorded, and analyzed by nanoparticle tracking analysis (NTA, Meerbusch, Germany). 2.4. Construction and treatment of pancreatic IR injury rat model Six-week-old male Sprague-Dawley rats (200-250g) were used in this study. Pancreatic IR injury was induced according to an established protocol[ 21 ]. Briefly, after one week of acclimatization under controlled conditions (12 h light/dark cycle, temperature 23 ± 2°C, humidity 45–55%), the rats were randomly divided into three groups (n = 8 per group) such as sham-operated group (Control), IR model group (IR), and IR + iPS-EXOs treatment group (IR + iPS-EXOs). All animal experiments study in this study were approval by the Animal Ethics Committee of the Wenzhou Institute, University of Chinese Academy of Sciences. Anesthesia was induced by intraperitoneal injection of ketamine (50 mg/kg). Following laparotomy, the splenic branch of the pancreatic artery was clamped with a microvascular clip to induce ischemia for 60 min. Reperfusion was initiated by clip removal, after which the abdominal cavity was closed. Sham-operated rats underwent the same surgical procedures except for vascular clamping. Postoperatively, the animals were monitored every 8 h for the first two days. Fluid resuscitation was administered via subcutaneous injection of Ringer's solution immediately after surgery, and again at 12 h and 24 h. iPS-EXOs treatment (50 µg/kg or 100 µg/kg) was initiated 24 h before surgery and continued daily via tail intravenous injection. The severity of pancreatitis was assessed on postoperative days 1, 2, 5, 9, and 14. 2.5. Cellular uptake of DiI-labeled iPS-EXOs IPS-EXOs were labeled using DiI (Beyotime), a lipophilic fluorescent dye commonly employed for membrane labeling and cell tracking. The labeling procedure was initiated by mixing 2.5 mL of DiI (400×) with 2.5 mL of dye enhancer solution, followed by the addition of 500 mL of staining buffer. The resulting mixture was incubated at room temperature for 10 min. Subsequently, 50 mL of iPS-EXOs were added and incubated at 37°C for 20 min. To terminate the reaction and minimize nonspecific binding, 1 mL of PBS was added and incubated at room temperature for additional 5 min. The labeled iPS-EXOs were then collected by centrifugation at 120,000 g for 90 min at 4°C. Rats were administered DiI-labeled iPS-EXOs via tail vein injection at a dose of 50 µg/kg. An equal volume of PBS was given to the control group. After 24 h, the animals were euthanized, and pancreatic tissues were collected for in viv o imaging analysis. 2.6. Histological analysis The pancreatic tissue samples were fixed in 4% paraformaldehyde at 4°C for 24 h, followed by dehydration through a graded ethanol series, paraffin embedding, and sectioning into 5 µm thick slices. The sections were deparaffinized using xylene and a graded ethanol series, then subjected to hematoxylin and eosin (HE) staining. After staining, the sections were mounted with neutral balsam and examined under a pathological scanning system (KFBIO, Ningbo, China) for histological analysis. 2.7. Immunohistochemical staining Paraffin sections of pancreas tissues in different groups were prepared following the above described procedure. After being deparaffinized and rehydrated through a graded xylene and ethanol series, the sections underwent antigen retrieval by incubation in sodium citrate at 96°C for 30 min. Following three washes with PBS, the sections were blocked with 5% bovine serum albumin at room temperature for 30 min. Next, the sections were incubated overnight at 4°C with primary antibodies (supplementary table 1). After three additional PBS washes, they were treated with enzyme-labeled secondary antibodies (1:50, Beyotime) in the dark for 2 h at room temperature, followed by three more washes with PBS. The sections were then developed using 3, 3’-diaminobenzidine (DAB) chromogen (Zsbio, Beijing, China) until a yellow color appeared. After counterstaining with hematoxylin for 4 min and subsequent washing, the sections underwent dehydration and clearing with ethanol and xylene. Finally, the sections were mounted with neutral mounting medium, and their morphological features were captured using a pathological scanning system. 2.8. Real-time quantitative polymerase chain reaction (RT-qPCR) Total RNA was extracted from rat pancreatic tissues using Trizol reagent. RNA concentration and purity (OD260 nm) were measured with a microplate spectrophotometer (TECAN, Männedorf‌, Switzerland). cDNA was synthesized from RNA samples using the HiScript II Q RT SuperMix kit (Vazyme, Nanjing, China) according to the manufacturer's instructions. RT-qPCR was performed with Taq Pro Universal SYBR Green Master Mix (Vazyme Q712) using cDNA as templates on a Bio-Rad CFX Manager system. The relative mRNA expression levels of TNF-α , IL-1β , and IL-6 were calculated by the 2^–ΔΔCt method and normalized to the endogenous control β-actin . All experiments included three technical replicates. Primer sequences are provided in supplementary table 2. 2.9. TUNEL staining Paraffin sections from each group were deparaffinized in xylene, rehydrated through a graded ethanol series, and washed three times (3 min each) with PBS. The sections were then incubated with the TUNEL reaction mixture (Elascience, Wuhan, China) at 37°C for 60 min in the dark. After washing with PBS to terminate the reaction, the nuclei were counterstained with DAPI-containing anti-fade mounting medium. Images were captured using a fully automated multi-channel fluorescence microscope. The number of TUNEL-positive (green) cells was counted, and the apoptotic index was calculated. 2.10. Western blot analysis Total protein was extracted from rat pancreatic tissues using RIPA lysis buffer (Solarbio, Beijing, China) supplemented with phosphatase and serine protease inhibitors. Protein concentration was determined with the BCA protein assay kit (Beyotime). Denatured protein samples (20–30 µg) were separated by 7.5%-12.5% SDS-polyacrylamide gel electrophoresis and transferred to PVDF membranes (Thermo Scientific, MA, USA). The membranes were blocked with 5% non-fat milk in TBST for 2 h at room temperature, followed by three washes with TBST. Subsequently, the membranes were incubated with primary antibodies (supplementary table 1) at 4°C overnight. After additional TBST washes, the membranes were incubated with horseradish peroxidase (HRP)-conjugated secondary antibodies (anti-rabbit or anti-mouse, 1:1000, Beyotime) for 2 h at room temperature. Following thorough washing with TBST, immunoreactive bands were visualized using an ECL chemiluminescence detection kit (NCM Biotech, Suzhou, China) on a ChemiDoc™ XRS imaging system (Bio-Rad, CA, USA). Band intensity was quantified using ImageJ software. 2.11. Determination of pancreatic blood flow At each experimental endpoint, the rats were anesthetized again with ketamine, and the abdominal cavity was carefully exposed. Following a previously reported method[ 20 ], pancreatic blood flow in the splenic region was measured using a laser Doppler flowmeter (PeriFlux 4001 Master monitor, Perimed AB, Järfälla, Sweden). The baseline blood flow of the sham-operated group, which only underwent laparotomy and saline injection without induction of acute pancreatitis, was used as a reference to calculate the percentage change in blood flow for each group. 2.12. Assay of serum biochemical profiles Immediately following the measurement of pancreatic blood flow, blood samples were collected from the abdominal aorta. Blood was immediately transferred into sterile, non-anticoagulant-containing vacuum tubes. The blood was allowed to clot completely by incubating the tubes at room temperature for 1 h. Following clot formation, the samples were centrifuged at 3,000 × g for 15 min at 4°C. The resulting supernatant (serum) was carefully aspirated using a micropipette, taking caution to avoid disturbing the clot or the buffy coat layer. The serum was stored at -80°C until subsequent analysis. The following parameters were measured using enzyme-linked immunosorbent assay (ELISA) according to the manufacturer’s instructions. Serum amylase and lipase concentrations were determined using the α-Amylase assay kit and the Lipase ELISA kit (Jiancheng Biotech, Nanjing, China), respectively, to evaluate pancreatic exocrine function. Serum insulin levels were measured using the rat insulin ELISA kit (Jianglai Biotech) to assess pancreatic endocrine function. In addition, the concentrations of inflammatory cytokines, including TNF-α, IL-6, and IL-1β, were quantified using ELISA kits (Thermo Fisher). 2.13. Assay of oxidative stress in pancreatic tissues Various oxidative stress and anti-oxidant biomarkers, including malondialdehyde (MDA), glutathione peroxidase (GPx), myeloperoxidase (MPO), and superoxide dismutase (SOD), were measured using commercial assay kits such as malondialdehyde detection kit, glutathione peroxidase assay kit (Servicebio), myeloperoxidase activity assay kit, and total superoxide dismutase detection kit (Servicebio, Wuhan, China). All assays were conducted in accordance with the manufacturer's instructions. 2.14. Measurement of pancreatic wet-to-dry weight ratio The pancreatic wet-to-dry weight ratio, defined as the ratio of the tissue's wet weight (measured after blotting surface moisture) to its dry weight (obtained after complete dehydration), serves as a quantitative indicator for assessing the severity of tissue edema in IR injured pancreatic regions. The specific procedure was as follows: tissue samples from the pancreatic body and tail were blotted with absorbent paper to remove surface moisture before wet weight measurement, then dried in a vacuum oven at 60°C until a constant dry weight was achieved. The wet-to-dry ratio was calculated using the formula: wet-to-dry ratio = (wet weight/dry weight)×100%. 2.15. Apoptosis assay Cell apoptosis was detected using an Annexin V-APC/PI apoptosis detection kit (Elabscience, Wuhan, China). Pancreatic tissues were collected from rats, and pancreatic cells were isolated. After washing with PBS, the cells were resuspended in 100 µL of 1×Annexin V Binding buffer. Then, 2.5 µL of Annexin V-APC reagent and 2.5 µL of PI reagent were added to the cell suspension. The mixture was thoroughly vortexed and incubated at room temperature in the dark for 20 min. After incubation, 400 µL of 1× Annexin V Binding Buffer was added and gently mixed. Finally, the apoptosis rate was analyzed using a flow cytometer (Beckman). 2.16. ROS detection Pancreatic cells were allocated into five groups: negative control, positive control, sham, IR, and iPS-EXO groups. Each sample was centrifuged at 300g for 5 min, followed by resuspension of the pellet in RPMI 1640 medium supplemented with 10% fetal bovine serum. For treatment, the negative control group was not labeled with a ROS probe, while the positive control group was treated with a ROS inducer and incubated at room temperature for 30 min. Subsequently, cells were combined with ROS assay buffer and centrifuged again at 300 × g for 5 min. The cell suspension was filtered through a 200-mesh sieve, and intracellular ROS levels were analyzed using flow cytometry 2.17. Identification of the differential expression genes (DEGs) and functional enrichment analysis The RNA sequencing data were obtained from the Gene Expression Omnibus (GEO) database (accession GSE18606) and processed using R software (version 4.4. 1). Differential expression analysis between healthy individuals and pancreatitis patients was performed using the Limma package (version 3.60.4) with its empirical Bayesian algorithm. Differentially expressed genes (DEGs) were identified using the following thresholds: absolute log2 fold change ≥ 1.5 and false discovery rate (FDR)-adjusted p -value < 0.05. Volcano plots and heatmaps visualizing the DEGs were generated using the ggplot2 (version 3.5. 1) and pheatmap (version 1.0. 12) packages, respectively. Functional enrichment analysis, including Gene Ontology (GO) term enrichment, was conducted on the identified DEGs using the clusterProfiler package (version 4.12.6), with an adjusted p -value < 0.05 considered statistically significant. Additionally, pathway enrichment and pathway interaction analyses were performed using the Enrichplot package. 2.18. Statistical analysis The data are presented as the mean ± standard deviation (mean ± SD) derived from a minimum of three independent experiments. Statistical analyses were evaluated by GraphPad Prism version 9 (GraphPad Software Inc., CA, USA). To evaluate differences between two groups, an independent Student’s t -test was utilized. For comparisons involving two or more groups, a one-way analysis of variance (ANOVA) was performed, followed by a post hoc Tukey test to adjust for multiple comparisons. A p -value of less than 0.05 was considered statistically significant, while a p -value greater than 0.05 was regarded as not significant ( ns ). 3. Results 3.1. Characterization and in vivo uptake of iPS-EXOs iPS-EXOs were successfully isolated from the culture supernatant of hiPSCs through ultracentrifugation. TEM revealed that iPS-EXOs exhibited the typical cup-shaped morphology (Fig. 1 A). The NTA results further demonstrated that the average particle diameter of iPS-EXOs was 100.00 ± 25.00 nm (Fig. 1 B). Moreover, western blot analysis confirmed the expressions of exosome-specific markers, including CD63, CD81, and CD9 (Fig. 1 C). Collectively, these data demonstrated that iPS-EXOs had been successfully isolated. To demonstrate the uptake of iPS-EXOs by pancreatic tissues in vivo , the exosomes were labeled with the lipophilic fluorescent dye DiI for subsequent traced within the tissues. The distribution of DiI-tagged iPS-EXOs in the rat pancreas was evaluated using small animal in vivo imaging. The results demonstrated that iPS-EXOs could be successfully taken up by pancreatic tissues and exhibited red fluorescence (Fig. 1 D). Quantitative analysis further revealed that the fluorescence intensity in the iPS-EXO group was significantly higher than that of the control group, which exhibited virtually no fluorescent signal (Fig. 1 E). These findings confirmed that iPS-EXOs could be effectively absorbed by pancreatic tissues. 3.2. Exploration of the optimal in vivo concentration of iPS-EXOs To determine the optimal in vivo dosage of iPS-EXOs, we examined 100 µg/kg and compared it with the previously established 50 µg/kg dose. Pancreatic injury was assessed using three complementary methods such as histopathology (HE staining), apoptosis (TUNEL assay), and serum inflammatory markers (ELISA). Results indicated that in rat models of pancreatic IR, administration of 100 µg/kg iPS-EXOs significantly reduced histopathological scores more effectively than the 50 µg/kg dose (Fig. S1A and S1B). Furthermore, TUNEL staining revealed a markedly lower percentage of apoptotic cells in the 100 µg/kg iPS-EXO group than that of the 50 µg/kg group (Fig. S1C and S1D). Concurrently, the 100 µg/kg dose led to a greater decrease in serum levels of inflammatory mediators than the 50 µg/kg dose (Fig. S1E). Collectively, these findings demonstrated that the 100 µg/kg dose of iPS-EXOs is more effective than the 50 µg/kg dose in promoting tissue repair, inhibiting apoptosis, and attenuating systemic inflammation. So, we chose the 100 µg/kg dose of iPS-EXOs as the working concentration for the following study. 3.3. iPS-EXOs alleviated pancreatic damage and promote tissue repair Our research found that treatment with iPS-EXOs could significantly increase the survival rate of IR injury rats (Fig. 2 A). To evaluate the effects of iPS-EXOs on pancreatic tissue damage, tissues were collected for HE staining (Fig. 2 B) and pathological analysis (Table 1). Pancreatic tissues in the control group displayed no signs of inflammatory cell infiltration, degeneration, or necrosis. In contrast, all experimental animals developed acute hemorrhagic necrotizing pancreatitis following IR injury. On the day 1 after reperfusion, the light microscope examination revealed moderate interlobular and intralobular edema in the pancreatic tissues. The tissues also exhibited moderate perivascular inflammatory cell infiltration and minimal diffuse leukocyte infiltration. Vacuolar changes were detected in fewer than 25% of acinar cells, and approximately 15%-35% of pancreatic cells displayed necrotic changes. Moreover, each histological slide displayed 1 to 5 hemorrhagic areas in the pancreatic tissues of IR-induced rats. Subsequent observations indicated spontaneous regenerative characteristics within the pancreatic tissues. By day 14 following injury, only mild interlobular edema and scattered perivascular inflammatory infiltrates were observed in the affected tissues, with acinar vacuolation consistently maintained below 25%. In the iPS-EXOs treatment group, significant improvements were observed as early as two days after administration. Compared to the IR group, the iPS-EXO group exhibited markedly reduced severity of pancreatic necrosis, attenuated inflammatory infiltration, and fewer hemorrhagic foci over the time of IR injury (Fig. 2 C). These results suggested that iPS-EXOs treatment could effectively promote the regeneration of pancreatic tissues. By the end of the observation period, no pathological indicators of pancreatic injury were detected in the iPS-EXO group, except for the presence of mild edema. Moreover, analysis based on wet-to-dry weight ratios systematically confirmed the accelerated resolution of edema (Fig. 2 D), thereby providing evidence for the comprehensive reparative effects of iPS-EXOs on pancreatic injury. 3.4. iPS-EXOs improved pancreatic microcirculation and functional recovery following IR injury To assess the impact of iPS-EXOs on pancreatic perfusion and exocrine/endocrine function after IR injury, we monitored hemodynamic (Fig. 3 A) and biochemical parameters. Compared with the sham-operated group (control), rats subjected to IR exhibited a severe decline in pancreatic blood flow, which dropped to approximately 20% of baseline levels within 24 h post-reperfusion. While the IR group showed a spontaneous but gradual recovery of blood flow over 14 days, administration of iPS-EXOs significantly accelerated this process, leading to earlier and more robust restoration of microcirculation (Fig. 3 B). Mechanistically, western blot analysis (Fig. 3 C) revealed that iPS-EXOs treatment up-regulated vascular endothelial growth factor A (VEGF-A) expression and enhanced phosphorylation of vascular endothelial growth factor receptor-2 (VEGFR2) (Fig. 3 D), suggesting promoted vascular repair. Functionally, IR injury triggered a significant increase in serum amylase and lipase levels, peaking at 24 h (-14-fold vs. control) and 48 h (15-fold vs. control), respectively, indicating substantial exocrine damage (Fig. 3 E and F). Concurrently, insulin levels decreased markedly, reaching a nadir of 25% of control values at 24 h (Fig. 3 G). Although these parameters gradually normalized over time in the IR group, iPS-EXOs treatment significantly shortened the recovery period for amylase and lipase levels and facilitated the restoration of insulin secretion, demonstrating enhanced functional protection. 3.5. iPS-EXOs alleviated oxidative stress The hallmark of pancreatic IR injury is the production of reactive oxygen species (ROS). This process subsequently triggers the infiltration of inflammatory cells, ultimately leading to the apoptosis of pancreatic cells[ 22 ]. We analyzed the ROS level in pancreatic cells by flow cytometry (Fig. 4 A). The fluorescence intensity of ROS demonstrated a significant increase in the IR group, whereas a notable decrease was observed in the iPS-EXO group (Fig. 4 B). Consistent with the above mechanism, IR-induced rat pancreatic tissues exhibited a significant increase in lipid peroxidation, as reflected by elevated malondialdehyde (MDA) levels (Fig. 4 C), together with enhanced activity of the neutrophil marker myeloperoxidase (MPO) (Fig. 4 D). These markers peaked on day 1 post-IR and subsequently declined. In contrast, the activities of key anti-oxidant enzymes, including glutathione peroxidase (GPx) (Fig. 4 E) and superoxide dismutase (SOD) (Fig. 4 F), were markedly suppressed reaching a nadir on day 1 before gradual recovery. iPS-EXOs treatment effectively counteracted these changes, reducing MDA and MPO levels while restoring GPx and SOD activities toward baseline, thereby promoting redox homeostasis. 3.6. iPS-EXOs attenuated inflammatory response in pancreatic IR injury To evaluate the anti-inflammatory effect of iPS-EXOs, we measured the expression of key pro-inflammatory cytokines. RT-qPCR and ELISA analyses revealed that IR injury induced a significant increase in the levels of IL-1β, IL-6, and TNF-α, which peaked on day 1 post-reperfusion and subsequently declined (Fig. 5 A and B). This dynamic pattern paralleled the rise in serum amylase and lipase. Notably, iPS-EXOs treatment significantly suppressed the up-regulation of these cytokines and promoted their return to homeostatic levels. Given the critical role of inducible nitric oxide synthase (iNOS), cluster of differentiation 45 (CD45), and tumor necrosis factor-alpha (TNF-α) in inflammation and oxidative stress, we assessed their expressions by immunohistochemistry (Fig. 5 C). While the staining of these markers was negative in the sham-operated group (control), strong immunoreactivity was observed in pancreatic tissues in the IR group. In contrast, iPS-EXOs administration markedly reduced these maker expressions, indicating mitigation of inflammatory and oxidative damage (Fig. 5 D). 3.7. iPS-EXOs inhibited pancreatic cell apoptosis To assess the anti-apoptotic effect of iPS-EXOs, apoptosis of pancreatic cells was analyzed by flow cytometry (Fig. 6 A). The results demonstrated a significantly higher apoptosis rate in pancreatic cells following IR injury compared to the sham operated group (control), which was markedly attenuated by iPS-EXOs treatment (Fig. 6 B). This observation was corroborated by TUNEL staining (Fig. 6 C), which showed a substantial increase in apoptotic cells in IR rats that was significantly attenuated following iPS-EXOs administration (Fig. 6 D). Western blot analysis (Fig. 6 E) of apoptosis-related protein expressions revealed that IR injury up-regulated the pro-apoptotic protein BAX and down-regulated the anti-apoptotic protein BCL-2, leading to a markedly declining BCL-2/BAX ratio as well as increased the the ratios of cleaved Caspase-3/Caspase-3 and cleaved Caspase-9/Caspase-9, but iPS-EXOs treatment could significanlty reversed these alterations (Fig. 6 F). These results indicated that iPS-EXOs could inhibit the mitochondrial apoptotic pathway of pancreatic cells in IR injury rats. 3.8. Identification of differentially expression genes (DEGs) and functional enrichment analysis To investigate the molecular mechanism by which iPS-EXOs exerted its protective effects in pancreatitis, we analyzed RNA sequencing data of healthy individuals and patients with pancreatitis. The analysis identified 3,291 differentially expressed genes (DEGs), comprising 1,647 down-regulated and 1,644 up-regulated genes in pancreatitis patients (Fig. 7 A). These DEGs provide significant insights into the potential molecular mechanisms underlying pancreatitis. A heatmap visually summarized these expression patterns (Fig. 7 B). Given the importance of exosomal microRNAs (miRNAs) in regulating pathological processes such as inflammation[ 23 – 25 ], we analyzed miRNA expression profiles from three iPS-EXO transcriptome datasets (GSM3597011, GSM3597012, and GSM3597013). Among these, hsa-miR-1976 was the most abundant miRNA in iPS-EXOs (Fig. 7 C). Using the databases miRTarBase, miRWalk, miRBD, and TargetScan, we identified 24 potential target genes of hsa-miR-1976, among which HRH4 was selected for further analysis due to its strong sequence complementarity (Fig. 7 D). KEGG pathway enrichment analysis of HRH4-associated DEGs revealed its involvement in the AMPK and NF-κB signaling pathways (Fig. 7 E). Consistent with this, GO biological process analysis indicated HRH4's role in NF-κB-related signal transduction (Fig. 7 F). RT-qPCR validation showed that HRH4 expression was significantly up-regulated in IR injury pancreatic tissues, while iPS-EXOs treatment could inhibit this effect. This suppression was notably reversed by the addition of AMPK inhibitor Compound C (CC) (Fig. 7 G). In conclusion, these results suggested that iPS-EXOs might mitigate pancreatic inflammation and apoptosis through the hsa-miR-1976/HRH4 axis to regulate AMPK and NF-κB signaling pathways. The 18 pathway enrichment diagrams related to HRH4 were displayed in the GO BP (Fig. S2A), and the gene overlap relationship emapplot enrichment diagram (Fig. S2B) and enrichment chord diagram (Fig. S2C) were also depicted, showing the close connections between HRH4 and NF-κB related pathways. Meanwhile, we also performed enrichment analysis on DEGs, generating a cnet plot category network diagram of HRH4 involved in the regulation pathway (Fig. S2D), to highlight the close connections between these pathways. Furthermore, we demonstrated a close association between the HRH4 gene and hsa-miR-1976 (Fig. S2E) and generated a volcano plot to visualize the DEGs between pancreatitis patients with high and low levels of HRH4 expression (Fig. S2F),. Moreover, a KEGG pathway enrichment analysis of DEGs with p < 0.05 about signal transduction revealed that pancreatitis was involved in the NF- κB and AMPK signaling pathways (Fig. S2G), and a GO biological process (BP) enrichment analysis of DEGs with p < 0.05 about signaling pathway showed that pancreatitis was also involved in NF-κB processes (Fig. S2H). In summary, iPS-EXOs may alleviate IR induced inflammation and apoptosis through hsa-miR-1976/HRH4 axis. 3.9. iPS-EXOs attenuated pancreatic IR injury through the AMPK/mTOR/NF-κB signaling pathway Previous studies have confirmed the close association between NF-κB signaling activation and pancreatic IR injury[ 25 ]. Bioinformatics analyses further indicated that HRH4 plays a role in the NF-κB pathway. Therefore, to investigate the mechanism underlying iPS-EXOs mediated protection, we assessed key proteins in the AMPK/mTOR/NF-κB pathway and HRH4 expression by western blot (Fig. 8 A). Quantitative analysis showed that IR injury significantly decreased the p-AMPK/AMPK ratio, while increasing p-mTOR/mTOR, p-NF-κB/NF-κB, and HRH4 levels compared to the control group. iPS-EXOs treatment effectively reversed these changes. However, co-administration of CC largely abolished the protective effects of iPS-EXOs (Fig. 8 B). Based on the predicted interaction between hsa-miR-1976 and HRH4, we used hsa-miR-1976-knockout exosomes (hsa-miR-1976-KO EXOs) to administer pancreatic IR rats. Western blot analysis (Fig. 8 C) revealed that, compared to the IR + iPS-EXO group, the IR + hsa-miR-1976-KO EXO group exhibited a significantly reduced p-AMPK/AMPK ratio, along with elevated p-mTOR/mTOR, p-NF-κB/NF-κB, and HRH4 levels (Fig. 8 D). These results underscore the essential role of hsa-miR-1976 in regulating the HRH4-dependent AMPK/mTOR/NF-κB pathway. In conclusion, we speculated that iPS-EXOs may release hsa-miR-1976 to alleviate the inhibitory effect of HRH4 on AMPK, lead to the activation of AMPK, and then inhibit the mTOR signal to further suppress the activities of NF-κB, thereby exerting anti-inflammatory and anti-apoptotic effects on pancreatic IR injury (Fig. 9 ). 4. Discussion Pancreatic IR injury represents a significant clinical challenge, particularly in surgical interventions involving vascular occlusion. The pathophysiology of IR injury is complex, arising from a cascade of events including microcirculatory failure, oxidative stress, inflammatory activation, and ultimately, apoptotic cell death[ 21 , 26 – 30 ]. In this study, we demonstrated that exosomes derived from iPSCs confer remarkable protection against pancreatic IR injury in rats. Our findings revealed that the therapeutic benefits of iPS-EXOs are multifaceted, encompassing the amelioration of microcirculatory dysfunction, attenuation of oxidative stress and inflammation, and inhibition of pancreatic cell apoptosis. Mechanistic studies confirmed that iPS-EXOs might exert their protective effects through the delivery of endogenous hsa-miR-1976, which targets HRH4 and then activated the AMPK/mTOR/NF-κB signaling pathway, thereby producing the therapeutic outcome. Researches have demonstrated that microcirculatory dysfunction is the primary feature of early pancreatic injury following ischemia, which subsequently leads to capillary thrombosis, leukocyte activation, and the release of proteolytic enzymes and pro-inflammatory cytokines[ 31 , 32 ]. A critical finding of our work is the potent effect of iPS-EXOs on restoring pancreatic microcirculation post-IR injury. The observed impairment in blood flow, characterized by approximately 80% reduction within 1 day of reperfusion, aligns with the established paradigm of microvascular thrombosis and dysfunction[ 30 , 33 ]. iPS-EXOs treatment not only accelerated the recovery of perfusion but also promoted the up-regulation of VEGF-A expression and phosphorylation level of VEGFR2. These suggestsed that iPS-EXOs could facilitate endothelial repair and microvascular remodeling. Beyond microcirculatory improvement, iPS-EXOs administration effectively countered the oxidative and inflammatory cascades that define IR injury. The previous study has shown that oxidative stress is the basic mechanism of IR injury in the pancreas[ 26 ]. Moreover, in several clinical studies, the severity of the disease in patients with acute pancreatitis is related to the elevation of oxidative stress[ 34 , 35 ]. During the IR process, a substantial quantity of reactive oxygen species (ROS) is produced. These ROS will assail and impair lysosomes, mitochondria, and other cellular components. Consequently, the initial ischemic injury is transformed into the activation of extensive detrimental inflammatory and apoptotic pathways[ 36 , 37 ]. Malondialdehyde (MDA) is the most commonly indicator for detecting lipid peroxides in cells and tissues, which is regarded as a crucial marker for assessing the severity of acute pancreatitis[ 38 ]. Moreover, myeloperoxidase (MPO) has been proven to exacerbate tissue damage in diverse inflammatory diseases[ 39 ]. Glutathione peroxidase (GPx) and Superoxide dismutase (SOD) can be used as indicators for assessing anti-oxidative stress. In our study, the treatment with iPS-EXOs could accelerate the normalization of ROS, MDA, MPO, GPx, and SOD levels, indicating the positive effect on the restoration of redox homeostasis. The activation of nuclear factor NF-κB represents a pivotal event in the pathogenesis of acute pancreatitis[ 40 , 41 ]. Although the inflammatory response and trypsin activation proceed occur through separate pathways and do not interfere with each other directly, oxidative stress acts as a common facilitating mechanism that can influence both processes. The ROS generated by NADPH oxidase can not only directly alter the mitochondrial permeability transition pore (MPTP), thereby resulting in apoptosis and necrosis, but also trigger the activation of the NF-κB signaling pathway to initiate an inflammatory response[ 42 ]. Substantial evidence indicated that neutrophils were critically involved in the initiation of acute pancreatitis (AP). When stimulated by inflammation, neutrophils released a series of potent mediators, such as IL-1β and ROS[ 43 , 44 ]. IL-1β is a critical mediator in the onset and progression of inflammatory responses. It not only exerts direct pro-inflammatory effects but also promotes the secretion of additional cytokines involved in the pro-inflammatory cascade[ 45 , 46 ]. This cascade of cycles can lead to severe circulatory failure and even organ failure. Our research indicated that iPS-EXOs treatment significantly mitigated the inflammatory response, as evidenced by reduced leukocyte infiltration, lower serum levels of IL-1β, IL-6, and TNF-α, as well as decreased iNOS, TNF-α, and CD45 expressions. In acute pancreatitis, amylases and lipases are released from acinar cells into the interstitial space[ 47 ], with their increased serum concentrations serving as highly sensitive and clinically relevant biomarkers for assessing disease severity[ 48 ]. The accelerated resolution of pancreatic edema and necrosis, coupled with the rapid decline of serum amylase and lipase, further demonstrated the ability of iPS-EXOs to curtail acinar cell injury and promote tissue repair. The protective effects of iPS-EXOs culminated in a significant reduction in pancreatic cell apoptosis. Data of TUNEL staining, flow cytometry, and western blot analysis consistently demonstrated that iPS-EXOs shifted the balance towards cell survival, increasing the BCL-2/BAX ratio and inhibiting the activation of Caspase-3 and Caspase-9. To elucidate the underlying molecular mechanism, we employed a bioinformatics approach and pinpointed the AMPK/mTOR/NF-κB pathway as well as HRH4 as key players. We further found iPS-EXOs are enriched with hsa-miR-1976. By leveraging public databases including miRTarBase, miRWalk, miRDB, and TargetScan, we predicted the potential target genes of hsa-miR-1976, revealing HRH4 as one of the most significant targets with a strong binding affinity to hsa-miR-1976. miR-548 is a large gene family in the human body that plays diverse biological roles, including the regulation of the actin cytoskeleton, the MAPK signaling pathway, and inflammatory responses[ 49 ]. hsa-miR-1976, as a critical member of the miR-548 family, has demonstrated significant potential in the treatment of pancreatic diseases[ 50 ]. Furthermore, as the predicted target gene of hsa-miR-1976, HRH4 plays a pivotal role in modulating inflammatory responses through the regulation of immune cell chemotaxis and activation[ 51 ]. In the context of IR injury, the AMPK/mTOR signaling axis serves a fundamental protective function by coordinating cellular adaptation to metabolic stress[ 52 ]. Cellular energy depletion during ischemia coupled with ROS generation upon reperfusion potently stimulated AMPK activity, principally through phosphorylation mediated by LKB1 and by increasing the AMP/ATP ratio[ 53 ]. This activation triggers a cascade of downstream events wherein AMPK directly phosphorylates the mTORC1 constituent Raptor while concurrently stimulating the TSC complex, leading to effective suppression of mTORC1 signaling[ 54 ]. This inhibition initiates a dual protective mechanism: it simultaneously enhances autophagic clearance of dysfunctional organelles and misfolded proteins by removing mTOR-mediated repression of autophagy initiation[ 55 ], while concurrently conserves cellular energy through reducing ribosomal biogenesis and protein synthesis, thereby prioritizing ATP allocation for critical survival processes[ 56 ]. Beyond mTOR regulation, AMPK activation further supports cellular recovery by modulating metabolic and inflammatory pathways[ 57 ], promoting mitochondrial biogenesis via PGC-1α activation and fatty acid oxidation through ACC phosphorylation[ 58 ], while simultaneously restrains inflammatory responses through suppression of NLRP3 inflammasome formation and NF-κB transcriptional activity, ultimately diminishing production of pro-inflammatory mediators including IL-1β and TNF-α[ 59 ]. Our study confirmed that iPS-EXOs could promote AMPK phosphorylation while concurrently suppressing HRH4 expression and mTOR/NF-κB activation. Furthermore, the benefits of iPS-EXOs were abolished by either AMPK inhibitor Compound C (CC) or hsa-miR-1976 knockdown, demonstrating that the hsa-miR-1976/HRH4/AMPK axis may be the central to its therapeutic mechanism. Therefore, we proposed that the endogenous miR-1976 of iPS-EXOs, alleviated the inhibitory effect of HRH4 on AMPK, lead to the activation of AMPK, and then inhibit the mTOR signal, thereby suppressing the pro-inflammatory and pro-apoptotic activities of NF-κB and breaking the vicious cycle of IR damage. Although this study provides new insights, there are still some limitations. The translational relevance of findings from rodent models to human patients requires careful validation, given inherent species differences. The absence of a robust in vitro model using pancreatic exocrine cells limited our ability to dissect cell-autonomous mechanisms. Establishing a reliable oxygen-glucose deprivation (OGD) cell model would be a valuable future direction. Finally, the potential contribution of other cargo within iPS-EXOs to the overall therapeutic effect warrants further investigation using multi-omics approaches and gene knockout animal or cell models. 5. Conclusion This study demonstrated that iPS-EXOs could significantly alleviate IR-induced pancreatic injury. The core mechanism underlying their anti-inflammatory and anti-apoptotic effects lies in the activation of the AMPK/mTOR/NF-κB signaling pathway, mediated by their endogenous hsa-miR-1976 targeting HRH4. This finding provides a novel therapeutic strategy for the prevention and treatment of pancreatic IR injury. Declarations Acknowledgments Funding: This work was supported, in part, by Grant Name the Zhejiang Provincial Natural Science Foundation of China (LTGY23H030003 and LY24H020008)，the Key Research and Development Program of Zhejiang Province (2023C03018). Ethics approval statement None reported Conflict of Interest Disclosure The authors declare no competing financial interest CRediT authorship contribution statement Bowen Yu : Writing-review & editing, Writing – original draft, Visualization, Validation, Supervision, Software, Methodology, Investigation, Formal analysis, Data curation, Conceptualization. Xiaofeng Shen: Supervision, Methodology, Investigation, Formal analysis, Data curation. Jiahui Lin: Methodology, Supervision. Yihao Wang: Methodology, Validation. Ke Chen ： Methodology, Supervision. Yanli Xiao: Methodology, Validation. Wanying Wu: Methodology, Validation. Yuchong Fu: Methodology, Validation. Shuhui Zhao: Methodology, Validation. Ao Zhang: Methodology, Validation. Guanghui Zhu: Supervision. Weiping Ji : Data curation, Funding acquisition, Resources, Supervision, Writing-review & editing. Xiaoling Guo : Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing-review & editing Data availability The data used to support the findings of this study are available from the corresponding author upon reasonable request. Clinical trial number not applicable References Zhou W, Lin D, Zhong Z, Ye Q. Roles of TRAFs in Ischemia-Reperfusion Injury. Front Cell Dev Biol. 2020;8:586487. http://dx.doi.org/10.3389/fcell.2020.586487 Kervella D, Mesnard B, Prudhomme T, Bruneau S, Masset C, Cantarovich D, et al. Sterile Pancreas Inflammation during Preservation and after Transplantation. Int J Mol Sci. 2023;24(5). http://dx.doi.org/10.3390/ijms24054636 Chen CF, Chen HT, Wang D, Li JP, Fong Y. Restrictive ventilatory insufficiency and lung injury induced by ischemia/reperfusion of the pancreas in rats. 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(A) Representative morphological features of the pancreas. Scale bar 50 μm. (B) Histological score of pancreatic damage in the course of IR (n=6). (C) The apoptosis of pancreas with different treatments was assessed using TUNEL staining. Scale bar 50 μm. (D) The quantitative graph of TUNEL staining in each group (n=6). (E) Serum concentration of IL-1β, IL-6, and TNF-α in the course of IR (n=6). All data are presented as mean ± SD. ** p <0.01， * p <0.05 vs. Control. # p <0.05 vs. IR group. Supplemental Fig.S2. The further Gene Set Enrichment Analysis (GSEA) and clustering analysis of the AMPK/mTOR/NF-κB pathway. (A) The circular plot of HRH4 involvement in related pathway regulation. (B) Enrichment map plot of the pathway’s clustering analysis. (C) GO biological process (BP) enrichment analysis of genes. (D) Cnet plot category network diagram of HRH4 involvement in related pathway regulation. (E) The correlation between HRH4 and hsa-miR-1976. (F) Volcano plot of differentially expressed genes (DEGs) in patients with pancreatitis with high and low expression of HRH4. (G) KEGG pathway enrichment analysis of the signal transduction. (H) GO biological process (BP) enrichment analysis of the signaling pathway. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-8586494","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":591533892,"identity":"c2cb868d-cf29-45a0-8073-08f64a3a045b","order_by":0,"name":"Bowen Yu","email":"","orcid":"","institution":"Second Affiliated Hospital \u0026 Yuying Children's Hospital of Wenzhou Medical University","correspondingAuthor":false,"prefix":"","firstName":"Bowen","middleName":"","lastName":"Yu","suffix":""},{"id":591533893,"identity":"9d975367-7063-4797-afef-5a39f250cb4a","order_by":1,"name":"Xiaofeng Shen","email":"","orcid":"","institution":"Second Affiliated Hospital \u0026 Yuying Children's Hospital of Wenzhou Medical University","correspondingAuthor":false,"prefix":"","firstName":"Xiaofeng","middleName":"","lastName":"Shen","suffix":""},{"id":591533894,"identity":"bbc522db-e941-4dca-8b11-cda7b255d0c4","order_by":2,"name":"Jiahui Lin","email":"","orcid":"","institution":"Second Affiliated Hospital \u0026 Yuying Children's Hospital of Wenzhou Medical University","correspondingAuthor":false,"prefix":"","firstName":"Jiahui","middleName":"","lastName":"Lin","suffix":""},{"id":591533895,"identity":"f741732e-f5c8-4402-b910-e99eda44de0e","order_by":3,"name":"Yihao Wang","email":"","orcid":"","institution":"Second Affiliated Hospital \u0026 Yuying Children's Hospital of Wenzhou Medical University","correspondingAuthor":false,"prefix":"","firstName":"Yihao","middleName":"","lastName":"Wang","suffix":""},{"id":591533896,"identity":"467dc565-7293-40d3-9838-9dd69b11a899","order_by":4,"name":"Ke Chen","email":"","orcid":"","institution":"Second Affiliated Hospital \u0026 Yuying Children's Hospital of Wenzhou Medical University","correspondingAuthor":false,"prefix":"","firstName":"Ke","middleName":"","lastName":"Chen","suffix":""},{"id":591533897,"identity":"e4858898-24bd-4d36-8e84-3685b0b70ebf","order_by":5,"name":"Wanying Wu","email":"","orcid":"","institution":"Second Affiliated Hospital \u0026 Yuying Children's Hospital of Wenzhou Medical University","correspondingAuthor":false,"prefix":"","firstName":"Wanying","middleName":"","lastName":"Wu","suffix":""},{"id":591533898,"identity":"00921ac8-7ce3-4956-a056-f23017986275","order_by":6,"name":"Yanli Xiao","email":"","orcid":"","institution":"Second Affiliated Hospital \u0026 Yuying Children's Hospital of Wenzhou Medical University","correspondingAuthor":false,"prefix":"","firstName":"Yanli","middleName":"","lastName":"Xiao","suffix":""},{"id":591533899,"identity":"32f14f98-2711-4a3f-8b4f-20fd1777bf0b","order_by":7,"name":"Yuchong Fu","email":"","orcid":"","institution":"Second Affiliated Hospital \u0026 Yuying Children's Hospital of Wenzhou Medical University","correspondingAuthor":false,"prefix":"","firstName":"Yuchong","middleName":"","lastName":"Fu","suffix":""},{"id":591533900,"identity":"1645f37f-f65b-40fb-934b-640b79e4b6af","order_by":8,"name":"Shuhui Zhao","email":"","orcid":"","institution":"Second Affiliated Hospital \u0026 Yuying Children's Hospital of Wenzhou Medical University","correspondingAuthor":false,"prefix":"","firstName":"Shuhui","middleName":"","lastName":"Zhao","suffix":""},{"id":591533901,"identity":"5e6593cd-340c-47ee-925a-6d7309b95366","order_by":9,"name":"Ao Zhang","email":"","orcid":"","institution":"Second Affiliated Hospital \u0026 Yuying Children's Hospital of Wenzhou Medical University","correspondingAuthor":false,"prefix":"","firstName":"Ao","middleName":"","lastName":"Zhang","suffix":""},{"id":591533902,"identity":"c150a8a5-265a-4930-8f7d-a3fafda89898","order_by":10,"name":"Guanghui Zhu","email":"","orcid":"","institution":"Second Affiliated Hospital \u0026 Yuying Children's Hospital of Wenzhou Medical University","correspondingAuthor":false,"prefix":"","firstName":"Guanghui","middleName":"","lastName":"Zhu","suffix":""},{"id":591533903,"identity":"f6efccfb-c964-4fea-af90-0060bd83b5da","order_by":11,"name":"Weiping Ji","email":"","orcid":"","institution":"Cancer Hospital of Chinese Academy of Medical Sciences","correspondingAuthor":false,"prefix":"","firstName":"Weiping","middleName":"","lastName":"Ji","suffix":""},{"id":591533904,"identity":"ad1421a6-8270-4040-8c53-579224d567ca","order_by":12,"name":"Xiaoling Guo","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA3UlEQVRIiWNgGAWjYLCCBwYMDPwSYKaEDHFaEoBaJGcwMDYAtfAQqQWIDW6AtTAQ1iIfkXxMIqHgjt3m283HH92oseBhYD98dAM+LYY30pINEgyeJW+7cyyxOecY0GE8aWk38GqZkWP4IMHgcLLZjRzD5hw2oBYJHjNCWgwOgLQYzwBp+UeEFnkJiC12BkBGc24bEVoMeJ6B/HI4QeJGWuLs3D4JHjZCfpFvB4bYhz+H7flnJB/4nPOtTo6f/fAx/LYcgNCJDTARNnzKwbZAldoTUjgKRsEoGAUjGAAAey9JUKm+GssAAAAASUVORK5CYII=","orcid":"","institution":"Second Affiliated Hospital \u0026 Yuying Children's Hospital of Wenzhou Medical University","correspondingAuthor":true,"prefix":"","firstName":"Xiaoling","middleName":"","lastName":"Guo","suffix":""}],"badges":[],"createdAt":"2026-01-13 02:53:09","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-8586494/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-8586494/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":102933550,"identity":"b3cf855b-b82d-4106-8023-a4311d1edbc3","added_by":"auto","created_at":"2026-02-18 15:34:08","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":185791,"visible":true,"origin":"","legend":"\u003cp\u003eCharacterization and pancreatic uptake of iPS-EXOs.\u003cstrong\u003e \u003c/strong\u003e(A) Transmission electron micrograph of iPS-EXOs. (B) Particle size and intensity of iPS-EXOs. (C) Western blot analysis of exosomal surface CD9, CD63, and CD81 expressions. (D) Uptake of Dil-labeled iPS-EXOs (red) by rat pancreatic tissue. Nuclei are stained with DAPI (blue). (E) Quantitative analysis of DiI fluorescence intensity in the pancreas (n=6). All data are presented as mean ± SD. \u003csup\u003e***\u003c/sup\u003e\u003cem\u003ep\u003c/em\u003e＜0.001 vs. Control.\u003c/p\u003e","description":"","filename":"1.png","url":"https://assets-eu.researchsquare.com/files/rs-8586494/v1/04e2f36c6f0a2da601aad32e.png"},{"id":102964514,"identity":"5aaf87ab-156c-4b3b-a285-59687c4f96f3","added_by":"auto","created_at":"2026-02-19 04:22:34","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":413465,"visible":true,"origin":"","legend":"\u003cp\u003eiPS-EXOs attenuated pancreatic IR injury in rats.\u0026nbsp;(A) Survival rates of rats models with pancreatic IR over time (n=6). (B) Representative HE staining images of pancreatic tissues. Scale bar 50 μm. (C) Histological scores of pancreatic damage (n=6). (D) Pancreatic tissue dry-to-wet ratio (n=6). Treatments (saline or iPS-EXOs at 100 μg/kg/dose) were administered once daily, starting 24 h after the induction of acute pancreatitis. All data are presented as mean ± SD. \u003csup\u003e*\u003c/sup\u003e\u003cem\u003ep\u003c/em\u003e\u0026lt;0.05 and \u003csup\u003e**\u003c/sup\u003e\u003cem\u003ep\u003c/em\u003e\u0026lt;0.01 vs. Control. \u003csup\u003e#\u003c/sup\u003e\u003cem\u003ep\u003c/em\u003e\u0026lt;0.05 and \u003csup\u003e##\u003c/sup\u003e\u003cem\u003ep\u003c/em\u003e\u0026lt;0.01 vs. IR group.\u003c/p\u003e","description":"","filename":"2.png","url":"https://assets-eu.researchsquare.com/files/rs-8586494/v1/642a4bb8a95211ca49d17aa4.png"},{"id":102964214,"identity":"2eee20c8-5a8a-415a-93aa-cd9f2e12045a","added_by":"auto","created_at":"2026-02-19 04:21:45","extension":"png","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":632005,"visible":true,"origin":"","legend":"\u003cp\u003eiPS-EXOs promoted pancreatic blood flow and functional recovery via the VEGF/VEGFR2 pathway.\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e(A) Representative images of pancreatic blood flow over time. (B) Quantitative analysis of pancreatic blood flow (n=6). (C) Western blot analysis of VEGF, VEGFR2, and p-VEGFR2 protein expressions. (D) Densitometric quantification of protein bands (n=5). (E) Serum levels of amylase (n=6). (F) Serum levels of lipase (n=6). (G) Serum levels of insulin (n=6). All data are presented as mean ± SD. \u003csup\u003e*\u003c/sup\u003e\u003cem\u003ep\u003c/em\u003e\u0026lt;0.05, \u003csup\u003e**\u003c/sup\u003e\u003cem\u003ep\u003c/em\u003e\u0026lt;0.01 vs. Control. \u003csup\u003e#\u003c/sup\u003e\u003cem\u003ep\u003c/em\u003e\u0026lt;0.05, \u003csup\u003e##\u003c/sup\u003e\u003cem\u003ep\u003c/em\u003e\u0026lt;0.01 vs. IR group.\u003c/p\u003e","description":"","filename":"3.png","url":"https://assets-eu.researchsquare.com/files/rs-8586494/v1/fba1f3a37c2377900d89bb2a.png"},{"id":103056548,"identity":"59c425e7-8e33-4261-bb1f-0cc81250dcdf","added_by":"auto","created_at":"2026-02-20 09:14:28","extension":"png","order_by":4,"title":"Figure 4","display":"","copyAsset":false,"role":"figure","size":203500,"visible":true,"origin":"","legend":"\u003cp\u003eiPS-EXOs alleviated oxidative stress in pancreatic IR injury.\u0026nbsp;(A) Representative flow cytometry plots of intracellular ROS levels. (B) Quantitative analysis of ROS fluorescence intensity (n=6). (C-F) Levels of oxidative stress biomarkers in pancreatic tissues (n=6). All data are presented as mean ± SD. \u003csup\u003e*\u003c/sup\u003e\u003cem\u003ep\u003c/em\u003e\u0026lt; 0.05, \u003csup\u003e**\u003c/sup\u003e\u003cem\u003ep\u003c/em\u003e\u0026lt;0.01 vs. Control group. \u003csup\u003e#\u003c/sup\u003e\u003cem\u003ep\u003c/em\u003e\u0026lt;0.05, \u003csup\u003e##\u003c/sup\u003e\u003cem\u003ep\u003c/em\u003e\u0026lt;0.01 vs. IR group.\u003c/p\u003e","description":"","filename":"4.png","url":"https://assets-eu.researchsquare.com/files/rs-8586494/v1/3cc98d51b8efa5431f052275.png"},{"id":102964637,"identity":"bd1157d1-62d8-4c5b-b0e9-20cc88c3ed99","added_by":"auto","created_at":"2026-02-19 04:23:03","extension":"png","order_by":5,"title":"Figure 5","display":"","copyAsset":false,"role":"figure","size":647245,"visible":true,"origin":"","legend":"\u003cp\u003eiPS-EXOs attenuated the inflammatory response in pancreatic IR injury.\u0026nbsp;(A) Serum levels of pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) measured by ELISA (n=6). (B) mRNA expression levels of inflammatory cytokines in pancreatic tissues determined by RT-qPCR (n=6). Data are presented as mean ± SD. \u003csup\u003e*\u003c/sup\u003e\u003cem\u003ep\u003c/em\u003e\u0026lt;0.05, \u003csup\u003e**\u003c/sup\u003e\u003cem\u003ep\u003c/em\u003e\u0026lt;0.01 vs. Control group. \u003csup\u003e#\u003c/sup\u003e\u003cem\u003ep\u003c/em\u003e\u0026lt;0.05, \u003csup\u003e##\u003c/sup\u003e\u003cem\u003ep\u003c/em\u003e\u0026lt;0.01 vs. IR group. (C) Representative immunohistochemical staining of iNOS, CD45, and TNF-α in pancreatic tissue sections. Scale bar 50 μm. (D) Quantitative analysis of immunohistochemical staining intensity (n=6). Data are presented as mean ± SD. \u003csup\u003e*\u003c/sup\u003e\u003cem\u003ep\u003c/em\u003e\u0026lt;0.05, \u003csup\u003e**\u003c/sup\u003e\u003cem\u003ep\u003c/em\u003e\u0026lt;0.01 indicate significant difference.\u003c/p\u003e","description":"","filename":"5.png","url":"https://assets-eu.researchsquare.com/files/rs-8586494/v1/a58df0c1d00492ff5e4e23ea.png"},{"id":102964499,"identity":"100c8c55-1f9b-441a-af97-eeb0fd058a1c","added_by":"auto","created_at":"2026-02-19 04:22:31","extension":"png","order_by":6,"title":"Figure 6","display":"","copyAsset":false,"role":"figure","size":423314,"visible":true,"origin":"","legend":"\u003cp\u003eiPS-EXOs suppressed cell apoptosis in pancreatic IR injury. (A) The apoptosis rates of pancreatic cells was detected by flow cytometry analysis. (B) The quantitative apoptosis rates from Q1-LR (early apoptosis) and Q1- UR (late apoptosis) (n=6). (C) The apoptosis of pancreas was assessed using TUNEL staining. Scale bar 100 μm. (D) The quantitative graph of TUNEL staining (n=6) . (E) The expressions of BAX, BCL-2, Caspase-3, Cleaved Caspase-3, Caspase-9 and Cleaved Caspase-9 were detected by western blot. (F) The quantification of protein bands (n=5). Data are presented as mean ± SD. \u003csup\u003e*\u003c/sup\u003e\u003cem\u003ep\u003c/em\u003e\u0026lt;0.05, \u003csup\u003e**\u003c/sup\u003e\u003cem\u003ep\u003c/em\u003e\u0026lt;0.01 indicate significant difference.\u003c/p\u003e","description":"","filename":"6.png","url":"https://assets-eu.researchsquare.com/files/rs-8586494/v1/3591b4dcdf8f5f2fea64d472.png"},{"id":102933551,"identity":"6d0bb72a-fb9c-4932-a212-f056fdac0ecc","added_by":"auto","created_at":"2026-02-18 15:34:08","extension":"png","order_by":7,"title":"Figure 7","display":"","copyAsset":false,"role":"figure","size":362303,"visible":true,"origin":"","legend":"\u003cp\u003eiPS-EXOs ameliorated pancreatic IR injury by delivering hsa-miR-1976 to target HRH4. (A) Volcano plot of differentially expressed genes (DEGs) between Control (healthy) and pancreatitis patient samples. (B) Heatmap of DEGs. (C) Top 5 abundant miRNAs identified in iPS-EXOs. (D) Venn diagram of overlapping target genes and predicted binding sites for hsa-miR-1976 on HRH4. (E) KEGG pathway enrichment analysis and (F) GO biological process (BP) enrichment analysis of DEGs with \u003cem\u003ep\u003c/em\u003e\u0026lt;0.05 related to HRH4. (G) HRH4 mRNA expression levels in pancreatic tissue across different groups (n=6). Data are presented as mean ± SD. \u003csup\u003e**\u003c/sup\u003e\u003cem\u003ep\u003c/em\u003e\u0026lt;0.01 indicates significant difference, and \u003cem\u003ens\u003c/em\u003e \u0026gt;0.05 indicates no significant difference.\u003c/p\u003e","description":"","filename":"7.png","url":"https://assets-eu.researchsquare.com/files/rs-8586494/v1/94276ec84cc1483f2589ec39.png"},{"id":102933552,"identity":"0bd195d9-0042-46a5-89d8-fa8450d11552","added_by":"auto","created_at":"2026-02-18 15:34:08","extension":"png","order_by":8,"title":"Figure 8","display":"","copyAsset":false,"role":"figure","size":365714,"visible":true,"origin":"","legend":"\u003cp\u003eiPS-EXOs exerted protective effects on pancreatic IR injury rats through activating the AMPK/mTOR/NF-κB pathway. (A) The expressions of the AMPK/mTOR/NF-κB pathway related indicators were detected using western blot. (B) The quantitative graph of protein bands (n=5) . (C) The expression of the AMPK/mTOR/NF-κB pathway related indicators were further examined using western blot. (D) The quantitative protein bands in different group (n=5). All data are presented as mean ± SD. \u003csup\u003e*\u003c/sup\u003e\u003cem\u003ep\u003c/em\u003e\u0026lt;0.05, \u003csup\u003e**\u003c/sup\u003e\u003cem\u003ep\u003c/em\u003e\u0026lt;0.01 indicate significant difference, and \u003cem\u003ens\u003c/em\u003e\u0026gt;0.05 indicates no significant.\u003c/p\u003e","description":"","filename":"8.png","url":"https://assets-eu.researchsquare.com/files/rs-8586494/v1/3e9c83e892cac1cc0cc6b461.png"},{"id":102964626,"identity":"48753a4f-96c3-443a-9e1b-c6def4897627","added_by":"auto","created_at":"2026-02-19 04:23:01","extension":"png","order_by":9,"title":"Figure 9","display":"","copyAsset":false,"role":"figure","size":351457,"visible":true,"origin":"","legend":"\u003cp\u003eThe schematic diagram of the potential mechanism of iPS-EXOs on pancreatic IR injury rats through endogenous hsa-miR-1976 targeting HRH4 to activate the AMPK/mTOR/ NF-κB pathway.\u003c/p\u003e","description":"","filename":"9.png","url":"https://assets-eu.researchsquare.com/files/rs-8586494/v1/e4d48e663fec033f398088e9.png"},{"id":105185726,"identity":"6b0285ef-e258-44e4-b91b-14d6f3f488b9","added_by":"auto","created_at":"2026-03-23 08:29:12","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":4862913,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-8586494/v1/e5f0c80c-d8ed-401f-a766-243280f66cfa.pdf"},{"id":102964627,"identity":"2265cc65-cbd0-43d0-b7e9-8e24cd4273d6","added_by":"auto","created_at":"2026-02-19 04:23:01","extension":"docx","order_by":1,"title":"","display":"","copyAsset":false,"role":"supplement","size":1566058,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eSupplemental Fig.S1. \u003c/strong\u003eExploration of the optimal \u003cem\u003ein vivo\u003c/em\u003e dose of iPS-EXOs. (A) Representative morphological features of the pancreas. Scale bar 50 μm. (B) Histological score of pancreatic damage in the course of IR (n=6). (C) The apoptosis of pancreas with different treatments was assessed using TUNEL staining. Scale bar 50 μm. (D) The quantitative graph of TUNEL staining in each group (n=6). (E) Serum concentration of IL-1β, IL-6, and TNF-α in the course of IR (n=6). All data are presented as mean ± SD. \u003csup\u003e**\u003c/sup\u003e\u003cem\u003ep\u003c/em\u003e\u0026lt;0.01，\u003csup\u003e*\u003c/sup\u003e\u003cem\u003ep\u003c/em\u003e\u0026lt;0.05 vs. Control. \u003csup\u003e#\u003c/sup\u003e\u003cem\u003ep\u003c/em\u003e\u0026lt;0.05 vs. IR group.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eSupplemental Fig.S2. \u003c/strong\u003eThe further Gene Set Enrichment Analysis (GSEA) and clustering analysis of the AMPK/mTOR/NF-κB pathway. (A) The circular plot of HRH4 involvement in related pathway regulation. (B) Enrichment map plot of the pathway’s clustering analysis. (C) GO biological process (BP) enrichment analysis of genes. (D) Cnet plot category network diagram of HRH4 involvement in related pathway regulation. (E) The correlation between HRH4 and hsa-miR-1976. (F) Volcano plot of differentially expressed genes (DEGs) in patients with pancreatitis with high and low expression of HRH4. (G) KEGG pathway enrichment analysis of the signal transduction. (H) GO biological process (BP) enrichment analysis of the signaling pathway.\u003c/p\u003e","description":"","filename":"Supplementaryfigures.docx","url":"https://assets-eu.researchsquare.com/files/rs-8586494/v1/28ba148aeec13fc773cde6c8.docx"}],"financialInterests":"No competing interests reported.","formattedTitle":"iPS-derived exosomes alleviated pancreatic ischemia reperfusion injury through activating the AMPK/mTOR/NF-κB pathway","fulltext":[{"header":"1. Introduction","content":"\u003cp\u003eBlood flow obstruction or tissue ischemia is a common and pivotal pathological event in clinical surgical procedures, pharmacotherapy implementation, and pathophysiological processes[\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e]. It not only directly compromises treatment efficacy but also often induces subsequent tissue damage and functional impairment[\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e, \u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e]. Pancreatic transplantation is an important therapeutic option for patients with end-stage pancreatic diseases, such as severe chronic pancreatitis or post-resection advanced pancreatic cancer. Although it offers the potential to improve quality of life and prolong survival, its clinical outcomes remain inferior to those of other solid organ transplants, such as liver and kidney transplantation[\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e]. This is primarily due to its relatively low long-term survival rates and unfavorable graft prognosis[\u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e]. According to clinical data, the incidence of acute rejection post-pancreatic transplantation is approximately 15%, while chronic rejection occurs at an even higher rate of 21%. Moreover, the graft failure rate within five years after transplantation can climb to 40%[\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e, \u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e]. Previous studies have shown that these adverse clinical outcomes are directly or indirectly linked to the unavoidable ischemia-reperfusion (IR) injury during the transplantation process[\u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eIR injury refers to the pathophysiological process in transplantation characterized by an initial interruption of blood supply followed by subsequent restoration of perfusion[\u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e]. The core pathological mechanism underlying IR injury-induced pancreatic cell apoptosis begins with ischemic insult during organ procurement and implantation. After reperfusion, a series of pathological responses are triggered, including oxidative stress caused by excessive production of reactive oxygen species (ROS), toxic damage to cell membranes and organelles by oxygen free radicals, aberrant release and amplification of inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), as well as calcium overload resulting from loss of intracellular calcium homeostasis[\u003cspan additionalcitationids=\"CR10 CR11\" citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e]. These mechanisms collectively exacerbate necrosis of pancreatic parenchymal cells and interstitial injury. Although the negative impact of IR injury on pancreatic transplant outcomes is well recognized, the progress of clinical treatment research for pancreatic IR injury remains slow. Therefore, developing novel therapeutic strategies against pancreatic IR injury is a critical and urgent clinical need.\u003c/p\u003e \u003cp\u003eInduced pluripotent stem cells (iPSCs) are obtained through somatic cell reprogramming and possess all kinds of cell differentiation potential equivalent to that of embryonic stem cells (ESCs), while avoiding ethical controversies and immune rejection[\u003cspan citationid=\"CR13\" class=\"CitationRef\"\u003e13\u003c/span\u003e]. They are regarded as cell sources that are closer to clinical application[\u003cspan citationid=\"CR11\" class=\"CitationRef\"\u003e11\u003c/span\u003e]. Their secreted exosomes (iPS-EXOs), with a diameter of 30\u0026ndash;150 nm, are rich in proteins, nucleic acids, and metabolites. These exosomes can stably exist in body fluids such as blood and urine, and remotely regulate the functions of target cells[\u003cspan citationid=\"CR14\" class=\"CitationRef\"\u003e14\u003c/span\u003e, \u003cspan citationid=\"CR15\" class=\"CitationRef\"\u003e15\u003c/span\u003e]. Previous studies have confirmed that iPS-EXOs significantly alleviate various inflammatory injuries by suppressing key pro-inflammatory factors such as IL-1β, IL-6, and TNF-α[\u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e16\u003c/span\u003e]. Similarly, umbilical cord mesenchymal stem cell-derived exosomes (MSC-EXOs) have been shown to reduce inflammatory infiltration and apoptosis in traumatic pancreatitis models[\u003cspan citationid=\"CR17\" class=\"CitationRef\"\u003e17\u003c/span\u003e]. Furthermore, iPS-EXOs can scavenge ROS, repair DNA damage, and stabilize mitochondrial function, demonstrating a broad-spectrum protective activity against oxidative stress-related injuries[\u003cspan citationid=\"CR18\" class=\"CitationRef\"\u003e18\u003c/span\u003e]. However, whether iPS-EXOs have protective effects on pancreatic IR injury remains unreported.\u003c/p\u003e \u003cp\u003eIn this study, we will utilize a surgically induced pancreatic IR injury model in rats to investigate the protective effects of iPS-EXOs and attempt to elucidate the potential mechanism. This research aims to provide a novel cell-free therapeutic strategy for the treatment of IR injury.\u003c/p\u003e"},{"header":"2. Materials and methods","content":"\u003cdiv id=\"Sec3\" class=\"Section2\"\u003e \u003ch2\u003e2.1. Isolation and purification of exosomes\u003c/h2\u003e \u003cp\u003eHuman-induced pluripotent stem cells (hiPSCs) were purchased from CELLAPY Biotechnology Co., Ltd. (hiPSC-U1, Beijing, China). The cells were cultured in PSCeasy\u003csup\u003e\u0026reg;\u003c/sup\u003eII human pluripotent stem cell medium (CA1014500, CELLAPY) at 37\u0026deg;C, 5% CO2 incubator. Next, the supernatant of cells in the logarithmic growth phase (~\u0026thinsp;80% confluency) was collected for exosome purification. The collected supernatant was stored at -80\u0026deg;C. Exosomes were isolated using a combination of differential centrifugation and ultracentrifugation[\u003cspan citationid=\"CR19\" class=\"CitationRef\"\u003e19\u003c/span\u003e, \u003cspan citationid=\"CR20\" class=\"CitationRef\"\u003e20\u003c/span\u003e]. Briefly, the collected conditioned medium was subjected to gradient centrifugation (300 \u0026times; g for 10 min, 2000 \u0026times; g for 10 min, 10,000 \u0026times; g for 1 h) at 4\u0026deg;C to remove cellular debris. The supernatant was filtered through a 0.22 \u0026micro;m sterile membrane filter (Millipore, MA, USA) into ultracentrifuge tubes. Exosomes were pelleted by ultracentrifugation at 120,000 \u0026times; g for 1.5 h at 4\u0026deg;C using a SW32Ti rotor (Beckman, CA, USA). The final exosome pellet (iPS-EXOs) was resuspended in PBS buffer for the following analysis.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec4\" class=\"Section2\"\u003e \u003ch2\u003e2.2. Construction of hsa-miR-1976-knockout iPS-EXOs\u003c/h2\u003e \u003cp\u003esiRNA targeting hsa-miR-1976 was synthesized by GenScript Biotech (Nanjing, China) and transfected into hiPSCs via electroporation. Subsequently, iPS-EXOs were isolated and purified from the collected conditioned medium of the transfected cells. These exosomes are named as hsa-miR-1976-knockout iPS-EXOs (hsa-miR-1976-KO iPS-EXOs), and used for the next experiments.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec5\" class=\"Section2\"\u003e \u003ch2\u003e2.3. Characterization of exosomes\u003c/h2\u003e \u003cp\u003eThe protein concentration of iPS-EXOs was first quantified using the BCA assay (Beyotime, Shanghai, China), and the expressions of exosomal markers such as CD9, CD63, and CD81 were confirmed by western blot. Exosomes were fixed with 2.5% glutaraldehyde, followed by agitation and storage at 4\u0026deg;C. After fixation, the samples were washed three times with PBS for 15 min each time. Subsequently, post-fixation was performed using 0.5 mL of 2% osmium tetroxide for 2 h, followed by another three PBS washes. Dehydration was carried out using a series of graded ethanol (50%, 70%, 80%, and 90%, 15 min per step), followed by two additional treatments with absolute ethanol (20 min each). The samples were then treated with acetone twice (15 min each) for solvent replacement. Following infiltration, the specimens were embedded in pure embedding resin and polymerized at 65\u0026deg;C for 48 h. Ultrathin sections were stained with uranyl acetate and lead citrate, each for 10 min, and finally observed under a transmission electron microscope (FEI, OR, USA). Furthermore, the isolated exosomes were resuspended and diluted 20-fold in sterile PBS. Following the manufacturer's protocol for the DynaPro system (Malvern Britain), the cuvette was first rinsed twice with pure water to ensure cleanliness. An appropriate amount of pure water was then applied to confirm the absence of particulate contamination. Subsequently, the diluted iPS-EXOs suspension was loaded into the cuvette, and the hydrodynamic diameter distribution of the particles was measured, recorded, and analyzed by nanoparticle tracking analysis (NTA, Meerbusch, Germany).\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec6\" class=\"Section2\"\u003e \u003ch2\u003e2.4. Construction and treatment of pancreatic IR injury rat model\u003c/h2\u003e \u003cp\u003eSix-week-old male Sprague-Dawley rats (200-250g) were used in this study. Pancreatic IR injury was induced according to an established protocol[\u003cspan citationid=\"CR21\" class=\"CitationRef\"\u003e21\u003c/span\u003e]. Briefly, after one week of acclimatization under controlled conditions (12 h light/dark cycle, temperature 23\u0026thinsp;\u0026plusmn;\u0026thinsp;2\u0026deg;C, humidity 45\u0026ndash;55%), the rats were randomly divided into three groups (n\u0026thinsp;=\u0026thinsp;8 per group) such as sham-operated group (Control), IR model group (IR), and IR\u0026thinsp;+\u0026thinsp;iPS-EXOs treatment group (IR\u0026thinsp;+\u0026thinsp;iPS-EXOs). All animal experiments study in this study were approval by the Animal Ethics Committee of the Wenzhou Institute, University of Chinese Academy of Sciences. Anesthesia was induced by intraperitoneal injection of ketamine (50 mg/kg). Following laparotomy, the splenic branch of the pancreatic artery was clamped with a microvascular clip to induce ischemia for 60 min. Reperfusion was initiated by clip removal, after which the abdominal cavity was closed. Sham-operated rats underwent the same surgical procedures except for vascular clamping. Postoperatively, the animals were monitored every 8 h for the first two days. Fluid resuscitation was administered via subcutaneous injection of Ringer's solution immediately after surgery, and again at 12 h and 24 h. iPS-EXOs treatment (50 \u0026micro;g/kg or 100 \u0026micro;g/kg) was initiated 24 h before surgery and continued daily via tail intravenous injection. The severity of pancreatitis was assessed on postoperative days 1, 2, 5, 9, and 14.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec7\" class=\"Section2\"\u003e \u003ch2\u003e2.5. Cellular uptake of DiI-labeled iPS-EXOs\u003c/h2\u003e \u003cp\u003eIPS-EXOs were labeled using DiI (Beyotime), a lipophilic fluorescent dye commonly employed for membrane labeling and cell tracking. The labeling procedure was initiated by mixing 2.5 mL of DiI (400\u0026times;) with 2.5 mL of dye enhancer solution, followed by the addition of 500 mL of staining buffer. The resulting mixture was incubated at room temperature for 10 min. Subsequently, 50 mL of iPS-EXOs were added and incubated at 37\u0026deg;C for 20 min. To terminate the reaction and minimize nonspecific binding, 1 mL of PBS was added and incubated at room temperature for additional 5 min. The labeled iPS-EXOs were then collected by centrifugation at 120,000 g for 90 min at 4\u0026deg;C. Rats were administered DiI-labeled iPS-EXOs via tail vein injection at a dose of 50 \u0026micro;g/kg. An equal volume of PBS was given to the control group. After 24 h, the animals were euthanized, and pancreatic tissues were collected for \u003cem\u003ein viv\u003c/em\u003eo imaging analysis.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec8\" class=\"Section2\"\u003e \u003ch2\u003e2.6. Histological analysis\u003c/h2\u003e \u003cp\u003eThe pancreatic tissue samples were fixed in 4% paraformaldehyde at 4\u0026deg;C for 24 h, followed by dehydration through a graded ethanol series, paraffin embedding, and sectioning into 5 \u0026micro;m thick slices. The sections were deparaffinized using xylene and a graded ethanol series, then subjected to hematoxylin and eosin (HE) staining. After staining, the sections were mounted with neutral balsam and examined under a pathological scanning system (KFBIO, Ningbo, China) for histological analysis.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec9\" class=\"Section2\"\u003e \u003ch2\u003e2.7. Immunohistochemical staining\u003c/h2\u003e \u003cp\u003eParaffin sections of pancreas tissues in different groups were prepared following the above described procedure. After being deparaffinized and rehydrated through a graded xylene and ethanol series, the sections underwent antigen retrieval by incubation in sodium citrate at 96\u0026deg;C for 30 min. Following three washes with PBS, the sections were blocked with 5% bovine serum albumin at room temperature for 30 min. Next, the sections were incubated overnight at 4\u0026deg;C with primary antibodies (supplementary table 1). After three additional PBS washes, they were treated with enzyme-labeled secondary antibodies (1:50, Beyotime) in the dark for 2 h at room temperature, followed by three more washes with PBS. The sections were then developed using 3, 3\u0026rsquo;-diaminobenzidine (DAB) chromogen (Zsbio, Beijing, China) until a yellow color appeared. After counterstaining with hematoxylin for 4 min and subsequent washing, the sections underwent dehydration and clearing with ethanol and xylene. Finally, the sections were mounted with neutral mounting medium, and their morphological features were captured using a pathological scanning system.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec10\" class=\"Section2\"\u003e \u003ch2\u003e2.8. Real-time quantitative polymerase chain reaction (RT-qPCR)\u003c/h2\u003e \u003cp\u003eTotal RNA was extracted from rat pancreatic tissues using Trizol reagent. RNA concentration and purity (OD260 nm) were measured with a microplate spectrophotometer (TECAN, M\u0026auml;nnedorf\u0026zwnj;, Switzerland). cDNA was synthesized from RNA samples using the HiScript II Q RT SuperMix kit (Vazyme, Nanjing, China) according to the manufacturer's instructions. RT-qPCR was performed with Taq Pro Universal SYBR Green Master Mix (Vazyme Q712) using cDNA as templates on a Bio-Rad CFX Manager system. The relative mRNA expression levels of \u003cem\u003eTNF-α\u003c/em\u003e, \u003cem\u003eIL-1β\u003c/em\u003e, and \u003cem\u003eIL-6\u003c/em\u003e were calculated by the 2^\u0026ndash;ΔΔCt method and normalized to the endogenous control \u003cem\u003eβ-actin\u003c/em\u003e. All experiments included three technical replicates. Primer sequences are provided in supplementary table 2.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec11\" class=\"Section2\"\u003e \u003ch2\u003e2.9. TUNEL staining\u003c/h2\u003e \u003cp\u003eParaffin sections from each group were deparaffinized in xylene, rehydrated through a graded ethanol series, and washed three times (3 min each) with PBS. The sections were then incubated with the TUNEL reaction mixture (Elascience, Wuhan, China) at 37\u0026deg;C for 60 min in the dark. After washing with PBS to terminate the reaction, the nuclei were counterstained with DAPI-containing anti-fade mounting medium. Images were captured using a fully automated multi-channel fluorescence microscope. The number of TUNEL-positive (green) cells was counted, and the apoptotic index was calculated.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec12\" class=\"Section2\"\u003e \u003ch2\u003e2.10. Western blot analysis\u003c/h2\u003e \u003cp\u003eTotal protein was extracted from rat pancreatic tissues using RIPA lysis buffer (Solarbio, Beijing, China) supplemented with phosphatase and serine protease inhibitors. Protein concentration was determined with the BCA protein assay kit (Beyotime). Denatured protein samples (20\u0026ndash;30 \u0026micro;g) were separated by 7.5%-12.5% SDS-polyacrylamide gel electrophoresis and transferred to PVDF membranes (Thermo Scientific, MA, USA). The membranes were blocked with 5% non-fat milk in TBST for 2 h at room temperature, followed by three washes with TBST. Subsequently, the membranes were incubated with primary antibodies (supplementary table 1) at 4\u0026deg;C overnight. After additional TBST washes, the membranes were incubated with horseradish peroxidase (HRP)-conjugated secondary antibodies (anti-rabbit or anti-mouse, 1:1000, Beyotime) for 2 h at room temperature. Following thorough washing with TBST, immunoreactive bands were visualized using an ECL chemiluminescence detection kit (NCM Biotech, Suzhou, China) on a ChemiDoc\u0026trade; XRS imaging system (Bio-Rad, CA, USA). Band intensity was quantified using ImageJ software.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec13\" class=\"Section2\"\u003e \u003ch2\u003e2.11. Determination of pancreatic blood flow\u003c/h2\u003e \u003cp\u003eAt each experimental endpoint, the rats were anesthetized again with ketamine, and the abdominal cavity was carefully exposed. Following a previously reported method[\u003cspan citationid=\"CR20\" class=\"CitationRef\"\u003e20\u003c/span\u003e], pancreatic blood flow in the splenic region was measured using a laser Doppler flowmeter (PeriFlux 4001 Master monitor, Perimed AB, J\u0026auml;rf\u0026auml;lla, Sweden). The baseline blood flow of the sham-operated group, which only underwent laparotomy and saline injection without induction of acute pancreatitis, was used as a reference to calculate the percentage change in blood flow for each group.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec14\" class=\"Section2\"\u003e \u003ch2\u003e2.12. Assay of serum biochemical profiles\u003c/h2\u003e \u003cp\u003eImmediately following the measurement of pancreatic blood flow, blood samples were collected from the abdominal aorta. Blood was immediately transferred into sterile, non-anticoagulant-containing vacuum tubes. The blood was allowed to clot completely by incubating the tubes at room temperature for 1 h. Following clot formation, the samples were centrifuged at 3,000 \u0026times; g for 15 min at 4\u0026deg;C. The resulting supernatant (serum) was carefully aspirated using a micropipette, taking caution to avoid disturbing the clot or the buffy coat layer. The serum was stored at -80\u0026deg;C until subsequent analysis. The following parameters were measured using enzyme-linked immunosorbent assay (ELISA) according to the manufacturer\u0026rsquo;s instructions. Serum amylase and lipase concentrations were determined using the α-Amylase assay kit and the Lipase ELISA kit (Jiancheng Biotech, Nanjing, China), respectively, to evaluate pancreatic exocrine function. Serum insulin levels were measured using the rat insulin ELISA kit (Jianglai Biotech) to assess pancreatic endocrine function. In addition, the concentrations of inflammatory cytokines, including TNF-α, IL-6, and IL-1β, were quantified using ELISA kits (Thermo Fisher).\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec15\" class=\"Section2\"\u003e \u003ch2\u003e2.13. Assay of oxidative stress in pancreatic tissues\u003c/h2\u003e \u003cp\u003eVarious oxidative stress and anti-oxidant biomarkers, including malondialdehyde (MDA), glutathione peroxidase (GPx), myeloperoxidase (MPO), and superoxide dismutase (SOD), were measured using commercial assay kits such as malondialdehyde detection kit, glutathione peroxidase assay kit (Servicebio), myeloperoxidase activity assay kit, and total superoxide dismutase detection kit (Servicebio, Wuhan, China). All assays were conducted in accordance with the manufacturer's instructions.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec16\" class=\"Section2\"\u003e \u003ch2\u003e2.14. Measurement of pancreatic wet-to-dry weight ratio\u003c/h2\u003e \u003cp\u003eThe pancreatic wet-to-dry weight ratio, defined as the ratio of the tissue's wet weight (measured after blotting surface moisture) to its dry weight (obtained after complete dehydration), serves as a quantitative indicator for assessing the severity of tissue edema in IR injured pancreatic regions. The specific procedure was as follows: tissue samples from the pancreatic body and tail were blotted with absorbent paper to remove surface moisture before wet weight measurement, then dried in a vacuum oven at 60\u0026deg;C until a constant dry weight was achieved. The wet-to-dry ratio was calculated using the formula: wet-to-dry ratio = (wet weight/dry weight)\u0026times;100%.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec17\" class=\"Section2\"\u003e \u003ch2\u003e2.15. Apoptosis assay\u003c/h2\u003e \u003cp\u003eCell apoptosis was detected using an Annexin V-APC/PI apoptosis detection kit (Elabscience, Wuhan, China). Pancreatic tissues were collected from rats, and pancreatic cells were isolated. After washing with PBS, the cells were resuspended in 100 \u0026micro;L of 1\u0026times;Annexin V Binding buffer. Then, 2.5 \u0026micro;L of Annexin V-APC reagent and 2.5 \u0026micro;L of PI reagent were added to the cell suspension. The mixture was thoroughly vortexed and incubated at room temperature in the dark for 20 min. After incubation, 400 \u0026micro;L of 1\u0026times; Annexin V Binding Buffer was added and gently mixed. Finally, the apoptosis rate was analyzed using a flow cytometer (Beckman).\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec18\" class=\"Section2\"\u003e \u003ch2\u003e2.16. ROS detection\u003c/h2\u003e \u003cp\u003ePancreatic cells were allocated into five groups: negative control, positive control,\u003c/p\u003e \u003cp\u003esham, IR, and iPS-EXO groups. Each sample was centrifuged at 300g for 5 min, followed by resuspension of the pellet in RPMI 1640 medium supplemented with 10% fetal bovine serum. For treatment, the negative control group was not labeled with a ROS probe, while the positive control group was treated with a ROS inducer and incubated at room temperature for 30 min. Subsequently, cells were combined with ROS assay buffer and centrifuged again at 300 \u0026times; g for 5 min. The cell suspension was filtered through a 200-mesh sieve, and intracellular ROS levels were analyzed using flow cytometry\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec19\" class=\"Section2\"\u003e \u003ch2\u003e2.17. Identification of the differential expression genes (DEGs) and functional enrichment analysis\u003c/h2\u003e \u003cp\u003eThe RNA sequencing data were obtained from the Gene Expression Omnibus (GEO) database (accession GSE18606) and processed using R software (version 4.4. 1). Differential expression analysis between healthy individuals and pancreatitis patients was performed using the Limma package (version 3.60.4) with its empirical Bayesian algorithm. Differentially expressed genes (DEGs) were identified using the following thresholds: absolute log2 fold change\u0026thinsp;\u0026ge;\u0026thinsp;1.5 and false discovery rate (FDR)-adjusted \u003cem\u003ep\u003c/em\u003e-value\u0026thinsp;\u0026lt;\u0026thinsp;0.05. Volcano plots and heatmaps visualizing the DEGs were generated using the ggplot2 (version 3.5. 1) and pheatmap (version 1.0. 12) packages, respectively. Functional enrichment analysis, including Gene Ontology (GO) term enrichment, was conducted on the identified DEGs using the clusterProfiler package (version 4.12.6), with an adjusted \u003cem\u003ep\u003c/em\u003e-value\u0026thinsp;\u0026lt;\u0026thinsp;0.05 considered statistically significant. Additionally, pathway enrichment and pathway interaction analyses were performed using the Enrichplot package.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec20\" class=\"Section2\"\u003e \u003ch2\u003e2.18. Statistical analysis\u003c/h2\u003e \u003cp\u003eThe data are presented as the mean\u0026thinsp;\u0026plusmn;\u0026thinsp;standard deviation (mean\u0026thinsp;\u0026plusmn;\u0026thinsp;SD) derived from a minimum of three independent experiments. Statistical analyses were evaluated by GraphPad Prism version 9 (GraphPad Software Inc., CA, USA). To evaluate differences between two groups, an independent Student\u0026rsquo;s \u003cem\u003et\u003c/em\u003e-test was utilized. For comparisons involving two or more groups, a one-way analysis of variance (ANOVA) was performed, followed by a post hoc Tukey test to adjust for multiple comparisons. A \u003cem\u003ep\u003c/em\u003e-value of less than 0.05 was considered statistically significant, while a \u003cem\u003ep\u003c/em\u003e-value greater than 0.05 was regarded as not significant (\u003cem\u003ens\u003c/em\u003e).\u003c/p\u003e \u003c/div\u003e"},{"header":"3. Results","content":"\u003cdiv id=\"Sec22\" class=\"Section2\"\u003e \u003ch2\u003e3.1. Characterization and in vivo uptake of iPS-EXOs\u003c/h2\u003e \u003cp\u003eiPS-EXOs were successfully isolated from the culture supernatant of hiPSCs through ultracentrifugation. TEM revealed that iPS-EXOs exhibited the typical cup-shaped morphology (Fig.\u0026nbsp;\u003cspan refid=\"Fig1\" class=\"InternalRef\"\u003e1\u003c/span\u003eA). The NTA results further demonstrated that the average particle diameter of iPS-EXOs was 100.00\u0026thinsp;\u0026plusmn;\u0026thinsp;25.00 nm (Fig.\u0026nbsp;\u003cspan refid=\"Fig1\" class=\"InternalRef\"\u003e1\u003c/span\u003eB). Moreover, western blot analysis confirmed the expressions of exosome-specific markers, including CD63, CD81, and CD9 (Fig.\u0026nbsp;\u003cspan refid=\"Fig1\" class=\"InternalRef\"\u003e1\u003c/span\u003eC). Collectively, these data demonstrated that iPS-EXOs had been successfully isolated.\u003c/p\u003e \u003cp\u003eTo demonstrate the uptake of iPS-EXOs by pancreatic tissues \u003cem\u003ein vivo\u003c/em\u003e, the exosomes were labeled with the lipophilic fluorescent dye DiI for subsequent traced within the tissues. The distribution of DiI-tagged iPS-EXOs in the rat pancreas was evaluated using small animal \u003cem\u003ein vivo\u003c/em\u003e imaging. The results demonstrated that iPS-EXOs could be successfully taken up by pancreatic tissues and exhibited red fluorescence (Fig.\u0026nbsp;\u003cspan refid=\"Fig1\" class=\"InternalRef\"\u003e1\u003c/span\u003eD). Quantitative analysis further revealed that the fluorescence intensity in the iPS-EXO group was significantly higher than that of the control group, which exhibited virtually no fluorescent signal (Fig.\u0026nbsp;\u003cspan refid=\"Fig1\" class=\"InternalRef\"\u003e1\u003c/span\u003eE). These findings confirmed that iPS-EXOs could be effectively absorbed by pancreatic tissues.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec23\" class=\"Section2\"\u003e \u003ch2\u003e3.2. Exploration of the optimal in vivo concentration of iPS-EXOs\u003c/h2\u003e \u003cp\u003eTo determine the optimal \u003cem\u003ein vivo\u003c/em\u003e dosage of iPS-EXOs, we examined 100 \u0026micro;g/kg and compared it with the previously established 50 \u0026micro;g/kg dose. Pancreatic injury was assessed using three complementary methods such as histopathology (HE staining), apoptosis (TUNEL assay), and serum inflammatory markers (ELISA). Results indicated that in rat models of pancreatic IR, administration of 100 \u0026micro;g/kg iPS-EXOs significantly reduced histopathological scores more effectively than the 50 \u0026micro;g/kg dose (Fig. S1A and S1B). Furthermore, TUNEL staining revealed a markedly lower percentage of apoptotic cells in the 100 \u0026micro;g/kg iPS-EXO group than that of the 50 \u0026micro;g/kg group (Fig. S1C and S1D). Concurrently, the 100 \u0026micro;g/kg dose led to a greater decrease in serum levels of inflammatory mediators than the 50 \u0026micro;g/kg dose (Fig. S1E). Collectively, these findings demonstrated that the 100 \u0026micro;g/kg dose of iPS-EXOs is more effective than the 50 \u0026micro;g/kg dose in promoting tissue repair, inhibiting apoptosis, and attenuating systemic inflammation. So, we chose the 100 \u0026micro;g/kg dose of iPS-EXOs as the working concentration for the following study.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec24\" class=\"Section2\"\u003e \u003ch2\u003e3.3. iPS-EXOs alleviated pancreatic damage and promote tissue repair\u003c/h2\u003e \u003cp\u003eOur research found that treatment with iPS-EXOs could significantly increase the survival rate of IR injury rats (Fig.\u0026nbsp;\u003cspan refid=\"Fig2\" class=\"InternalRef\"\u003e2\u003c/span\u003eA). To evaluate the effects of iPS-EXOs on pancreatic tissue damage, tissues were collected for HE staining (Fig.\u0026nbsp;\u003cspan refid=\"Fig2\" class=\"InternalRef\"\u003e2\u003c/span\u003eB) and pathological analysis (Table\u0026nbsp;1). Pancreatic tissues in the control group displayed no signs of inflammatory cell infiltration, degeneration, or necrosis. In contrast, all experimental animals developed acute hemorrhagic necrotizing pancreatitis following IR injury. On the day 1 after reperfusion, the light microscope examination revealed moderate interlobular and intralobular edema in the pancreatic tissues. The tissues also exhibited moderate perivascular inflammatory cell infiltration and minimal diffuse leukocyte infiltration. Vacuolar changes were detected in fewer than 25% of acinar cells, and approximately 15%-35% of pancreatic cells displayed necrotic changes. Moreover, each histological slide displayed 1 to 5 hemorrhagic areas in the pancreatic tissues of IR-induced rats. Subsequent observations indicated spontaneous regenerative characteristics within the pancreatic tissues. By day 14 following injury, only mild interlobular edema and scattered perivascular inflammatory infiltrates were observed in the affected tissues, with acinar vacuolation consistently maintained below 25%. In the iPS-EXOs treatment group, significant improvements were observed as early as two days after administration. Compared to the IR group, the iPS-EXO group exhibited markedly reduced severity of pancreatic necrosis, attenuated inflammatory infiltration, and fewer hemorrhagic foci over the time of IR injury (Fig.\u0026nbsp;\u003cspan refid=\"Fig2\" class=\"InternalRef\"\u003e2\u003c/span\u003eC). These results suggested that iPS-EXOs treatment could effectively promote the regeneration of pancreatic tissues. By the end of the observation period, no pathological indicators of pancreatic injury were detected in the iPS-EXO group, except for the presence of mild edema. Moreover, analysis based on wet-to-dry weight ratios systematically confirmed the accelerated resolution of edema (Fig.\u0026nbsp;\u003cspan refid=\"Fig2\" class=\"InternalRef\"\u003e2\u003c/span\u003eD), thereby providing evidence for the comprehensive reparative effects of iPS-EXOs on pancreatic injury.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec25\" class=\"Section2\"\u003e \u003ch2\u003e3.4. iPS-EXOs improved pancreatic microcirculation and functional recovery following IR injury\u003c/h2\u003e \u003cp\u003eTo assess the impact of iPS-EXOs on pancreatic perfusion and exocrine/endocrine function after IR injury, we monitored hemodynamic (Fig.\u0026nbsp;\u003cspan refid=\"Fig3\" class=\"InternalRef\"\u003e3\u003c/span\u003eA) and biochemical parameters. Compared with the sham-operated group (control), rats subjected to IR exhibited a severe decline in pancreatic blood flow, which dropped to approximately 20% of baseline levels within 24 h post-reperfusion. While the IR group showed a spontaneous but gradual recovery of blood flow over 14 days, administration of iPS-EXOs significantly accelerated this process, leading to earlier and more robust restoration of microcirculation (Fig.\u0026nbsp;\u003cspan refid=\"Fig3\" class=\"InternalRef\"\u003e3\u003c/span\u003eB). Mechanistically, western blot analysis (Fig.\u0026nbsp;\u003cspan refid=\"Fig3\" class=\"InternalRef\"\u003e3\u003c/span\u003eC) revealed that iPS-EXOs treatment up-regulated vascular endothelial growth factor A (VEGF-A) expression and enhanced phosphorylation of vascular endothelial growth factor receptor-2 (VEGFR2) (Fig.\u0026nbsp;\u003cspan refid=\"Fig3\" class=\"InternalRef\"\u003e3\u003c/span\u003eD), suggesting promoted vascular repair. Functionally, IR injury triggered a significant increase in serum amylase and lipase levels, peaking at 24 h (-14-fold vs. control) and 48 h (15-fold vs. control), respectively, indicating substantial exocrine damage (Fig.\u0026nbsp;\u003cspan refid=\"Fig3\" class=\"InternalRef\"\u003e3\u003c/span\u003eE and F). Concurrently, insulin levels decreased markedly, reaching a nadir of 25% of control values at 24 h (Fig.\u0026nbsp;\u003cspan refid=\"Fig3\" class=\"InternalRef\"\u003e3\u003c/span\u003eG). Although these parameters gradually normalized over time in the IR group, iPS-EXOs treatment significantly shortened the recovery period for amylase and lipase levels and facilitated the restoration of insulin secretion, demonstrating enhanced functional protection.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec26\" class=\"Section2\"\u003e \u003ch2\u003e3.5. iPS-EXOs alleviated oxidative stress\u003c/h2\u003e \u003cp\u003eThe hallmark of pancreatic IR injury is the production of reactive oxygen species (ROS). This process subsequently triggers the infiltration of inflammatory cells, ultimately leading to the apoptosis of pancreatic cells[\u003cspan citationid=\"CR22\" class=\"CitationRef\"\u003e22\u003c/span\u003e]. We analyzed the ROS level in pancreatic cells by flow cytometry (Fig.\u0026nbsp;\u003cspan refid=\"Fig4\" class=\"InternalRef\"\u003e4\u003c/span\u003eA). The fluorescence intensity of ROS demonstrated a significant increase in the IR group, whereas a notable decrease was observed in the iPS-EXO group (Fig.\u0026nbsp;\u003cspan refid=\"Fig4\" class=\"InternalRef\"\u003e4\u003c/span\u003eB). Consistent with the above mechanism, IR-induced rat pancreatic tissues exhibited a significant increase in lipid peroxidation, as reflected by elevated malondialdehyde (MDA) levels (Fig.\u0026nbsp;\u003cspan refid=\"Fig4\" class=\"InternalRef\"\u003e4\u003c/span\u003eC), together with enhanced activity of the neutrophil marker myeloperoxidase (MPO) (Fig.\u0026nbsp;\u003cspan refid=\"Fig4\" class=\"InternalRef\"\u003e4\u003c/span\u003eD). These markers peaked on day 1 post-IR and subsequently declined. In contrast, the activities of key anti-oxidant enzymes, including glutathione peroxidase (GPx) (Fig.\u0026nbsp;\u003cspan refid=\"Fig4\" class=\"InternalRef\"\u003e4\u003c/span\u003eE) and superoxide dismutase (SOD) (Fig.\u0026nbsp;\u003cspan refid=\"Fig4\" class=\"InternalRef\"\u003e4\u003c/span\u003eF), were markedly suppressed reaching a nadir on day 1 before gradual recovery. iPS-EXOs treatment effectively counteracted these changes, reducing MDA and MPO levels while restoring GPx and SOD activities toward baseline, thereby promoting redox homeostasis.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec27\" class=\"Section2\"\u003e \u003ch2\u003e3.6. iPS-EXOs attenuated inflammatory response in pancreatic IR injury\u003c/h2\u003e \u003cp\u003eTo evaluate the anti-inflammatory effect of iPS-EXOs, we measured the expression of key pro-inflammatory cytokines. RT-qPCR and ELISA analyses revealed that IR injury induced a significant increase in the levels of IL-1β, IL-6, and TNF-α, which peaked on day 1 post-reperfusion and subsequently declined (Fig.\u0026nbsp;\u003cspan refid=\"Fig5\" class=\"InternalRef\"\u003e5\u003c/span\u003eA and B). This dynamic pattern paralleled the rise in serum amylase and lipase. Notably, iPS-EXOs treatment significantly suppressed the up-regulation of these cytokines and promoted their return to homeostatic levels.\u003c/p\u003e \u003cp\u003eGiven the critical role of inducible nitric oxide synthase (iNOS), cluster of differentiation 45 (CD45), and tumor necrosis factor-alpha (TNF-α) in inflammation and oxidative stress, we assessed their expressions by immunohistochemistry (Fig.\u0026nbsp;\u003cspan refid=\"Fig5\" class=\"InternalRef\"\u003e5\u003c/span\u003eC). While the staining of these markers was negative in the sham-operated group (control), strong immunoreactivity was observed in pancreatic tissues in the IR group. In contrast, iPS-EXOs administration markedly reduced these maker expressions, indicating mitigation of inflammatory and oxidative damage (Fig.\u0026nbsp;\u003cspan refid=\"Fig5\" class=\"InternalRef\"\u003e5\u003c/span\u003eD).\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec28\" class=\"Section2\"\u003e \u003ch2\u003e3.7. iPS-EXOs inhibited pancreatic cell apoptosis\u003c/h2\u003e \u003cp\u003eTo assess the anti-apoptotic effect of iPS-EXOs, apoptosis of pancreatic cells was analyzed by flow cytometry (Fig.\u0026nbsp;\u003cspan refid=\"Fig6\" class=\"InternalRef\"\u003e6\u003c/span\u003eA). The results demonstrated a significantly higher apoptosis rate in pancreatic cells following IR injury compared to the sham operated group (control), which was markedly attenuated by iPS-EXOs treatment (Fig.\u0026nbsp;\u003cspan refid=\"Fig6\" class=\"InternalRef\"\u003e6\u003c/span\u003eB). This observation was corroborated by TUNEL staining (Fig.\u0026nbsp;\u003cspan refid=\"Fig6\" class=\"InternalRef\"\u003e6\u003c/span\u003eC), which showed a substantial increase in apoptotic cells in IR rats that was significantly attenuated following iPS-EXOs administration (Fig.\u0026nbsp;\u003cspan refid=\"Fig6\" class=\"InternalRef\"\u003e6\u003c/span\u003eD). Western blot analysis (Fig.\u0026nbsp;\u003cspan refid=\"Fig6\" class=\"InternalRef\"\u003e6\u003c/span\u003eE) of apoptosis-related protein expressions revealed that IR injury up-regulated the pro-apoptotic protein BAX and down-regulated the anti-apoptotic protein BCL-2, leading to a markedly declining BCL-2/BAX ratio as well as increased the the ratios of cleaved Caspase-3/Caspase-3 and cleaved Caspase-9/Caspase-9, but iPS-EXOs treatment could significanlty reversed these alterations (Fig.\u0026nbsp;\u003cspan refid=\"Fig6\" class=\"InternalRef\"\u003e6\u003c/span\u003eF). These results indicated that iPS-EXOs could inhibit the mitochondrial apoptotic pathway of pancreatic cells in IR injury rats.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec29\" class=\"Section2\"\u003e \u003ch2\u003e3.8. Identification of differentially expression genes (DEGs) and functional enrichment analysis\u003c/h2\u003e \u003cp\u003eTo investigate the molecular mechanism by which iPS-EXOs exerted its protective effects in pancreatitis, we analyzed RNA sequencing data of healthy individuals and patients with pancreatitis. The analysis identified 3,291 differentially expressed genes (DEGs), comprising 1,647 down-regulated and 1,644 up-regulated genes in pancreatitis patients (Fig.\u0026nbsp;\u003cspan refid=\"Fig7\" class=\"InternalRef\"\u003e7\u003c/span\u003eA). These DEGs provide significant insights into the potential molecular mechanisms underlying pancreatitis. A heatmap visually summarized these expression patterns (Fig.\u0026nbsp;\u003cspan refid=\"Fig7\" class=\"InternalRef\"\u003e7\u003c/span\u003eB).\u003c/p\u003e \u003cp\u003eGiven the importance of exosomal microRNAs (miRNAs) in regulating pathological processes such as inflammation[\u003cspan additionalcitationids=\"CR24\" citationid=\"CR23\" class=\"CitationRef\"\u003e23\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR25\" class=\"CitationRef\"\u003e25\u003c/span\u003e], we analyzed miRNA expression profiles from three iPS-EXO transcriptome datasets (GSM3597011, GSM3597012, and GSM3597013). Among these, hsa-miR-1976 was the most abundant miRNA in iPS-EXOs (Fig.\u0026nbsp;\u003cspan refid=\"Fig7\" class=\"InternalRef\"\u003e7\u003c/span\u003eC). Using the databases miRTarBase, miRWalk, miRBD, and TargetScan, we identified 24 potential target genes of hsa-miR-1976, among which HRH4 was selected for further analysis due to its strong sequence complementarity (Fig.\u0026nbsp;\u003cspan refid=\"Fig7\" class=\"InternalRef\"\u003e7\u003c/span\u003eD). KEGG pathway enrichment analysis of HRH4-associated DEGs revealed its involvement in the AMPK and NF-κB signaling pathways (Fig.\u0026nbsp;\u003cspan refid=\"Fig7\" class=\"InternalRef\"\u003e7\u003c/span\u003eE). Consistent with this, GO biological process analysis indicated HRH4's role in NF-κB-related signal transduction (Fig.\u0026nbsp;\u003cspan refid=\"Fig7\" class=\"InternalRef\"\u003e7\u003c/span\u003eF). RT-qPCR validation showed that HRH4 expression was significantly up-regulated in IR injury pancreatic tissues, while iPS-EXOs treatment could inhibit this effect. This suppression was notably reversed by the addition of AMPK inhibitor Compound C (CC) (Fig.\u0026nbsp;\u003cspan refid=\"Fig7\" class=\"InternalRef\"\u003e7\u003c/span\u003eG). In conclusion, these results suggested that iPS-EXOs might mitigate pancreatic inflammation and apoptosis through the hsa-miR-1976/HRH4 axis to regulate AMPK and NF-κB signaling pathways.\u003c/p\u003e \u003cp\u003eThe 18 pathway enrichment diagrams related to HRH4 were displayed in the GO BP (Fig. S2A), and the gene overlap relationship emapplot enrichment diagram (Fig. S2B) and enrichment chord diagram (Fig. S2C) were also depicted, showing the close connections between HRH4 and NF-κB related pathways. Meanwhile, we also performed enrichment analysis on DEGs, generating a cnet plot category network diagram of HRH4 involved in the regulation pathway (Fig. S2D), to highlight the close connections between these pathways. Furthermore, we demonstrated a close association between the HRH4 gene and hsa-miR-1976 (Fig. S2E) and generated a volcano plot to visualize the DEGs between pancreatitis patients with high and low levels of HRH4 expression (Fig. S2F),. Moreover, a KEGG pathway enrichment analysis of DEGs with \u003cem\u003ep\u003c/em\u003e\u0026thinsp;\u0026lt;\u0026thinsp;0.05 about signal transduction revealed that pancreatitis was involved in the NF- κB and AMPK signaling pathways (Fig. S2G), and a GO biological process (BP) enrichment analysis of DEGs with \u003cem\u003ep\u003c/em\u003e\u0026thinsp;\u0026lt;\u0026thinsp;0.05 about signaling pathway showed that pancreatitis was also involved in NF-κB processes (Fig. S2H). In summary, iPS-EXOs may alleviate IR induced inflammation and apoptosis through hsa-miR-1976/HRH4 axis.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec30\" class=\"Section2\"\u003e \u003ch2\u003e3.9. iPS-EXOs attenuated pancreatic IR injury through the AMPK/mTOR/NF-κB signaling pathway\u003c/h2\u003e \u003cp\u003ePrevious studies have confirmed the close association between NF-κB signaling activation and pancreatic IR injury[\u003cspan citationid=\"CR25\" class=\"CitationRef\"\u003e25\u003c/span\u003e]. Bioinformatics analyses further indicated that HRH4 plays a role in the NF-κB pathway. Therefore, to investigate the mechanism underlying iPS-EXOs mediated protection, we assessed key proteins in the AMPK/mTOR/NF-κB pathway and HRH4 expression by western blot (Fig.\u0026nbsp;\u003cspan refid=\"Fig8\" class=\"InternalRef\"\u003e8\u003c/span\u003eA). Quantitative analysis showed that IR injury significantly decreased the p-AMPK/AMPK ratio, while increasing p-mTOR/mTOR, p-NF-κB/NF-κB, and HRH4 levels compared to the control group. iPS-EXOs treatment effectively reversed these changes. However, co-administration of CC largely abolished the protective effects of iPS-EXOs (Fig.\u0026nbsp;\u003cspan refid=\"Fig8\" class=\"InternalRef\"\u003e8\u003c/span\u003eB). Based on the predicted interaction between hsa-miR-1976 and HRH4, we used hsa-miR-1976-knockout exosomes (hsa-miR-1976-KO EXOs) to administer pancreatic IR rats. Western blot analysis (Fig.\u0026nbsp;\u003cspan refid=\"Fig8\" class=\"InternalRef\"\u003e8\u003c/span\u003eC) revealed that, compared to the IR\u0026thinsp;+\u0026thinsp;iPS-EXO group, the IR\u0026thinsp;+\u0026thinsp;hsa-miR-1976-KO EXO group exhibited a significantly reduced p-AMPK/AMPK ratio, along with elevated p-mTOR/mTOR, p-NF-κB/NF-κB, and HRH4 levels (Fig.\u0026nbsp;\u003cspan refid=\"Fig8\" class=\"InternalRef\"\u003e8\u003c/span\u003eD). These results underscore the essential role of hsa-miR-1976 in regulating the HRH4-dependent AMPK/mTOR/NF-κB pathway. In conclusion, we speculated that iPS-EXOs may release hsa-miR-1976 to alleviate the inhibitory effect of HRH4 on AMPK, lead to the activation of AMPK, and then inhibit the mTOR signal to further suppress the activities of NF-κB, thereby exerting anti-inflammatory and anti-apoptotic effects on pancreatic IR injury (Fig.\u0026nbsp;\u003cspan refid=\"Fig9\" class=\"InternalRef\"\u003e9\u003c/span\u003e).\u003c/p\u003e \u003c/div\u003e"},{"header":"4. Discussion","content":"\u003cp\u003ePancreatic IR injury represents a significant clinical challenge, particularly in surgical interventions involving vascular occlusion. The pathophysiology of IR injury is complex, arising from a cascade of events including microcirculatory failure, oxidative stress, inflammatory activation, and ultimately, apoptotic cell death[\u003cspan citationid=\"CR21\" class=\"CitationRef\"\u003e21\u003c/span\u003e, \u003cspan additionalcitationids=\"CR27 CR28 CR29\" citationid=\"CR26\" class=\"CitationRef\"\u003e26\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR30\" class=\"CitationRef\"\u003e30\u003c/span\u003e]. In this study, we demonstrated that exosomes derived from iPSCs confer remarkable protection against pancreatic IR injury in rats. Our findings revealed that the therapeutic benefits of iPS-EXOs are multifaceted, encompassing the amelioration of microcirculatory dysfunction, attenuation of oxidative stress and inflammation, and inhibition of pancreatic cell apoptosis. Mechanistic studies confirmed that iPS-EXOs might exert their protective effects through the delivery of endogenous hsa-miR-1976, which targets HRH4 and then activated the AMPK/mTOR/NF-κB signaling pathway, thereby producing the therapeutic outcome.\u003c/p\u003e \u003cp\u003eResearches have demonstrated that microcirculatory dysfunction is the primary feature of early pancreatic injury following ischemia, which subsequently leads to capillary thrombosis, leukocyte activation, and the release of proteolytic enzymes and pro-inflammatory cytokines[\u003cspan citationid=\"CR31\" class=\"CitationRef\"\u003e31\u003c/span\u003e, \u003cspan citationid=\"CR32\" class=\"CitationRef\"\u003e32\u003c/span\u003e]. A critical finding of our work is the potent effect of iPS-EXOs on restoring pancreatic microcirculation post-IR injury. The observed impairment in blood flow, characterized by approximately 80% reduction within 1 day of reperfusion, aligns with the established paradigm of microvascular thrombosis and dysfunction[\u003cspan citationid=\"CR30\" class=\"CitationRef\"\u003e30\u003c/span\u003e, \u003cspan citationid=\"CR33\" class=\"CitationRef\"\u003e33\u003c/span\u003e]. iPS-EXOs treatment not only accelerated the recovery of perfusion but also promoted the up-regulation of VEGF-A expression and phosphorylation level of VEGFR2. These suggestsed that iPS-EXOs could facilitate endothelial repair and microvascular remodeling.\u003c/p\u003e \u003cp\u003eBeyond microcirculatory improvement, iPS-EXOs administration effectively countered the oxidative and inflammatory cascades that define IR injury. The previous study has shown that oxidative stress is the basic mechanism of IR injury in the pancreas[\u003cspan citationid=\"CR26\" class=\"CitationRef\"\u003e26\u003c/span\u003e]. Moreover, in several clinical studies, the severity of the disease in patients with acute pancreatitis is related to the elevation of oxidative stress[\u003cspan citationid=\"CR34\" class=\"CitationRef\"\u003e34\u003c/span\u003e, \u003cspan citationid=\"CR35\" class=\"CitationRef\"\u003e35\u003c/span\u003e]. During the IR process, a substantial quantity of reactive oxygen species (ROS) is produced. These ROS will assail and impair lysosomes, mitochondria, and other cellular components. Consequently, the initial ischemic injury is transformed into the activation of extensive detrimental inflammatory and apoptotic pathways[\u003cspan citationid=\"CR36\" class=\"CitationRef\"\u003e36\u003c/span\u003e, \u003cspan citationid=\"CR37\" class=\"CitationRef\"\u003e37\u003c/span\u003e]. Malondialdehyde (MDA) is the most commonly indicator for detecting lipid peroxides in cells and tissues, which is regarded as a crucial marker for assessing the severity of acute pancreatitis[\u003cspan citationid=\"CR38\" class=\"CitationRef\"\u003e38\u003c/span\u003e]. Moreover, myeloperoxidase (MPO) has been proven to exacerbate tissue damage in diverse inflammatory diseases[\u003cspan citationid=\"CR39\" class=\"CitationRef\"\u003e39\u003c/span\u003e]. Glutathione peroxidase (GPx) and Superoxide dismutase (SOD) can be used as indicators for assessing anti-oxidative stress. In our study, the treatment with iPS-EXOs could accelerate the normalization of ROS, MDA, MPO, GPx, and SOD levels, indicating the positive effect on the restoration of redox homeostasis. The activation of nuclear factor NF-κB represents a pivotal event in the pathogenesis of acute pancreatitis[\u003cspan citationid=\"CR40\" class=\"CitationRef\"\u003e40\u003c/span\u003e, \u003cspan citationid=\"CR41\" class=\"CitationRef\"\u003e41\u003c/span\u003e]. Although the inflammatory response and trypsin activation proceed occur through separate pathways and do not interfere with each other directly, oxidative stress acts as a common facilitating mechanism that can influence both processes. The ROS generated by NADPH oxidase can not only directly alter the mitochondrial permeability transition pore (MPTP), thereby resulting in apoptosis and necrosis, but also trigger the activation of the NF-κB signaling pathway to initiate an inflammatory response[\u003cspan citationid=\"CR42\" class=\"CitationRef\"\u003e42\u003c/span\u003e]. Substantial evidence indicated that neutrophils were critically involved in the initiation of acute pancreatitis (AP). When stimulated by inflammation, neutrophils released a series of potent mediators, such as IL-1β and ROS[\u003cspan citationid=\"CR43\" class=\"CitationRef\"\u003e43\u003c/span\u003e, \u003cspan citationid=\"CR44\" class=\"CitationRef\"\u003e44\u003c/span\u003e]. IL-1β is a critical mediator in the onset and progression of inflammatory responses. It not only exerts direct pro-inflammatory effects but also promotes the secretion of additional cytokines involved in the pro-inflammatory cascade[\u003cspan citationid=\"CR45\" class=\"CitationRef\"\u003e45\u003c/span\u003e, \u003cspan citationid=\"CR46\" class=\"CitationRef\"\u003e46\u003c/span\u003e]. This cascade of cycles can lead to severe circulatory failure and even organ failure. Our research indicated that iPS-EXOs treatment significantly mitigated the inflammatory response, as evidenced by reduced leukocyte infiltration, lower serum levels of IL-1β, IL-6, and TNF-α, as well as decreased iNOS, TNF-α, and CD45 expressions. In acute pancreatitis, amylases and lipases are released from acinar cells into the interstitial space[\u003cspan citationid=\"CR47\" class=\"CitationRef\"\u003e47\u003c/span\u003e], with their increased serum concentrations serving as highly sensitive and clinically relevant biomarkers for assessing disease severity[\u003cspan citationid=\"CR48\" class=\"CitationRef\"\u003e48\u003c/span\u003e]. The accelerated resolution of pancreatic edema and necrosis, coupled with the rapid decline of serum amylase and lipase, further demonstrated the ability of iPS-EXOs to curtail acinar cell injury and promote tissue repair.\u003c/p\u003e \u003cp\u003eThe protective effects of iPS-EXOs culminated in a significant reduction in pancreatic cell apoptosis. Data of TUNEL staining, flow cytometry, and western blot analysis consistently demonstrated that iPS-EXOs shifted the balance towards cell survival, increasing the BCL-2/BAX ratio and inhibiting the activation of Caspase-3 and Caspase-9. To elucidate the underlying molecular mechanism, we employed a bioinformatics approach and pinpointed the AMPK/mTOR/NF-κB pathway as well as HRH4 as key players. We further found iPS-EXOs are enriched with hsa-miR-1976. By leveraging public databases including miRTarBase, miRWalk, miRDB, and TargetScan, we predicted the potential target genes of hsa-miR-1976, revealing HRH4 as one of the most significant targets with a strong binding affinity to hsa-miR-1976. miR-548 is a large gene family in the human body that plays diverse biological roles, including the regulation of the actin cytoskeleton, the MAPK signaling pathway, and inflammatory responses[\u003cspan citationid=\"CR49\" class=\"CitationRef\"\u003e49\u003c/span\u003e]. hsa-miR-1976, as a critical member of the miR-548 family, has demonstrated significant potential in the treatment of pancreatic diseases[\u003cspan citationid=\"CR50\" class=\"CitationRef\"\u003e50\u003c/span\u003e]. Furthermore, as the predicted target gene of hsa-miR-1976, HRH4 plays a pivotal role in modulating inflammatory responses through the regulation of immune cell chemotaxis and activation[\u003cspan citationid=\"CR51\" class=\"CitationRef\"\u003e51\u003c/span\u003e]. In the context of IR injury, the AMPK/mTOR signaling axis serves a fundamental protective function by coordinating cellular adaptation to metabolic stress[\u003cspan citationid=\"CR52\" class=\"CitationRef\"\u003e52\u003c/span\u003e]. Cellular energy depletion during ischemia coupled with ROS generation upon reperfusion potently stimulated AMPK activity, principally through phosphorylation mediated by LKB1 and by increasing the AMP/ATP ratio[\u003cspan citationid=\"CR53\" class=\"CitationRef\"\u003e53\u003c/span\u003e]. This activation triggers a cascade of downstream events wherein AMPK directly phosphorylates the mTORC1 constituent Raptor while concurrently stimulating the TSC complex, leading to effective suppression of mTORC1 signaling[\u003cspan citationid=\"CR54\" class=\"CitationRef\"\u003e54\u003c/span\u003e]. This inhibition initiates a dual protective mechanism: it simultaneously enhances autophagic clearance of dysfunctional organelles and misfolded proteins by removing mTOR-mediated repression of autophagy initiation[\u003cspan citationid=\"CR55\" class=\"CitationRef\"\u003e55\u003c/span\u003e], while concurrently conserves cellular energy through reducing ribosomal biogenesis and protein synthesis, thereby prioritizing ATP allocation for critical survival processes[\u003cspan citationid=\"CR56\" class=\"CitationRef\"\u003e56\u003c/span\u003e]. Beyond mTOR regulation, AMPK activation further supports cellular recovery by modulating metabolic and inflammatory pathways[\u003cspan citationid=\"CR57\" class=\"CitationRef\"\u003e57\u003c/span\u003e], promoting mitochondrial biogenesis via PGC-1α activation and fatty acid oxidation through ACC phosphorylation[\u003cspan citationid=\"CR58\" class=\"CitationRef\"\u003e58\u003c/span\u003e], while simultaneously restrains inflammatory responses through suppression of NLRP3 inflammasome formation and NF-κB transcriptional activity, ultimately diminishing production of pro-inflammatory mediators including IL-1β and TNF-α[\u003cspan citationid=\"CR59\" class=\"CitationRef\"\u003e59\u003c/span\u003e]. Our study confirmed that iPS-EXOs could promote AMPK phosphorylation while concurrently suppressing HRH4 expression and mTOR/NF-κB activation. Furthermore, the benefits of iPS-EXOs were abolished by either AMPK inhibitor Compound C (CC) or hsa-miR-1976 knockdown, demonstrating that the hsa-miR-1976/HRH4/AMPK axis may be the central to its therapeutic mechanism. Therefore, we proposed that the endogenous miR-1976 of iPS-EXOs, alleviated the inhibitory effect of HRH4 on AMPK, lead to the activation of AMPK, and then inhibit the mTOR signal, thereby suppressing the pro-inflammatory and pro-apoptotic activities of NF-κB and breaking the vicious cycle of IR damage.\u003c/p\u003e \u003cp\u003eAlthough this study provides new insights, there are still some limitations. The translational relevance of findings from rodent models to human patients requires careful validation, given inherent species differences. The absence of a robust \u003cem\u003ein vitro\u003c/em\u003e model using pancreatic exocrine cells limited our ability to dissect cell-autonomous mechanisms. Establishing a reliable oxygen-glucose deprivation (OGD) cell model would be a valuable future direction. Finally, the potential contribution of other cargo within iPS-EXOs to the overall therapeutic effect warrants further investigation using multi-omics approaches and gene knockout animal or cell models.\u003c/p\u003e"},{"header":"5. Conclusion","content":"\u003cp\u003eThis study demonstrated that iPS-EXOs could significantly alleviate IR-induced pancreatic injury. The core mechanism underlying their anti-inflammatory and anti-apoptotic effects lies in the activation of the AMPK/mTOR/NF-κB signaling pathway, mediated by their endogenous hsa-miR-1976 targeting HRH4. This finding provides a novel therapeutic strategy for the prevention and treatment of pancreatic IR injury.\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eAcknowledgments\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eFunding: This work was supported, in part, by Grant Name the Zhejiang Provincial Natural Science Foundation of China (LTGY23H030003 and LY24H020008)，the Key Research and Development Program of Zhejiang Province (2023C03018).\u003cstrong\u003e\u003cbr\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eEthics approval statement\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNone reported\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConflict of Interest Disclosure\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors declare no competing financial interest\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCRediT authorship contribution statement\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eBowen Yu\u003c/strong\u003e\u003cstrong\u003e:\u003c/strong\u003e Writing-review \u0026amp; editing, Writing \u0026ndash; original draft, Visualization, Validation, Supervision, Software, Methodology, Investigation, Formal analysis, Data curation, Conceptualization. \u003cstrong\u003eXiaofeng Shen:\u003c/strong\u003e Supervision, Methodology, Investigation, Formal analysis, Data curation. \u003cstrong\u003eJiahui Lin:\u0026nbsp;\u003c/strong\u003eMethodology, Supervision. \u003cstrong\u003eYihao Wang:\u003c/strong\u003e Methodology, Validation. \u003cstrong\u003eKe Chen\u003c/strong\u003e\u003cstrong\u003e：\u003c/strong\u003eMethodology, Supervision. \u003cstrong\u003eYanli Xiao:\u003c/strong\u003e Methodology, Validation. \u003cstrong\u003eWanying Wu:\u0026nbsp;\u003c/strong\u003eMethodology, Validation. \u003cstrong\u003eYuchong Fu:\u003c/strong\u003e Methodology, Validation. \u003cstrong\u003eShuhui Zhao:\u003c/strong\u003e Methodology, Validation. \u003cstrong\u003eAo Zhang:\u003c/strong\u003e Methodology, Validation. \u003cstrong\u003eGuanghui Zhu:\u003c/strong\u003e Supervision. \u003cstrong\u003eWeiping Ji\u003c/strong\u003e: Data curation, Funding acquisition, Resources, Supervision, Writing-review \u0026amp; editing. \u003cstrong\u003eXiaoling Guo\u003c/strong\u003e: Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing-review \u0026amp; editing\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eData availability\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe data used to support the findings of this study are available from the corresponding author upon reasonable request.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eClinical trial number\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003enot applicable\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\u003cli\u003e\u003cspan\u003eZhou W, Lin D, Zhong Z, Ye Q. 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Natural plant polyphenols contribute to the ecological and healthy swine production. J Anim Sci Biotechnol. 2024;15(1):146.\u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003ehttp://dx.doi.org/10.1186/s40104-024-01096-3\u003c/span\u003e\u003cspan address=\"10.1186/s40104-024-01096-3\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/li\u003e\u003c/ol\u003e"},{"header":"Table","content":"\u003cp\u003e\u003cimg 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This study investigated the therapeutic potential of exosomes derived from induced pluripotent stem cells (iPS-EXOs), a novel, cell-free therapeutic strategy, in a rat model of pancreatic IR injury induced by splenic artery occlusion. Administration of iPS-EXOs significantly improved survival, attenuated pancreatic edema, and ameliorated histopathological damage. The protective effects were mediated through multi-faceted actions that iPS-EXOs restored microcirculatory perfusion through promoting VEGF-A/VEGFR2 signaling, mitigated oxidative stress via normalizing levels of ROS, MDA, MPO, GPx, and SOD, and suppressed the inflammatory cascade by reducing serum levels of IL-1β, IL-6, and TNF-α. Furthermore, iPS-EXOs exerted anti-apoptotic effects, as evidenced by decreased TUNEL-positive cells and modulation of BCL-2/BAX and Caspase-3/9 pathways. We identified that hsa-miR-1976 in iPS-EXOs could target HRH4, leading to AMPK activation and subsequent inhibition of the mTOR/NF-κB signaling pathway. Collectively, our reuslts demonstrated that iPS-EXOs exerted protection against pancreatic IR injury of rat by coordinating microvascular repair, anti-oxidant, anti-inflammatory, and anti-apoptosis through endogenous hsa-miR-1976 binding to HRH4 to activate AMPK/mTOR/NF-κB pathway. These findings indicated that iPS-EXOs could be a promising therapeutic agent for pancreatic IR injury.\u003c/p\u003e","manuscriptTitle":"iPS-derived exosomes alleviated pancreatic ischemia reperfusion injury through activating the AMPK/mTOR/NF-κB pathway","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2026-02-18 15:34:03","doi":"10.21203/rs.3.rs-8586494/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"1e0ec0b8-e53c-45b8-916b-d083a2c8a6d3","owner":[],"postedDate":"February 18th, 2026","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2026-03-23T08:28:23+00:00","versionOfRecord":[],"versionCreatedAt":"2026-02-18 15:34:03","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-8586494","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-8586494","identity":"rs-8586494","version":["v1"]},"buildId":"XKTyCvWXoU3ODBz1xrDgd","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}