Tactics for predicting hyperproliferative processes of the uterus in women of reproductive age

Olga Leshchova
In: Perinatology and reproductology: from research to practice · 2026 · vol. 6(2) , pp. 56 · doi:10.52705/2788-6190-2026-02-7 · W7165526934
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⚙ AI-generated summary by claude@2026-07, 2026-07-09 ⓘ

A predictive model incorporating obesity, autoimmune thyroiditis, diabetes mellitus, and age was developed to assess leiomyoma risk in reproductive-aged women.

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The paper aimed to develop tactics for predicting hyperproliferative processes of the uterus in women of reproductive age by studying 1002 women with hyperplastic processes of the endometrium and/or myometrium and comparing them with 80 healthy controls without endometrial or myometrial pathology. Using subgroup comparisons of combined conditions involving uterine leiomyoma with adenomyosis and/or endometrial hyperplasia versus isolated leiomyoma, isolated adenomyosis, or isolated endometrial hyperplastic processes, the authors reported that leiomyoma risk could be estimated from a function incorporating obesity, autoimmune thyroiditis, diabetes mellitus, and age. They concluded that risk factors for combined benign proliferative diseases of the endometrium and myometrium included obesity and selected cardiovascular, gastrointestinal, and hepatobiliary diseases, and they described more frequent and intense pain and uterine bleeding with anemia in combined forms versus solitary ones. This paper is centrally about endometriosis — it includes adenomyosis as a key uterine hyperproliferative condition and analyzes risk and clinical features in combinations involving adenomyosis.

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Abstract

The objective: to develop tactics for predicting hyperproliferative processes of the uterus in women of reproductive age. Materials and methods. The study included 1002 women of reproductive age with hyperplastic processes of the endo- and myometrium and 80 healthy women who did not have pathology of the endo- and myometrium (control group). The main group consisted of 470 patients, who were divided into 3 subgroups: the 1st subgroup included patients with a combination of uterine leiomyoma and adenomyosis (n = 109); the 2nd subgroup – patients with uterine leiomyoma combined with endometrial hyperplastic processes (n = 179); the 3rd subgroup – patients having a combination of uterine leiomyoma, adenomyosis, and endometrial hyperplasia (n = 182). The comparison group consisted of 532 patients, who were divided into 3 subgroups: subgroup A – patients with isolated uterine leiomyoma (n = 147); subgroup B – with isolated adenomyosis (n = 143); subgroup C – with isolated endometrial hyperplastic processes (n = 242). Results. The risk of leiomyoma occurrence in a patient with the presence of endocrine system diseases can be assessed using the following function: Risk of leiomyoma development: 1.979 • variable value for obesity + 0.102 • variable value for autoimmune thyroiditis + 0.064 • variable value for diabetes mellitus + 0.046 • age – 2.445. Variable values for diabetes mellitus, autoimmune thyroiditis, obesity: 0 – absence of the disease, 1 – presence. If the function value is closer to zero, the risk of developing uterine leiomyoma is minimal; if closer to 1, the risk is high. Conclusions. Risk factors for the development of combined benign proliferative diseases of the endo- and myometrium in women of reproductive age include the presence of obesity, diseases of the cardiovascular system, gastrointestinal tract, and hepatobiliary system in the patient. Features of the clinical course of combined uterine hyperplastic processes, unlike solitary ones, are: a significantly higher frequency and intensity of pain syndrome, the prevalence of various forms of uterine bleeding and anemia caused by them, including severe degrees. Patients with the proliferative form of fibrocystic breast disease and combined hyperplastic diseases of the uterus belong to the high-risk group for developing breast cancer.
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Keywords

proliferative processes of the uterus, prediction, reproductive ageAbstract DOI: 10.52705/2788-6190-2026-02-7 УДК 618.14-006.03-02:618.17/.5-037 The objective: to develop tactics for predicting hyperproliferative processes of the uterus in women of reproductive age.

Materials

and methods. The study included 1002 women of reproductive age with hyperplastic processes of the endo- and myometrium and 80 healthy women who did not have pathology of the endo- and myometrium (control group). The main group consisted of 470 patients, who were divided into 3 subgroups: the 1st subgroup included patients with a combination of uterine leiomyoma and adenomyosis (n = 109); the 2nd subgroup – patients with uterine leiomyoma combined with endometrial hyperplastic processes (n = 179); the 3rd subgroup – patients having a combination of uterine leiomyoma, adenomyosis, and endometrial hyperplasia (n = 182). The comparison group consisted of 532 patients, who were divided into 3 subgroups: subgroup A – patients with isolated uterine leiomyoma (n = 147); subgroup B – with isolated adenomyosis (n = 143); subgroup C – with isolated endometrial hyperplastic processes (n = 242). Results. The risk of leiomyoma occurrence in a patient with the presence of endocrine system diseases can be assessed using the following function: Risk of leiomyoma development: 1.979 • variable value for obesity + 0.102 • variable value for autoimmune thyroiditis + 0.064 • variable value for diabetes mellitus + 0.046 • age – 2.445. Variable values for diabetes mellitus, autoimmune thyroiditis, obesity: 0 – absence of the disease, 1 – presence. If the function value is closer to zero, the risk of developing uterine leiomyoma is minimal; if closer to 1, the risk is high. Conclusions. Risk factors for the development of combined benign proliferative diseases of the endo- and myometrium in women of reproductive age include the presence of obesity, diseases of the cardiovascular system, gastrointestinal tract, and hepatobiliary system in the patient. Features of the clinical course of combined uterine hyperplastic processes, unlike solitary ones, are: a significantly higher frequency and intensity of pain syndrome, the prevalence of various forms of uterine bleeding and anemia caused by them, including severe degrees. Patients with the proliferative form of fibrocystic breast disease and combined hyperplastic diseases of the uterus belong to the high-risk group for developing breast cancer. Downloads Published How to Cite Issue Section License This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

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