Evaluation the Impact of Prescribed Metformin on Health-related quality of Life: A Cross- sectional Study

Introduction: Metformin is commonly prescribed to manage polycystic ovary syndrome (PCOS), which is one of the most common endocrine disorders among women of reproductive age, and is associated with high prevalence rates of psychiatric disorders. This study’s objective was to determine the impact of metformin on psychosocial wellbeing in terms of mental health issues which affect the QoL among Iranian women with PCOS. Materials: and Method The present cross-sectional study was carried out on 400 patients diagnosed with PCOS and equally divided 200 respondents into with metformin group and remaining 200 respondents into without metformin group. All participants were asked to fill out the valid and reliable questionnaires of FSFI (Female Sexual Function Index), HADS (Hospital Depression and Anxiety Scale) and SF-12. Results: : There were statistically significant difference between without metformin and with metformin in terms of arousal, lubrication, pain and total FSFI score. There were statistically significant difference between the mean score of MCS, anxiety and depression in without metformin and with metformin (P<0.001). Conclusion: Metformin may have a role in the management of psychosocial wellbeing among patient with PCOS; however, its potential effects should be further examined in randomized double-blind placebo-controlled clinical trials.