MicroRNA-513b-5p Contributes to the Development of Osteosarcoma via Inhibiting Sirtuin 1

Abstract Objective The objective of this research was to clarify the role of miR-513b-5p in osteosarcoma (OS). Methods In OS cells, the miR-513b-5p expression was determined, and the impact of miR-513b-5p on malignant phenotypes of MG-63 cells was investigated. Moreover, the association between miR-513b-5p and sirtuin 1 (SIRT1) was studied. Results In OS, miR-513b-5p expression was reduced. Enhancing miR-513b-5p expression significantly reduced the proliferation, invasion, and migration of MG-63 cells. SIRT1 was one of the targets of miR-513b-5p, and overexpression of SIRT1 reversed the inhibitory effects of miR-513b-5p mimic on the malignant characteristic of MG-63 cells. Conclusion miR-513b-5p functions as a tumor suppressor in OS by inhibiting SIRT1. The therapeutic strategies targeting the miR-513b-5p/SIRT1 axis may improve the clinical outcomes of OS.