Clinical Value of Neutrophil-to-Lymphocyte Ratio in Endometriosis

This study investigated the clinical value of neutrophil-to-lymphocyte ratio (NLR) for diagnosing endometriosis in 90 women with tissue-pathology confirmed endometriosis who underwent surgery, compared with 60 women with benign ovarian tumors and 60 healthy controls; endometriosis cases were staged using the revised American Fertility Society criteria, creating ≤II and ≥III subgroups. Serum CA125 and NLR were measured from fasting cubital venous blood. NLR values and CA125 levels were significantly higher in the endometriosis group than in both comparison groups, but within the endometriosis cohort NLR did not differ significantly between ≤II and ≥III stages, whereas CA125 did show significant stage-related differences. This paper concludes that NLR may have value for endometriosis primary screening and early diagnosis, with the main limitation being the absence of a demonstrated stage-discriminating role for NLR. This paper is centrally about endometriosis — it evaluates NLR as an inflammatory biomarker to aid diagnosis of endometriosis and compares it with CA125 across disease stage.

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