Clinical Value of Neutrophil-to-Lymphocyte Ratio in Endometriosis

Qun Tao; Bo Li

doi:10.3877/cma.j.issn.1673-5250.2012.03.019

Clinical Value of Neutrophil-to-Lymphocyte Ratio in Endometriosis

Qun Tao, Bo Li

In: Chung-Hua Fu Ch'an K'o Tsa Chih · 2012 · vol. 8(3) , pp. 317–319 · doi:10.3877/cma.j.issn.1673-5250.2012.03.019 · W3029580084

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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Neutrophil-to-lymphocyte ratio and CA125 levels were significantly higher in endometriosis patients compared to those with benign ovarian tumors or healthy controls, suggesting NLR's value in screening and early diagnosis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 · read from full text ⓘ

This study investigated the clinical value of neutrophil-to-lymphocyte ratio (NLR) for diagnosing endometriosis in 90 women with tissue-pathology confirmed endometriosis who underwent surgery, compared with 60 women with benign ovarian tumors and 60 healthy controls; endometriosis cases were staged using the revised American Fertility Society criteria, creating ≤II and ≥III subgroups. Serum CA125 and NLR were measured from fasting cubital venous blood. NLR values and CA125 levels were significantly higher in the endometriosis group than in both comparison groups, but within the endometriosis cohort NLR did not differ significantly between ≤II and ≥III stages, whereas CA125 did show significant stage-related differences. This paper concludes that NLR may have value for endometriosis primary screening and early diagnosis, with the main limitation being the absence of a demonstrated stage-discriminating role for NLR. This paper is centrally about endometriosis — it evaluates NLR as an inflammatory biomarker to aid diagnosis of endometriosis and compares it with CA125 across disease stage.

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Abstract

Objective To explore the clinical value of neutrophil-to-lymphocyte ratio (NLR) in endometriosis(EMs). Methods From January 2006 to December 2010, 90 patients with EMs, 60 patients with benign ovarian tumors, 60 healthy women were included in the study. They were divided into EMs group[n=90, with ≤stageⅡsubgroup(n=36)and ≥ stage Ⅲ subgroup(n=54)], benign ovarian tumors group(n=60)and control group(n=60). NLR value and serum CA125 level were measured and calculated. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Chaohu First Hospital. Informed consent was obtained from each patients. Results The NLR value and CA125 level in EMs group were significantly higher than those in benign ovarian tumor group and control group, respectively (P<0.05). There had significant differences of CA125 level and the positive rate between ≤stageⅡsubgroup and ≥ stage Ⅲ subgroup in EMs group. And there had no significant difference in NLR value and the positive rate between two subgroups. Conclusions NLR value is a new inflammatory target, which has a good value on EMs primary screening and early diagnosis. Key words: endometriosis; neutrophil-to-lymphocyte ratio; CA125

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Objective

To explore the clinical value of neutrophil-to-lymphocyte ratio (NLR) in endometriosis(EMs).

Methods

From January 2006 to December 2010, 90 patients with EMs, 60 patients with benign ovarian tumors, 60 healthy women were included in the study. They were divided into EMs group[n=90, with ≤stageⅡsubgroup(n=36)and ≥ stage Ⅲ subgroup(n=54)], benign ovarian tumors group(n=60)and control group(n=60). NLR value and serum CA125 level were measured and calculated. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Chaohu First Hospital. Informed consent was obtained from each patients.

Results

The NLR value and CA125 level in EMs group were significantly higher than those in benign ovarian tumor group and control group, respectively (P<0.05). There had significant differences of CA125 level and the positive rate between ≤stageⅡsubgroup and ≥ stage Ⅲ subgroup in EMs group. And there had no significant difference in NLR value and the positive rate between two subgroups.

Conclusions

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