Dyslipidemia is associated with sarcopenia: A systematic review and meta-analysis of the elderly

Purpose: Sarcopenia is a pathological change characterized by muscle loss in older people. It was reported that sarcopenia was 3.1 mg/dL more common in females than in nonsarcopenic females. However, in another study, TG (1.57 ± 0.92 mmol/L) in sarcopenia patients was much lower than that in nonsarcopenia patients. Therefore, this meta-analysis aimed to explore the association between sarcopenia and dyslipidemia. Methods: We searched the Cochrane Library, Web of Science, PubMed, China National Knowledge Infrastructure (CNKI), Wan Fang, China Science and Technology Journal Database (VIP Database) for case‒control studies to extract data on the odds ratio (OR) between sarcopenia and dyslipidemia and the mean values of TC, LDL-C, HDL-C, TG, and TG/HDL-C between sarcopenia and nonsarcopenia. The JBI guidelines were used to evaluate the quality. Excel 2021, Review Manager 5.3 and Stata 16.0 were used for the statistical analysis. Results: Twenty studies were included in the meta-analysis, 19 of which were evaluated as good quality. The overall OR of the relationship between sarcopenia and dyslipidemia was 1.47, and the MD values of TC, LDL-C, HDL-C, TG, and TG/HDL-C were 1.10, 1.95, 1.27, 30.13, and 0.16, respectively. The MD of LDL-C in females was greater than that in males. The OR of the non-China region was greater than that of China. The MD of TC in people (> 60) was higher than that in people (20 to 60). Conclusion: Dyslipidemia was associated with sarcopenia, dyslipidemia was a risk factor for sarcopenia, and sex, region and age were the influencing factors. The control of dyslipidemia plays a significant role in sarcopenia.