EXPRESSION OF STEROID HORMONE RECEPTORS IN THE TISSUE OF ENDOMETRIOMAS IN FIRST-TIME AND RELAPSING PATIENTS

L.S. Bulatova, A.A. Solomatina, Е. Н. Карева, N. A Kotsyubinskaya
In: Bulletin of Russian State Medical University · 2018 · pp. 55–59 · doi:10.24075/brsmu.2018.014 · W2800816255
OA: diamond CC0
📄 Open PDF Full text JSON View on OpenAlex View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite+body, 2026-07-19 ⓘ

This study compared steroid hormone receptor gene expression in endometriomas from first-time and relapsing patients, finding altered estrogen receptor expression but unchanged progesterone receptor expression in recurrent cases.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by qwen3.7-flash, 2026-10-05 · read from full text ⓘ

This study compared the expression of steroid hormone receptor genes in ovarian endometrioma tissue from 94 women, distinguishing between 82 first-time patients and 12 with recurrent disease. Using reverse transcription polymerase chain reaction, researchers found that relapsing cases exhibited significantly elevated levels of estrogen receptors, including a three-fold increase in mER and substantial rises in ERβ and ERα transcripts. In contrast, the expression profile of progesterone receptors remained unchanged regardless of whether the condition was initial or recurrent. This paper is centrally about endometriosis — specifically examining molecular markers associated with recurrence in ovarian endometriomas to inform post-operative treatment strategies.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Full text 2,358 characters · extracted from oa-doi-fallback · click to expand
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY). ORIGINAL RESEARCH Expression of steroid hormone receptors in the tissue of endometriomas in first-time and relapsing patients 1 Department of Obstetrics and Gynecology, Pediatrics Faculty, Pirogov Russian National Research Medical University, Moscow, Russia 2 Department of Molecular Pharmacology and Radiobiology named after Academician P.V.Sergeev, Medical-Biological Faculty, Pirogov Russian National Research Medical University, Moscow, Russia Correspondence should be addressed: Lolita Bulatova Ostrovityanova 1, Moscow, 117997; [email protected] A molecular marker for the risk of endometriosis recurrence can help to customize a post-operative treatment plan for an individual patient. The aim of this study was to compare the expression of genes coding for estradiol (mER, ERα, ERβ) and progesterone (PGRmC1, mPR, РR-А, PR-B) receptors in first-time and relapsing patients with ovarian endometriosis. Our study included 94 women of reproductive age with ovarian endometriosis: 82 first-time and 12 relapsing patients. The expression of genes coding for steroid receptors was measured using reverse transcription polymerase chain reaction. Recurrent conditions were characterized by a change in the expression of estrogen receptors and unchanged expression of progesterone receptors. Expression of mER in the tissue of patients with first-time endometriosis was 15.09 ± 1.18. Patients undergoing recurrence demonstrated a 3-fold increase in mER expression (from 15.09 ± 1.18 to 44.45 ± 9.1). Also, in such patients ERβ expression was 5 times higher increasing from 11.71 ± 0.22, which is an average value for first-time patients, to 10.02 ± 3.81, while ERα expression surged 7-fold from 10.47 ± 1.05 to 1.68 ± 0.55 (p < 0.05). Transcription of the studied receptors in the pathological tissue depended on the stage of the disease: in relapsing patients expression of estradiol receptors underwent some changes, while expression profile of progesterone receptors remained unchanged. Sensitivity of endometrial tissue to gestogens is clinically important and serves as a basis for a successful hormone-based relapse prevention. Keywords: ovarian endometriosis, PCR, estradiol receptors, progesterone receptors

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. The paper's references may be in our DB but unresolved to ``paper_id`` (resolution happens at ingest when the cited DOI matches a row we already have). Run the cross-source citation reconcile pass to retry.

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK