Analysis of NK and γδT cells in patients with endometriosis

Objective:To investigate the activity and amount of NK and γδT cells in peripheral blood(PB) and peritoneal fluid(PF) in patients with endometriosis Methods:Analysis the amount and killing activity of NK and γδT cells in PB and PF in 15 cases with endometriosis by immunofluorescence method and flow cytometry,etc Results:1 In comparison with the controlled group,the amount of γδT cells in PF of endometriosis was higher(P0 05) However,the controlled group had no difference As in the same individual of endometriosis,the amount of these two killer cells in PF were higher than those in PB(P0 05) But this can not be find in controlled group 2 Except for γδT cell in PB,NK cell activity in PB and PF or γδT cell activity in PF of patients with endometriosis were declined(P0 05) In the cases,the activity of those two cells in PF had been found significantly lower than that in PB(P0 05) Conclusion:The declined activity of NK and γδT cells is linked with decreased clearance of endometrial cells which allows implantation and growth of ectopic endometrium It could be the possibility of the pathogenesis due to endometriosis