Whole-genome methylation profiling of menstrual stem cells identifies novel biomarkers for endometriosis

Raúl Pérez-Moraga, Cemsel Bafligil
2025 · doi:10.5281/zenodo.15878285 · W7151827614
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study analyzed whole-genome DNA methylation in menstrual stem cells to identify novel biomarkers associated with endometriosis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 · read from full text ⓘ

The study aimed to identify endometriosis-related biomarkers by performing whole-genome DNA methylation profiling on menstrual blood-derived mesenchymal stem cells (MenSCs), using accompanying bioinformatics analysis scripts. The investigators generated methylation data from these cells and focused the downstream analysis on discovering candidate methylation markers associated with endometriosis. A key limitation noted in the repository context is that this publication primarily provides the analysis scripts for methylation profiling rather than a full clinical validation workflow or experimental details within the text provided. This paper is centrally about endometriosis — it uses whole-genome methylation profiling of menstrual stem cells to discover novel endometriosis biomarkers.

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Abstract

This repository contains scripts used in the bioinformatics analysis of DNA methylation in menstrual blood-derived mesenchymal stem cells (MenSCs), aiming to identify biomarkers related to endometriosis.
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Published July 14, 2025 | Version v1 Data paper Open Whole-genome methylation profiling of menstrual stem cells identifies novel biomarkers for endometriosis Contributors Contact person: - 1. endogene.bio - 2. Complejo Hosiptalario Universitario Insular Materno Infantil de Canarias, Las Palmas de Gran Canaria, Spain - 3. Department of Gynecology, Institut Clínic of Gynecology, Obstetrics and Neonatology, Hospital Clínic of Barcelona, Institut d'Investigacions Biomédiques August Pi I Sunyer (IDIBAPS), Barcelona Spain - 4. Service of Gynecology, Institut Clínic of Gynecology, Obstetrics and Neonatology, Hospital Clínic of Barcelona, Universitat de Barcelona, Institut d'Investigacions Biomédiques August Pi I Sunyer (IDIBAPS), Barcelona Spain Description This repository contains scripts used in the bioinformatics analysis of DNA methylation in menstrual blood-derived mesenchymal stem cells (MenSCs), aiming to identify biomarkers related to endometriosis.

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endometriosis

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