Baseline characteritics of the population-based cohort in Iga City – the Iga City Cohort Study

Baseline characteristics of the population-based cohort in Iga City - the Iga City Cohort Study | medRxiv /* */ /* */ <!-- <!-- /*! * yepnope1.5.4 * (c) WTFPL, GPLv2 */ (function(a,b,c){function d(a){return"[object Function]"==o.call(a)}function e(a){return"string"==typeof a}function f(){}function g(a){return!a||"loaded"==a||"complete"==a||"uninitialized"==a}function h(){var a=p.shift();q=1,a?a.t?m(function(){("c"==a.t?B.injectCss:B.injectJs)(a.s,0,a.a,a.x,a.e,1)},0):(a(),h()):q=0}function i(a,c,d,e,f,i,j){function k(b){if(!o&&g(l.readyState)&&(u.r=o=1,!q&&h(),l.onload=l.onreadystatechange=null,b)){"img"!=a&&m(function(){t.removeChild(l)},50);for(var d in y[c])y[c].hasOwnProperty(d)&&y[c][d].onload()}}var j=j||B.errorTimeout,l=b.createElement(a),o=0,r=0,u={t:d,s:c,e:f,a:i,x:j};1===y[c]&&(r=1,y[c]=[]),"object"==a?l.data=c:(l.src=c,l.type=a),l.width=l.height="0",l.onerror=l.onload=l.onreadystatechange=function(){k.call(this,r)},p.splice(e,0,u),"img"!=a&&(r||2===y[c]?(t.insertBefore(l,s?null:n),m(k,j)):y[c].push(l))}function j(a,b,c,d,f){return q=0,b=b||"j",e(a)?i("c"==b?v:u,a,b,this.i++,c,d,f):(p.splice(this.i++,0,a),1==p.length&&h()),this}function k(){var a=B;return a.loader={load:j,i:0},a}var l=b.documentElement,m=a.setTimeout,n=b.getElementsByTagName("script")[0],o={}.toString,p=[],q=0,r="MozAppearance"in l.style,s=r&&!!b.createRange().compareNode,t=s?l:n.parentNode,l=a.opera&&"[object Opera]"==o.call(a.opera),l=!!b.attachEvent&&!l,u=r?"object":l?"script":"img",v=l?"script":u,w=Array.isArray||function(a){return"[object Array]"==o.call(a)},x=[],y={},z={timeout:function(a,b){return b.length&&(a.timeout=b[0]),a}},A,B;B=function(a){function b(a){var a=a.split("!"),b=x.length,c=a.pop(),d=a.length,c={url:c,origUrl:c,prefixes:a},e,f,g;for(f=0;f<d;f++)g=a[f].split("="),(e=z[g.shift()])&&(c=e(c,g));for(f=0;f<b;f++)c=x[f](c);return c}function g(a,e,f,g,h){var i=b(a),j=i.autoCallback;i.url.split(".").pop().split("?").shift(),i.bypass||(e&&(e=d(e)?e:e[a]||e[g]||e[a.split("/").pop().split("?")[0]]),i.instead?i.instead(a,e,f,g,h):(y[i.url]?i.noexec=!0:y[i.url]=1,f.load(i.url,i.forceCSS||!i.forceJS&&"css"==i.url.split(".").pop().split("?").shift()?"c":c,i.noexec,i.attrs,i.timeout),(d(e)||d(j))&&f.load(function(){k(),e&&e(i.origUrl,h,g),j&&j(i.origUrl,h,g),y[i.url]=2})))}function h(a,b){function c(a,c){if(a){if(e(a))c||(j=function(){var a=[].slice.call(arguments);k.apply(this,a),l()}),g(a,j,b,0,h);else if(Object(a)===a)for(n in m=function(){var b=0,c;for(c in a)a.hasOwnProperty(c)&&b++;return b}(),a)a.hasOwnProperty(n)&&(!c&&!--m&&(d(j)?j=function(){var a=[].slice.call(arguments);k.apply(this,a),l()}:j[n]=function(a){return function(){var b=[].slice.call(arguments);a&&a.apply(this,b),l()}}(k[n])),g(a[n],j,b,n,h))}else!c&&l()}var h=!!a.test,i=a.load||a.both,j=a.callback||f,k=j,l=a.complete||f,m,n;c(h?a.yep:a.nope,!!i),i&&c(i)}var i,j,l=this.yepnope.loader;if(e(a))g(a,0,l,0);else if(w(a))for(i=0;i (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0];var j=d.createElement(s);var dl=l!='dataLayer'?'&l='+l:'';j.src='//www.googletagmanager.com/gtm.js?id='+i+dl;j.type='text/javascript';j.async=true;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-P4HH5NV'); Skip to main content Home About Submit ALERTS / RSS Search for this keyword Advanced Search Baseline characteristics of the population-based cohort in Iga City - the Iga City Cohort Study Asahi Hishida , Yumiko Shirai , Itsuki Kageyama , Sayo Kawai , Tae Sasakabe , View ORCID Profile Yingsong Lin , Makiko Yamamoto , Michiko Nishio , Hideyuki Okuda , Koji Tanaka , Kazuaki Miyata , Takashi Tamura , Mako Nagayoshi , Takashi Matsunaga , Nobuyuki Hamajima , Kenji Wakai doi: https://doi.org/10.1101/2025.08.05.25333011 Asahi Hishida 1 Aichi Medical University; Find this author on Google Scholar Find this author on PubMed Search for this author on this site For correspondence: a-hishida{at}aichi-med-u.ac.jp Yumiko Shirai 2 Iga General Hospital; Find this author on Google Scholar Find this author on PubMed Search for this author on this site Itsuki Kageyama 1 Aichi Medical University; Find this author on Google Scholar Find this author on PubMed Search for this author on this site Sayo Kawai 1 Aichi Medical University; Find this author on Google Scholar Find this author on PubMed Search for this author on this site Tae Sasakabe 1 Aichi Medical University; Find this author on Google Scholar Find this author on PubMed Search for this author on this site Yingsong Lin 1 Aichi Medical University; Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Yingsong Lin Makiko Yamamoto 2 Iga General Hospital; Find this author on Google Scholar Find this author on PubMed Search for this author on this site Michiko Nishio 2 Iga General Hospital; Find this author on Google Scholar Find this author on PubMed Search for this author on this site Hideyuki Okuda 2 Iga General Hospital; Find this author on Google Scholar Find this author on PubMed Search for this author on this site Koji Tanaka 2 Iga General Hospital; Find this author on Google Scholar Find this author on PubMed Search for this author on this site Kazuaki Miyata 3 Shiga University of Medical Sciences; Find this author on Google Scholar Find this author on PubMed Search for this author on this site Takashi Tamura 4 Nagoya University Find this author on Google Scholar Find this author on PubMed Search for this author on this site Mako Nagayoshi 4 Nagoya University Find this author on Google Scholar Find this author on PubMed Search for this author on this site Takashi Matsunaga 4 Nagoya University Find this author on Google Scholar Find this author on PubMed Search for this author on this site Nobuyuki Hamajima 4 Nagoya University Find this author on Google Scholar Find this author on PubMed Search for this author on this site Kenji Wakai 4 Nagoya University Find this author on Google Scholar Find this author on PubMed Search for this author on this site Abstract Info/History Metrics Data/Code Preview PDF Abstract We conducted a population-based genome cohort in Iga City, named Iga City Cohort Study, from March 2013 until July 2014, and recruited 1,578 participants in alliance with the J-MICC (Japan Multi-Institutional Collaborative Cohort) Study, under the cooperation of Iga citizens and the support of medical staffs in Iga City General Hospital with the aim of establishing the evidence for personalized disease prevention based on genomic information of each individual. After obtaining informed consent, interviews were conducted using the questionnaire constructed based on those practically used in J-MICC Study, where information on smoking behaviors, drinking habits, physical activities, food intake (food frequency questionnaire, FFQ) and socioeconomic status (SES) including educational backgrounds was asked and collected. Biological samples were collected together with the health check-up examination samples. The samples collected included serum, plasma and buffy coat from which genomic DNA was extracted after centrifuge procedures. In parallel, we performed a public service for Helicobacter pylori (HP) eradication to Iga citizens, and research on the minimally invasive diagnostic testing for early detection of cancer is now ongoing. After exclusion of ineligible participants and participants who withdrew, 1,505 subjects remain under follow-up. Effective utilization of the collected data in this cohort study for the health promotion of Iga citizens as well as Japanese citizens is greatly expected. Competing Interest Statement The authors have declared no competing interest. Funding Statement This study was supported by Grants-in-Aid for Scientific Research for Priority Areas of Cancer (No. 17015018) and Innovative Areas (No. 221S0001) and by the Japan Society for the Promotion of Science (JSPS) KAKENHI Grant (No. 16H06277 [CoBiA]) from the Japanese Ministry of Education, Culture, Sports, Science and Technology. Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: The study protocol was approved by the Ethics Committee of Nagoya University Graduate School of Medicine (Approval No. 2012-0138) and the Ethics Committee of Aichi Medical University (Approval No. 2023-167), and written informed consent including permission for follow-up was obtained from all participants. I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable. Yes Footnotes The affiliation of a co-author has been updated in this revised version to reflect the author's current institutional affiliation. All co-authors approved the final version of the manuscript. Data Availability All data produced in the present study are available upon reasonable request to the authors Copyright The copyright holder for this preprint is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license . View the discussion thread. Back to top Previous Next Posted May 18, 2026. Download PDF Data/Code Email Thank you for your interest in spreading the word about medRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. You are going to email the following Baseline characteristics of the population-based cohort in Iga City - the Iga City Cohort Study Message Subject (Your Name) has forwarded a page to you from medRxiv Message Body (Your Name) thought you would like to see this page from the medRxiv website. Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions. Share Baseline characteristics of the population-based cohort in Iga City - the Iga City Cohort Study Asahi Hishida , Yumiko Shirai , Itsuki Kageyama , Sayo Kawai , Tae Sasakabe , Yingsong Lin , Makiko Yamamoto , Michiko Nishio , Hideyuki Okuda , Koji Tanaka , Kazuaki Miyata , Takashi Tamura , Mako Nagayoshi , Takashi Matsunaga , Nobuyuki Hamajima , Kenji Wakai medRxiv 2025.08.05.25333011; doi: https://doi.org/10.1101/2025.08.05.25333011 Share This Article: Copy Citation Tools Baseline characteristics of the population-based cohort in Iga City - the Iga City Cohort Study Asahi Hishida , Yumiko Shirai , Itsuki Kageyama , Sayo Kawai , Tae Sasakabe , Yingsong Lin , Makiko Yamamoto , Michiko Nishio , Hideyuki Okuda , Koji Tanaka , Kazuaki Miyata , Takashi Tamura , Mako Nagayoshi , Takashi Matsunaga , Nobuyuki Hamajima , Kenji Wakai medRxiv 2025.08.05.25333011; doi: https://doi.org/10.1101/2025.08.05.25333011 Citation Manager Formats BibTeX Bookends EasyBib EndNote (tagged) EndNote 8 (xml) Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero Tweet Widget Facebook Like Google Plus One Subject Area Epidemiology Subject Areas All Articles Addiction Medicine (567) Allergy and Immunology (863) Anesthesia (297) Cardiovascular Medicine (4411) Dentistry and Oral Medicine (443) Dermatology (380) Emergency Medicine (606) Endocrinology (including Diabetes Mellitus and Metabolic Disease) (1505) Epidemiology (15205) Forensic Medicine (30) Gastroenterology (1119) Genetic and Genomic Medicine (6574) Geriatric Medicine (666) Health Economics (994) Health Informatics (4511) Health Policy (1365) Health Systems and Quality Improvement (1608) Hematology (537) HIV/AIDS (1263) Infectious Diseases (except HIV/AIDS) (15903) Intensive Care and Critical Care Medicine (1103) Medical Education (620) Medical Ethics (144) Nephrology (666) Neurology (6573) Nursing (345) Nutrition (998) Obstetrics and Gynecology (1139) Occupational and Environmental Health (954) Oncology (3319) Ophthalmology (968) Orthopedics (369) Otolaryngology (420) Pain Medicine (435) Palliative Medicine (129) Pathology (662) Pediatrics (1689) Pharmacology and Therapeutics (691) Primary Care Research (710) Psychiatry and Clinical Psychology (5422) Public and Global Health (9205) Radiology and Imaging (2191) Rehabilitation Medicine and Physical Therapy (1367) Respiratory Medicine (1191) Rheumatology (593) Sexual and Reproductive Health (709) Sports Medicine (529) Surgery (709) Toxicology (99) Transplantation (288) Urology (265) (function(){function c(){var b=a.contentDocument||a.contentWindow.document;if(b){var d=b.createElement('script');d.innerHTML="window.__CF$cv$params={r:'9fe9ab6808c61b23',t:'MTc3OTI2MjU3Nw=='};var a=document.createElement('script');a.src='/cdn-cgi/challenge-platform/scripts/jsd/main.js';document.getElementsByTagName('head')[0].appendChild(a);";b.getElementsByTagName('head')[0].appendChild(d)}}if(document.body){var a=document.createElement('iframe');a.height=1;a.width=1;a.style.position='absolute';a.style.top=0;a.style.left=0;a.style.border='none';a.style.visibility='hidden';document.body.appendChild(a);if('loading'!==document.readyState)c();else if(window.addEventListener)document.addEventListener('DOMContentLoaded',c);else{var e=document.onreadystatechange||function(){};document.onreadystatechange=function(b){e(b);'loading'!==document.readyState&&(document.onreadystatechange=e,c())}}}})();