A novel T cell function positive regulators-related signature for the immunotherapeutic efficacy prediction to colorectal cancer

T-cell function positive regulators (TFPRs) as T-cell proliferation and activation factors seem to be a prognostic value for colorectal cancer (CRC). However, the roles of the tumor microenvironment (TME) and immunotherapeutic response are still unknown. We analyzed their expression patterns based on the prognostic top-ranked TFPRs using the four independent transcriptome datasets. According to the differential expression genes (DEGs) of two subtypes, the TFPR risk scoring model was constructed using the LASSO and Cox regression. Then, we analyzed the association of the TFPR risk model with the survival time, clinical information, TME, tumor mutation, microsatellite instability (MSI), Cell stem cells (CSC) index, chemotherapy, targeted therapy, and immunotherapy. The TFPR risk model had a significant predictive association with CRC and predicted the immune cell content, HLA, immune checkpoint blade expression levels, mutation burden, CSC index characteristic, and immunotherapeutic efficacy. These findings may improve our understanding of TFPRs in CRC development and provide a new assessment system for CRC immunotherapy.