MP39-12 CHANGES IN WHOLE BODY PAIN INTENSITY AND WIDESPREAD-NESS DURING UROLOGIC CHRONIC PELVIC PAIN SYNDROME SYMPTOM (UCPPS) FLARES – FINDINGS FROM ONE SITE OF THE MAPP STUDY

shift artifacts in the measurements of bladder wall thickness (BWT), CNR and T1 from 20 pixels. RESULTS: Subjects did not complain of any pain or discomfort from 50mL NCM instillation, beyond that caused by the catheterization process. Four-fold increase in bladder wall CNR (*p<0.02) and spatial resolution of 0.35mm with minimal influence of artifacts made it feasible to determine the significant bladder wall thinning of ~0.46mm (*p<0.05) from 50mL NCM. Pre-contrast bladder wall T1 of 1544AE 34.2ms was shortened by Gadobutrol diffusion into the bladder wall to 860.09 AE13.95 ms in Hunner type IC (*p<0.0001, two way ANOVA) relative to only 1257.42AE 20.59 ms and 1258.16 AE 6.16ms in non-Hunner type IC and controls, respectively. Post-contrast pixel-wise T1 mapping differentiated the bladder wall into layers with greater Gadobutrol mediated T1 shortening in pixels representing the urothelium and lamina propria (blue and green) compared to the detrusor region (yellow in attached picture).