HYDANTOIN AND SUCCINIMIDE-SUBSTITUTED DERIVATIVES OF SPIROINDANYLCAMPHORSULFONYL OXYTOCIN ANTAGONISTS

GILBERT Kevin, HOBBS DOUG W, VEBER Daniel F., Williams Peter D., Evans Ben E.
1995
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Hydantoin and succinimide-substituted derivatives of spiroindanylcamphorsulfonyl oxytocin antagonists were developed as treatments for endometriosis, dysmenorrhea, preterm labor, and other conditions involving uterine hyperactivity or vasopressin activity.

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Abstract

Compounds of formula (I) where X is (a) or (b), R is Het, wherein Het is as defined in the description. These compounds are oxytocin and vasopressin antagonists useful in the treatment of preterm labor, dysmenorrhea, and for the stoppage of labor preparatory to cesarean delivery, timing of parturition, uterine hyperactivity, endometriosis, hypertension, congestive heart failure, hyponatremia and cognitive disorders.

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europepmc
last seen: 2026-08-03T06:10:56.557307+00:00