The Changes and Their Clinical Implication of Cytokines and Antiendometrial Antibody in Patients with Endometriosis

Objective: To study the changes and their clinical implication of cytokines and antiendometrial antibody with endom-etriosis. Methods:The serum levels of interleukin 6 (1L-6),tumor necrosis factor-α (TNF-α) .soluble interleukin-2 receptor (sIL-2R),antiendometrial antibody (EM Ab) and serum cancer antigen 125 (CA 125) in 75 patients with endometriosis and 30 control members were investigated using enzyme linked immunosorbent assay (ELISA) and radio-immunol assay (RIA). We also observed the changes of serum levels of IL-6,TNF-α,sIL-2R and EM Ab in 25 patients treated with opera-tion and Nemestran for 3 months. Results:The serum levels of IL-6,TNF-α,sIL-2R and EM Ab were significantly increased in patients with endometriosis compared with control group (P0.01). There was a positive correlation between EM Ab and IL-6 (γ = 0.674,P0.01).Serum levels of IL-6,TNF-α,sIL-2R and EM Ab in patients were significantly different before and after treatment (P 0.01). Conclusion:Detecting the serum levels of these cytokines and EM Ab may provide experimental basis for the study of pathogenic mechanism,and for the diagnosis and treatment to the patients with endom-etriosis.