Genomic analyses identify signaling pathways and biological processes in small and large melanoma

Melanoma is a skin malignancy that involves different signaling pathways with different sizes and phenotypes. However, the mechanism and function of small and large melanoma are unknown. Here, the aim of this study is to identify the functional molecules and signaling pathways by analyzing the RNA-seq data. The GSE164357 was created by the Illumina MouseWG-6 v2.0 expression bead chip. The KEGG and GO analyses indicated that Antigen processing and presentation and Phagosome are the main processes between the large and small melanoma. Moreover, we identified ten interactive molecules including STAT1, TTN, CALR, ACTA1, FN1, TNNT3, MYL1, TNNI2, RHOA, and TCAP. Therefore, our study may help to further understand the mechanism of melanoma.