Factors Associated with Survival in Patients with Cervical Cancer at a Tertiary Referral Hospital

Introduction: Cervical cancer remains a significant global health concern, with survival outcomes influenced by a complex interplay of clinical, biological, and socioeconomic factors. Disease stage at diagnosis remains the strongest prognostic indicator, while tumor characteristics, treatment modalities, and socioeconomic disparities further modify survival outcomes. This study aims to comprehensively evaluate these multifactorial determinants through multivariate analysis of a diverse patient cohort, with the goal of identifying modifiable factors to improve risk stratification, treatment allocation, and ultimately reduce global disparities in cervical cancer survival. Materials and Methods: This study was conducted as a retrospective cohort with the aim of determining factors associated with survival in patients with cervical cancer. The process of data collection initiated by accessing the clinical records of patients in Rasoul Akram Hospital in Tehran, Iran. Patients referred to this tertiary referral hospital in years between 2009-2019 with a proven diagnosis of cervical cancer were included in the study. Data collection was performed by registering the independent variables in a pre-designed checklist from the information of clinical records. The survival of patients within five years and the time period between referral and mortality if indicated was asked from the relatives by phone call after explaining the scope of study comprehensively and ensuring the informed consent. The collected information was entered into SPSS v.26 for statistical analysis. Results: 282 women diagnosed with cervical cancer were evaluated in this study with a mean age of 57.61 ± 14.82 years. The overall 5-year survival estimate for women with cervical cancer was 57.8% with a mean duration of 53.28 months in 5-year follow-up. Age at diagnosis, tobacco use, and cancer stage were significantly correlated with survival (P<0.05); In this way, older age at the time of cancer diagnosis (P=0.002), tobacco use (P=0.007), and stage III/IV of cancer (P=0.001) were significantly associated with lower survival of patients. Discussion: The stage-dependent survival pattern emphasizes the critical importance of early detection through effective screening programs and public awareness campaigns. The age and smoking associations suggest biological and behavioral factors that may require tailored therapeutic approaches. These findings should inform both clinical practice and public health strategies aimed at reducing cervical cancer mortality. Information & Authors Information Version history Copyright This work is licensed under a Non Exclusive No Reuse License.

Authors Metrics & Citations Metrics Article Usage 266views 116downloads Citations Download citation Amir Abbas Esmaeilzadeh, Dorsa Azizi Khezri, Zhina zarei, et al. Factors Associated with Survival in Patients with Cervical Cancer at a Tertiary Referral Hospital. Authorea. 28 May 2025. DOI: https://doi.org/10.22541/au.174845406.62074320/v1 DOI: https://doi.org/10.22541/au.174845406.62074320/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu.