Integrative whole-exome and transcriptome analyses reveal an invasion-like “motility–adhesion–cytoskeleton” program in endometriosis and validate its PI3K/AKT dependency in vitro

Qiming Wang
2026 · doi:10.6084/m9.figshare.32576619.v2 · W7164296244
dataset OA: green CC0
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Integrative whole-exome and transcriptome analyses revealed an invasion-like motility-adhesion-cytoskeleton program in endometriosis that is functionally dependent on PI3K/AKT signaling.

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Abstract

Integrative WES–RNA‑seq profiling highlights a coordinated invasion‑like program in endometriosis with functional dependence on PI3K/AKT signaling, supporting PI3K/AKT as a mechanistically grounded target for anti‑invasive strategies in endometriosis.

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last seen: 2026-08-27T06:01:51.984654+00:00
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