A case of polypoid endometriosis with malignant transformation

case-report OA: closed public-domain-us
Full text JSON View on PubMed View at publisher
AI-generated summary by claude@2026-06, 2026-06-08

This paper describes the magnetic resonance imaging findings of a rare polypoid endometriosis case exhibiting malignant transformation, characterized by specific signal intensities and contrast enhancement patterns.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

AI-generated deep summary by claude@2026-06, 2026-06-09 · read from full text

This paper reports an imaging case of polypoid endometriosis with malignant transformation, using MRI findings to characterize multiple polypoid nodules in the cul-de-sac. The authors describe T2-weighted high-signal nodules with a low-signal rim and fibrous adhesion, weak contrast enhancement relative to uterine myometrium, and slight high diffusion-weighted signal with relatively high mean apparent diffusion coefficient. They note a pattern observed across reported cases: malignant transformation may be suggested when enhancement resembles that of endometrial carcinoma rather than the more intense myometrium-like enhancement typical of benign polypoid endometriosis. This paper is centrally about endometriosis — it presents a case of polypoid endometriosis complicated by malignant transformation and discusses MRI enhancement features linked to that event.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Polypoid endometriosis is a benign, rare variant of endometriosis which forms multiple polypoid nodules in the female pelvis mimicking malignant tumors; however, it may rarely cause malignant transformation. We report magnetic resonance imaging findings of a case of polypoid endometriosis with malignant transformation. Multiple high-signal intensity polypoid nodules in the cul-de-sac surrounded by low-signal intensity rim-like fibrous adhesion protruding to the posterior wall of the uterine body were demonstrated on T2-weighted images. The polypoid nodules showed weak contrast enhancement compared with that of uterine myometrium on post-contrast T1-weighted images, and slight high signal intensity on diffusion-weighted images with relatively high mean apparent diffusion coefficient. Reported cases of polypoid endometriosis showed intense contrast enhancement similar to that of uterine myometrium, and weak contrast enhancement similar to that of endometrial carcinoma may be suggestive for malignant transformation of polypoid endometriosis.
Full text 4,514 characters · extracted from oa-doi-fallback · 2 sections · click to expand

Abstract

Polypoid endometriosis is a benign, rare variant of endometriosis which forms multiple polypoid nodules in the female pelvis mimicking malignant tumors; however, it may rarely cause malignant transformation. We report magnetic resonance imaging findings of a case of polypoid endometriosis with malignant transformation. Multiple high-signal intensity polypoid nodules in the cul-de-sac surrounded by low-signal intensity rim-like fibrous adhesion protruding to the posterior wall of the uterine body were demonstrated on T2-weighted images. The polypoid nodules showed weak contrast enhancement compared with that of uterine myometrium on post-contrast T1-weighted images, and slight high signal intensity on diffusion-weighted images with relatively high mean apparent diffusion coefficient. Reported cases of polypoid endometriosis showed intense contrast enhancement similar to that of uterine myometrium, and weak contrast enhancement similar to that of endometrial carcinoma may be suggestive for malignant transformation of polypoid endometriosis. Similar content being viewed by others

References

Parker RL, Dadmanesh F, Young RH, Clement PB (2004) Polypoid endometriosis: a clinicopathologic analysis of 24 cases and a review of the literature. Am J Surg Pathol 28:285–297 Hansen K, Simon RA, Lawrence WD, Quddus MR (2012) Unilateral pelvic mass presenting in postmenopausal patients: report of two unusual cases. Ann Diagn Pathol 16:298–301 Takeuchi M, Matsuzaki K, Furumoto H, Nishitani H (2008) Case report: a case of polypoid endometriosis: MR pathological correlation. Br J Radiol 81:e118–e119. doi:10.1259/bjr/23847518 Kozawa E, Inoue K, Iwasa N, et al. (2012) MR imaging of polypoid endometriosis of the ovary. Magn Reson Med Sci 11:201–204 Kraft JK, Hughes T (2006) Polypoid endometriosis and other benign gynaecological complications associated with tamoxifen therapy—a case to illustrate features on magnetic resonance imaging. Clin Radiol 61:198–201 Marugami N, Hirohashi S, Kitano S, et al. (2008) Polypoid endometriosis of the ureter mimicking fibroepithelial polyps. Radiat Med 26:42–45. doi:10.1007/s11604-007-0188-5 Yamada Y, Miyamoto T, Horiuchi A, Ohya A, Shiozawa T (2014) Polypoid endometriosis of the ovary mimicking ovarian carcinoma dissemination: a case report and literature review. J Obstet Gynaecol Res 40:1426–1430. doi:10.1111/jog.12358 Syrcle SM, Pelch KE, Schroder AL, et al. (2011) Altered gene expression profile in vaginal polypoid endometriosis resembles peritoneal endometriosis and is consistent with increased local estrogen production. Gynecol Obstet Invest 71:77–86. doi:10.1159/000320736 Takeuchi M, Matsuzaki K, Nishitani H (2009) Diffusion-weighted magnetic resonance imaging of endometrial cancer: differentiation from benign endometrial lesions and preoperative assessment of myometrial invasion. Acta Radiol 50:947–953. doi:10.1080/02841850903099981 Wang J, Yu T, Bai R, et al. (2010) The value of the apparent diffusion coefficient in differentiating stage IA endometrial carcinoma from normal endometrium and benign diseases of the endometrium: initial study at 3-T magnetic resonance scanner. J Comput Assist Tomogr 34:332–337. doi:10.1097/RCT.0b013e3181d0f666 Kierans AS, Bennett GL, Haghighi M, Rosenkrantz AB (2014) Utility of conventional and diffusion-weighted MRI features in distinguishing benign from malignant endometrial lesions. Eur J Radiol 83:726–732. doi:10.1016/j.ejrad.2013.11.030 Imaoka I, Sugimura K, Masui T, et al. (1999) Abnormal uterine cavity: differential diagnosis with MR imaging. Magn Reson Imaging 17:1445–1455 Park BK, Kim B, Park JM, et al. (2006) Differentiation of the various lesions causing an abnormality of the endometrial cavity using MR imaging: emphasis on enhancement patterns on dynamic studies and late contrast-enhanced T1-weighted images. Eur Radiol 16:1591–1598 Author information Authors and Affiliations Corresponding author Ethics declarations Conflict of interest The authors declare that they have no conflict of interest. Informed consent For this type of study, formal consent is not required, and the written informed consent of the patient was obtained for the MR examination. Rights and permissions About this article Cite this article Takeuchi, M., Matsuzaki, K., Bando, Y. et al. A case of polypoid endometriosis with malignant transformation. Abdom Radiol 41, 1699–1702 (2016). https://doi.org/10.1007/s00261-016-0696-9 Published: Issue date: DOI: https://doi.org/10.1007/s00261-016-0696-9

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrial Neoplasms Female Humans Magnetic Resonance Imaging

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. The paper's references may be in our DB but unresolved to ``paper_id`` (resolution happens at ingest when the cited DOI matches a row we already have). Run the cross-source citation reconcile pass to retry.

Source provenance

europepmc
last seen: 2026-06-17T06:13:18.893374+00:00
pubmed
last seen: 2026-05-13T22:21:13.485820+00:00
unpaywall
last seen: 2026-06-13T06:42:57.164913+00:00
License: public-domain-us · commercial use OK · attribution required
Courtesy of the U.S. National Library of Medicine