Among women undergoing uterus-preserving surgery for uterine fibroids, does laparoscopic myomectomy, compared with open (laparotomic) myomectomy, result in differences in length of hospital stay, postoperative morbidity and complications in a five-year single-center retrospective cohort?

Among women undergoing uterus-preserving surgery for uterine fibroids, does laparoscopic myomectomy, compared with open (laparotomic) myomectomy, result in differences in length of hospital stay, postoperative morbidity and complications in a five-year single-center retrospective cohort? | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Among women undergoing uterus-preserving surgery for uterine fibroids, does laparoscopic myomectomy, compared with open (laparotomic) myomectomy, result in differences in length of hospital stay, postoperative morbidity and complications in a five-year single-center retrospective cohort? Kamila Askarova, Ruziqul Fozilbekov, Azimjon Tursunkulov This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8627218/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background Uterine fibroids are the most common benign tumors of the female reproductive tract and a major cause of gynecologic morbidity in women of reproductive age. For women wishing to preserve fertility, myomectomy remains the standard surgical treatment. Although laparoscopic myomectomy has increasingly replaced open abdominal myomectomy in selected patients, real-world comparative data on perioperative outcomes and postoperative morbidity remain limited. This study aimed to compare laparoscopic and open myomectomy in women undergoing uterus-preserving surgery, focusing on hospital stay, postoperative morbidity, and patient-centered outcomes. Methods This retrospective single-center cohort study included 207 women who underwent myomectomy for uterine fibroids at the Gynecology Department of the University Hospital in Tashkent between January 2020 and November 2025. Patients were divided into laparoscopic (n = 69) and open surgery (n = 138) groups. Women undergoing hysteroscopic myomectomy or hysterectomy and those with adenomyosis were excluded. Preoperative characteristics, fibroid features, perioperative outcomes, postoperative recovery, complications, and patient satisfaction were analyzed. Continuous variables were compared using Student’s t-test or the Mann–Whitney U test, and categorical variables using the chi-square or Fisher’s exact test. Statistical significance was defined as p < 0.05. Results The mean age of the study population was 40 ± 8 years. Open surgery was more frequently performed in women with larger and multiple fibroids, whereas laparoscopic procedures predominated in patients with smaller and fewer fibroids (p < 0.001). Length of hospital stay was significantly shorter in the laparoscopic group (p < 0.001), with 87.0% discharged within 1–2 days compared with 7.2% after open surgery. Postoperative recovery was significantly faster after laparoscopy (p = 0.013). Overall complication rates were comparable between groups (p = 0.716). Patient satisfaction was significantly higher following laparoscopic myomectomy (100% vs. 84.8%, p = 0.002), and laparoscopic surgery was associated with significantly smaller surgical scars (p < 0.001). Conclusions In this five-year single-center cohort, laparoscopic myomectomy was associated with shorter hospitalization, faster recovery, higher patient satisfaction, and superior cosmetic outcomes compared with open myomectomy, without increased postoperative complications. These findings support laparoscopic myomectomy as the preferred uterus-preserving surgical approach in appropriately selected patients Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-8627218","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":585785548,"identity":"061ef633-4779-48e9-a465-80f972b7faf6","order_by":0,"name":"Kamila Askarova","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAABE0lEQVRIie3RsUrDQBjA8S8cXJbTrHcUzlf4SiDg21xwtTgInToECnGx7dq8hVIQx8hBugR8AZFIIZNDQqEo1OJVB5ecdnS4PxyEu/yG7w7A5fqHcbO85OuT5N9bvlnqMEL3/6GhhxOGP+S3REJW7Xz0LHFZtk17v70IxmTVVKMnwMe8k/SARuKmuAyxHCxEVuLpXNOIq6IGzLuJBIi8iqo4SwZ35ChFBA0RKKoBHxIL8ddttTNk9lqTD0NOtL9u1M4Q3T1Lz0wtblMVz/g5JZ4hqBnyODWksIw/ZkORTVUY8DoUkzTEvmZDHk81E2U34curRXu9UZIGZy/NeypR7nfeNloeW27M/grMduByuVyuv/sEadRdBvxt8qMAAAAASUVORK5CYII=","orcid":"","institution":"Akfa Medline University Hospital","correspondingAuthor":true,"prefix":"","firstName":"Kamila","middleName":"","lastName":"Askarova","suffix":""},{"id":585785549,"identity":"2de6057a-da03-4485-ab22-884a4d8b66d5","order_by":1,"name":"Ruziqul Fozilbekov","email":"","orcid":"","institution":"Akfa Medline University Hospital","correspondingAuthor":false,"prefix":"","firstName":"Ruziqul","middleName":"","lastName":"Fozilbekov","suffix":""},{"id":585785550,"identity":"a1cdeff4-dc4d-42ab-ba68-927ae5f9101e","order_by":2,"name":"Azimjon Tursunkulov","email":"","orcid":"","institution":"Akfa Medline University Hospital","correspondingAuthor":false,"prefix":"","firstName":"Azimjon","middleName":"","lastName":"Tursunkulov","suffix":""}],"badges":[],"createdAt":"2026-01-17 16:08:27","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-8627218/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-8627218/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":104398174,"identity":"8b862629-fcef-4d1a-9b51-91a333702413","added_by":"auto","created_at":"2026-03-11 12:00:14","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":596834,"visible":true,"origin":"","legend":"","description":"","filename":"RetrospectiveAnalysis.pdf","url":"https://assets-eu.researchsquare.com/files/rs-8627218/v1_covered_666c72a6-c0d6-4e3e-85be-399231cd61b3.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Among women undergoing uterus-preserving surgery for uterine fibroids, does laparoscopic myomectomy, compared with open (laparotomic) myomectomy, result in differences in length of hospital stay, postoperative morbidity and complications in a five-year single-center retrospective cohort?","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"","lastPublishedDoi":"10.21203/rs.3.rs-8627218/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-8627218/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003ch2\u003eBackground\u003c/h2\u003e \u003cp\u003eUterine fibroids are the most common benign tumors of the female reproductive tract and a major cause of gynecologic morbidity in women of reproductive age. For women wishing to preserve fertility, myomectomy remains the standard surgical treatment. Although laparoscopic myomectomy has increasingly replaced open abdominal myomectomy in selected patients, real-world comparative data on perioperative outcomes and postoperative morbidity remain limited. This study aimed to compare laparoscopic and open myomectomy in women undergoing uterus-preserving surgery, focusing on hospital stay, postoperative morbidity, and patient-centered outcomes.\u003c/p\u003e\u003ch2\u003eMethods\u003c/h2\u003e \u003cp\u003eThis retrospective single-center cohort study included 207 women who underwent myomectomy for uterine fibroids at the Gynecology Department of the University Hospital in Tashkent between January 2020 and November 2025. Patients were divided into laparoscopic (n\u0026thinsp;=\u0026thinsp;69) and open surgery (n\u0026thinsp;=\u0026thinsp;138) groups. Women undergoing hysteroscopic myomectomy or hysterectomy and those with adenomyosis were excluded. Preoperative characteristics, fibroid features, perioperative outcomes, postoperative recovery, complications, and patient satisfaction were analyzed. Continuous variables were compared using Student\u0026rsquo;s t-test or the Mann\u0026ndash;Whitney U test, and categorical variables using the chi-square or Fisher\u0026rsquo;s exact test. Statistical significance was defined as p\u0026thinsp;\u0026lt;\u0026thinsp;0.05.\u003c/p\u003e\u003ch2\u003eResults\u003c/h2\u003e \u003cp\u003eThe mean age of the study population was 40\u0026thinsp;\u0026plusmn;\u0026thinsp;8 years. Open surgery was more frequently performed in women with larger and multiple fibroids, whereas laparoscopic procedures predominated in patients with smaller and fewer fibroids (p\u0026thinsp;\u0026lt;\u0026thinsp;0.001). Length of hospital stay was significantly shorter in the laparoscopic group (p\u0026thinsp;\u0026lt;\u0026thinsp;0.001), with 87.0% discharged within 1\u0026ndash;2 days compared with 7.2% after open surgery. Postoperative recovery was significantly faster after laparoscopy (p\u0026thinsp;=\u0026thinsp;0.013). Overall complication rates were comparable between groups (p\u0026thinsp;=\u0026thinsp;0.716). Patient satisfaction was significantly higher following laparoscopic myomectomy (100% vs. 84.8%, p\u0026thinsp;=\u0026thinsp;0.002), and laparoscopic surgery was associated with significantly smaller surgical scars (p\u0026thinsp;\u0026lt;\u0026thinsp;0.001).\u003c/p\u003e\u003ch2\u003eConclusions\u003c/h2\u003e \u003cp\u003eIn this five-year single-center cohort, laparoscopic myomectomy was associated with shorter hospitalization, faster recovery, higher patient satisfaction, and superior cosmetic outcomes compared with open myomectomy, without increased postoperative complications. These findings support laparoscopic myomectomy as the preferred uterus-preserving surgical approach in appropriately selected patients\u003c/p\u003e","manuscriptTitle":"Among women undergoing uterus-preserving surgery for uterine fibroids, does laparoscopic myomectomy, compared with open (laparotomic) myomectomy, result in differences in length of hospital stay, postoperative morbidity and complications in a five-year single-center retrospective cohort?","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2026-02-05 21:03:22","doi":"10.21203/rs.3.rs-8627218/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"5272c958-0fcd-4de3-8af3-e2047dee50a1","owner":[],"postedDate":"February 5th, 2026","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2026-02-27T08:13:27+00:00","versionOfRecord":[],"versionCreatedAt":"2026-02-05 21:03:22","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-8627218","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-8627218","identity":"rs-8627218","version":["v1"]},"buildId":"B-jG_2CBjPDmsCi4Wdhf-","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}