Neuronal resonance in the theta (4-10 Hz) frequency range is modulated by dynamic changes in the input resistance

Most neurons of the mammalian brain display intrinsic resonance with frequency selectivity ( f R ) for inputs within the theta-range (4-10 Hz). Variations in network oscillation along this range depend on the animal behavior; however, whether neurons can dynamically tune their f R has not been addressed. Using slice electrophysiology, dynamic clamping and computer modeling we studied three types of cortical neurons, finding that the input resistance ( R in ) inversely sets f R into the theta range, following a power law. We demonstrate that physiological changes in R in modulate f R and response phase, serving as a mechanism that instantaneously tunes oscillatory responses. Moreover, these modulations are translated into spiking regimes, modifying spike frequency and timing. Since synaptic inputs reduce R in , this modulation provides a mean for adjusting the frequency and timing of firing of individual neurons in interplay with the network fluctuations. This might be a widespread property among resonant neurons.