From Pregnancy Desire to Pregnancy Attempt: Why Words Matter in Reproductive Research — A Nationwide Prospective Cohort Study

From Pregnancy Desire to Pregnancy Attempt: Why Words Matter in Reproductive Research — A Nationwide Prospective Cohort Study | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 22 November 2025 V1 Latest version Share on From Pregnancy Desire to Pregnancy Attempt: Why Words Matter in Reproductive Research — A Nationwide Prospective Cohort Study Authors : Rayan Kabirian 0000-0001-5165-9743 , Raphaëlle Bas , Agathe Chabassier , Clara Sebbag , Christine Rousset-Jablonski 0000-0001-7087-5687 , Angelique Bobrie , Florence Coussy , … Show All … , Marie Préau , Marc Espie , Elise Dumas , Fabien Reyal , Guillemette Jacob , Floriane Jochum , and Anne-Sophie Hamy [email protected] Show Fewer Authors Info & Affiliations https://doi.org/10.22541/au.176379318.87458492/v1 117 views 45 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract [1]¿p#1 Objective To quantify the gap between pregnancy desire and pregnancy attempts among young women with and without a history of breast cancer (BC), and to identify factors associated with this gap. Design Nationwide prospective cohort study. Setting The FEERIC study, conducted in France. Population Women aged 18–43 years with or without prior BC who completed baseline and six-monthly follow-up questionnaires for up to three years. Methods Pregnancy desire was assessed by self-report (“Do you currently desire a pregnancy?”). Attempts were defined as engaging in unprotected intercourse with the intention to conceive. The pregnancy desire–attempt gap was defined as expressing a desire for pregnancy without actively trying to conceive. Logistic regression was used to evaluate associated demographic, clinical, and treatment-related factors. Main outcome measures Prevalence of the pregnancy desire–attempt gap and predictors of this gap among BC survivors. Results Of 4,351 participants(517 with BC and 3,834 controls), 735(16.9%) reported a pregnancy desire at inclusion. During follow-up, 54% attempted conception and 46% did not. The desire–attempt gap was significantly more frequent in women with BC (OR=1.62, 95%CI[1.15–2.30]). Among BC survivors, younger age (<30years), nulliparity, being single, and ongoing endocrine therapy were independently associated with the gap, whereas prior chemotherapy or trastuzumab were not. Conclusions Nearly half of women desiring pregnancy did not initiate attempts, with a larger gap among BC survivors. These findings highlight the need for integrated fertility counseling and psychosocial support in survivorship care. Supplementary Material File (desire_attempts_full.docx) Download 39.34 KB File (desire_attempts_table2.docx) Download 26.33 KB File (table1.docx) Download 15.64 KB Information & Authors Information Version history V1 Version 1 22 November 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords gynaecological surgery medical sociology Authors Affiliations Rayan Kabirian 0000-0001-5165-9743 Institut Curie Departement d'Oncologie Medicale View all articles by this author Raphaëlle Bas Institut Curie Departement d'Oncologie Medicale View all articles by this author Agathe Chabassier Institut Curie View all articles by this author Clara Sebbag Institut Curie Departement d'Oncologie Medicale View all articles by this author Christine Rousset-Jablonski 0000-0001-7087-5687 Centre Leon Berard View all articles by this author Angelique Bobrie Institut Regional du Cancer de Montpellier View all articles by this author Florence Coussy Institut Curie Departement d'Oncologie Medicale View all articles by this author Marie Préau Universite Lumiere Lyon 2 Institut de Psychologie View all articles by this author Marc Espie Hopital Saint-Louis View all articles by this author Elise Dumas Institut Curie View all articles by this author Fabien Reyal Institut Curie View all articles by this author Guillemette Jacob Ensemble Hospitalier de l'Institut Curie View all articles by this author Floriane Jochum Institut Curie View all articles by this author Anne-Sophie Hamy [email protected] Institut Curie Departement d'Oncologie Medicale View all articles by this author Metrics & Citations Metrics Article Usage 117 views 45 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Rayan Kabirian, Raphaëlle Bas, Agathe Chabassier, et al. From Pregnancy Desire to Pregnancy Attempt: Why Words Matter in Reproductive Research — A Nationwide Prospective Cohort Study. Authorea . 22 November 2025. DOI: https://doi.org/10.22541/au.176379318.87458492/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . Format Please select one from the list RIS (ProCite, Reference Manager) EndNote BibTex Medlars RefWorks Direct import Tips for downloading citations document.getElementById('citMgrHelpLink').addEventListener('click', function() { popupHelp(this.href); return false; }); $(".js__slcInclude").on("change", function(e){ if ($(this).val() == 'refworks') $('#direct').prop("checked", false); $('#direct').prop("disabled", ($(this).val() == 'refworks')); }); View Options View options PDF View PDF Figures Tables Media Share Share Share article link Copy Link Copied! Copying failed. Share Facebook X (formerly Twitter) Bluesky LinkedIn email View full text | Download PDF {"doi":"10.22541/au.176379318.87458492/v1","type":"Article"} Now Reading: Share Figures Tables Close figure viewer Back to article Figure title goes here Change zoom level Go to figure location within the article Download figure Toggle share panel Toggle share panel Share Toggle information panel Toggle information panel Go to previous graphic Go to next graphic Go to previous table Go to next table All figures All tables View all material View all material xrefBack.goTo xrefBack.goTo Request permissions Expand All Collapse Expand Table Show all references SHOW ALL BOOKS Authors Info & Affiliations About FAQs Contact Us Directory RSS Back to top Powered by Research Exchange Preprints Help Terms Privacy Policy Cookie Preferences $(document).ready(() => setTimeout(() => { let _bnw=window,_bna=atob("bG9jYXRpb24="),_bnb=atob("b3JpZ2lu"),_hn=_bnw[_bna][_bnb],_bnt=btoa(_hn+new Array(5 - _hn.length % 4).join(" ")); $.get("/resource/lodash?t="+_bnt); },4000)); (function(){function c(){var b=a.contentDocument||a.contentWindow.document;if(b){var d=b.createElement('script');d.innerHTML="window.__CF$cv$params={r:'a00e40e0de39f047',t:'MTc3OTY0NjE4Nw=='};var a=document.createElement('script');a.src='/cdn-cgi/challenge-platform/scripts/jsd/main.js';document.getElementsByTagName('head')[0].appendChild(a);";b.getElementsByTagName('head')[0].appendChild(d)}}if(document.body){var a=document.createElement('iframe');a.height=1;a.width=1;a.style.position='absolute';a.style.top=0;a.style.left=0;a.style.border='none';a.style.visibility='hidden';document.body.appendChild(a);if('loading'!==document.readyState)c();else if(window.addEventListener)document.addEventListener('DOMContentLoaded',c);else{var e=document.onreadystatechange||function(){};document.onreadystatechange=function(b){e(b);'loading'!==document.readyState&&(document.onreadystatechange=e,c())}}}})();