Childhood motor speech disorders: who to prioritise for genetic testing

Childhood motor speech disorders: who to prioritise for genetic testing | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Childhood motor speech disorders: who to prioritise for genetic testing Angela Morgan, Halianna Van Niel, Mariana Lauretta, Emma Baker, and 13 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6900966/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 13 Jan, 2026 Read the published version in European Journal of Human Genetics → Version 1 posted 11 You are reading this latest preprint version Abstract The aetiology of childhood motor speech disorders of dysarthria and apraxia has been poorly understood. Recent evidence suggests a moderate genetic contribution for these rare and severe speech disorders. To date however, no studies have examined genetic diagnostic yield for apraxia and dysarthria in a clinical setting. Here we used a clinically accredited genomics pipeline to investigate genetic diagnostic yield and variables predictive of a genetic diagnosis in a tertiary hospital speech clinic. A cohort of 153 children (range 2;7–16;5 years, 42 female) ascertained for motor speech disorder were assessed by a clinical geneticist and speech pathologist and underwent chromosomal microarray, Fragile X and exome sequencing. Odds ratios identified predictors of genetic diagnosis. 44/153 (29%, 15 female) had pathogenic variants (30 de novo ), encompassing monogenic conditions (n = 35) and copy number variants (n = 9) across 38 distinct disorders. Delayed walking, fine and gross motor disorder, receptive language impairment and/or cognitive impairment, and dysmorphism were associated with a genetic diagnosis. The presence of CAS and dysarthria was more commonly associated with a genetic diagnosis than CAS alone. Autism spectrum disorder was less commonly associated with a genetic diagnosis. No child had a Fragile X diagnosis. The clinical genetic diagnostic yield for motor speech disorders is comparable to epilepsy and cerebral palsy, conditions where genetic testing is routine in most centres, unlike for motor speech disorders. Children with motor speech disorder with co-occurring motor, language and/or learning deficits, should be prioritised for genomic testing. Health sciences/Medical research/Genetics research Biological sciences/Genetics/Clinical genetics/Disease genetics Speech disorder dysarthria childhood apraxia of speech genetics child Figures Figure 1 Figure 2 Introduction Speech disorders are a common presenting concern for children referred to paediatricians and primary care physicians 1 . Associated poor language, literacy, educational, employment and social outcomes mean speech disorders come with significant individual, societal and health system burden 2 – 4 . Up to 5% of children develop common speech disorders including articulation and phonological impairments 1 . These conditions are highly tractable and typically resolve by 7 years of age, with or without intervention 4 , 5 . By contrast, 1 in 1000 children follow a severely disrupted developmental path to intractable motor speech disorders of childhood apraxia of speech (CAS) and/or dysarthria 6 . CAS affects the ability to plan and sequence speech movements, decreasing the precision, consistency and intelligibility of speech 7 . Children with CAS need explicit teaching and practice of new sounds and words, often requiring speech therapy into adolescence or adulthood 8 . A diagnosis of CAS implicates disruption of inferior frontal lobe and basal ganglia pathways, whereas dysarthria is a disorder of the control and execution of neuromuscular movements for speech implicating the ‘final common’ motor pathway or corticobulbar tract 9 – 11 . A major challenge of managing motor speech disorders has been a lack of etiological knowledge. Families search for explanatory causes in a long diagnostic journey 12 , attending multiple primary care physician, pediatric, neurology, and other specialist appointments, involving serial investigations (e.g. MRI, metabolic testing) with significant costs and psychological stress and without explanatory results 13 . In the past five years, genomic sequencing, performed in a research setting, has shown a substantial genetic contribution to these conditions 14 – 18 , even in the absence of intellectual disability 15 , 16 , with a diagnostic yield of 30% [3]. This research yield is comparable to that seen in cerebral palsy, epilepsy and intellectual disability, conditions for which genomic clinical testing is routine in many centres 3 . However, clinical genomic testing is not yet the standard of care for motor speech disorders, despite such testing being highly valued by families with lived experience 13 . In this study, we offered clinical genomic testing, consisting of chromosomal microarray, fragile X PCR and exome sequencing, to a clinically ascertained population of children referred to a speech genomics clinic at a pediatric tertiary hospital. We examined diagnostic yield and clinical variables predictive of a genetic diagnosis. Materials and methods Ethical consent The study was approved by the Human Research Ethics Committee of The Royal Children’s Hospital, Melbourne, Australia (#37353). Written informed consent was obtained from parents or legal guardians. Study design This prospective single-centre cohort study recruited probands referred to the Genetics of Speech Disorders clinic at the Royal Children’s Hospital, in Melbourne, Australia between August 2020 and December 2023. Recruitment Children were referred for motor speech testing by their treating primary care physician, paediatrician, pediatric sub-specialist (metabolic, genetics, neurology) or speech pathologist. Probands were triaged for eligibility by the clinical nurse co-ordinator with input from the clinical team where indicated (e.g. psychologist to interpret cognitive assessments; clinical geneticist to interpret past genetic reports). Inclusion criteria were: (1) probands aged 2;7 to 17 years with CAS or dysarthria in the absence of known or previously diagnosed intellectual disability, autism spectrum disorder (ASD) level III, or acquired brain injury; and (2) parent, speech pathologist and treating physician reporting the primary presenting feature and clinical concern as motor speech disorder 15 , 16 . Phenotyping Probands were prospectively assessed by a speech pathologist (AM, ML, CB); paediatrician and clinical geneticist (DA, dual-qualified); and psychologist (EB, CB) using a protocol outlined below; see clinical pipeline Fig. 1 a. A detailed family history and pedigree were recorded and prospective phenotyping documented medical and developmental history including presence of dysmorphism 15 , 16 (Table 1, Supplemental Tables 1, 2a,b). All secondary neurodevelopmental outcomes were defined using standardised testing and a professional report for validation, e.g. multi- disciplinary assessment standardised testing for a formal diagnosis of ASD; physiotherapist confirmed fine or gross motor disorder. Where children had not yet received a formal ASD or attention deficit hyperactivity disorder (ADHD) diagnosis, the paediatrician (DA) recorded the presence of ASD/ADHD features (Table 1; Supplemental Tables 1, 2a,b). For speech, CAS was confirmed if the American Speech-Language-Hearing Association (ASHA) criteria for CAS were met: (1) inconsistent errors on consonants and vowels in repeated productions of syllables or words; (2) lengthened and disrupted coarticulatory transitions between sounds and syllables, and (3) inappropriate prosody; all relative to age and stage of development 7 . ASHA criteria were operationally defined and rated from: phonetic transcriptions of 55 single words speech test designed to elicit all sounds of English, a test of speech consistency (children repeat 15/55 stimuli words twice) and a 5 minute conversational speech sample as described previously 15 , 16 , 19 . Dysarthria was diagnosed as an oral tone or coordination disturbance examined by paediatrician and speech pathologist and speech dysarthric features identified during the conversation sample, using the Mayo Clinic Dysarthria rating scale 15 , 16 , 19 , 20 . Receptive and expressive language was assessed where time and resources were available 21 – 24 (Table 1, Supplemental Tables 1,2a,b). Cognition was assessed by a psychologist using standardized testing 25 – 27 . Genetic and genomic analysis for variants linked to disorders relevant to proband phenotype following a tiered approach. Initially, variants in genes associated with intellectual disability were evaluated ( https://panelapp-aus.org/panels/250/ ). Analysis was then expanded to a virtual panel of ~ 6000 genes known to cause Mendelian disorders ( https://panelapp-aus.org/panels/137/ ). Variants were classified according to the current American College of Medical Genetics and Genomics (ACMG) guidelines for variant interpretation 29 . Statistical analysis We report the proportion and type of pathogenic variants causative for motor speech disorder from CMA, Fragile X and ES testing. For variables predictive of a genetic diagnosis, baseline clinical variables are recorded as frequencies ( n , %) and medians (range), as dictated by data type. Odds ratios have been used to identify variables associated with a genetic diagnostic result. The variables of ASD, ADHD, dysmorphism, intelligence quotient (IQ), receptive and expressive language were all dichotomised for the odds ratio analysis. Results Genetic diagnostic yield and genomic findings 172 probands met inclusion criteria, of whom 153 (88.9%; 111 males, 42 females) completed genetic testing (153 CMA, 143 ES), at an average age of 5 years 8 months (range 2 years 7 months to 16 years 5 months). Two probands withdrew from the study and 4 declined genetic testing. Despite three reminders to do so, the remaining 13 either did not respond to the genetic testing appointment invitation, did not send back their consent form, or did not return their saliva sample (Fig. 1 b). Overall, 44/153 (29%) probands received a genetic diagnosis (15 females; median 5 years 1 month; Table 3). 30 findings were confirmed de novo and 9 inherited (5 maternal; 4 paternal). Inheritance status could not be confirmed for 5 pathogenic variants due to missing parental DNA (Table 2, Supplemental Fig. 1a). 9 were aneuploidies or copy number variants (CNVs) (all > 50kb) detected on CMA: del 15q13.2q13.3, del 22q11.21, dup 22q11.21q11.22, dup 1q21.1q21.2, del 16p12.2, dup 17q12, 47,XXX, 48,XXYY, 48,XYYY. There were 35 monogenic diagnoses including single nucleotide variants (SNVs) and intragenic deletions (< 50kb). 34/35 were identified from ES: ADGRL1 , ANK2 , BPTF , CACNA1A (n = 3), CAMK2A , CAMTA1 , EBF3 , EHMT1 (n = 2), FBXW7 , FOXP1 , GNAI1 , KCND3, KDM5C , NSD1 , PPP2R5D , RAF1 , SCN8A , SET , SETBP1 (n = 2), SETD1A, SETD2 , SETD5 , SLC6A1 , SLC6A8, SMARCA2 (n = 2), SPTBN1, SRRM2, TAB2, TRIM8 . 1/35 was identified from CMA: CUX1 (Tables 1, 2). Variant types for SNVs (n = 32) included missense (n = 13), frameshift (n = 9), nonsense (n = 7), in-frame deletions (n = 2), and splicing (n = 1) (Table 2). All variants were deposited in ClinVar ( https://www.ncbi.nlm.nih.gov/clinvar/ ; accession numbers SCV002557839.2- SCV005399598.1). 13 candidate variants of uncertain significance (VUS) were identified in probands without a diagnosis; comprising SNVs in the following genes: AP1G, BCORL1, BRPF1, CRY, DPF2, FGF13 IQSEC2, USP9X (n = 2 ) ; and the following CNVs: 14q12 del ( de novo ), 7p22.3 del (maternal), 3p14.2 del ( de novo ), and 2q37.2q37.3 del (maternal) (Supplemental Table 3). Two additional VUSs were identified in solved probands ID8 FOXP2 , and ID5 TRRAP 29 . All (likely) pathogenic variants identified were in genes previously associated with syndromic or non-syndromic intellectual disability, epilepsy, ASD and cerebral palsy, Supplemental Table 4. No child received a diagnosis of Fragile X syndrome or Fragile X- associated disorder/pre-mutation carrier status. Phenotyping: variables predictive of a genetic diagnosis Phenotypes of 44 probands with a genetic diagnosis, and 109 without a genetic diagnosis are presented in Fig. 2 and Supplemental Tables 1,2,5. Compared to those without a genetic diagnosis, a higher proportion of children with genetic diagnoses had dysarthria (with and without CAS; 18.2% vs 8.3%), gross motor delays (68.2% vs. 37.6%), fine motor delays (65.9% vs. 40.4%), or a delayed age of walking (52.3% vs. 6.4%), dysmorphism (45.5% vs. 5.5%) and/or borderline or mild intellectual disability (55.9% vs. 15.2%); and a lower proportion had confirmed ASD (9.1% vs 18.3%). No participant with a genetic diagnosis had seizures or a diagnosis of epilepsy, although participant 6 had staring spells with normal EEG. Of those without genetic diagnoses, only two had seizures; participant 147 had absence seizures; participant 71 had a history of febrile seizure. No potential environmental factors contributing to CAS were identified. No probands had a history of congenital infection, teratogen exposure, birth injury, severe prematurity or acquired brain injury. Six probands had a history of moderate to late prematurity (32 − 26 weeks) and none of these had a genetic diagnosis. Consistent with these descriptive findings, the odds of having a genetic diagnosis were highest for individuals with delayed age of walking (OR:15.96, 95% CI: 6.34, 44.86), receptive language impairment (OR: 7.14, 95% CI: 2.96, 18.62), borderline or mildly impaired intellect (OR: 7.07, 95% CI: 2.89, 18.18), dysmorphism (present/features) (OR: 5.59, 95% CI: 2.66–12.19), expressive language impairment (OR: 3.62, 95% CI: 1.28, 13.04), gross motor delay/disorder (OR: 3.55, 95% CI: 1.72, 7.65); and fine motor delay/disorder (OR: 2.86, 95% CI: 1.39, 6.09), respectively (Supplemental Table 5). The odds of having a genetic diagnosis were lowest for individuals with formal diagnoses of ADHD or autism. The odds of having a genetic diagnosis were lowest for children with confirmed diagnoses of ADHD or ASD. Wide confidence intervals for the OR reflect the relatively small sample size for children with a genetic diagnosis. Discussion We identified a specific genetic diagnosis in 29% of children referred to a motor speech disorders clinic at a pediatric tertiary hospital. This yield replicates research findings in a clinical setting for the first time. Previous research-based cohorts ascertained for a primary motor speech diagnosis have identified genetic diagnoses in 42%, 33%, 26%, and 21% respectively 14–17 , but may have been subject to ascertainment bias. Importantly, this diagnostic yield is comparable to that of genomic testing in other neurodevelopmental conditions, such as epilepsy, cerebral palsy and intellectual disability, for which genomic testing is increasingly routine 30 – 33 . Mendelian diagnoses were present in 23% (35/153) of the cohort. We implicate 15 mendelian disorder genes as novel explanations for CAS and dysarthria: ADGRL1 , ANK2, BPTF, CAMK2A, CUX1, FBXW7, KCND3, NSD1, RAF1, SETD2, SLC6A8, SPTBN1, SRRM2 , Table 2, TRIM8). We also confirm involvement of CACNA1A, CAMTA1 , EBF3 EHMT1 , GNAI1, KDM5C, PPP2R5D, SCN8A, SET, SETBP1, SETD1A, SETD5, SLC6A1, SMARCA2 and FOXP1 , now recurrent in unrelated cases across cohorts ascertained for CAS and dysarthria 14 – 18 . Past work led to development of the first publicly available clinical speech panel in July 2024, which we have now expanded to include newly implicated genes with sufficient evidence for inclusion ( https://panelapp-aus.org/panels/4290/ ). We highlight that two of our implicated genes are associated with multiple speech disorder phenotypes: SPTBN1 in CAS, stuttering 34 and speech delay 35 ; and SETD1A in CAS and speech delay 35 . Although we excluded children with a pre-existing diagnosis of intellectual disability, our subsequent assessment indicated that 9.7% had mild and 17.7% had borderline intellectual disability. Probands with a genetic diagnosis were more likely to have cognitive impairment compared to those without a genetic diagnosis. This result was not unexpected, given that all genes associated with CAS to date are also associated with intellectual disability 3 . Of those children with a genetic diagnosis and normal IQ, most had an IQ at the lower end of the normal range; although, there were some exceptions: an IQ above 100 was recorded in female participant 47 with 48,XXX (Trisomy X), male participant 10 with an EBF3 variant, and male participant 38 with 16p12.2 deletion. Children with a genetic diagnosis were also more likely to have impairments in motor domains, with delays in walking and fine and gross motor function commonly reported (52.3%, 65.9%, 68.2%, respectively). Overall, these data support the hypothesis that in monogenic forms of CAS, the speech phenotype is part of a broader neurodevelopmental impairment. We also noted that children with CAS and co-occurring dysarthria were more likely to have a genetic diagnosis than children with CAS alone. This is the first evidence of this observation to our knowledge however and requires independent replication. It is notable that children with a genetic diagnosis ascertained via CAS and/or dysarthria in our cohort were typically towards the milder end of the reported severity spectrum for their disorder. This is likely explained by ascertainment biases favouring (1) severe cases in the published literature, and (2) milder cases in our CAS cohort, also seen in our past studies 15 , 16 . For example, we identified CACNA1A variants in three unrelated probands in the absence of epilepsy or intellectual disability 36 . By extension from these data, milder forms of monogenic neurodevelopmental disorders are likely to be more common than currently recognised, and a case can be made for expanding the application of genomic sequencing to children (and adults) with mild and borderline ID. In the 71% of our cohort without a specific genetic diagnosis, a different phenotypic profile emerged. A significant majority of this group had average FSIQ and expected age of walking, and nearly half (47.7%) had either features of ASD, or a formal ASD diagnosis. The genetic basis of these undiagnosed cases remains unclear, but the clinical overlap with ASD implicates polygenic inheritance 37 , 38 . Based on these observations, we hypothesize that the genetic architecture of CAS comprises at least two distinct causal pathways: (1) monogenic CAS, characterised by variable cognitive impairment, motor impairment and syndromic features, and (2) polygenic CAS, in which cognition and motor skills are relatively spared, but ASD features are more common The association between CAS abnormalities on CMA has yet to be fully characterised. Only 4% of our cohort had a copy number variant. All six CNVs in our study are recognized recurrent CNVs with incomplete penetrance, and each was detected in only one patient. An additional 2% of patients had sex chromosome aneuploidies, including two patients with four sex chromosomes (XXYY and XYYY). The association between sex chromosome trisomies and quadrisomies has been previously recognized 39 . An overall yield of 6% for CMA in CAS is lower than reported previously in an Italian CAS cohort (13%) 17 and for intellectual disability, but comparable to the yield in some other neurodevelopmental phenotypes, such as autism and epilepsy, and microarray remains an important front-line test for motor speech disorders. By contrast, we found no cases of fragile X (neither premutation nor full mutation), suggesting that this test may be less useful in children with CAS. We found no significant evidence for environmental factors contributing to CAS, including pregnancy-related and neonatal complications. Moderate to late prematurity (32–36 weeks) was reported in 5.5% of patients without a genetic diagnosis, comparable to the general population. Prematurity was not seen in any participants with a genetic diagnosis. Our data are in line with past studies showing no evidence of CAS or dysarthria diagnoses in children born pre-term 40 . The range of genetic diagnoses in our cohort underscore the role of chromatin modifiers and transcriptional regulators (BPTF, CAMTA1, CUX1, EBF3, EHMT1, FOXP1, KDM5C, NSD1, SET, SETD1A, SETD2, SETD5, SMARCA2, SETBP1, SRRM2) in speech disorder pathogenicity, consistent with our prior reports 3 . We highlight the commonality of genes encoding SET domain proteins (SETD1A, SETD2, SETD5, NSD1, EHMT1), as these are part of a methyltransferase superfamily integral in post translational protein regulation with a well-established role in neurodevelopmental disorders 15 , 16 . Other protein classes enriched for pathogenic variants were ion channel and solute carriers (ANK2, SCN8A, KCND3, CACNA1A, SLC6A1, SLC6A8) and cell signalling pathway members (FBXW7, PPP2R5D, TAB2, RAF1, SET). Whilst further replication and verification of results is warranted given the modest size of our cohort, motor speech disorders are extremely rare (1 in 1000) when compared to other neurodevelopmental conditions (1 in 100 for intellectual disability, autism; 4–10 per 1000 for epilepsy) and greater collaboration will be necessary to build sizeable cohorts for independent replication. Conclusion Our findings confirm a diagnostic yield for motor speech disorder that is comparable to other neurodevelopmental conditions. We have identified predictors of genetic diagnosis, that can be used to guide advances in clinical practice and health services for motor speech disorder. We suggest prioritisation of clinical genomic testing for children with a primary motor speech disorder on a background of delayed walking, persistent fine and gross motor delays/disorder, receptive language impairment, dysmorphism, and/or borderline IQ. The presence of ASD appears to be less commonly associated with a genetic diagnosis. Motor speech conditions are distinctive, socially debilitating disorders, and clinical genomic testing should be warranted to end the diagnostic odyssey and position them for precision therapies. Declarations Ethical Approval: The study was approved by the Human Research Ethics Committee of The Royal Children’s Hospital, Melbourne, Australia (#37353). Written informed consent was obtained from all parents or legal guardians for their child to take part in our study and to publish their data. We have archived this data in our REDCap database held at the Murdoch Children’s Research Institute at the Royal Children’s Hospital campus. Competing interests: The authors have no competing interests relevant to this article to disclose. Funding: This work was primarily funded by a Royal Children’s Hospital Foundation grant (AM, IS, DA). The work was also supported by National Health and Medical Research Council (NHMRC) Centre of Research Excellence Grants (CRE-SLANG: 1116976, AM, MH, IS, DA; and Translational Centre for Speech Disorders: 2015727, AM, IS, MH, DA) and an NHMRC project grant (1160893, AM, DA, MH). AM was supported by an NHMRC Practitioner Fellowship (1105008) and Investigator grant (1195955). DA is supported by the Lorenzo and Pamela Galli Research Trust. IS was supported by an NHMRC Investigator grant (1172897). Additional funding was provided by the Independent Research Institute Infrastructure Support Scheme and the Victorian State Government Operational Infrastructure Program. Open Access funding enabled and organized by CAUL and its Member Institutions. Author Contributions: Professors Morgan and Amor conceptualized and designed the study, coordinated and supervised the study, collected data, carried out analyses, drafted the initial manuscript, and reviewed and revised the manuscript. 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Mar 2012;160(3):402-408 e1. doi:10.1016/j.jpeds.2011.08.055 Tables Table 1. Phenotype of participants with genetic diagnosis (n=44) Sex Age y;m Speech diagnosis Genetic diagnosis Dys-morphology IQ Receptive language Expressive language Delayed walking Gross motor impairment Fine motor impairment ASD diagnosis ADHD diagnosis 1 M 5;5 CAS, PDis, Artic ADGRL1 + Borderline Severe Severe - - + - - 744 M 4;1 CAS ANK2 - Moderate Moderate - - - - - 622 F 5;5 CAS, DYS BPTF + Borderline - - + - - 888 M 4;10 CAS CACNA1A - Mild - - + Features - 880 M 6;10 CAS, DYS CACNA1A Features Low average Severe + + + - - 823 M 7;3 CAS CACNA1A - Average Severe + + - Features Features 601 F 3;4 CAS CAMK2A - Mild Average Low average + + + - Features 420 M 8;0 CAS, DYS CAMTA1 Features Low average Moderate Severe + + + - + 669 M 4;8 CAS, PDis CUX1 Features Borderline Severe Mild - + + + - 624 M 17 DYS EBF3 + High average Average Mild + + + Features - 649 M 4;3 CAS EHMT1 + Mild + + - - - 762 M 6;1 CAS, PDel EHMT1 + Borderline Mild Severe + - + - - 664 M 6;7 CAS, PDel FBXW7 + Mild Severe Severe + + - - - 689 M 4;6 CAS, PDel FOXP1 - Moderate Severe + + + Features - 505 F 4;3 CAS, PDis GNAI1 + Borderline Mild Severe + + - - - 584 F 4;2 CAS KCND3 - Borderline Moderate Moderate + + + - - 694 M 3;7 CAS, PDis KDM5C - Average Severe - - - + Features 659 F 5;9 CAS, Stutter, PDel NSD1 + Borderline Mild Severe + + - - - 670 F 3;7 CAS PPP2R5D - Average + + - - - 758 F 4;6 CAS RAF1 Features Mild Severe - + + Features - 804 F 4;6 CAS SCN8A Features Low average Average Mild - - + - - 301 F 10;9 CAS, PDel SET - Borderline Mild Severe + - - - - 617 F 3;9 CAS, PDis SETBP1 + Mild + + + - - 653 F 14;6 CAS, DYS SETBP1 + Mild Mild Mild + + + - - 905 M 3;11 CAS SETD1A + Low average Average Moderate + + + - - 846 M 4;8 CAS SETD2 Features - + + - - 834 F 5;2 CAS SETD5 + Moderate Severe + + + - - 768 M 3;5 CAS, PDis SLC6A1 + Mild Moderate - + - - - 695 F 16;5 DYS SLC6A8 Features Mild Moderate Severe + + + + - 673 F 3;6 CAS, PDis SMARCA2 + Low average Low average Average - + - - - 586 M 3;9 CAS SMARCA2 + Mild Severe Severe + + - + - 663 M 7;3 CAS, PDis, Artic SPTBN1 - Borderline Severe Severe - + + Features + 666 M 13 CAS, PDis SRRM2 + Borderline - + + - - 777 M 7;2 CAS TAB2 - - Below average Below average - - + - - 507 M 4;2 CAS, PDis TRIM8 + Mild Severe Severe + + + Features - 677 M 5;3 CAS 1q21.1q21.2 dup - Average - - - - - 414 M 9;7 CAS, PDis 15q13.2q13.3 del - Borderline Mild Severe - - - - - 697 M 5;1 CAS, PDel 16p12.2 del Features Average Moderate Average - + + - - 810 M 5;2 CAS 17q12 dup - Average + - + - - 443 M 4;9 CAS 22q11.21 del + + + + - - 685 M 6;6 CAS, Stutter, PDel 22q11.21q11.22 dup + Average Average Average - + + - - 681 F 4;1 CAS, DYS 47, XXX Features High average Average - + + - - 789 M 8;5 CAS, DYS 48, XXYY + Low average Moderate - - - - - 794 M 6 CAS 48, XYYY - Low average Average Average - - + - - F: female; M: male; y: year: m: month; CAS: childhood apraxia of speech; PDis: Phonological disorder; PDel: Phonological delay; DYS: Dysarthria; +: Present; -: Absent; IQ: Full Scale Intelligence Quotient; blank: not tested; ASD: Autism spectrum disorder; ADHD: Attention deficit hyperactivity. Table 2. Genetic diagnoses N=44 2a. Monogenic findings (including single nucleotide variations and intragenic deletions), n=35 ID Gene Variant (GRCh38/hg38) Chr Inheritance ACMG Class Type 1 ADGRL1 g. 14151115_14152393del 19 Maternal 5 Deletion 2 ANK2 c.9539_9545delinsTGGATGATGAG; p.(Asp3180Valfs*7) 4 Paternal 5 Frameshift 3 BPTF c.3157_3158delAA; p.(Lys1053Glufs*12) 17 De novo 5 Frameshift 4 CACNA1A c.3829C>T; p.(Arg1277*) 19 Paternal 5 Nonsense 5 CACNA1A c.492C>G; p.(Tyr164*) 19 Maternal 5 Nonsense 6 CACNA1A c.592C>T; p.(Arg198*) 19 Maternal 5 Nonsense 7 CAMK2A c.635C>T; p.(Pro212Leu) 5 De novo 5 Missense 8 CAMTA1 c.2072_2075del; p.(Thr691Argfs*35) 1 De novo 5 Frameshift 9 CUX1 g.102070411_102114170del 7 Unknown 4 Intragenic deletion exon 4-7 10 EBF3 c.708_710delCAA; p.(Asn237del) 10 De novo 5 Deletion 11 EHMT1 c.3229C>T; p.Gln1077* (GRCh37) 9 Unknown 5 Nonsense 12 EHMT1 c.2842C>T; p.(Arg948Trp) 9 De novo 5 Missense 13 FBXW7 c.1919delG; p.(Ser640Thrfs*7) 4 Unknown 4 Frameshift 14 FOXP1 c.1426C>T; p.(Gln476*) 3 Unknown 4 Nonsense 15 GNAI1 c.518A>T; p.(Asp173Val) 7 De novo 4 Missense 16 KCND3 c.983T>G; p.(Leu328Arg) 1 De novo 4 Missense 17 KDM5C c.1178C>T; p.(Thr393Ile) X De novo 4 Missense 18 NSD1 c.4972_4974delTTG; p.(Leu1658del) 5 De novo 4 Deletion 19 PPP2R5D c.751G>T; p.(Asp251Tyr) 6 De novo 5 Missense 20 RAF1 c.1423T>C; p.(Phe475Leu) 3 De novo 5 Missense 21 SCN8A c.417G>A; p.(Met139Ile) 12 De novo 5 Missense 22 SET c.103_104del; p.(Ile35*) 9 De novo 4 Nonsense 23 SETBP1 c.623del; p.(Pro208Glnfs*135) 18 De novo 5 Frameshift 24 SETBP1 c.2087dupC; p.(Glu697Argfs*10) 18 De novo 5 Frameshift 25 SETD1A c.273del; p.(Pro92Hisfs*2) 16 De novo 5 Frameshift 26 SETD2 c.6284dup; p.(Asp2096Argfs*2) 3 De novo 5 Frameshift 27 SETD5 c.2347-7A>G 3 De novo 5 Splicing 28 SLC6A1 c.1097_1098delinsCT; p.(Leu366Pro) 3 De novo 4 Missense 29 SLC6A8 c.257G>A; p.(Gly86Asp) X De novo 4 Missense 30 SMARCA2 c.3484C>T; p.(Arg1162Cys) 9 De novo 5 Missense 31 SMARCA2 c.2870A>G; p.(Gln957Arg) 9 De novo 4 Missense 32 SPTBN1 c.1429C>T; p.(Arg477Cys) 2 De novo 4 Missense 33 SRRM2 g.2707830_2757509del 16 De novo 5 Intragenic deletion of exon 1,2 and part of 3 34 TAB2 c.363_364insGTTA; p.(Phe122Valfs*18) 6 Maternal 5 Frameshift 35 TRIM8 c.1357C>T; p.(Gln453*) 10 De novo 5 Nonsense 2b. Copy number variants (CNVs) and aneuploidies, n=9 ID Genetic finding Molecular karyotype (GRCh38/hg38) Inheritance 36 1q21.1q21.2 dup 1q21.1-21.2(chr1:146891138-148353326)x3 Paternal 37 15q13.2q13.3 del 15q13.2-13.3(chr15:30648301-32222899)x1 Unknown 38 16p12.2 del 16p12.2(chr16:21945136-22403142)x1 Paternal 39 17q12 dup 17q12(chr17:36459737-37889808)x3 Maternal 40 22q11.21 del 22q11.21(chr22:18890274-20324123)x1 De novo 41 22q11.21q11.22 dup 22q11.21-11.22(chr22:21450614-22457038)x3 De novo 42 47,XXX (chrX)x3 De novo 43 48, XXYY (chrX)x2, (chrY)x2 De novo 44 48, XYYY (chrX)x1, (chrY)x3 De novo Additional Declarations There is no duality of interest Supplementary Files SupplementalTable1.docx Supplemental Table 1 SupplementalTable2a.docx Supplemental Table 2a SupplementalTable2b.docx Supplemental Table 2b SupplementalTable3.docx Supplemental Table 3 SupplementalTable4.docx Supplemental Table 4 SupplementalTable5.docx Supplemental Table 5 SupplementalFigure1.docx Supplemental Figure 1 Cite Share Download PDF Status: Published Journal Publication published 13 Jan, 2026 Read the published version in European Journal of Human Genetics → Version 1 posted Editorial decision: revise 11 Sep, 2025 Review # 3 received at journal 10 Sep, 2025 Review # 1 received at journal 26 Aug, 2025 Reviewer # 3 agreed at journal 21 Aug, 2025 Review # 2 received at journal 20 Aug, 2025 Reviewer # 2 agreed at journal 19 Aug, 2025 Reviewer # 1 agreed at journal 01 Aug, 2025 Reviewers invited by journal 14 Jul, 2025 Submission checks completed at journal 17 Jun, 2025 Editor assigned by journal 15 Jun, 2025 First submitted to journal 15 Jun, 2025 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Institute","correspondingAuthor":false,"prefix":"","firstName":"David","middleName":"","lastName":"Amor","suffix":""}],"badges":[],"createdAt":"2025-06-16 02:50:06","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-6900966/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-6900966/v1","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1038/s41431-025-01993-9","type":"published","date":"2026-01-13T05:00:00+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":87268653,"identity":"5d4906bf-426e-4aeb-993c-8b634ebc3da1","added_by":"auto","created_at":"2025-07-22 08:11:08","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":166706,"visible":true,"origin":"","legend":"\u003cp\u003ea. Clinical workflow\u003c/p\u003e\n\u003cp\u003ePCR = Polymerase chain reaction; CNV = Copy number variant; *Monogenic findings include single nucleotide variants (SNVs) and intragenic deletions.\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eReferral received by clinical co-ordinator (nurse, LO) at Motor Speech Disorders Clinic. Triage by nurse (LO) and speech pathologist (AM). Proband seen by speech pathologist (AM, ML, CB, AG) to confirm speech motor disorder. Medical work-up by paediatrician and clinical geneticist (DA, dual- qualified). Psychologists (EB, CB) determined IQ status at further appointment. Genetic counsellor (ML) or clinical geneticist (DA) performed pre-test genetic counselling and genetic consent. Saliva sample for chromosomal microarray and exome sequencing were collected using paediatric\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eOracollect kits from DNAGenotek. Clinically accredited genomic sequencing was performed at the Victorian Clinical Genetics Service, including: initial computational bioinformatics analysis; meeting to prioritise variants for assessment attending by senior medical genomic scientist, clinical geneticists and genetic counsellors; variant curation as per American College of Medical Genetics and Genomics guidelines. Next, review of variant and phenotypic data undertaken by multidisciplinary\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003e\u003cem\u003espeech clinic team, with laboratory scientists, clinical geneticists and genetic counsellors independent to the speech clinic, to reach consensus and ensure genotype concordant with phenotype prior to\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003e\u003cem\u003ereporting. Proband attended further clinic appointment (in-person or telehealth) for return of results with post-test genetic counselling and segregation encouraged where appropriate.\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003eb. Flowchart of recruitment and genetic results\u003c/p\u003e","description":"","filename":"1.png","url":"https://assets-eu.researchsquare.com/files/rs-6900966/v1/b0f2cb640e7c9a783f076c28.png"},{"id":87266758,"identity":"b17e938e-b868-4ebc-ac43-e52760e321a3","added_by":"auto","created_at":"2025-07-22 08:03:08","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":184284,"visible":true,"origin":"","legend":"\u003cp\u003eRadar chart of phenotypic overlap for participants with and without clinical genetic diagnoses.\u003c/p\u003e\n\u003cp\u003eADHD = ADHD diagnosis or ADHD features; ASD = ASD diagnosis or ASD features; Dysmorphism = Dysmorphic or dysmorphic features; Intellectual impairment = borderline ID or mild ID; Expressive language impairment = mildly impaired, moderately impaired, severely impaired, minimally verbal or could not be assessed due to severity; Receptive language impairment = mildly impaired, moderately impaired or severely impaired.\u003c/p\u003e","description":"","filename":"2.png","url":"https://assets-eu.researchsquare.com/files/rs-6900966/v1/dabe5b2bffbc852975fe93b3.png"},{"id":100213099,"identity":"4dd8fc84-f7f1-4173-888c-e58c5b9e955d","added_by":"auto","created_at":"2026-01-14 08:05:39","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1690312,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-6900966/v1/f7c43266-910c-4a01-82f4-348e13b5b65a.pdf"},{"id":87266756,"identity":"dd1ffe63-d0f2-48ff-a8c6-d315057f7f6e","added_by":"auto","created_at":"2025-07-22 08:03:08","extension":"docx","order_by":1,"title":"","display":"","copyAsset":false,"role":"supplement","size":67391,"visible":true,"origin":"","legend":"Supplemental Table 1","description":"","filename":"SupplementalTable1.docx","url":"https://assets-eu.researchsquare.com/files/rs-6900966/v1/7fd77f0284e2f6f054dfe965.docx"},{"id":87266761,"identity":"228395ca-b8aa-4062-9663-aaf7a8689c3d","added_by":"auto","created_at":"2025-07-22 08:03:08","extension":"docx","order_by":2,"title":"","display":"","copyAsset":false,"role":"supplement","size":47716,"visible":true,"origin":"","legend":"Supplemental Table 2a","description":"","filename":"SupplementalTable2a.docx","url":"https://assets-eu.researchsquare.com/files/rs-6900966/v1/785ecbd6cd906a92ff6ca601.docx"},{"id":87270329,"identity":"3d24b37f-9c2d-4bd6-86a1-876fbff702f5","added_by":"auto","created_at":"2025-07-22 08:19:08","extension":"docx","order_by":3,"title":"","display":"","copyAsset":false,"role":"supplement","size":62800,"visible":true,"origin":"","legend":"Supplemental Table 2b","description":"","filename":"SupplementalTable2b.docx","url":"https://assets-eu.researchsquare.com/files/rs-6900966/v1/d6aea18dd9734f7fdae72ee6.docx"},{"id":87268655,"identity":"b47fa554-430f-4cd2-a589-9f3a9f55f903","added_by":"auto","created_at":"2025-07-22 08:11:08","extension":"docx","order_by":4,"title":"","display":"","copyAsset":false,"role":"supplement","size":24591,"visible":true,"origin":"","legend":"Supplemental Table 3","description":"","filename":"SupplementalTable3.docx","url":"https://assets-eu.researchsquare.com/files/rs-6900966/v1/1492b2763f178631fd8f71d7.docx"},{"id":87268654,"identity":"de18bde8-5faa-4c5d-8b74-f3c0e45c1eee","added_by":"auto","created_at":"2025-07-22 08:11:08","extension":"docx","order_by":5,"title":"","display":"","copyAsset":false,"role":"supplement","size":18574,"visible":true,"origin":"","legend":"\u003cp\u003eSupplemental Table 4\u003c/p\u003e","description":"","filename":"SupplementalTable4.docx","url":"https://assets-eu.researchsquare.com/files/rs-6900966/v1/6bf204f071f9b6edea0da7da.docx"},{"id":87266766,"identity":"875c7ace-27c4-42ee-a9c7-ff8e286ea3d1","added_by":"auto","created_at":"2025-07-22 08:03:08","extension":"docx","order_by":6,"title":"","display":"","copyAsset":false,"role":"supplement","size":43924,"visible":true,"origin":"","legend":"\u003cp\u003eSupplemental Table 5\u003c/p\u003e","description":"","filename":"SupplementalTable5.docx","url":"https://assets-eu.researchsquare.com/files/rs-6900966/v1/f05328f2d1de6017712c975a.docx"},{"id":87268662,"identity":"ad7d4c09-a0cf-4f32-aa42-fb9f07b1e5a1","added_by":"auto","created_at":"2025-07-22 08:11:09","extension":"docx","order_by":7,"title":"","display":"","copyAsset":false,"role":"supplement","size":126048,"visible":true,"origin":"","legend":"Supplemental Figure 1","description":"","filename":"SupplementalFigure1.docx","url":"https://assets-eu.researchsquare.com/files/rs-6900966/v1/be82d466cc854e43edb7d557.docx"}],"financialInterests":"There is no duality of interest","formattedTitle":"Childhood motor speech disorders: who to prioritise for genetic testing","fulltext":[{"header":"Introduction","content":"\u003cp\u003eSpeech disorders are a common presenting concern for children referred to paediatricians and primary care physicians\u003csup\u003e\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e\u003c/sup\u003e. Associated poor language, literacy, educational, employment and social outcomes mean speech disorders come with significant individual, societal and health system burden\u003csup\u003e\u003cspan additionalcitationids=\"CR3\" citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e\u003c/sup\u003e.\u003c/p\u003e \u003cp\u003eUp to 5% of children develop common speech disorders including articulation and phonological impairments\u003csup\u003e\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e\u003c/sup\u003e. These conditions are highly tractable and typically resolve by 7 years of age, with or without intervention\u003csup\u003e\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e,\u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e\u003c/sup\u003e. By contrast, 1 in 1000 children follow a severely disrupted developmental path to intractable motor speech disorders of childhood apraxia of speech (CAS) and/or dysarthria\u003csup\u003e\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e\u003c/sup\u003e. CAS affects the ability to plan and sequence speech movements, decreasing the precision, consistency and intelligibility of speech \u003csup\u003e\u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e\u003c/sup\u003e. Children with CAS need explicit teaching and practice of new sounds and words, often requiring speech therapy into adolescence or adulthood\u003csup\u003e\u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e\u003c/sup\u003e. A diagnosis of CAS implicates disruption of inferior frontal lobe and basal ganglia pathways, whereas dysarthria is a disorder of the control and execution of neuromuscular movements for speech implicating the \u0026lsquo;final common\u0026rsquo; motor pathway or corticobulbar tract\u003csup\u003e\u003cspan additionalcitationids=\"CR10\" citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR11\" class=\"CitationRef\"\u003e11\u003c/span\u003e\u003c/sup\u003e.\u003c/p\u003e \u003cp\u003eA major challenge of managing motor speech disorders has been a lack of etiological knowledge. Families search for explanatory causes in a long diagnostic journey\u003csup\u003e\u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e\u003c/sup\u003e, attending multiple primary care physician, pediatric, neurology, and other specialist appointments, involving serial investigations (e.g. MRI, metabolic testing) with significant costs and psychological stress and without explanatory results\u003csup\u003e\u003cspan citationid=\"CR13\" class=\"CitationRef\"\u003e13\u003c/span\u003e\u003c/sup\u003e. In the past five years, genomic sequencing, performed in a research setting, has shown a substantial genetic contribution to these conditions\u003csup\u003e\u003cspan additionalcitationids=\"CR15 CR16 CR17\" citationid=\"CR15\" class=\"CitationRef\"\u003e14\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR19\" class=\"CitationRef\"\u003e18\u003c/span\u003e\u003c/sup\u003e, even in the absence of intellectual disability\u003csup\u003e\u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e15\u003c/span\u003e,\u003cspan citationid=\"CR17\" class=\"CitationRef\"\u003e16\u003c/span\u003e\u003c/sup\u003e, with a diagnostic yield of 30% [3]. This research yield is comparable to that seen in cerebral palsy, epilepsy and intellectual disability, conditions for which genomic clinical testing is routine in many centres\u003csup\u003e\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e\u003c/sup\u003e. However, clinical genomic testing is not yet the standard of care for motor speech disorders, despite such testing being highly valued by families with lived experience\u003csup\u003e\u003cspan citationid=\"CR13\" class=\"CitationRef\"\u003e13\u003c/span\u003e\u003c/sup\u003e.\u003c/p\u003e \u003cp\u003eIn this study, we offered clinical genomic testing, consisting of chromosomal microarray, fragile X PCR and exome sequencing, to a clinically ascertained population of children referred to a speech genomics clinic at a pediatric tertiary hospital. We examined diagnostic yield and clinical variables predictive of a genetic diagnosis.\u003c/p\u003e"},{"header":"Materials and methods","content":"\u003cdiv id=\"Sec3\" class=\"Section2\"\u003e \u003ch2\u003eEthical consent\u003c/h2\u003e \u003cp\u003e The study was approved by the Human Research Ethics Committee of The Royal Children\u0026rsquo;s Hospital, Melbourne, Australia (#37353). Written informed consent was obtained from parents or legal guardians.\u003c/p\u003e \u003c/div\u003e\n\u003ch3\u003eStudy design\u003c/h3\u003e\n\u003cp\u003eThis prospective single-centre cohort study recruited probands referred to the Genetics of Speech Disorders clinic at the Royal Children\u0026rsquo;s Hospital, in Melbourne, Australia between August 2020 and December 2023.\u003c/p\u003e\n\u003ch3\u003eRecruitment\u003c/h3\u003e\n\u003cp\u003eChildren were referred for motor speech testing by their treating primary care physician, paediatrician, pediatric sub-specialist (metabolic, genetics, neurology) or speech pathologist. Probands were triaged for eligibility by the clinical nurse co-ordinator with input from the clinical team where indicated (e.g. psychologist to interpret cognitive assessments; clinical geneticist to interpret past genetic reports). Inclusion criteria were: (1) probands aged 2;7 to 17 years with CAS or dysarthria in the absence of known or previously diagnosed intellectual disability, autism spectrum disorder (ASD) level III, or acquired brain injury; and (2) parent, speech pathologist and treating physician reporting the primary presenting feature and clinical concern as motor speech disorder \u003csup\u003e\u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e15\u003c/span\u003e,\u003cspan citationid=\"CR17\" class=\"CitationRef\"\u003e16\u003c/span\u003e\u003c/sup\u003e.\u003c/p\u003e\n\u003ch3\u003ePhenotyping\u003c/h3\u003e\n\u003cp\u003eProbands were prospectively assessed by a speech pathologist (AM, ML, CB); paediatrician and clinical geneticist (DA, dual-qualified); and psychologist (EB, CB) using a protocol outlined below; see clinical pipeline Fig.\u0026nbsp;\u003cspan refid=\"Fig3\" class=\"InternalRef\"\u003e1\u003c/span\u003ea.\u003c/p\u003e \u003cp\u003eA detailed family history and pedigree were recorded and prospective phenotyping documented medical and developmental history including presence of dysmorphism \u003csup\u003e\u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e15\u003c/span\u003e,\u003cspan citationid=\"CR17\" class=\"CitationRef\"\u003e16\u003c/span\u003e\u003c/sup\u003e(Table\u0026nbsp;1, Supplemental Tables\u0026nbsp;1, 2a,b). All secondary neurodevelopmental outcomes were defined using standardised testing and a professional report for validation, e.g. multi- disciplinary assessment standardised testing for a formal diagnosis of ASD; physiotherapist confirmed fine or gross motor disorder. Where children had not yet received a formal ASD or attention deficit hyperactivity disorder (ADHD) diagnosis, the paediatrician (DA) recorded the presence of ASD/ADHD features (Table\u0026nbsp;1; Supplemental Tables\u0026nbsp;1, 2a,b).\u003c/p\u003e \u003cp\u003eFor speech, CAS was confirmed if the American Speech-Language-Hearing Association (ASHA) criteria for CAS were met: (1) inconsistent errors on consonants and vowels in repeated productions of syllables or words; (2) lengthened and disrupted coarticulatory transitions between sounds and syllables, and (3) inappropriate prosody; all relative to age and stage of development\u003csup\u003e\u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e\u003c/sup\u003e. ASHA criteria were operationally defined and rated from: phonetic transcriptions of 55 single words speech test designed to elicit all sounds of English, a test of speech consistency (children repeat 15/55 stimuli words twice) and a 5 minute conversational speech sample as described previously\u003csup\u003e\u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e15\u003c/span\u003e,\u003cspan citationid=\"CR17\" class=\"CitationRef\"\u003e16\u003c/span\u003e,\u003cspan citationid=\"CR20\" class=\"CitationRef\"\u003e19\u003c/span\u003e\u003c/sup\u003e. Dysarthria was diagnosed as an oral tone or coordination disturbance examined by paediatrician and speech pathologist and speech dysarthric features identified during the conversation sample, using the Mayo Clinic Dysarthria rating scale\u003csup\u003e\u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e15\u003c/span\u003e,\u003cspan citationid=\"CR17\" class=\"CitationRef\"\u003e16\u003c/span\u003e,\u003cspan citationid=\"CR20\" class=\"CitationRef\"\u003e19\u003c/span\u003e,\u003cspan citationid=\"CR21\" class=\"CitationRef\"\u003e20\u003c/span\u003e\u003c/sup\u003e. Receptive and expressive language was assessed where time and resources were available\u003csup\u003e\u003cspan additionalcitationids=\"CR22 CR23\" citationid=\"CR22\" class=\"CitationRef\"\u003e21\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR25\" class=\"CitationRef\"\u003e24\u003c/span\u003e\u003c/sup\u003e (Table\u0026nbsp;1, Supplemental Tables\u0026nbsp;1,2a,b). Cognition was assessed by a psychologist using standardized testing\u003csup\u003e\u003cspan additionalcitationids=\"CR26\" citationid=\"CR26\" class=\"CitationRef\"\u003e25\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR28\" class=\"CitationRef\"\u003e27\u003c/span\u003e\u003c/sup\u003e.\u003c/p\u003e\n\u003ch3\u003eGenetic and genomic analysis\u003c/h3\u003e\n\u003cp\u003e \u003c/p\u003e \u003cp\u003efor variants linked to disorders relevant to proband phenotype following a tiered approach. Initially, variants in genes associated with intellectual disability were evaluated (\u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003ehttps://panelapp-aus.org/panels/250/\u003c/span\u003e\u003cspan address=\"https://panelapp-aus.org/panels/250/\" targettype=\"URL\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e). Analysis was then expanded to a virtual panel of\u003c/p\u003e \u003cp\u003e~\u0026thinsp;6000 genes known to cause Mendelian disorders (\u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003ehttps://panelapp-aus.org/panels/137/\u003c/span\u003e\u003cspan address=\"https://panelapp-aus.org/panels/137/\" targettype=\"URL\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e). Variants were classified according to the current American College of Medical Genetics and Genomics (ACMG) guidelines for variant interpretation\u003csup\u003e\u003cspan citationid=\"CR30\" class=\"CitationRef\"\u003e29\u003c/span\u003e\u003c/sup\u003e.\u003c/p\u003e \u003cdiv id=\"Sec8\" class=\"Section2\"\u003e \u003ch2\u003eStatistical analysis\u003c/h2\u003e \u003cp\u003eWe report the proportion and type of pathogenic variants causative for motor speech disorder from CMA, Fragile X and ES testing. For variables predictive of a genetic diagnosis, baseline clinical variables are recorded as frequencies (\u003cem\u003en\u003c/em\u003e, %) and medians (range), as dictated by data type. Odds ratios have been used to identify variables associated with a genetic diagnostic result. The variables of ASD, ADHD, dysmorphism, intelligence quotient (IQ), receptive and expressive language were all dichotomised for the odds ratio analysis.\u003c/p\u003e \u003c/div\u003e"},{"header":"Results","content":"\u003cdiv id=\"Sec10\" class=\"Section2\"\u003e \u003ch2\u003eGenetic diagnostic yield and genomic findings\u003c/h2\u003e \u003cp\u003e172 probands met inclusion criteria, of whom 153 (88.9%; 111 males, 42 females) completed\u003c/p\u003e \u003cp\u003egenetic testing (153 CMA, 143 ES), at an average age of 5 years 8 months (range 2 years 7 months to 16 years 5 months). Two probands withdrew from the study and 4 declined genetic testing. Despite three reminders to do so, the remaining 13 either did not respond to the genetic testing appointment invitation, did not send back their consent form, or did not return their saliva sample (Fig.\u0026nbsp;\u003cspan refid=\"Fig3\" class=\"InternalRef\"\u003e1\u003c/span\u003eb).\u003c/p\u003e \u003cp\u003eOverall, 44/153 (29%) probands received a genetic diagnosis (15 females; median 5 years 1 month; Table\u0026nbsp;3). 30 findings were confirmed \u003cem\u003ede novo\u003c/em\u003e and 9 inherited (5 maternal; 4 paternal). Inheritance status could not be confirmed for 5 pathogenic variants due to missing parental DNA (Table\u0026nbsp;2, Supplemental Fig.\u0026nbsp;1a). 9 were aneuploidies or copy number variants (CNVs) (all \u0026gt;\u0026thinsp;50kb) detected on CMA: del 15q13.2q13.3, del 22q11.21, dup 22q11.21q11.22, dup 1q21.1q21.2, del 16p12.2, dup 17q12, 47,XXX, 48,XXYY, 48,XYYY. There were 35 monogenic diagnoses including single nucleotide variants (SNVs) and intragenic deletions (\u0026lt;\u0026thinsp;50kb). 34/35 were identified from ES: \u003cem\u003eADGRL1\u003c/em\u003e, \u003cem\u003eANK2\u003c/em\u003e, \u003cem\u003eBPTF\u003c/em\u003e, \u003cem\u003eCACNA1A\u003c/em\u003e (n\u0026thinsp;=\u0026thinsp;3), \u003cem\u003eCAMK2A\u003c/em\u003e, \u003cem\u003eCAMTA1\u003c/em\u003e, \u003cem\u003eEBF3\u003c/em\u003e, \u003cem\u003eEHMT1\u003c/em\u003e (n\u0026thinsp;=\u0026thinsp;2), \u003cem\u003eFBXW7\u003c/em\u003e, \u003cem\u003eFOXP1\u003c/em\u003e, \u003cem\u003eGNAI1\u003c/em\u003e, \u003cem\u003eKCND3, KDM5C\u003c/em\u003e, \u003cem\u003eNSD1\u003c/em\u003e, \u003cem\u003ePPP2R5D\u003c/em\u003e, \u003cem\u003eRAF1\u003c/em\u003e, \u003cem\u003eSCN8A\u003c/em\u003e, \u003cem\u003eSET\u003c/em\u003e, \u003cem\u003eSETBP1\u003c/em\u003e (n\u0026thinsp;=\u0026thinsp;2), \u003cem\u003eSETD1A, SETD2\u003c/em\u003e, \u003cem\u003eSETD5\u003c/em\u003e, \u003cem\u003eSLC6A1\u003c/em\u003e, \u003cem\u003eSLC6A8, SMARCA2\u003c/em\u003e (n\u0026thinsp;=\u0026thinsp;2), \u003cem\u003eSPTBN1, SRRM2, TAB2, TRIM8\u003c/em\u003e. 1/35 was identified from CMA:\u003c/p\u003e \u003cp\u003e \u003cem\u003eCUX1\u003c/em\u003e (Tables\u0026nbsp;1, 2). Variant types for SNVs (n\u0026thinsp;=\u0026thinsp;32) included missense (n\u0026thinsp;=\u0026thinsp;13), frameshift (n\u0026thinsp;=\u0026thinsp;9), nonsense (n\u0026thinsp;=\u0026thinsp;7), in-frame deletions (n\u0026thinsp;=\u0026thinsp;2), and splicing (n\u0026thinsp;=\u0026thinsp;1) (Table\u0026nbsp;2). All variants were deposited in ClinVar (\u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003ehttps://www.ncbi.nlm.nih.gov/clinvar/\u003c/span\u003e\u003cspan address=\"https://www.ncbi.nlm.nih.gov/clinvar/\" targettype=\"URL\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e; accession numbers SCV002557839.2- SCV005399598.1).\u003c/p\u003e \u003cp\u003e13 candidate variants of uncertain significance (VUS) were identified in probands without a diagnosis; comprising SNVs in the following genes: \u003cem\u003eAP1G, BCORL1, BRPF1, CRY, DPF2, FGF13 IQSEC2, USP9X\u003c/em\u003e (n\u0026thinsp;=\u0026thinsp;2\u003cem\u003e)\u003c/em\u003e; and the following CNVs: 14q12 del (\u003cem\u003ede novo\u003c/em\u003e), 7p22.3 del (maternal), 3p14.2 del (\u003cem\u003ede novo\u003c/em\u003e), and 2q37.2q37.3 del (maternal) (Supplemental Table\u0026nbsp;3). Two additional VUSs were identified in solved probands ID8 \u003cem\u003eFOXP2\u003c/em\u003e, and ID5 \u003cem\u003eTRRAP\u003c/em\u003e\u003csup\u003e\u003cspan citationid=\"CR30\" class=\"CitationRef\"\u003e29\u003c/span\u003e\u003c/sup\u003e.\u003c/p\u003e \u003cp\u003eAll (likely) pathogenic variants identified were in genes previously associated with syndromic or non-syndromic intellectual disability, epilepsy, ASD and cerebral palsy,\u003c/p\u003e \u003cp\u003eSupplemental Table\u0026nbsp;4. No child received a diagnosis of Fragile X syndrome or Fragile X- associated disorder/pre-mutation carrier status.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec11\" class=\"Section2\"\u003e \u003ch2\u003ePhenotyping: variables predictive of a genetic diagnosis\u003c/h2\u003e \u003cp\u003ePhenotypes of 44 probands with a genetic diagnosis, and 109 without a genetic diagnosis are presented in Fig.\u0026nbsp;\u003cspan refid=\"Fig4\" class=\"InternalRef\"\u003e2\u003c/span\u003e and Supplemental Tables\u0026nbsp;1,2,5. Compared to those without a genetic diagnosis, a higher proportion of children with genetic diagnoses had dysarthria (with and without CAS; 18.2% vs 8.3%), gross motor delays (68.2% vs. 37.6%), fine motor delays (65.9% vs. 40.4%), or a delayed age of walking (52.3% vs. 6.4%), dysmorphism (45.5% vs. 5.5%) and/or borderline or mild intellectual disability (55.9% vs. 15.2%); and a lower\u003c/p\u003e \u003cp\u003eproportion had confirmed ASD (9.1% vs 18.3%). No participant with a genetic diagnosis had seizures or a diagnosis of epilepsy, although participant 6 had staring spells with normal EEG. Of those without genetic diagnoses, only two had seizures; participant 147 had absence seizures; participant 71 had a history of febrile seizure.\u003c/p\u003e \u003cp\u003eNo potential environmental factors contributing to CAS were identified. No probands had a history of congenital infection, teratogen exposure, birth injury, severe prematurity or acquired brain injury. Six probands had a history of moderate to late prematurity (32\u0026thinsp;\u0026minus;\u0026thinsp;26 weeks) and none of these had a genetic diagnosis.\u003c/p\u003e \u003cp\u003eConsistent with these descriptive findings, the odds of having a genetic diagnosis were highest for individuals with delayed age of walking (OR:15.96, 95% CI: 6.34, 44.86), receptive language impairment (OR: 7.14, 95% CI: 2.96, 18.62), borderline or mildly\u003c/p\u003e \u003cp\u003eimpaired intellect (OR: 7.07, 95% CI: 2.89, 18.18), dysmorphism (present/features) (OR:\u003c/p\u003e \u003cp\u003e5.59, 95% CI: 2.66\u0026ndash;12.19), expressive language impairment (OR: 3.62, 95% CI: 1.28, 13.04),\u003c/p\u003e \u003cp\u003egross motor delay/disorder (OR: 3.55, 95% CI: 1.72, 7.65); and fine motor delay/disorder\u003c/p\u003e \u003cp\u003e(OR: 2.86, 95% CI: 1.39, 6.09), respectively (Supplemental Table\u0026nbsp;5). The odds of having a genetic diagnosis were lowest for individuals with formal diagnoses of ADHD or autism. The odds of having a genetic diagnosis were lowest for children with confirmed diagnoses of ADHD or ASD. Wide confidence intervals for the OR reflect the relatively small sample size for children with a genetic diagnosis.\u003c/p\u003e \u003c/div\u003e"},{"header":"Discussion","content":"\u003cp\u003eWe identified a specific genetic diagnosis in 29% of children referred to a motor speech disorders clinic at a pediatric tertiary hospital. This yield replicates research findings in a clinical setting for the first time. Previous research-based cohorts ascertained for a primary motor speech diagnosis have identified genetic diagnoses in 42%, 33%, 26%, and 21% respectively\u003csup\u003e14\u0026ndash;17\u003c/sup\u003e, but may have been subject to ascertainment bias. Importantly, this diagnostic yield is comparable to that of genomic testing in other neurodevelopmental conditions, such as epilepsy, cerebral palsy and intellectual disability, for which genomic testing is increasingly routine\u003csup\u003e\u003cspan additionalcitationids=\"CR31 CR32\" citationid=\"CR31\" class=\"CitationRef\"\u003e30\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR34\" class=\"CitationRef\"\u003e33\u003c/span\u003e\u003c/sup\u003e.\u003c/p\u003e \u003cp\u003eMendelian diagnoses were present in 23% (35/153) of the cohort. We implicate 15 mendelian disorder genes as novel explanations for CAS and dysarthria: \u003cem\u003eADGRL1\u003c/em\u003e, \u003cem\u003eANK2, BPTF, CAMK2A, CUX1, FBXW7, KCND3, NSD1, RAF1, SETD2, SLC6A8, SPTBN1, SRRM2\u003c/em\u003e,\u003c/p\u003e \u003cp\u003e \u003cem\u003eTable\u0026nbsp;2, TRIM8).\u003c/em\u003e We also confirm involvement of \u003cem\u003eCACNA1A, CAMTA1\u003c/em\u003e, \u003cem\u003eEBF3 EHMT1\u003c/em\u003e,\u003c/p\u003e \u003cdiv id=\"Sec13\" class=\"Section2\"\u003e \u003ch2\u003eGNAI1, KDM5C, PPP2R5D, SCN8A, SET, SETBP1, SETD1A, SETD5, SLC6A1, SMARCA2\u003c/h2\u003e \u003cp\u003eand \u003cem\u003eFOXP1\u003c/em\u003e, now recurrent in unrelated cases across cohorts ascertained for CAS and dysarthria\u003csup\u003e\u003cspan additionalcitationids=\"CR15 CR16 CR17\" citationid=\"CR15\" class=\"CitationRef\"\u003e14\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR19\" class=\"CitationRef\"\u003e18\u003c/span\u003e\u003c/sup\u003e. Past work led to development of the first publicly available clinical speech panel in July 2024, which we have now expanded to include newly implicated genes with sufficient evidence for inclusion (\u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003ehttps://panelapp-aus.org/panels/4290/\u003c/span\u003e\u003cspan address=\"https://panelapp-aus.org/panels/4290/\" targettype=\"URL\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e\u003cspan type=\"Underline\" class=\"Underline\" name=\"Emphasis\"\u003e).\u003c/span\u003e We highlight that two of our implicated genes are associated with multiple speech disorder phenotypes:\u003c/p\u003e \u003cp\u003e \u003cem\u003eSPTBN1\u003c/em\u003e in CAS, stuttering\u003csup\u003e\u003cspan citationid=\"CR35\" class=\"CitationRef\"\u003e34\u003c/span\u003e\u003c/sup\u003e and speech delay\u003csup\u003e\u003cspan citationid=\"CR36\" class=\"CitationRef\"\u003e35\u003c/span\u003e\u003c/sup\u003e; and \u003cem\u003eSETD1A\u003c/em\u003e in CAS and speech delay\u003csup\u003e\u003cspan citationid=\"CR36\" class=\"CitationRef\"\u003e35\u003c/span\u003e\u003c/sup\u003e.\u003c/p\u003e \u003cp\u003eAlthough we excluded children with a pre-existing diagnosis of intellectual disability, our subsequent assessment indicated that 9.7% had mild and 17.7% had borderline intellectual disability. Probands with a genetic diagnosis were more likely to have cognitive impairment compared to those without a genetic diagnosis. This result was not unexpected, given that all genes associated with CAS to date are also associated with intellectual disability\u003csup\u003e\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e\u003c/sup\u003e. Of those children with a genetic diagnosis and normal IQ, most had an IQ at the lower end of the normal range; although, there were some exceptions: an IQ above 100 was recorded in female participant 47 with 48,XXX (Trisomy X), male participant 10 with an \u003cem\u003eEBF3\u003c/em\u003e variant, and male participant 38 with 16p12.2 deletion. Children with a genetic diagnosis were also more likely to have impairments in motor domains, with delays in walking and fine and gross motor function commonly reported (52.3%, 65.9%, 68.2%, respectively). Overall, these data support the hypothesis that in monogenic forms of CAS, the speech phenotype is part of a broader neurodevelopmental impairment. We also noted that children with CAS and co-occurring dysarthria were more likely to have a genetic diagnosis than children with CAS alone. This is the first evidence of this observation to our knowledge however and requires independent replication.\u003c/p\u003e \u003cp\u003eIt is notable that children with a genetic diagnosis ascertained via CAS and/or dysarthria in our cohort were typically towards the milder end of the reported severity spectrum for their disorder. This is likely explained by ascertainment biases favouring (1) severe cases in the published literature, and (2) milder cases in our CAS cohort, also seen in our past studies \u003csup\u003e\u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e15\u003c/span\u003e,\u003cspan citationid=\"CR17\" class=\"CitationRef\"\u003e16\u003c/span\u003e\u003c/sup\u003e. For example, we identified \u003cem\u003eCACNA1A\u003c/em\u003e variants in three unrelated probands in the absence of epilepsy or intellectual disability \u003csup\u003e\u003cspan citationid=\"CR37\" class=\"CitationRef\"\u003e36\u003c/span\u003e\u003c/sup\u003e. By extension from these data, milder forms of monogenic neurodevelopmental disorders are likely to be more common than currently recognised, and a case can be made for expanding the application of genomic sequencing to children (and adults) with mild and borderline ID.\u003c/p\u003e \u003cp\u003eIn the 71% of our cohort without a specific genetic diagnosis, a different phenotypic profile emerged. A significant majority of this group had average FSIQ and expected age of walking, and nearly half (47.7%) had either features of ASD, or a formal ASD diagnosis. The genetic basis of these undiagnosed cases remains unclear, but the clinical overlap with ASD implicates polygenic inheritance \u003csup\u003e\u003cspan citationid=\"CR38\" class=\"CitationRef\"\u003e37\u003c/span\u003e,\u003cspan citationid=\"CR39\" class=\"CitationRef\"\u003e38\u003c/span\u003e\u003c/sup\u003e. Based on these observations, we hypothesize that the genetic architecture of CAS comprises at least two distinct causal pathways: (1) monogenic CAS, characterised by variable cognitive impairment, motor impairment and syndromic features, and (2) polygenic CAS, in which cognition and motor skills are relatively spared, but ASD features are more common\u003c/p\u003e \u003cp\u003eThe association between CAS abnormalities on CMA has yet to be fully characterised. Only 4% of our cohort had a copy number variant. All six CNVs in our study are recognized recurrent CNVs with incomplete penetrance, and each was detected in only one patient. An additional 2% of patients had sex chromosome aneuploidies, including two patients with four sex chromosomes (XXYY and XYYY). The association between sex chromosome trisomies and quadrisomies has been previously recognized \u003csup\u003e\u003cspan citationid=\"CR40\" class=\"CitationRef\"\u003e39\u003c/span\u003e\u003c/sup\u003e. An overall yield of 6% for CMA in CAS is lower than reported previously in an Italian CAS cohort (13%) \u003csup\u003e\u003cspan citationid=\"CR18\" class=\"CitationRef\"\u003e17\u003c/span\u003e\u003c/sup\u003e and for intellectual disability, but comparable to the yield in some other neurodevelopmental phenotypes, such as autism and epilepsy, and microarray remains an important front-line test for motor speech disorders. By contrast, we found no cases of fragile X (neither premutation nor full mutation), suggesting that this test may be less useful in children with CAS.\u003c/p\u003e \u003cp\u003eWe found no significant evidence for environmental factors contributing to CAS, including pregnancy-related and neonatal complications. Moderate to late prematurity (32\u0026ndash;36 weeks) was reported in 5.5% of patients without a genetic diagnosis, comparable to the general population. Prematurity was not seen in any participants with a genetic diagnosis. Our data are in line with past studies showing no evidence of CAS or dysarthria diagnoses in children born pre-term \u003csup\u003e\u003cspan citationid=\"CR41\" class=\"CitationRef\"\u003e40\u003c/span\u003e\u003c/sup\u003e.\u003c/p\u003e \u003cp\u003eThe range of genetic diagnoses in our cohort underscore the role of chromatin modifiers and transcriptional regulators (BPTF, CAMTA1, CUX1, EBF3, EHMT1, FOXP1, KDM5C, NSD1, SET, SETD1A, SETD2, SETD5, SMARCA2, SETBP1, SRRM2) in speech disorder\u003c/p\u003e \u003cp\u003epathogenicity, consistent with our prior reports \u003csup\u003e\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e\u003c/sup\u003e. We highlight the commonality of genes encoding SET domain proteins (SETD1A, SETD2, SETD5, NSD1, EHMT1), as these are part of a methyltransferase superfamily integral in post translational protein regulation with a well-established role in neurodevelopmental disorders \u003csup\u003e\u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e15\u003c/span\u003e,\u003cspan citationid=\"CR17\" class=\"CitationRef\"\u003e16\u003c/span\u003e\u003c/sup\u003e. Other protein classes enriched for pathogenic variants were ion channel and solute carriers (ANK2, SCN8A, KCND3, CACNA1A, SLC6A1, SLC6A8) and cell signalling pathway members (FBXW7, PPP2R5D, TAB2, RAF1, SET).\u003c/p\u003e \u003cp\u003eWhilst further replication and verification of results is warranted given the modest size of our cohort, motor speech disorders are extremely rare (1 in 1000) when compared to other neurodevelopmental conditions (1 in 100 for intellectual disability, autism; 4\u0026ndash;10 per 1000 for epilepsy) and greater collaboration will be necessary to build sizeable cohorts for independent replication.\u003c/p\u003e \u003c/div\u003e"},{"header":"Conclusion","content":"\u003cp\u003eOur findings confirm a diagnostic yield for motor speech disorder that is comparable to other neurodevelopmental conditions. We have identified predictors of genetic diagnosis, that can be used to guide advances in clinical practice and health services for motor speech disorder. We suggest prioritisation of clinical genomic testing for children with a primary motor speech disorder on a background of delayed walking, persistent fine and gross motor delays/disorder, receptive language impairment, dysmorphism, and/or borderline IQ. The presence of ASD appears to be less commonly associated with a genetic diagnosis. Motor speech conditions are distinctive, socially debilitating disorders, and clinical genomic testing should be warranted to end the diagnostic odyssey and position them for precision therapies.\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e \u003ch2\u003eEthical Approval:\u003c/h2\u003e \u003cp\u003eThe study was approved by the Human Research Ethics Committee of The Royal Children\u0026rsquo;s Hospital, Melbourne, Australia (#37353). Written informed consent was obtained from all parents or legal guardians for their child to take part in our study and to publish their data. We have archived this data in our REDCap database held at the Murdoch Children\u0026rsquo;s Research Institute at the Royal Children\u0026rsquo;s Hospital campus.\u003c/p\u003e \u003c/p\u003e \u003cp\u003e \u003cstrong\u003eCompeting interests:\u003c/strong\u003e \u003cp\u003eThe authors have no competing interests relevant to this article to disclose.\u003c/p\u003e \u003c/p\u003e\u003ch2\u003eFunding:\u003c/h2\u003e \u003cp\u003eThis work was primarily funded by a Royal Children\u0026rsquo;s Hospital Foundation grant (AM, IS, DA). The work was also supported by National Health and Medical Research Council (NHMRC) Centre of Research Excellence Grants (CRE-SLANG: 1116976, AM, MH, IS, DA; and Translational Centre for Speech Disorders: 2015727, AM, IS, MH, DA) and an NHMRC project grant (1160893, AM, DA, MH). AM was supported by an NHMRC Practitioner Fellowship (1105008) and Investigator grant (1195955). DA is supported by the Lorenzo and Pamela Galli Research Trust. IS was supported by an NHMRC Investigator grant (1172897). Additional funding was provided by the Independent Research Institute Infrastructure Support Scheme and the Victorian State Government Operational Infrastructure Program. Open Access funding enabled and organized by CAUL and its Member Institutions.\u003c/p\u003e\u003ch2\u003eAuthor Contributions:\u003c/h2\u003e \u003cp\u003eProfessors Morgan and Amor conceptualized and designed the study, coordinated and supervised the study, collected data, carried out analyses, drafted the initial manuscript, and reviewed and revised the manuscript.\u003c/p\u003e\u003ch2\u003eData Availability Statement:\u003c/h2\u003e \u003cp\u003eThe datasets are included in this study and in supplementary information files or are available from the corresponding author on reasonable. Variant data is available in ClinVar (\u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003ehttps://www.ncbi.nlm.nih.gov/clinvar/\u003c/span\u003e\u003cspan address=\"https://www.ncbi.nlm.nih.gov/clinvar/\" targettype=\"URL\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e)\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eMorgan A, Ttofari Eecen K, Pezic A, et al. Who to Refer for Speech Therapy at 4 Years of Age Versus Who to \u0026quot;Watch and Wait\u0026quot;? \u003cem\u003eJ Pediatr\u003c/em\u003e. Jun 2017;185:200-204 e1. doi:10.1016/j.jpeds.2017.02.059\u003c/li\u003e\n\u003cli\u003eForce USPST, Barry MJ, Nicholson WK, et al. Screening for Speech and Language Delay and Disorders in Children: US Preventive Services Task Force Recommendation Statement. \u003cem\u003eJAMA\u003c/em\u003e. Jan 23 2024;331(4):329-334. doi:10.1001/jama.2023.26952\u003c/li\u003e\n\u003cli\u003eMorgan AT, Amor DJ, St John MD, Scheffer IE, Hildebrand MS. Genetic architecture of childhood speech disorder: a review. \u003cem\u003eMol Psychiatry\u003c/em\u003e. May 2024;29(5):1281-1292. doi:10.1038/s41380-024-02409-8\u003c/li\u003e\n\u003cli\u003eEadie P, Morgan A, Ukoumunne OC, Ttofari Eecen K, Wake M, Reilly S. Speech sound disorder at 4 years: prevalence, comorbidities, and predictors in a community cohort of children. \u003cem\u003eDev Med Child Neurol\u003c/em\u003e. Jun 2015;57(6):578-84. doi:10.1111/dmcn.12635\u003c/li\u003e\n\u003cli\u003eReilly S, McKean C, Morgan A, Wake M. Identifying and managing common childhood language and speech impairments. \u003cem\u003eBMJ\u003c/em\u003e. May 14 2015;350:h2318. doi:10.1136/bmj.h2318\u003c/li\u003e\n\u003cli\u003eShriberg LD, Aram DM, Kwiatkowski J. Developmental apraxia of speech: I. 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Expanding the molecular landscape of childhood apraxia of speech: evidence from a single-center experience. \u003cem\u003eFront Neurosci\u003c/em\u003e. 2024;18:1396240. doi:10.3389/fnins.2024.1396240\u003c/li\u003e\n\u003cli\u003eMitchel MW, Oetjens M, Berry ASF, et al. Monogenic disorders associated with motor speech phenotypes in children and adolescents undergoing clinical exome sequencing. \u003cem\u003eGenet Med\u003c/em\u003e. Feb 7 2025:101374. doi:10.1016/j.gim.2025.101374\u003c/li\u003e\n\u003cli\u003eMei C, Fedorenko E, Amor DJ, et al. Deep phenotyping of speech and language skills in individuals with 16p11.2 deletion. \u003cem\u003eEur J Hum Genet\u003c/em\u003e. May 2018;26(5):676-686. doi:10.1038/s41431-018-0102-x\u003c/li\u003e\n\u003cli\u003eMorison LD, Kennis MGP, Rots D, et al. Expanding the phenotype of Kleefstra syndrome: speech, language and cognition in 103 individuals. \u003cem\u003eJ Med Genet\u003c/em\u003e. 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San Antonio, TX: Pearson; 2012.\u003c/li\u003e\n\u003cli\u003eWechsler D. Wechsler Intelligence Scale for Children Fifth Edition (WISC-V). Bloomington, MN: Pearson 2014.\u003c/li\u003e\n\u003cli\u003eSadedin SP, Dashnow H, James PA, et al. Cpipe: a shared variant detection pipeline designed for diagnostic settings. \u003cem\u003eGenome Med\u003c/em\u003e. 2015;7(1):68. doi:10.1186/s13073- 015-0191-x\u003c/li\u003e\n\u003cli\u003eRichards S, Aziz N, Bale S, et al. Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. \u003cem\u003eGenet Med\u003c/em\u003e. May 2015;17(5):405-24. doi:10.1038/gim.2015.30\u003c/li\u003e\n\u003cli\u003eSheidley BR, Malinowski J, Bergner AL, et al. Genetic testing for the epilepsies: A systematic review. \u003cem\u003eEpilepsia\u003c/em\u003e. Feb 2022;63(2):375-387. doi:10.1111/epi.17141\u003c/li\u003e\n\u003cli\u003eStefanski A, Calle-Lopez Y, Leu C, Perez-Palma E, Pestana-Knight E, Lal D. Clinical sequencing yield in epilepsy, autism spectrum disorder, and intellectual disability: A systematic review and meta-analysis. \u003cem\u003eEpilepsia\u003c/em\u003e. Jan 2021;62(1):143-151. doi:10.1111/epi.16755\u003c/li\u003e\n\u003cli\u003eLewis SA, Chopra M, Cohen JS, et al. Clinical actionability of genetic findings in cerebral palsy. \u003cem\u003emedRxiv\u003c/em\u003e. Sep 11 2023;doi:10.1101/2023.09.08.23295195\u003c/li\u003e\n\u003cli\u003eManickam K, McClain MR, Demmer LA, et al. Exome and genome sequencing for pediatric patients with congenital anomalies or intellectual disability: an evidence- based clinical guideline of the American College of Medical Genetics and Genomics (ACMG). \u003cem\u003eGenet Med\u003c/em\u003e. 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Genomic architecture of autism from comprehensive whole-genome sequence annotation. \u003cem\u003eCell\u003c/em\u003e. Nov 10 2022;185(23):4409-4427 e18. doi:10.1016/j.cell.2022.10.009\u003c/li\u003e\n\u003cli\u003eSamango-Sprouse C, Keen C, Mitchell F, Sadeghin T, Gropman A. Neurodevelopmental variability in three young girls with a rare chromosomal disorder, 48, XXXX. \u003cem\u003eAm J Med Genet A\u003c/em\u003e. Oct 2015;167A(10):2251-9. doi:10.1002/ajmg.a.37198\u003c/li\u003e\n\u003cli\u003eNortham GB, Liegeois F, Chong WK, et al. Speech and oromotor outcome in adolescents born preterm: relationship to motor tract integrity. \u003cem\u003eJ Pediatr\u003c/em\u003e. Mar 2012;160(3):402-408 e1. doi:10.1016/j.jpeds.2011.08.055\u003c/li\u003e\n\u003c/ol\u003e"},{"header":"Tables","content":"\u003cp\u003eTable 1. Phenotype of participants with genetic diagnosis (n=44)\u0026nbsp;\u003c/p\u003e\n\u003ctable style=\"border-collapse: collapse;border: none;width: 1063px;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width: 28.4pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 16pt;vertical-align: top;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 16pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eSex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 16pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eAge y;m\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 16pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eSpeech diagnosis\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 16pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eGenetic diagnosis\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 70.9pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 16pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eDys-morphology\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 16pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eIQ\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 16pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eReceptive\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003elanguage\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 16pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eExpressive language\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 16pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eDelayed walking\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 16pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eGross motor impairment\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 16pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eFine motor impairment\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 16pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eASD\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003ediagnosis\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 16pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eADHD\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003ediagnosis\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width: 28.4pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid rgb(127, 127, 127);padding: 0in 5.4pt;height: 42pt;vertical-align: top;\"\u003e\n \u003cdiv style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\n \u003col style=\"margin-bottom:0in;list-style-type: decimal;\"\u003e\n \u003cli style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;font-size:13px;color:black;'\u003e1\u003c/span\u003e\u003c/strong\u003e\u003c/li\u003e\n \u003c/ol\u003e\n \u003c/div\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid rgb(127, 127, 127);padding: 0in 5.4pt;height: 42pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eM\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid rgb(127, 127, 127);padding: 0in 5.4pt;height: 42pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e5;5\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid rgb(127, 127, 127);padding: 0in 5.4pt;height: 42pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eCAS, PDis, Artic\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid rgb(127, 127, 127);padding: 0in 5.4pt;height: 42pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cem\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eADGRL1\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;border-bottom:solid #7F7F7F 1.0pt;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:42.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 63.8pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid rgb(127, 127, 127);background: rgb(250, 226, 213);padding: 0in 5.4pt;height: 42pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eBorderline\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid rgb(127, 127, 127);background: rgb(241, 169, 131);padding: 0in 5.4pt;height: 42pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eSevere\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid rgb(127, 127, 127);background: rgb(241, 169, 131);padding: 0in 5.4pt;height: 42pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eSevere\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border:none;border-bottom:solid #7F7F7F 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:42.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border:none;border-bottom:solid #7F7F7F 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:42.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border:none;border-bottom:solid #7F7F7F 1.0pt;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:42.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border:none;border-bottom:solid #7F7F7F 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:42.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;border-bottom:solid #7F7F7F 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:42.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 26.7pt;border: none;padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cdiv style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\n \u003col start=\"2\" style=\"margin-bottom:0in;list-style-type: decimal;\"\u003e\n \u003cli style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;font-size:13px;color:black;'\u003e744\u003c/span\u003e\u003c/strong\u003e\u003c/li\u003e\n \u003c/ol\u003e\n \u003c/div\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border: none;padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eM\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;border: none;padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e4;1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border: none;padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eCAS\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border: none;padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cem\u003e\u003cspan style='font-size:14px;font-family: \"Times New Roman\",serif;color:black;'\u003eANK2\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:17.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(246, 197, 172);padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eModerate\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(246, 197, 172);padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eModerate\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:17.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:17.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:17.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:17.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:17.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 26.7pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 13.75pt;vertical-align: top;\"\u003e\n \u003cdiv style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\n \u003col start=\"3\" style=\"margin-bottom:0in;list-style-type: decimal;\"\u003e\n \u003cli style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;font-size:13px;color:black;'\u003e622\u003c/span\u003e\u003c/strong\u003e\u003c/li\u003e\n \u003c/ol\u003e\n \u003c/div\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 13.75pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eF\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 13.75pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e5;5\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 13.75pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eCAS, DYS\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 13.75pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cem\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eBPTF\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:13.75pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;background: rgb(250, 226, 213);padding: 0in 5.4pt;height: 13.75pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eBorderline\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 13.75pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 13.75pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:13.75pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:13.75pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:13.75pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:13.75pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:13.75pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 26.7pt;border: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cdiv style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\n \u003col start=\"4\" style=\"margin-bottom:0in;list-style-type: decimal;\"\u003e\n \u003cli style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;font-size:13px;color:black;'\u003e888\u003c/span\u003e\u003c/strong\u003e\u003c/li\u003e\n \u003c/ol\u003e\n \u003c/div\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eM\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;border: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e4;10\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eCAS\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cem\u003e\u003cspan style='font-size:14px;font-family: \"Times New Roman\",serif;color:black;'\u003eCACNA1A\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(250, 226, 213);padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eMild\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border:none;background:#FAE2D5;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eFeatures\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 26.7pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cdiv style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\n \u003col start=\"5\" style=\"margin-bottom:0in;list-style-type: decimal;\"\u003e\n \u003cli style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;font-size:13px;color:black;'\u003e880\u003c/span\u003e\u003c/strong\u003e\u003c/li\u003e\n \u003c/ol\u003e\n \u003c/div\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eM\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e6;10\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eCAS, DYS\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cem\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eCACNA1A\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#FAE2D5;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eFeatures\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eLow average\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;background: rgb(241, 169, 131);padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eSevere\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border:none;border-bottom:solid #7F7F7F 1.0pt;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border:none;border-bottom:solid #7F7F7F 1.0pt;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 26.7pt;border: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cdiv style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\n \u003col start=\"6\" style=\"margin-bottom:0in;list-style-type: decimal;\"\u003e\n \u003cli style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;font-size:13px;color:black;'\u003e823\u003c/span\u003e\u003c/strong\u003e\u003c/li\u003e\n \u003c/ol\u003e\n \u003c/div\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eM\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;border: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e7;3\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eCAS\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cem\u003e\u003cspan style='font-size:14px;font-family: \"Times New Roman\",serif;color:black;'\u003eCACNA1A\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eAverage\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(241, 169, 131);padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eSevere\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border:none;background:#FAE2D5;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eFeatures\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;background:#FAE2D5;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eFeatures\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 26.7pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cdiv style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\n \u003col start=\"7\" style=\"margin-bottom:0in;list-style-type: decimal;\"\u003e\n \u003cli style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;font-size:13px;color:black;'\u003e601\u003c/span\u003e\u003c/strong\u003e\u003c/li\u003e\n \u003c/ol\u003e\n \u003c/div\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eF\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e3;4\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eCAS\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cem\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eCAMK2A\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;background: rgb(246, 197, 172);padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eMild\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eAverage\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eLow average\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#FAE2D5;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eFeatures\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 26.7pt;border: none;padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cdiv style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\n \u003col start=\"8\" style=\"margin-bottom:0in;list-style-type: decimal;\"\u003e\n \u003cli style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;font-size:13px;color:black;'\u003e420\u003c/span\u003e\u003c/strong\u003e\u003c/li\u003e\n \u003c/ol\u003e\n \u003c/div\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border: none;padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eM\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;border: none;padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e8;0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border: none;padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eCAS, DYS\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border: none;padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cem\u003e\u003cspan style='font-size:14px;font-family: \"Times New Roman\",serif;color:black;'\u003eCAMTA1\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;background:#FAE2D5;padding:0in 5.4pt 0in 5.4pt;height:17.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eFeatures\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eLow average\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(246, 197, 172);padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eModerate\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(241, 169, 131);padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eSevere\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:17.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:17.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:17.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:17.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:17.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 26.7pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cdiv style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\n \u003col start=\"9\" style=\"margin-bottom:0in;list-style-type: decimal;\"\u003e\n \u003cli style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;font-size:13px;color:black;'\u003e669\u003c/span\u003e\u003c/strong\u003e\u003c/li\u003e\n \u003c/ol\u003e\n \u003c/div\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eM\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e4;8\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eCAS, PDis\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cem\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eCUX1\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#FAE2D5;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eFeatures\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;background: rgb(250, 226, 213);padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eBorderline\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;background: rgb(241, 169, 131);padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eSevere\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;background: rgb(250, 226, 213);padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eMild\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 26.7pt;border: none;padding: 0in 5.4pt;height: 12.85pt;vertical-align: top;\"\u003e\n \u003cdiv style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\n \u003col start=\"10\" style=\"margin-bottom:0in;list-style-type: decimal;\"\u003e\n \u003cli style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;font-size:13px;color:black;'\u003e624\u003c/span\u003e\u003c/strong\u003e\u003c/li\u003e\n \u003c/ol\u003e\n \u003c/div\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border: none;padding: 0in 5.4pt;height: 12.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eM\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;border: none;padding: 0in 5.4pt;height: 12.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e17\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border: none;padding: 0in 5.4pt;height: 12.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eDYS\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border: none;padding: 0in 5.4pt;height: 12.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cem\u003e\u003cspan style='font-size:14px;font-family: \"Times New Roman\",serif;color:black;'\u003eEBF3\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:12.85pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;height: 12.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eHigh average\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;height: 12.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eAverage\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(250, 226, 213);padding: 0in 5.4pt;height: 12.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eMild\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:12.85pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:12.85pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:12.85pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border:none;background:#FAE2D5;padding:0in 5.4pt 0in 5.4pt;height:12.85pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eFeatures\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:12.85pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 26.7pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 16.6pt;vertical-align: top;\"\u003e\n \u003cdiv style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\n \u003col start=\"11\" style=\"margin-bottom:0in;list-style-type: decimal;\"\u003e\n \u003cli style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;font-size:13px;color:black;'\u003e649\u003c/span\u003e\u003c/strong\u003e\u003c/li\u003e\n \u003c/ol\u003e\n \u003c/div\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 16.6pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eM\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 16.6pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e4;3\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 16.6pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eCAS\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 16.6pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cem\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eEHMT1\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:16.6pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;background: rgb(246, 197, 172);padding: 0in 5.4pt;height: 16.6pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eMild\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 16.6pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 16.6pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:16.6pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:16.6pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:16.6pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:16.6pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:16.6pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 26.7pt;border: none;padding: 0in 5.4pt;height: 2.55pt;vertical-align: top;\"\u003e\n \u003cdiv style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\n \u003col start=\"12\" style=\"margin-bottom:0in;list-style-type: decimal;\"\u003e\n \u003cli style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;font-size:13px;color:black;'\u003e762\u003c/span\u003e\u003c/strong\u003e\u003c/li\u003e\n \u003c/ol\u003e\n \u003c/div\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border: none;padding: 0in 5.4pt;height: 2.55pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eM\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;border: none;padding: 0in 5.4pt;height: 2.55pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e6;1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border: none;padding: 0in 5.4pt;height: 2.55pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eCAS, PDel\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border: none;padding: 0in 5.4pt;height: 2.55pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cem\u003e\u003cspan style='font-size:14px;font-family: \"Times New Roman\",serif;color:black;'\u003eEHMT1\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:2.55pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 63.8pt;border: none;background: rgb(250, 226, 213);padding: 0in 5.4pt;height: 2.55pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eBorderline\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(250, 226, 213);padding: 0in 5.4pt;height: 2.55pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eMild\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(241, 169, 131);padding: 0in 5.4pt;height: 2.55pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eSevere\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:2.55pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:2.55pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:2.55pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:2.55pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:2.55pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 26.7pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 17.3pt;vertical-align: top;\"\u003e\n \u003cdiv style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\n \u003col start=\"13\" style=\"margin-bottom:0in;list-style-type: decimal;\"\u003e\n \u003cli style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;font-size:13px;color:black;'\u003e664\u003c/span\u003e\u003c/strong\u003e\u003c/li\u003e\n \u003c/ol\u003e\n \u003c/div\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 17.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eM\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 17.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e6;7\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 17.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eCAS, PDel\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 17.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cem\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eFBXW7\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:17.3pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;background: rgb(246, 197, 172);padding: 0in 5.4pt;height: 17.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eMild\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;background: rgb(241, 169, 131);padding: 0in 5.4pt;height: 17.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eSevere\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;background: rgb(241, 169, 131);padding: 0in 5.4pt;height: 17.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eSevere\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:17.3pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:17.3pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:17.3pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:17.3pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:17.3pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 26.7pt;border: none;padding: 0in 5.4pt;height: 14.3pt;vertical-align: top;\"\u003e\n \u003cdiv style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\n \u003col start=\"14\" style=\"margin-bottom:0in;list-style-type: decimal;\"\u003e\n \u003cli style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;font-size:13px;color:black;'\u003e689\u003c/span\u003e\u003c/strong\u003e\u003c/li\u003e\n \u003c/ol\u003e\n \u003c/div\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border: none;padding: 0in 5.4pt;height: 14.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eM\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;border: none;padding: 0in 5.4pt;height: 14.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e4;6\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border: none;padding: 0in 5.4pt;height: 14.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eCAS, PDel\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border: none;padding: 0in 5.4pt;height: 14.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cem\u003e\u003cspan style='font-size:14px;font-family: \"Times New Roman\",serif;color:black;'\u003eFOXP1\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:14.3pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;height: 14.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(246, 197, 172);padding: 0in 5.4pt;height: 14.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eModerate\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(241, 169, 131);padding: 0in 5.4pt;height: 14.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eSevere\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:14.3pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:14.3pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:14.3pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border:none;background:#FAE2D5;padding:0in 5.4pt 0in 5.4pt;height:14.3pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eFeatures\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:14.3pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 26.7pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 14.05pt;vertical-align: top;\"\u003e\n \u003cdiv style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\n \u003col start=\"15\" style=\"margin-bottom:0in;list-style-type: decimal;\"\u003e\n \u003cli style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;font-size:13px;color:black;'\u003e505\u003c/span\u003e\u003c/strong\u003e\u003c/li\u003e\n \u003c/ol\u003e\n \u003c/div\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 14.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eF\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 14.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e4;3\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 14.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eCAS, PDis\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 14.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cem\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eGNAI1\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:14.05pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;background: rgb(250, 226, 213);padding: 0in 5.4pt;height: 14.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eBorderline\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;background: rgb(250, 226, 213);padding: 0in 5.4pt;height: 14.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eMild\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;background: rgb(241, 169, 131);padding: 0in 5.4pt;height: 14.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eSevere\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:14.05pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:14.05pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:14.05pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:14.05pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:14.05pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 26.7pt;border: none;padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cdiv style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\n \u003col start=\"16\" style=\"margin-bottom:0in;list-style-type: decimal;\"\u003e\n \u003cli style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;font-size:13px;color:black;'\u003e584\u003c/span\u003e\u003c/strong\u003e\u003c/li\u003e\n \u003c/ol\u003e\n \u003c/div\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border: none;padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eF\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;border: none;padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e4;2\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border: none;padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eCAS\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border: none;padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cem\u003e\u003cspan style='font-size:14px;font-family: \"Times New Roman\",serif;color:black;'\u003eKCND3\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:17.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 63.8pt;border: none;background: rgb(250, 226, 213);padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eBorderline\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(246, 197, 172);padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eModerate\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(246, 197, 172);padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eModerate\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:17.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:17.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:17.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:17.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:17.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 26.7pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 15.3pt;vertical-align: top;\"\u003e\n \u003cdiv style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\n \u003col start=\"17\" style=\"margin-bottom:0in;list-style-type: decimal;\"\u003e\n \u003cli style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;font-size:13px;color:black;'\u003e694\u003c/span\u003e\u003c/strong\u003e\u003c/li\u003e\n \u003c/ol\u003e\n \u003c/div\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 15.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eM\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 15.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e3;7\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 15.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eCAS, PDis\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 15.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cem\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eKDM5C\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.3pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 15.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eAverage\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 15.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;background: rgb(241, 169, 131);padding: 0in 5.4pt;height: 15.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eSevere\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.3pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.3pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.3pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:15.3pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#FAE2D5;padding:0in 5.4pt 0in 5.4pt;height:15.3pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eFeatures\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 26.7pt;border: none;padding: 0in 5.4pt;height: 30.1pt;vertical-align: top;\"\u003e\n \u003cdiv style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\n \u003col start=\"18\" style=\"margin-bottom:0in;list-style-type: decimal;\"\u003e\n \u003cli style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;font-size:13px;color:black;'\u003e659\u003c/span\u003e\u003c/strong\u003e\u003c/li\u003e\n \u003c/ol\u003e\n \u003c/div\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border: none;padding: 0in 5.4pt;height: 30.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eF\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;border: none;padding: 0in 5.4pt;height: 30.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e5;9\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border: none;padding: 0in 5.4pt;height: 30.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eCAS, Stutter, PDel\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border: none;padding: 0in 5.4pt;height: 30.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cem\u003e\u003cspan style='font-size:14px;font-family: \"Times New Roman\",serif;color:black;'\u003eNSD1\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:30.1pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 63.8pt;border: none;background: rgb(250, 226, 213);padding: 0in 5.4pt;height: 30.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eBorderline\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(250, 226, 213);padding: 0in 5.4pt;height: 30.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eMild\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(241, 169, 131);padding: 0in 5.4pt;height: 30.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eSevere\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:30.1pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:30.1pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:30.1pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:30.1pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:30.1pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 26.7pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cdiv style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\n \u003col start=\"19\" style=\"margin-bottom:0in;list-style-type: decimal;\"\u003e\n \u003cli style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;font-size:13px;color:black;'\u003e670\u003c/span\u003e\u003c/strong\u003e\u003c/li\u003e\n \u003c/ol\u003e\n \u003c/div\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eF\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e3;7\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eCAS\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cem\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003ePPP2R5D\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eAverage\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 26.7pt;border: none;padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cdiv style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\n \u003col start=\"20\" style=\"margin-bottom:0in;list-style-type: decimal;\"\u003e\n \u003cli style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;font-size:13px;color:black;'\u003e758\u003c/span\u003e\u003c/strong\u003e\u003c/li\u003e\n \u003c/ol\u003e\n \u003c/div\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border: none;padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eF\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;border: none;padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e4;6\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border: none;padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eCAS\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border: none;padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cem\u003e\u003cspan style='font-size:14px;font-family: \"Times New Roman\",serif;color:black;'\u003eRAF1\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;background:#FAE2D5;padding:0in 5.4pt 0in 5.4pt;height:17.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eFeatures\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(250, 226, 213);padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eMild\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(241, 169, 131);padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eSevere\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:17.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:17.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:17.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border:none;background:#FAE2D5;padding:0in 5.4pt 0in 5.4pt;height:17.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eFeatures\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:17.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 26.7pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cdiv style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\n \u003col start=\"21\" style=\"margin-bottom:0in;list-style-type: decimal;\"\u003e\n \u003cli style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;font-size:13px;color:black;'\u003e804\u003c/span\u003e\u003c/strong\u003e\u003c/li\u003e\n \u003c/ol\u003e\n \u003c/div\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eF\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e4;6\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eCAS\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cem\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eSCN8A\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#FAE2D5;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eFeatures\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eLow average\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eAverage\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;background: rgb(250, 226, 213);padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eMild\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 26.7pt;border: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cdiv style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\n \u003col start=\"22\" style=\"margin-bottom:0in;list-style-type: decimal;\"\u003e\n \u003cli style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;font-size:13px;color:black;'\u003e301\u003c/span\u003e\u003c/strong\u003e\u003c/li\u003e\n \u003c/ol\u003e\n \u003c/div\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eF\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;border: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e10;9\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eCAS, PDel\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cem\u003e\u003cspan style='font-size:14px;font-family: \"Times New Roman\",serif;color:black;'\u003eSET\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 63.8pt;border: none;background: rgb(250, 226, 213);padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eBorderline\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(250, 226, 213);padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eMild\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(241, 169, 131);padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eSevere\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 26.7pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cdiv style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\n \u003col start=\"23\" style=\"margin-bottom:0in;list-style-type: decimal;\"\u003e\n \u003cli style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;font-size:13px;color:black;'\u003e617\u003c/span\u003e\u003c/strong\u003e\u003c/li\u003e\n \u003c/ol\u003e\n \u003c/div\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eF\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e3;9\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eCAS, PDis\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cem\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eSETBP1\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;background: rgb(246, 197, 172);padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eMild\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 26.7pt;border: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cdiv style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\n \u003col start=\"24\" style=\"margin-bottom:0in;list-style-type: decimal;\"\u003e\n \u003cli style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;font-size:13px;color:black;'\u003e653\u003c/span\u003e\u003c/strong\u003e\u003c/li\u003e\n \u003c/ol\u003e\n \u003c/div\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eF\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;border: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e14;6\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eCAS, DYS\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cem\u003e\u003cspan style='font-size:14px;font-family: \"Times New Roman\",serif;color:black;'\u003eSETBP1\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 63.8pt;border: none;background: rgb(246, 197, 172);padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eMild\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(250, 226, 213);padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eMild\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(250, 226, 213);padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eMild\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 26.7pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 15.65pt;vertical-align: top;\"\u003e\n \u003cdiv style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\n \u003col start=\"25\" style=\"margin-bottom:0in;list-style-type: decimal;\"\u003e\n \u003cli style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;font-size:13px;color:black;'\u003e905\u003c/span\u003e\u003c/strong\u003e\u003c/li\u003e\n \u003c/ol\u003e\n \u003c/div\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 15.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eM\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 15.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e3;11\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 15.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eCAS\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 15.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cem\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eSETD1A\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:15.65pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 15.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eLow average\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 15.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eAverage\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;background: rgb(246, 197, 172);padding: 0in 5.4pt;height: 15.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eModerate\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:15.65pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:15.65pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:15.65pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.65pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:15.65pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 26.7pt;border: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cdiv style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\n \u003col start=\"26\" style=\"margin-bottom:0in;list-style-type: decimal;\"\u003e\n \u003cli style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;font-size:13px;color:black;'\u003e846\u003c/span\u003e\u003c/strong\u003e\u003c/li\u003e\n \u003c/ol\u003e\n \u003c/div\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eM\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;border: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e4;8\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eCAS\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cem\u003e\u003cspan style='font-size:14px;font-family: \"Times New Roman\",serif;color:black;'\u003eSETD2\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;background:#FAE2D5;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eFeatures\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 26.7pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cdiv style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\n \u003col start=\"27\" style=\"margin-bottom:0in;list-style-type: decimal;\"\u003e\n \u003cli style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;font-size:13px;color:black;'\u003e834\u003c/span\u003e\u003c/strong\u003e\u003c/li\u003e\n \u003c/ol\u003e\n \u003c/div\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eF\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e5;2\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eCAS\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cem\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eSETD5\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;background: rgb(246, 197, 172);padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eModerate\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;background: rgb(241, 169, 131);padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eSevere\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 26.7pt;border: none;padding: 0in 5.4pt;height: 14pt;vertical-align: top;\"\u003e\n \u003cdiv style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\n \u003col start=\"28\" style=\"margin-bottom:0in;list-style-type: decimal;\"\u003e\n \u003cli style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;font-size:13px;color:black;'\u003e768\u003c/span\u003e\u003c/strong\u003e\u003c/li\u003e\n \u003c/ol\u003e\n \u003c/div\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border: none;padding: 0in 5.4pt;height: 14pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eM\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;border: none;padding: 0in 5.4pt;height: 14pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e3;5\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border: none;padding: 0in 5.4pt;height: 14pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eCAS, PDis\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border: none;padding: 0in 5.4pt;height: 14pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cem\u003e\u003cspan style='font-size:14px;font-family: \"Times New Roman\",serif;color:black;'\u003eSLC6A1\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;height: 14pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(250, 226, 213);padding: 0in 5.4pt;height: 14pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eMild\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(246, 197, 172);padding: 0in 5.4pt;height: 14pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eModerate\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 26.7pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 16.2pt;vertical-align: top;\"\u003e\n \u003cdiv style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\n \u003col start=\"29\" style=\"margin-bottom:0in;list-style-type: decimal;\"\u003e\n \u003cli style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;font-size:13px;color:black;'\u003e695\u003c/span\u003e\u003c/strong\u003e\u003c/li\u003e\n \u003c/ol\u003e\n \u003c/div\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 16.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eF\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 16.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e16;5\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 16.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eDYS\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 16.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cem\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eSLC6A8\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#FAE2D5;padding:0in 5.4pt 0in 5.4pt;height:16.2pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eFeatures\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;background: rgb(246, 197, 172);padding: 0in 5.4pt;height: 16.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eMild\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;background: rgb(246, 197, 172);padding: 0in 5.4pt;height: 16.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eModerate\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;background: rgb(241, 169, 131);padding: 0in 5.4pt;height: 16.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eSevere\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:16.2pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:16.2pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:16.2pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:16.2pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:16.2pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 26.7pt;border: none;padding: 0in 5.4pt;height: 16.2pt;vertical-align: top;\"\u003e\n \u003cdiv style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\n \u003col start=\"30\" style=\"margin-bottom:0in;list-style-type: decimal;\"\u003e\n \u003cli style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;font-size:13px;color:black;'\u003e673\u003c/span\u003e\u003c/strong\u003e\u003c/li\u003e\n \u003c/ol\u003e\n \u003c/div\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border: none;padding: 0in 5.4pt;height: 16.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eF\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;border: none;padding: 0in 5.4pt;height: 16.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e3;6\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border: none;padding: 0in 5.4pt;height: 16.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eCAS, PDis\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border: none;padding: 0in 5.4pt;height: 16.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cem\u003e\u003cspan style='font-size:14px;font-family: \"Times New Roman\",serif;color:black;'\u003eSMARCA2\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:16.2pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;height: 16.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eLow average\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;height: 16.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eLow average\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;height: 16.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eAverage\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:16.2pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:16.2pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:16.2pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:16.2pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:16.2pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 26.7pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cdiv style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\n \u003col start=\"31\" style=\"margin-bottom:0in;list-style-type: decimal;\"\u003e\n \u003cli style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;font-size:13px;color:black;'\u003e586\u003c/span\u003e\u003c/strong\u003e\u003c/li\u003e\n \u003c/ol\u003e\n \u003c/div\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eM\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e3;9\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eCAS\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cem\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eSMARCA2\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;background: rgb(246, 197, 172);padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eMild\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;background: rgb(241, 169, 131);padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eSevere\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;background: rgb(241, 169, 131);padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eSevere\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 26.7pt;border: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cdiv style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\n \u003col start=\"32\" style=\"margin-bottom:0in;list-style-type: decimal;\"\u003e\n \u003cli style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;font-size:13px;color:black;'\u003e663\u003c/span\u003e\u003c/strong\u003e\u003c/li\u003e\n \u003c/ol\u003e\n \u003c/div\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eM\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;border: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e7;3\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eCAS, PDis, Artic\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cem\u003e\u003cspan style='font-size:14px;font-family: \"Times New Roman\",serif;color:black;'\u003eSPTBN1\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 63.8pt;border: none;background: rgb(250, 226, 213);padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eBorderline\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(241, 169, 131);padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eSevere\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(241, 169, 131);padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eSevere\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border:none;background:#FAE2D5;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eFeatures\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 26.7pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cdiv style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\n \u003col start=\"33\" style=\"margin-bottom:0in;list-style-type: decimal;\"\u003e\n \u003cli style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;font-size:13px;color:black;'\u003e666\u003c/span\u003e\u003c/strong\u003e\u003c/li\u003e\n \u003c/ol\u003e\n \u003c/div\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eM\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e13\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eCAS, PDis\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cem\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eSRRM2\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;background: rgb(250, 226, 213);padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eBorderline\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 26.7pt;border: none;padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cdiv style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\n \u003col start=\"34\" style=\"margin-bottom:0in;list-style-type: decimal;\"\u003e\n \u003cli style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;font-size:13px;color:black;'\u003e777\u003c/span\u003e\u003c/strong\u003e\u003c/li\u003e\n \u003c/ol\u003e\n \u003c/div\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border: none;padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eM\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;border: none;padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e7;2\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border: none;padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eCAS\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border: none;padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cem\u003e\u003cspan style='font-size:14px;font-family: \"Times New Roman\",serif;color:black;'\u003eTAB2\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:17.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(250, 226, 213);padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eBelow average\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(250, 226, 213);padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eBelow average\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:17.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:17.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:17.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:17.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:17.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 26.7pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cdiv style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\n \u003col start=\"35\" style=\"margin-bottom:0in;list-style-type: decimal;\"\u003e\n \u003cli style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;font-size:13px;color:black;'\u003e507\u003c/span\u003e\u003c/strong\u003e\u003c/li\u003e\n \u003c/ol\u003e\n \u003c/div\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eM\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e4;2\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eCAS, PDis\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cem\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eTRIM8\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;background: rgb(246, 197, 172);padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eMild\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;background: rgb(241, 169, 131);padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eSevere\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;background: rgb(241, 169, 131);padding: 0in 5.4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eSevere\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#FAE2D5;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eFeatures\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:10.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width: 28.4pt;border: none;padding: 0in 5.4pt;height: 17.05pt;vertical-align: top;\"\u003e\n \u003cdiv style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\n \u003col start=\"36\" style=\"margin-bottom:0in;list-style-type: decimal;\"\u003e\n \u003cli style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;font-size:13px;color:black;'\u003e677\u003c/span\u003e\u003c/strong\u003e\u003c/li\u003e\n \u003c/ol\u003e\n \u003c/div\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border: none;padding: 0in 5.4pt;height: 17.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eM\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;border: none;padding: 0in 5.4pt;height: 17.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e5;3\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border: none;padding: 0in 5.4pt;height: 17.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eCAS\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border: none;padding: 0in 5.4pt;height: 17.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e1q21.1q21.2 dup\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:17.05pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;height: 17.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eAverage\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;height: 17.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;height: 17.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:17.05pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:17.05pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:17.05pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:17.05pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:17.05pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 26.7pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cdiv style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\n \u003col start=\"37\" style=\"margin-bottom:0in;list-style-type: decimal;\"\u003e\n \u003cli style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;font-size:13px;color:black;'\u003e414\u003c/span\u003e\u003c/strong\u003e\u003c/li\u003e\n \u003c/ol\u003e\n \u003c/div\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eM\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e9;7\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eCAS, PDis\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e15q13.2q13.3 del\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:14.5pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;background: rgb(250, 226, 213);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eBorderline\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;background: rgb(250, 226, 213);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eMild\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;background: rgb(241, 169, 131);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eSevere\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:14.5pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:14.5pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:14.5pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:14.5pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:14.5pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 26.7pt;border: none;padding: 0in 5.4pt;height: 15.1pt;vertical-align: top;\"\u003e\n \u003cdiv style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\n \u003col start=\"38\" style=\"margin-bottom:0in;list-style-type: decimal;\"\u003e\n \u003cli style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;font-size:13px;color:black;'\u003e697\u003c/span\u003e\u003c/strong\u003e\u003c/li\u003e\n \u003c/ol\u003e\n \u003c/div\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border: none;padding: 0in 5.4pt;height: 15.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eM\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;border: none;padding: 0in 5.4pt;height: 15.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e5;1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border: none;padding: 0in 5.4pt;height: 15.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eCAS, PDel\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border: none;padding: 0in 5.4pt;height: 15.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e16p12.2 del\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;background:#FAE2D5;padding:0in 5.4pt 0in 5.4pt;height:15.1pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eFeatures\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;height: 15.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eAverage\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(246, 197, 172);padding: 0in 5.4pt;height: 15.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eModerate\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;height: 15.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eAverage\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:15.1pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:15.1pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:15.1pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:15.1pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:15.1pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 26.7pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cdiv style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\n \u003col start=\"39\" style=\"margin-bottom:0in;list-style-type: decimal;\"\u003e\n \u003cli style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;font-size:13px;color:black;'\u003e810\u003c/span\u003e\u003c/strong\u003e\u003c/li\u003e\n \u003c/ol\u003e\n \u003c/div\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eM\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e5;2\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eCAS\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e17q12 dup\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:17.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eAverage\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:17.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:17.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:17.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:17.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:17.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;border-bottom:solid #7F7F7F 1.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 26.7pt;border: none;padding: 0in 5.4pt;height: 16.65pt;vertical-align: top;\"\u003e\n \u003cdiv style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\n \u003col start=\"40\" style=\"margin-bottom:0in;list-style-type: decimal;\"\u003e\n \u003cli style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;font-size:13px;color:black;'\u003e443\u003c/span\u003e\u003c/strong\u003e\u003c/li\u003e\n \u003c/ol\u003e\n \u003c/div\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border: none;padding: 0in 5.4pt;height: 16.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eM\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;border: none;padding: 0in 5.4pt;height: 16.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e4;9\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border: none;padding: 0in 5.4pt;height: 16.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eCAS\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border: none;padding: 0in 5.4pt;height: 16.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e22q11.21 del\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:16.65pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;height: 16.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;height: 16.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;height: 16.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:16.65pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:16.65pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:16.65pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:16.65pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:16.65pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width: 28.4pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid rgb(127, 127, 127);padding: 0in 5.4pt;height: 27.45pt;vertical-align: top;\"\u003e\n \u003cdiv style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\n \u003col start=\"41\" style=\"margin-bottom:0in;list-style-type: decimal;\"\u003e\n \u003cli style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;font-size:13px;color:black;'\u003e685\u003c/span\u003e\u003c/strong\u003e\u003c/li\u003e\n \u003c/ol\u003e\n \u003c/div\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 27.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eM\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 27.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e6;6\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 27.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eCAS, Stutter, PDel\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 27.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e22q11.21q11.22 dup\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:27.45pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 27.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eAverage\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 27.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eAverage\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;height: 27.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eAverage\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:27.45pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:27.45pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:27.45pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:27.45pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border-top:solid #7F7F7F 1.0pt;border-left:none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:27.45pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width: 28.4pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 11.8pt;vertical-align: top;\"\u003e\n \u003cdiv style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\n \u003col start=\"42\" style=\"margin-bottom:0in;list-style-type: decimal;\"\u003e\n \u003cli style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;font-size:13px;color:black;'\u003e681\u003c/span\u003e\u003c/strong\u003e\u003c/li\u003e\n \u003c/ol\u003e\n \u003c/div\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 11.8pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eF\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 11.8pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e4;1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 11.8pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eCAS, DYS\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 11.8pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e47, XXX\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;border-bottom:solid windowtext 1.0pt;background:#FAE2D5;padding:0in 5.4pt 0in 5.4pt;height:11.8pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eFeatures\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 63.8pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 11.8pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eHigh average\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 11.8pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eAverage\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 11.8pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:11.8pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border:none;border-bottom:solid windowtext 1.0pt;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:11.8pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border:none;border-bottom:solid windowtext 1.0pt;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:11.8pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:11.8pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:11.8pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width: 28.4pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid rgb(127, 127, 127);padding: 0in 5.4pt;height: 11.8pt;vertical-align: top;\"\u003e\n \u003cdiv style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\n \u003col start=\"43\" style=\"margin-bottom:0in;list-style-type: decimal;\"\u003e\n \u003cli style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;font-size:13px;color:black;'\u003e789\u003c/span\u003e\u003c/strong\u003e\u003c/li\u003e\n \u003c/ol\u003e\n \u003c/div\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid rgb(127, 127, 127);padding: 0in 5.4pt;height: 11.8pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eM\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid rgb(127, 127, 127);padding: 0in 5.4pt;height: 11.8pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e8;5\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid rgb(127, 127, 127);padding: 0in 5.4pt;height: 11.8pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eCAS, DYS\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid rgb(127, 127, 127);padding: 0in 5.4pt;height: 11.8pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e48, XXYY\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;border-bottom:solid #7F7F7F 1.0pt;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:11.8pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 63.8pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid rgb(127, 127, 127);padding: 0in 5.4pt;height: 11.8pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eLow average\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid rgb(127, 127, 127);background: rgb(246, 197, 172);padding: 0in 5.4pt;height: 11.8pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eModerate\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid rgb(127, 127, 127);padding: 0in 5.4pt;height: 11.8pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border:none;border-bottom:solid #7F7F7F 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:11.8pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border:none;border-bottom:solid #7F7F7F 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:11.8pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border:none;border-bottom:solid #7F7F7F 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:11.8pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border:none;border-bottom:solid #7F7F7F 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:11.8pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;border-bottom:solid #7F7F7F 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:11.8pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width: 28.4pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid rgb(127, 127, 127);padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cdiv style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\n \u003col start=\"44\" style=\"margin-bottom:0in;list-style-type: decimal;\"\u003e\n \u003cli style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;font-size:13px;color:black;'\u003e794\u003c/span\u003e\u003c/strong\u003e\u003c/li\u003e\n \u003c/ol\u003e\n \u003c/div\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid rgb(127, 127, 127);padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003eM\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid rgb(127, 127, 127);padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e6\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid rgb(127, 127, 127);padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eCAS\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid rgb(127, 127, 127);padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e48, XYYY\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;border-bottom:solid #7F7F7F 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:17.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 63.8pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid rgb(127, 127, 127);padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eLow average\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid rgb(127, 127, 127);padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eAverage\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid rgb(127, 127, 127);padding: 0in 5.4pt;height: 17pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eAverage\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border:none;border-bottom:solid #7F7F7F 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:17.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border:none;border-bottom:solid #7F7F7F 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:17.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border:none;border-bottom:solid #7F7F7F 1.0pt;background:#F6C5AC;padding:0in 5.4pt 0in 5.4pt;height:17.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;color:black;'\u003e+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border:none;border-bottom:solid #7F7F7F 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:17.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;border-bottom:solid #7F7F7F 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:17.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;text-align:center;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eF: female; M: male; y: year: m: month; CAS: childhood apraxia of speech; PDis: Phonological disorder; PDel: Phonological delay; DYS: Dysarthria; +: Present; -: Absent; IQ: Full Scale Intelligence Quotient; blank: not tested; ASD: Autism spectrum disorder; ADHD: Attention deficit hyperactivity.\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin:0in;font-size:16px;font-family:\"Aptos\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eTable 2. Genetic diagnoses N=44\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e2a. Monogenic findings (including single nucleotide variations and intragenic deletions), n=35\u0026nbsp;\u003c/p\u003e\n\u003ctable border=\"1\" cellspacing=\"0\" cellpadding=\"0\" width=\"869\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 47px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eID\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 95px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eGene\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 265px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eVariant (GRCh38/hg38)\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eChr\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 140px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eInheritance\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 82px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eACMG Class\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 184px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eType\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 47px;\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 95px;\"\u003e\n \u003cp\u003e\u003cem\u003eADGRL1\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 265px;\"\u003e\n \u003cp\u003eg. 14151115_14152393del\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\n \u003cp\u003e19\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 140px;\"\u003e\n \u003cp\u003eMaternal\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 82px;\"\u003e\n \u003cp\u003e5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 184px;\"\u003e\n \u003cp\u003eDeletion\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 47px;\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 95px;\"\u003e\n \u003cp\u003e\u003cem\u003eANK2\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 265px;\"\u003e\n \u003cp\u003ec.9539_9545delinsTGGATGATGAG; p.(Asp3180Valfs*7)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\n \u003cp\u003e4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 140px;\"\u003e\n \u003cp\u003ePaternal\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 82px;\"\u003e\n \u003cp\u003e5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 184px;\"\u003e\n \u003cp\u003eFrameshift\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 47px;\"\u003e\n \u003cp\u003e3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 95px;\"\u003e\n \u003cp\u003e\u003cem\u003eBPTF\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 265px;\"\u003e\n \u003cp\u003ec.3157_3158delAA; p.(Lys1053Glufs*12)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\n \u003cp\u003e17\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 140px;\"\u003e\n \u003cp\u003e\u003cem\u003eDe novo\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 82px;\"\u003e\n \u003cp\u003e5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 184px;\"\u003e\n \u003cp\u003eFrameshift\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 47px;\"\u003e\n \u003cp\u003e4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 95px;\"\u003e\n \u003cp\u003e\u003cem\u003eCACNA1A\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 265px;\"\u003e\n \u003cp\u003ec.3829C\u0026gt;T; p.(Arg1277*)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\n \u003cp\u003e19\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 140px;\"\u003e\n \u003cp\u003ePaternal\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 82px;\"\u003e\n \u003cp\u003e5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 184px;\"\u003e\n \u003cp\u003eNonsense\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 47px;\"\u003e\n \u003cp\u003e5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 95px;\"\u003e\n \u003cp\u003e\u003cem\u003eCACNA1A\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 265px;\"\u003e\n \u003cp\u003ec.492C\u0026gt;G; p.(Tyr164*)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\n \u003cp\u003e19\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 140px;\"\u003e\n \u003cp\u003eMaternal\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 82px;\"\u003e\n \u003cp\u003e5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 184px;\"\u003e\n \u003cp\u003eNonsense\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 47px;\"\u003e\n \u003cp\u003e6\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 95px;\"\u003e\n \u003cp\u003e\u003cem\u003eCACNA1A\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 265px;\"\u003e\n \u003cp\u003ec.592C\u0026gt;T; p.(Arg198*)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\n \u003cp\u003e19\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 140px;\"\u003e\n \u003cp\u003eMaternal\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 82px;\"\u003e\n \u003cp\u003e5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 184px;\"\u003e\n \u003cp\u003eNonsense\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 47px;\"\u003e\n \u003cp\u003e7\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 95px;\"\u003e\n \u003cp\u003e\u003cem\u003eCAMK2A\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 265px;\"\u003e\n \u003cp\u003ec.635C\u0026gt;T; p.(Pro212Leu)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\n \u003cp\u003e5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 140px;\"\u003e\n \u003cp\u003e\u003cem\u003eDe novo\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 82px;\"\u003e\n \u003cp\u003e5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 184px;\"\u003e\n \u003cp\u003eMissense\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 47px;\"\u003e\n \u003cp\u003e8\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 95px;\"\u003e\n \u003cp\u003e\u003cem\u003eCAMTA1\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 265px;\"\u003e\n \u003cp\u003ec.2072_2075del; p.(Thr691Argfs*35)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 140px;\"\u003e\n \u003cp\u003e\u003cem\u003eDe novo\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 82px;\"\u003e\n \u003cp\u003e5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 184px;\"\u003e\n \u003cp\u003eFrameshift\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 47px;\"\u003e\n \u003cp\u003e9\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 95px;\"\u003e\n \u003cp\u003e\u003cem\u003eCUX1\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 265px;\"\u003e\n \u003cp\u003eg.102070411_102114170del\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\n \u003cp\u003e7\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 140px;\"\u003e\n \u003cp\u003eUnknown\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 82px;\"\u003e\n \u003cp\u003e4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 184px;\"\u003e\n \u003cp\u003eIntragenic deletion exon 4-7\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 47px;\"\u003e\n \u003cp\u003e10\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 95px;\"\u003e\n \u003cp\u003e\u003cem\u003eEBF3\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 265px;\"\u003e\n \u003cp\u003ec.708_710delCAA; p.(Asn237del)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\n \u003cp\u003e10\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 140px;\"\u003e\n \u003cp\u003e\u003cem\u003eDe novo\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 82px;\"\u003e\n \u003cp\u003e5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 184px;\"\u003e\n \u003cp\u003eDeletion\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 47px;\"\u003e\n \u003cp\u003e11\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 95px;\"\u003e\n \u003cp\u003e\u003cem\u003eEHMT1\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 265px;\"\u003e\n \u003cp\u003ec.3229C\u0026gt;T; p.Gln1077* (GRCh37)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\n \u003cp\u003e9\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 140px;\"\u003e\n \u003cp\u003eUnknown\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 82px;\"\u003e\n \u003cp\u003e5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 184px;\"\u003e\n \u003cp\u003eNonsense\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 47px;\"\u003e\n \u003cp\u003e12\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 95px;\"\u003e\n \u003cp\u003e\u003cem\u003eEHMT1\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 265px;\"\u003e\n \u003cp\u003ec.2842C\u0026gt;T; p.(Arg948Trp)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\n \u003cp\u003e9\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 140px;\"\u003e\n \u003cp\u003e\u003cem\u003eDe novo\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 82px;\"\u003e\n \u003cp\u003e5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 184px;\"\u003e\n \u003cp\u003eMissense\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 47px;\"\u003e\n \u003cp\u003e13\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 95px;\"\u003e\n \u003cp\u003e\u003cem\u003eFBXW7\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 265px;\"\u003e\n \u003cp\u003ec.1919delG; p.(Ser640Thrfs*7)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\n \u003cp\u003e4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 140px;\"\u003e\n \u003cp\u003eUnknown\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 82px;\"\u003e\n \u003cp\u003e4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 184px;\"\u003e\n \u003cp\u003eFrameshift\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 47px;\"\u003e\n \u003cp\u003e14\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 95px;\"\u003e\n \u003cp\u003e\u003cem\u003eFOXP1\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 265px;\"\u003e\n \u003cp\u003ec.1426C\u0026gt;T; p.(Gln476*)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\n \u003cp\u003e3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 140px;\"\u003e\n \u003cp\u003eUnknown\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 82px;\"\u003e\n \u003cp\u003e4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 184px;\"\u003e\n \u003cp\u003eNonsense\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 47px;\"\u003e\n \u003cp\u003e15\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 95px;\"\u003e\n \u003cp\u003e\u003cem\u003eGNAI1\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 265px;\"\u003e\n \u003cp\u003ec.518A\u0026gt;T; p.(Asp173Val)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\n \u003cp\u003e7\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 140px;\"\u003e\n \u003cp\u003e\u003cem\u003eDe novo\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 82px;\"\u003e\n \u003cp\u003e4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 184px;\"\u003e\n \u003cp\u003eMissense\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 47px;\"\u003e\n \u003cp\u003e16\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 95px;\"\u003e\n \u003cp\u003e\u003cem\u003eKCND3\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 265px;\"\u003e\n \u003cp\u003ec.983T\u0026gt;G; p.(Leu328Arg)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 140px;\"\u003e\n \u003cp\u003e\u003cem\u003eDe novo\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 82px;\"\u003e\n \u003cp\u003e4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 184px;\"\u003e\n \u003cp\u003eMissense\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 47px;\"\u003e\n \u003cp\u003e17\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 95px;\"\u003e\n \u003cp\u003e\u003cem\u003eKDM5C\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 265px;\"\u003e\n \u003cp\u003ec.1178C\u0026gt;T; p.(Thr393Ile)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\n \u003cp\u003eX\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 140px;\"\u003e\n \u003cp\u003e\u003cem\u003eDe novo\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 82px;\"\u003e\n \u003cp\u003e4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 184px;\"\u003e\n \u003cp\u003eMissense\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 47px;\"\u003e\n \u003cp\u003e18\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 95px;\"\u003e\n \u003cp\u003e\u003cem\u003eNSD1\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 265px;\"\u003e\n \u003cp\u003ec.4972_4974delTTG; p.(Leu1658del)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\n \u003cp\u003e5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 140px;\"\u003e\n \u003cp\u003e\u003cem\u003eDe novo\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 82px;\"\u003e\n \u003cp\u003e4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 184px;\"\u003e\n \u003cp\u003eDeletion\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 47px;\"\u003e\n \u003cp\u003e19\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 95px;\"\u003e\n \u003cp\u003e\u003cem\u003ePPP2R5D\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 265px;\"\u003e\n \u003cp\u003ec.751G\u0026gt;T; p.(Asp251Tyr)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\n \u003cp\u003e6\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 140px;\"\u003e\n \u003cp\u003e\u003cem\u003eDe novo\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 82px;\"\u003e\n \u003cp\u003e5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 184px;\"\u003e\n \u003cp\u003eMissense\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 47px;\"\u003e\n \u003cp\u003e20\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 95px;\"\u003e\n \u003cp\u003e\u003cem\u003eRAF1\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 265px;\"\u003e\n \u003cp\u003ec.1423T\u0026gt;C; p.(Phe475Leu)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\n \u003cp\u003e3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 140px;\"\u003e\n \u003cp\u003e\u003cem\u003eDe novo\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 82px;\"\u003e\n \u003cp\u003e5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 184px;\"\u003e\n \u003cp\u003eMissense\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 47px;\"\u003e\n \u003cp\u003e21\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 95px;\"\u003e\n \u003cp\u003e\u003cem\u003eSCN8A\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 265px;\"\u003e\n \u003cp\u003ec.417G\u0026gt;A; p.(Met139Ile)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\n \u003cp\u003e12\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 140px;\"\u003e\n \u003cp\u003e\u003cem\u003eDe novo\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 82px;\"\u003e\n \u003cp\u003e5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 184px;\"\u003e\n \u003cp\u003eMissense\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 47px;\"\u003e\n \u003cp\u003e22\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 95px;\"\u003e\n \u003cp\u003e\u003cem\u003eSET\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 265px;\"\u003e\n \u003cp\u003ec.103_104del; p.(Ile35*)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\n \u003cp\u003e9\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 140px;\"\u003e\n \u003cp\u003e\u003cem\u003eDe novo\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 82px;\"\u003e\n \u003cp\u003e4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 184px;\"\u003e\n \u003cp\u003eNonsense\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 47px;\"\u003e\n \u003cp\u003e23\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 95px;\"\u003e\n \u003cp\u003e\u003cem\u003eSETBP1\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 265px;\"\u003e\n \u003cp\u003ec.623del; p.(Pro208Glnfs*135)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\n \u003cp\u003e18\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 140px;\"\u003e\n \u003cp\u003e\u003cem\u003eDe novo\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 82px;\"\u003e\n \u003cp\u003e5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 184px;\"\u003e\n \u003cp\u003eFrameshift\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 47px;\"\u003e\n \u003cp\u003e24\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 95px;\"\u003e\n \u003cp\u003e\u003cem\u003eSETBP1\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 265px;\"\u003e\n \u003cp\u003ec.2087dupC; p.(Glu697Argfs*10)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\n \u003cp\u003e18\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 140px;\"\u003e\n \u003cp\u003e\u003cem\u003eDe novo\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 82px;\"\u003e\n \u003cp\u003e5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 184px;\"\u003e\n \u003cp\u003eFrameshift\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 47px;\"\u003e\n \u003cp\u003e25\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 95px;\"\u003e\n \u003cp\u003e\u003cem\u003eSETD1A\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 265px;\"\u003e\n \u003cp\u003ec.273del; p.(Pro92Hisfs*2)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\n \u003cp\u003e16\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 140px;\"\u003e\n \u003cp\u003e\u003cem\u003eDe novo\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 82px;\"\u003e\n \u003cp\u003e5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 184px;\"\u003e\n \u003cp\u003eFrameshift\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 47px;\"\u003e\n \u003cp\u003e26\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 95px;\"\u003e\n \u003cp\u003e\u003cem\u003eSETD2\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 265px;\"\u003e\n \u003cp\u003ec.6284dup; p.(Asp2096Argfs*2)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\n \u003cp\u003e3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 140px;\"\u003e\n \u003cp\u003e\u003cem\u003eDe novo\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 82px;\"\u003e\n \u003cp\u003e5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 184px;\"\u003e\n \u003cp\u003eFrameshift\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 47px;\"\u003e\n \u003cp\u003e27\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 95px;\"\u003e\n \u003cp\u003e\u003cem\u003eSETD5\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 265px;\"\u003e\n \u003cp\u003ec.2347-7A\u0026gt;G\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\n \u003cp\u003e3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 140px;\"\u003e\n \u003cp\u003e\u003cem\u003eDe novo\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 82px;\"\u003e\n \u003cp\u003e5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 184px;\"\u003e\n \u003cp\u003eSplicing\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 47px;\"\u003e\n \u003cp\u003e28\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 95px;\"\u003e\n \u003cp\u003e\u003cem\u003eSLC6A1\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 265px;\"\u003e\n \u003cp\u003ec.1097_1098delinsCT; p.(Leu366Pro)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\n \u003cp\u003e3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 140px;\"\u003e\n \u003cp\u003e\u003cem\u003eDe novo\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 82px;\"\u003e\n \u003cp\u003e4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 184px;\"\u003e\n \u003cp\u003eMissense\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 47px;\"\u003e\n \u003cp\u003e29\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 95px;\"\u003e\n \u003cp\u003e\u003cem\u003eSLC6A8\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 265px;\"\u003e\n \u003cp\u003ec.257G\u0026gt;A; p.(Gly86Asp)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\n \u003cp\u003eX\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 140px;\"\u003e\n \u003cp\u003e\u003cem\u003eDe novo\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 82px;\"\u003e\n \u003cp\u003e4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 184px;\"\u003e\n \u003cp\u003eMissense\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 47px;\"\u003e\n \u003cp\u003e30\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 95px;\"\u003e\n \u003cp\u003e\u003cem\u003eSMARCA2\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 265px;\"\u003e\n \u003cp\u003ec.3484C\u0026gt;T; p.(Arg1162Cys)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\n \u003cp\u003e9\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 140px;\"\u003e\n \u003cp\u003e\u003cem\u003eDe novo\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 82px;\"\u003e\n \u003cp\u003e5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 184px;\"\u003e\n \u003cp\u003eMissense\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 47px;\"\u003e\n \u003cp\u003e31\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 95px;\"\u003e\n \u003cp\u003e\u003cem\u003eSMARCA2\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 265px;\"\u003e\n \u003cp\u003ec.2870A\u0026gt;G; p.(Gln957Arg)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\n \u003cp\u003e9\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 140px;\"\u003e\n \u003cp\u003e\u003cem\u003eDe novo\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 82px;\"\u003e\n \u003cp\u003e4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 184px;\"\u003e\n \u003cp\u003eMissense\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 47px;\"\u003e\n \u003cp\u003e32\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 95px;\"\u003e\n \u003cp\u003e\u003cem\u003eSPTBN1\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 265px;\"\u003e\n \u003cp\u003ec.1429C\u0026gt;T; p.(Arg477Cys)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 140px;\"\u003e\n \u003cp\u003e\u003cem\u003eDe novo\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 82px;\"\u003e\n \u003cp\u003e4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 184px;\"\u003e\n \u003cp\u003eMissense\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 47px;\"\u003e\n \u003cp\u003e33\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 95px;\"\u003e\n \u003cp\u003e\u003cem\u003eSRRM2\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 265px;\"\u003e\n \u003cp\u003eg.2707830_2757509del\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\n \u003cp\u003e16\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 140px;\"\u003e\n \u003cp\u003e\u003cem\u003eDe novo\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 82px;\"\u003e\n \u003cp\u003e5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 184px;\"\u003e\n \u003cp\u003eIntragenic deletion of exon 1,2 and part of 3\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 47px;\"\u003e\n \u003cp\u003e34\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 95px;\"\u003e\n \u003cp\u003e\u003cem\u003eTAB2\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 265px;\"\u003e\n \u003cp\u003ec.363_364insGTTA; p.(Phe122Valfs*18)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\n \u003cp\u003e6\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 140px;\"\u003e\n \u003cp\u003eMaternal\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 82px;\"\u003e\n \u003cp\u003e5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 184px;\"\u003e\n \u003cp\u003eFrameshift\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 47px;\"\u003e\n \u003cp\u003e35\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 95px;\"\u003e\n \u003cp\u003e\u003cem\u003eTRIM8\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 265px;\"\u003e\n \u003cp\u003ec.1357C\u0026gt;T; p.(Gln453*)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\n \u003cp\u003e10\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 140px;\"\u003e\n \u003cp\u003e\u003cem\u003eDe novo\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 82px;\"\u003e\n \u003cp\u003e5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 184px;\"\u003e\n \u003cp\u003eNonsense\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e2b. Copy number variants (CNVs) and aneuploidies, n=9\u003c/p\u003e\n\u003ctable border=\"1\" cellspacing=\"0\" cellpadding=\"0\" width=\"752\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 70px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eID\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 157px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eGenetic finding\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 333px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eMolecular karyotype (GRCh38/hg38)\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 192px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eInheritance\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 70px;\"\u003e\n \u003cp\u003e36\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 157px;\"\u003e\n \u003cp\u003e1q21.1q21.2 dup\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 333px;\"\u003e\n \u003cp\u003e1q21.1-21.2(chr1:146891138-148353326)x3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 192px;\"\u003e\n \u003cp\u003ePaternal\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 70px;\"\u003e\n \u003cp\u003e37\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 157px;\"\u003e\n \u003cp\u003e15q13.2q13.3 del\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 333px;\"\u003e\n \u003cp\u003e15q13.2-13.3(chr15:30648301-32222899)x1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 192px;\"\u003e\n \u003cp\u003eUnknown\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 70px;\"\u003e\n \u003cp\u003e38\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 157px;\"\u003e\n \u003cp\u003e16p12.2 del\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 333px;\"\u003e\n \u003cp\u003e16p12.2(chr16:21945136-22403142)x1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 192px;\"\u003e\n \u003cp\u003ePaternal\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 70px;\"\u003e\n \u003cp\u003e39\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 157px;\"\u003e\n \u003cp\u003e17q12 dup\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 333px;\"\u003e\n \u003cp\u003e17q12(chr17:36459737-37889808)x3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 192px;\"\u003e\n \u003cp\u003eMaternal\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 70px;\"\u003e\n \u003cp\u003e40\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 157px;\"\u003e\n \u003cp\u003e22q11.21 del\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 333px;\"\u003e\n \u003cp\u003e22q11.21(chr22:18890274-20324123)x1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 192px;\"\u003e\n \u003cp\u003e\u003cem\u003eDe novo\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 70px;\"\u003e\n \u003cp\u003e41\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 157px;\"\u003e\n \u003cp\u003e22q11.21q11.22 dup\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 333px;\"\u003e\n \u003cp\u003e22q11.21-11.22(chr22:21450614-22457038)x3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 192px;\"\u003e\n \u003cp\u003e\u003cem\u003eDe novo\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 70px;\"\u003e\n \u003cp\u003e42\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 157px;\"\u003e\n \u003cp\u003e47,XXX\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 333px;\"\u003e\n \u003cp\u003e(chrX)x3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 192px;\"\u003e\n \u003cp\u003e\u003cem\u003eDe novo\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 70px;\"\u003e\n \u003cp\u003e43\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 157px;\"\u003e\n \u003cp\u003e48, XXYY\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 333px;\"\u003e\n \u003cp\u003e(chrX)x2, (chrY)x2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 192px;\"\u003e\n \u003cp\u003e\u003cem\u003eDe novo\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 70px;\"\u003e\n \u003cp\u003e44\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 157px;\"\u003e\n \u003cp\u003e48, XYYY\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 333px;\"\u003e\n \u003cp\u003e(chrX)x1, (chrY)x3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 192px;\"\u003e\n \u003cp\u003e\u003cem\u003eDe novo\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"european-journal-of-human-genetics","isNatureJournal":false,"hasQc":false,"allowDirectSubmit":false,"externalIdentity":"ejhg","sideBox":"Learn more about [European Journal of Human Genetics](http://www.nature.com/ejhg/)","snPcode":"41431","submissionUrl":"https://mts-ejhg.nature.com/cgi-bin/main.plex","title":"European Journal of Human Genetics","twitterHandle":"@ejhg_journal","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"ejp","reportingPortfolio":"Nature AJ","inReviewEnabled":true,"inReviewRevisionsEnabled":false},"keywords":"Speech disorder, dysarthria, childhood apraxia of speech, genetics, child ","lastPublishedDoi":"10.21203/rs.3.rs-6900966/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-6900966/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eThe aetiology of childhood motor speech disorders of dysarthria and apraxia has been poorly understood. Recent evidence suggests a moderate genetic contribution for these rare and severe speech disorders. To date however, no studies have examined genetic diagnostic yield for apraxia and dysarthria in a clinical setting. Here we used a clinically accredited genomics pipeline to investigate genetic diagnostic yield and variables predictive of a genetic diagnosis in a tertiary hospital speech clinic. A cohort of 153 children (range 2;7\u0026ndash;16;5 years, 42 female) ascertained for motor speech disorder were assessed by a clinical geneticist and speech pathologist and underwent chromosomal microarray, Fragile X and exome sequencing. Odds ratios identified predictors of genetic diagnosis. 44/153 (29%, 15 female) had pathogenic variants (30 \u003cem\u003ede novo\u003c/em\u003e), encompassing monogenic conditions (n\u0026thinsp;=\u0026thinsp;35) and copy number variants (n\u0026thinsp;=\u0026thinsp;9) across 38 distinct disorders. Delayed walking, fine and gross motor disorder, receptive language impairment and/or cognitive impairment, and dysmorphism were associated with a genetic diagnosis. The presence of CAS and dysarthria was more commonly associated with a genetic diagnosis than CAS alone. Autism spectrum disorder was less commonly associated with a genetic diagnosis. No child had a Fragile X diagnosis. The clinical genetic diagnostic yield for motor speech disorders is comparable to epilepsy and cerebral palsy, conditions where genetic testing is routine in most centres, unlike for motor speech disorders. Children with motor speech disorder with co-occurring motor, language and/or learning deficits, should be prioritised for genomic testing.\u003c/p\u003e","manuscriptTitle":"Childhood motor speech disorders: who to prioritise for genetic testing","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-07-22 08:03:03","doi":"10.21203/rs.3.rs-6900966/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"revise","date":"2025-09-11T17:57:57+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"This content is not available.","date":"2025-09-10T13:57:03+00:00","index":3,"fulltext":"This content is not available."},{"type":"editorInvitedReview","content":"This content is not available.","date":"2025-08-26T11:24:24+00:00","index":1,"fulltext":"This content is not available."},{"type":"reviewerAgreed","content":"This content is not available.","date":"2025-08-22T01:49:09+00:00","index":3,"fulltext":"This content is not available."},{"type":"editorInvitedReview","content":"This content is not available.","date":"2025-08-20T08:20:39+00:00","index":2,"fulltext":"This content is not available."},{"type":"reviewerAgreed","content":"This content is not available.","date":"2025-08-19T14:17:08+00:00","index":2,"fulltext":"This content is not available."},{"type":"reviewerAgreed","content":"This content is not available.","date":"2025-08-01T08:50:33+00:00","index":1,"fulltext":"This content is not available."},{"type":"reviewersInvited","content":"","date":"2025-07-14T12:40:24+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2025-06-17T09:43:35+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2025-06-16T02:46:26+00:00","index":"","fulltext":""},{"type":"submitted","content":"European Journal of Human Genetics","date":"2025-06-16T02:46:25+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"european-journal-of-human-genetics","isNatureJournal":false,"hasQc":false,"allowDirectSubmit":false,"externalIdentity":"ejhg","sideBox":"Learn more about [European Journal of Human Genetics](http://www.nature.com/ejhg/)","snPcode":"41431","submissionUrl":"https://mts-ejhg.nature.com/cgi-bin/main.plex","title":"European Journal of Human Genetics","twitterHandle":"@ejhg_journal","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"ejp","reportingPortfolio":"Nature AJ","inReviewEnabled":true,"inReviewRevisionsEnabled":false}}],"origin":"","ownerIdentity":"710d6fcd-8a98-43ed-972c-ffa81418e9b2","owner":[],"postedDate":"July 22nd, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[{"id":51501914,"name":"Health sciences/Medical research/Genetics research"},{"id":51501915,"name":"Biological sciences/Genetics/Clinical genetics/Disease genetics"}],"tags":[],"updatedAt":"2026-01-14T08:05:30+00:00","versionOfRecord":{"articleIdentity":"rs-6900966","link":"https://doi.org/10.1038/s41431-025-01993-9","journal":{"identity":"european-journal-of-human-genetics","isVorOnly":false,"title":"European Journal of Human Genetics"},"publishedOn":"2026-01-13 05:00:00","publishedOnDateReadable":"January 13th, 2026"},"versionCreatedAt":"2025-07-22 08:03:03","video":"","vorDoi":"10.1038/s41431-025-01993-9","vorDoiUrl":"https://doi.org/10.1038/s41431-025-01993-9","workflowStages":[]},"version":"v1","identity":"rs-6900966","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-6900966","identity":"rs-6900966","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}