Association of serotonin gene (5-HTTLPR & 5-HTTVNTR) polymorphism with Fibromyalgia Syndrome in North Indian Women

Background: Several psychiatric disorders have been found associated with serotonin transporter gene polymorphisms. The purpose of this study was to explore the correlation between serotonin gene polymorphism (5-HTTLPR & 5-HTTVNTR) in North Indian Women with Fibromyalgia Syndrome (FMS). Results 105 FMS patients and 105 controls were enrolled in the study. Polymerase chain reaction (PCR) method was used to analyse the 5-HTTLPR & 5-HTTVNTR gene polymorphism. The psychopathology status of the 105 FMS patients and 105 healthy controls was assessed using the Beck Depression Inventory (BDI) and the Symptom Checklist-90-Revised questionnaires (SCL-90-R). Patients with psychiatric symptoms were excluded from the study. No significant differences were found in 5-HTTVNTR genotypes; 10/10 (OR 0.74, P = 1.000), 10/12 (OR 0.72, P = 0.4691) and 12/12 (OR 0.92, P = 0.3697) or 5-HTTLPR genotypes; L/L (OR 0.59, P = 0.7212), S/L (OR 1.10, P = 0.6700) and S/S (OR 0.92, P = 0.8890) between patients and controls. Conclusion Hence, we conclude that serotonin gene polymorphism (5-HTTLPR & 5-HTTVNTR) is not associated with FMS in north Indian women.