Curcumin a New Modality for Treatment of Uterine Myoma

Curcumin is known for its antitumor, anticancer, strong anti-inflammatory, antioxidative, antiangiogenic, proapoptotic, antiamyloid, antiarthritic, potent inhibitors of cytochrome p450, reduced cholesterol level. Uterine fibroid are the most common pelvic tumors and occur in 20 to 25% of premenopausal women .Current pharmacological therapies include gonadotrophin releasing hormone GnRH agonists/antagonists, oral contraceptive, progestin selective modulator of progesterone receptor( Aspprisnil) and mifipristone.The aim of this work is to use for the first time in the literature curcumin for treatment of uterine myoma. A total of 50 women had uterine myoma were enrolled in the study, the inclusion criteria were age between 20-35 yrs mean age 32±3.25, no more than (3) intramural myomas the main diameter at 3 D transvaginal ultrasound >5mm. Curcumin is used in the tablet form each tablet 450 mg one tablet after meal 3 times daily for 12 weeks, assessment of uterine bleeding by using daily bleeding diapers and Hb concentration, uterine dimensions and myoma dimensions are measured by 3D ultrasound. Result we found statistically significant decrease in the uterine volume and myoma volume (cm3) p<0.001, again we find statistically significant increases in Hb percentage after treatment (p <0.05) the bleeding stop completely in 88% after 2 weeks treatment and after 4 weeks in 12% of the cases In conclusion, curcumin is a new drug with multiple pharmacological actions, no reported side effects of significances for treatment of myoma.