Characteristics and prognosis of colorectal signet ring cell carcinoma in patients aged ≥ 65 years 

Characteristics and prognosis of colorectal signet ring cell carcinoma in patients aged ≥ 65 years | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Characteristics and prognosis of colorectal signet ring cell carcinoma in patients aged ≥ 65 years Di Zhou, Yong-jing Yang, Chun-cao Niu, Yong-jiang Yu, Jian-dong Diao This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-200148/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Objective: To evaluate the prognostic value of age on colorectal signet ring cell carcinoma (SRCC) and identify the prognosis factors of patients aged ≥ 65 years. Methods : Patients were recruited from the Surveillance, Epidemiology, and End Results (SEER) database. We ensured that all characteristics were well balanced through adopting the propensity score matching (PSM) method. In addition, the prognostic factors were evaluated by the Cox proportional hazardous model. Results : Altogether 3305 cases were enrolled, including 1564 in elderly group (aged ³65 years). As a result, more patients were female, unmarried, white, earlier AJCC stage, tumor size ≤5cm, grade III/IV and located in cecum–transverse colon in the elderly group; whereas significant fewer patients received chemotherapy and radiotherapy. After 1:1 PSM analysis, each group contained 1032 cases. As discovered by Kaplan-Meier analysis, the elderly group was associated with remarkably dismal survival compared with the younger group after PSM analysis ( P =0.0091).Moreover, grade, primary site, AJCC stage, tumor size, surgery and chemotherapy were identified as the independent prognostic factors for the elderly patients. Conclusion : The prognosis of colorectal SRCC aged ≥ 65 years was worse than the younger patients. We may need strengthen the chemotherapy of the eldly colorectal SRCC. Cancer Biology Oncology Signet ring cell carcinoma colorectal eldly prognosis SEER database. Figures Figure 1 Figure 2 Figure 3 Introduction In the USA, colorectal cancer (CRC) ranks the second place among the common causes of cancer-associated mortality, and it has became severe health threat in the world [ 1 ]. Of the diverse CRC subtypes, colorectal signet ring cell carcinoma (SRCC) arouses wide interests recently. Originally depicted by Laufman and Saphirin[ 2 ],SRCC is suggested to be mainly derived from undifferentiated colorectal mucosal stem cells; as a result, SRCC usually shows low differentiation, fast proliferation, high metastasis and diffuse infiltration[ 3 , 4 ]. Many diverse clinicopathological features and prognostic outcomes have been reported for the elderly CRC cases in existing studies. It has been suggested that, the younger CRC cases showed unfavorable pathological characteristics and advanced stage relative to the elderly patients[ 5 , 6 ]. However, other studies discover no difference in the pathological characteristics and tumor stage between the younger and elderly populations[ 7 , 8 ]. But no specific data on the elderly patients with colorectal SRCC are available at present due to the rarity of this disease. The aim of this study was to compare the clinicopathologic characteristics and survival of colorectal SRCC in two groups of patients (< 65 years and ≥65 years). We also aimed to identify the prognosis factors of patients aged ≥ 65 years. Materials And Methods Ethical statement The Surveillance, Epidemiology, and End Results (SEER) database formulated by the National Cancer Institute, which is started in 1973 and updated every year, utilizes the population-based data for the development of all-sided sources[ 9 ].This databases covers about 30% US population among different geographic areas[ 10 ]. To access the SEER database, we signed the SEER Research Data Agreement (reference number,18753-Nov2016). Related data were obtained according to the approved guidelines. The data analysis was considered by the Office for Human Research Protection to be non-human subjects who were researched by the United States Department of Health and Human Services, as they were publicly available and de-identified. Thus, it did not require approval by the institutional review board. Study population The eligible cases were screened by adopting the SEER*State v8.3.6 approach (released on August 8th, 2019). A total of 18 SEER areas were included from 2004 to 2015, including Arizona Indians, Alaska Native TumorRegistry, Connecticut,Cherokee Nation, Georgia Center for Cancer Statistics, Detroit, Greater California, Greater BayArea Cancer Registry, Iowa,Hawaii, Los Angeles, Kentucky, New Jersey, Louisiana, Seattle-Puget Sound, Utah, and New Mexico. Patients conforming to the criteria below were included: (1) patients with primary colorectal SRCC; (2) the diagnosis of SRCC was made according to the third edition of the International Classification of Disease for Oncology (ICD-O-3, 8490/3). The exclusion criteria were listed as following: (1) those with multiple primary tumor; (2)those only with the clinical diagnosis, or those diagnosed based on autopsy or the death certificate; (3)those with no available information on AJCC stage; and (4) those with no data on prognosis. All the rest participants were included into the initial SEER cohort. Covariates The clinicopathological features of patients shown below were examined, including age, sex, race, marital status, insurance status, year of diagnosis, tumor size, primary site, AJCC stage, grade, lymph node dissection (LND), surgery, chemotherapy and radiotherapy. In this study, the single (never married), widowed (having a domestic partner), separated and divorced cases were classified into unmarried category.With regard to primary tumor site, it was divided into cecum–transverse colon (like appendix, cecum, hepatic flexure, ascending colon, transverse colon), descending colon–sigmoid (like splenic flexure, descending colon, sigmoid colon), rectum, multiple or unknown[ 11 ]. As for the year of diagnosis, it was classified as 2004-2007, 2008-2011, 2012-2015, in accordance with previous studies[ 12 , 13 ]. Additionally, and tumor size[ 14 , 15 ]were also grouped in line with previous reports. Cancer stage was classified by the AJCC classification system (6th edition) adapting to SEER-derived patients diagnosed between 2004 and 2015[ 16 ]. In this study, we set cancer‐specific survival (CSS) as the endpoint, which referred to the duration between diagnosis and death because of colorectal SRCC. Propensity score matching (PSM) Selection bias was inevitable in the observational studies; as a result, confounding factors may be unequally distributed between the two groups. PSM refers to the process to assign conditional probabilities to the specific treatment based on diverse observed covariates[ 17 ]. For reducing the selection bias and avoiding the unequal confounding factor distribution, we adopted PSM in the present study[ 18 ]. In addition, the logistic regression model was utilized to predict the propensity score for each case using the SPSS plug-in PSM, including each survival-affecting covariate. Thereafter, PSM at the 1:1 nearest neighbor matching was carried out between the elderly and younger groups for all subgroups, and the caliper was set at 0.01 for the sake of accepting the matched pair. Statistical analysis All the categorical were expressed in the manner of number and percentage, while continuous variables were expressed as mean ±SD. Fisher’s exact test and Pearson’s chi-square test were used to compare clinicopathological features pre- and post-PSM. Meanwhile, the Kaplan–Meier method was utilized to estimate patients’ survival. Differences in patients’ survival between different groups were evaluated by log-rank test. Cox proportional hazards regression was adopted for assessing the relationships of different variables with survival. Later, significant variables obtained from univariate analysis ( P < 0.05) or those identified to be prognostic factors before were enrolled in multivariate analysis. SPSS23.0 (SPSS Inc., Chicago, USA) was utilized for statistical analysis. A two-sided P < 0.05 was considered as statistically significant. Results Patient selection procedure and age distribution A total of 3305 patients met the inclusion criteria for analyzing characteristics. Figure 1 presents the patients selection procedure. Median age at diagnosis of all patients was 63 years (12-103 years). The age of patients is almost normal distribution, and the age group of 50-70 accounted for 43.4%. Figure 2 shows the age distribution. Besides, in line with previous[ 19 , 20 ], the enrolled patients were classified as two age groups, including the older (³65 years, n=1564) and younger (˂65 years, n=1741) groups. Patient features between two groups Table 1 presents the patient demographic, tumor feature and treatment data. Differences in sex, race, insurance status, marital status, tumor size, grade, primary site, AJCC stage, LND number, chemotherapy and radiotherapy were statistically significant between the two groups. There were more female( P <0.001),unmarried( P <0.001), white ( P <0.001), medicaid/insured( P =0.023), earlier AJCC stage, tumor size ≤5cm, grade III/IV( P <0.001) and cecum–transverse colon( P <0.001) cancer patients in the elderly group; whereas a lower proportion of these patients received chemotherapy( P <0.001) and radiotherapy( P <0.001) in comparison with those in the younger group. Meanwhile, difference in received surgery was not significant between the two groups ( P =0.065). PSM and CSS post-PSM PSM incorporated factors such as age, sex, race, insurance status, marital status, tumor size, grade, primary site, LND number, AJCC stage, chemotherapy, surgery and radiotherapy. After 1:1 PSM analysis, both groups contained 1032 cases, respectively. None of the variables showed significant difference after PSM (Table 2). In addition, according to Kaplan–Meier analysis, the elderly patients had markedly poorer survival compared with the younger patients after PSM( P =0.0091) (Figure 3). Survival and prognostic factors for the elderly group patients For the 1564 elderly cases, the survival time ranged from 0 to 155 (median, 13.0) months. The CSS rates at 1, 3 and 5 years were 57.25%, 37.66% and 33.64%. As revealed by univariate analysis, sex, tumor size, primary site, AJCC stage, grade, LND number, surgery and chemotherapy were identified as the predicting factors for CSS (all P ˂0.05). According to multivariate analysis, tumor size ≤5cm, primary site at cecum–transverse colon, earlier AJCC stage and grade I/II were identified to be the favorable prognostic factors. Moreover, patients who received surgery or chemotherapy were associated with superior prognosis compared to those who did not [(HR:0.674, 95% CI: 0.498–0.912, P =0.010) and (HR:0.488, 95% CI: 0.424–0.562, P <0.001)] (Table 3). Discussion The present population-based, retrospective study was carried out to illustrate age distribution in colorectal SRCC and evaluate the significance of age in prognosis prediction. As far as we know, this study is the first large scale population-based study that utilizes PSM for assessing the significance of age in predicting colorectal SRCC prognosis. As a result, the age of colorectal SRCCs patients was almost distributed normally. Difference in survival was significant between patients of the two age groups. Moreover, tumor size, primary site, AJCC stage, grade, chemotherapy and surgery were identified to be the independent prognostic factors for the elderly patients. Colorectal SRCC, an uncommon CRC histological subtype, is classified by the WHO classification of tumors to be the colorectal adenocarcinoma variant, where over 50% cancer cells have obvious intracytoplasmic mucin[ 21 ]. Such cancer is featured by different clinical presentations and prognostic outcomes[ 22 ]. SRCC shows dismal prognostic outcome and high malignancy grade relative to additional CRC subtypes[ 23 , 24 ]. Due to the low prevalence of colorectal SRCC, little information is available regarding the role of age in predicting the colorectal SRCC prognosis.As discovered by Ping He, the elderly (³ 65 years old) showed dismal prognosis compared with the younger patients(˂ 65 years old)[ 19 ], which is conformed to our findings. In addition, our study suggested that chemotherapy and surgery were the factors for the favorable prognosis among the elderly patients, indicating that the aggressive and effective treatment markedly decreased the colorectal SRCC-associated mortality among the elderly patients. Surgery exerts an important part in treating locoregional tumors[ 25 ]. The value of chemotherapy has also been affirmed by many studies[ 14 , 19 , 26 ]. Our results suggested that the proportions of the patients who received surgery were similar between the two age groups, while that of patients who received chemotherapy significantly decreased in the elderly group (39.0% vs. 74.8%).Such finding is commonly found among the elderly patients who receive anticancer treatment in other tumors[ 27-29 ]. Therefore, we should strengthen the treatment of elderly patients. So far, the present study is the first large-scale retrospective analysis on the role of age in predicting colorectal SRCC prognosis. Our study assists the clinical workers in further understanding the clinicopathological characteristics and treatment for the elderly colorectal SRCC patients (³65 years old). Nonetheless, certain limitations should be noted in the present study. First of all, selection bias was inevitable in the observational study. The application of PSM analysis could reduced the bias resulting from the unequal distribution of covariates measured, but bias induced by the unmeasured variables were inevitable. Secondly, we enrolled altogether 14 variables, but some variables still could not enrolled in the SEER database, like vascular invasion, status of surgical margin or the molecular-genetic profiles. Thirdly, detailed information about chemotherapy was not available. Therefore, we can not further explore which chemotherapy regimen is safe and effective for elderly patients. Our future work will focus on solving the above limitations. Conclusion In conclusion, the clinicopathological features were significantly different between younger and older group, and the prognosis of colorectal SRCC in aged ³65 years patients was significantly worse than that in younger patients. Primary site, grade, tumor size, AJCC stage, surgery and chemotherapy were independent risk factors for the prognosis of elderly patients. Nevertheless, more studies are warranted to determine whether more intense treatment is necessary for colorectal SRCC patients if appropriate. Declarations Ethics approval Approval from the ethical board for this study was not required because of the public nature of all the data. Funding No funding. Conflict of interest All authors declare that they have no conflicts of interest. Acknowledgements We thank the staff members of the National Cancer Institute and their colleagues across the United States and at Information Management Services, Inc., who have been involved with the Surveillance, Epidemiology, and End Results (SEER) Program. Author contributions Jian-dong Diao conceived the study. Di Zhou searched the database and literature. Di Zhou, Yong-jing Yang, Chun-cao Niu and Yong-jiang Yu discussed and analyzed the data. Di Zhou wrote the manuscript. Jian-dong Diao revised the manuscript. All authors reviewed the manuscript. 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Characteristic A ll patients <65 years ≥65 years P -value N=3305 N=1741 N=1564 Sex <0.001 female 1620 (49.0%) 753 (43.3%) 867 (55.4%) male 1685 (51.0%) 988 (56.7%) 697 (44.6%) Race <0.001 black 313 (9.47%) 204 (11.7%) 109 (6.97%) other 282 (8.53%) 184 (10.6%) 98 (6.27%) white 2710 (82.0%) 1353 (77.7%) 1357 (86.8%) Marital status <0.001 married 1782 (53.9%) 1012 (58.1%) 770 (49.2%) unmarried 1523 (46.1%) 729 (41.9%) 794 (50.8%) Insurance 0.023 any medicaid/insured 2268 (68.6%) 1164 (66.9%) 1104 (70.6%) uninsured/unknown 1037 (31.4%) 577 (33.1%) 460 (29.4%) Primary site <0.001 cecum–transverse colon 2002 (60.6%) 919 (52.8%) 1083 (69.2%) descending colon–sigmoid 517 (15.6%) 323 (18.6%) 194 (12.4%) multiple 50 (1.51%) 25 (1.44%) 25 (1.60%) rectum 644 (19.5%) 425 (24.4%) 219 (14.0%) unknown 92 (2.78%) 49 (2.81%) 43 (2.75%) Grade 0.001 grade I/II 177 (5.36%) 90 (5.17%) 87 (5.56%) grade III/IV 2537 (76.8%) 1298 (74.6%) 1239 (79.2%) unknown 591 (17.9%) 353 (20.3%) 238 (15.2%) T umor size 5cm 1279 (38.7%) 638 (36.6%) 641 (41.0%) ≤5cm 1226 (37.1%) 612 (35.2%) 614 (39.3%) unknown 800 (24.2%) 491 (28.2%) 309 (19.8%) AJCC <0.001 I 158 (4.78%) 69 (3.96%) 89 (5.69%) II 465 (14.1%) 171 (9.82%) 294 (18.8%) III 1227 (37.1%) 615 (35.3%) 612 (39.1%) IV 1455 (44.0%) 886 (50.9%) 569 (36.4%) Surgery 0.065 no 676 (20.5%) 378 (21.7%) 298 (19.1%) yes 2629 (79.5%) 1363 (78.3%) 1266 (80.9%) Lymph node dissection 0.002 1 to 3 87 (2.63%) 46 (2.64%) 41 (2.62%) ≥4 2325 (70.3%) 1180 (67.8%) 1145 (73.2%) None or Biopsy 893 (27.0%) 515 (29.6%) 378 (24.2%) Chemotherapy <0.001 no/unknown 1393 (42.1%) 439 (25.2%) 954 (61.0%) yes 1912 (57.9%) 1302 (74.8%) 610 (39.0%) Radiotherapy <0.001 no/unknown 2868 (86.8%) 1427 (82.0%) 1441 (92.1%) yes 437 (13.2%) 314 (18.0%) 123 (7.86%) Year o f diagnosis 0.567 2004-2007 1120 (33.9%) 580 (33.3%) 540 (34.5%) 2008-2011 1069 (32.3%) 577 (33.1%) 492 (31.5%) 2012-2015 1116 (33.8%) 584 (33.5%) 532 (34.0%) Table 2 . Baseline characteristics after propensity score matching. Characteristic All patients <65 years ≥65 years P -value N=2064 N=1032 N=1032 Sex: 0.792 female 997 (48.3%) 495 (48.0%) 502 (48.6%) male 1067 (51.7%) 537 (52.0%) 530 (51.4%) Race: 0.985 black 189 (9.16%) 95 (9.21%) 94 (9.11%) other 168 (8.14%) 83 (8.04%) 85 (8.24%) white 1707 (82.7%) 854 (82.8%) 853 (82.7%) Marital_status: 0.566 married 1096 (53.1%) 555 (53.8%) 541 (52.4%) unmarried 968 (46.9%) 477 (46.2%) 491 (47.6%) Insurance: 0.771 any medicaid/insured 1465 (71.0%) 729 (70.6%) 736 (71.3%) uninsured/unknown 599 (29.0%) 303 (29.4%) 296 (28.7%) Primary_site: 0.705 cecum–transverse colon 1257 (60.9%) 639 (61.9%) 618 (59.9%) descending colon–sigmoid 311 (15.1%) 151 (14.6%) 160 (15.5%) multiple 41 (1.99%) 18 (1.74%) 23 (2.23%) rectum 387 (18.8%) 194 (18.8%) 193 (18.7%) unknown 68 (3.29%) 30 (2.91%) 38 (3.68%) Grade: 0.691 grade I/II 115 (5.57%) 54 (5.23%) 61 (5.91%) grade III/IV 1569 (76.0%) 792 (76.7%) 777 (75.3%) unknown 380 (18.4%) 186 (18.0%) 194 (18.8%) T umor size: 0.998 >5cm 780 (37.8%) 390 (37.8%) 390 (37.8%) ≤5cm 787 (38.1%) 394 (38.2%) 393 (38.1%) unknown 497 (24.1%) 248 (24.0%) 249 (24.1%) AJCC: 0.732 I 116 (5.62%) 53 (5.14%) 63 (6.10%) II 262 (12.7%) 130 (12.6%) 132 (12.8%) III 794 (38.5%) 394 (38.2%) 400 (38.8%) IV 892 (43.2%) 455 (44.1%) 437 (42.3%) Surgery: 0.392 no/unknown 445 (21.6%) 214 (20.7%) 231 (22.4%) yes 1619 (78.4%) 818 (79.3%) 801 (77.6%) Reg_LN_Sur: 0.166 1 to 3 57 (2.76%) 23 (2.23%) 34 (3.29%) ≥4 1420 (68.8%) 726 (70.3%) 694 (67.2%) None or Biopsy 587 (28.4%) 283 (27.4%) 304 (29.5%) Chemotherapy: 0.349 no/unknown 866 (42.0%) 422 (40.9%) 444 (43.0%) yes 1198 (58.0%) 610 (59.1%) 588 (57.0%) Radiotherapy: 0.836 no/unknown 1826 (88.5%) 911 (88.3%) 915 (88.7%) yes 238 (11.5%) 121 (11.7%) 117 (11.3%) Year_of_diagnosis: 0.774 2004-2007 660 (32.0%) 323 (31.3%) 337 (32.7%) 2008-2011 716 (34.7%) 359 (34.8%) 357 (34.6%) 2012-2015 688 (33.3%) 350 (33.9%) 338 (32.8%) Table 3 Univariate and multivariate analyses of cancer-specific s urvival (CSS) for patients with colorectal SRCC aged ≥ 65 . Characteristic Univariate analysis Multivariate analysis P -value HR(95%CI) P -value Year at diagnosis 0.761 NI 2004-2007 2008-2011 2012-2015 Sex 0.049 0.317 Female Reference male 1.069(0.938,1.219) Race 0.596 NI black white other . Marital status 0.374 NI unmarried married Insurance 0.284 NI uninsured/unknown any medicaid/insured Primary Site <0.001 0.026 cecum–transverse colon Reference descending colon–sigmoid 1.150(0.947,1.396) 0.158 multiple 1.361(0.865,2.140) 0.182 rectum 1.369(1.101,1.702) 0.005 unknown 1.374(0.962,1.962) 0.080 Grade <0.001 <0.001 grade I/II Reference grade III/IV 1.932(1.387,2.693) <0.001 unknown 2.071(1.446,2.968) <0.001 Tumor size <0.001 0.001 ≤5cm Reference ˃5cm 1.200 (1.031,1.395) 0.018 unknown 1.456(1.180,1.796) <0.001 AJCC stage <0.001 <0.001 I Reference II 1.419(0.889,2.267) 0.143 III 4.765(3.088,7.354) <0.001 IV 11.678(7.543,18.079) <0.001 Surgery <0.001 0.010 no surgery Reference yes 0.674(0.498,0.912) Dissected lymph node <0.001 0.480 none or biopsy Reference 1 - 3 1.118(0.700,1.785) 0.642 ≥4 0.899(0.673,1.202) 0.473 Chemotherapy 0.028 <0.001 no/unknown Reference yes 0.488(0.424,0.562) Radiotherapy 0.960 0.731 no/unknown Reference yes 1.049(0.800,1.375) Abbreviation: NI, not included in the multivariate survival analysis; Additional Declarations No competing interests reported. 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Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Yong-jing","middleName":"","lastName":"Yang","suffix":""},{"id":10978187,"identity":"828d8100-77be-4971-96c2-64318553dc4f","order_by":2,"name":"Chun-cao Niu","email":"","orcid":"","institution":"China-Japan Union Hospital of Jilin University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Chun-cao","middleName":"","lastName":"Niu","suffix":""},{"id":10978188,"identity":"3bc0963a-3606-4977-b1e2-3ccee9ed4e90","order_by":3,"name":"Yong-jiang Yu","email":"","orcid":"","institution":"Affiliated Hospital of Changchun University of Traditional Chinese Medicine","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Yong-jiang","middleName":"","lastName":"Yu","suffix":""},{"id":10978189,"identity":"b20d061c-fa79-42e8-8a99-fe9d044b1ec2","order_by":4,"name":"Jian-dong Diao","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAAyklEQVRIiWNgGAWjYDCCw0AswWbDzAfi8JCgJY2ZjXgtB0AE22EG4rXwHWd++MCi7Dw7m0QC44O3bQzy5oS0SB5mMzaQOHebGaiF2XBuG4PhzgYCWgwOM5hJSLaBtbBJ87YxJBgcIKiF/RtQyzmQFvbfRGrhAdlyAGwLM1FaJA/zFAP9kszMxvOwWXLOOQnDDYS08J0/vvGxRJldMj978sEPb8ps5AnaAgLMEgwMyQwMjA1AtgQR6oGA8QMDgx1xSkfBKBgFo2BEAgCn0zYAaP8EOAAAAABJRU5ErkJggg==","orcid":"","institution":"China-Japan Union Hospital of Jilin University","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Jian-dong","middleName":"","lastName":"Diao","suffix":""}],"badges":[],"createdAt":"2021-02-03 11:29:07","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-200148/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-200148/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":6072788,"identity":"7335a70b-b776-4875-85da-5a6b2a52857b","added_by":"auto","created_at":"2021-02-17 22:39:44","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":127783,"visible":true,"origin":"","legend":"Flow chart of patient selection.","description":"","filename":"Figure1.png","url":"https://assets-eu.researchsquare.com/files/rs-200148/v1/072b89369a19f70eb7be5194.png"},{"id":6072403,"identity":"a64b5f42-e918-476a-877c-078ba83f7d4d","added_by":"auto","created_at":"2021-02-17 22:36:43","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":64173,"visible":true,"origin":"","legend":"Age distribution for the enrolled patients.","description":"","filename":"Figure2.png","url":"https://assets-eu.researchsquare.com/files/rs-200148/v1/4f1bde606c3b049adebc692e.png"},{"id":6072789,"identity":"d620254b-5214-4f87-ad0b-7c93caea6439","added_by":"auto","created_at":"2021-02-17 22:39:44","extension":"png","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":124593,"visible":true,"origin":"","legend":"Comparison of the cancer-specific survival rates between the ˂65 years and \u003e65 years groups after propensity score matching.","description":"","filename":"Figure3.png","url":"https://assets-eu.researchsquare.com/files/rs-200148/v1/4bcd713100b3024da3f9ac05.png"},{"id":13666348,"identity":"82880581-7b3d-4be3-906f-63bfd72559cb","added_by":"auto","created_at":"2021-09-17 10:48:12","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":769242,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-200148/v1/084edc91-28a1-4bb4-940d-7632ca44eed0.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Characteristics and prognosis of colorectal signet ring cell carcinoma in patients aged ≥ 65 years ","fulltext":[{"header":"Introduction","content":"\u003cp\u003eIn the USA, colorectal cancer (CRC) ranks the second place among the common causes of cancer-associated mortality, and it has became severe health threat in the world [\u003cspan class=\"CitationRef\"\u003e1\u003c/span\u003e]. Of the diverse CRC subtypes, colorectal signet ring cell carcinoma (SRCC) arouses wide interests recently. Originally depicted by Laufman and Saphirin[\u003cspan class=\"CitationRef\"\u003e2\u003c/span\u003e],SRCC is suggested to be mainly derived from undifferentiated colorectal mucosal stem cells; as a result, SRCC usually shows low differentiation, fast proliferation, high metastasis and diffuse infiltration[\u003cspan class=\"CitationRef\"\u003e3\u003c/span\u003e, \u003cspan class=\"CitationRef\"\u003e4\u003c/span\u003e].\u003c/p\u003e\n\u003cp\u003eMany diverse clinicopathological features and prognostic outcomes have been reported for the elderly CRC cases in existing studies. It has been suggested that, the younger CRC cases showed unfavorable pathological characteristics and advanced stage relative to the elderly patients[\u003cspan class=\"CitationRef\"\u003e5\u003c/span\u003e, \u003cspan class=\"CitationRef\"\u003e6\u003c/span\u003e]. However, other studies discover no difference in the pathological characteristics and tumor stage between the younger and elderly populations[\u003cspan class=\"CitationRef\"\u003e7\u003c/span\u003e, \u003cspan class=\"CitationRef\"\u003e8\u003c/span\u003e]. But no specific data on the elderly patients with colorectal SRCC are available at present due to the rarity of this disease.\u003c/p\u003e\n\u003cp\u003eThe aim of this study was to compare the clinicopathologic characteristics and survival of colorectal SRCC in two groups of patients (\u0026lt;\u0026thinsp;65 years and \u0026ge;65 years). We also aimed to identify the prognosis factors of patients aged\u0026thinsp;\u0026ge;\u0026thinsp;65 years.\u003c/p\u003e"},{"header":"Materials And Methods","content":"\u003cp\u003e\u003cstrong\u003e\u003cem\u003eEthical statement\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe Surveillance, Epidemiology, and End Results (SEER) database formulated by the National Cancer Institute, which is started in 1973 and updated every year, utilizes the population-based data for the development of all-sided sources[\u003ca href=\"#_ENREF_9\"\u003e9\u003c/a\u003e].This databases covers about 30% US population among different geographic areas[\u003ca href=\"#_ENREF_10\"\u003e10\u003c/a\u003e]. To access the SEER database, we signed the SEER Research Data Agreement (reference number,18753-Nov2016). Related data were obtained according to the approved guidelines. The data analysis was considered by the Office for Human Research Protection to be non-human subjects who were researched by the United States Department of Health and Human Services, as they were publicly available and de-identified. Thus, it did not require approval by the institutional review board.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eStudy population\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe eligible cases were screened by adopting the SEER*State v8.3.6 approach (released on August 8th, 2019). A total of 18 SEER areas were included from 2004 to 2015, including Arizona Indians, Alaska Native TumorRegistry, Connecticut,Cherokee Nation, Georgia Center for Cancer Statistics, Detroit, Greater California, Greater BayArea Cancer Registry, Iowa,Hawaii, Los Angeles, Kentucky, New Jersey, Louisiana, Seattle-Puget Sound, Utah, and New Mexico. Patients conforming to the criteria below were included: (1) patients with primary colorectal SRCC; (2) the diagnosis of SRCC was made according to the third edition of the International Classification of Disease for Oncology (ICD-O-3, 8490/3). The exclusion criteria were listed as following: (1) those with multiple primary tumor; (2)those only with the clinical diagnosis, or those diagnosed based on autopsy or the death certificate; (3)those with no available information on AJCC stage; and (4) those with no data on prognosis. All the rest participants were included into the initial SEER cohort.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eCovariates\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe clinicopathological features of patients shown below were examined, including age, sex, race, marital status, insurance status, year of diagnosis, tumor size, primary site, AJCC stage, grade, lymph node dissection (LND), surgery, chemotherapy and radiotherapy.\u003c/p\u003e\n\u003cp\u003eIn this study, the single (never married), widowed (having a domestic partner), separated and divorced cases were classified into unmarried category.With regard to primary tumor site, it was divided into cecum\u0026ndash;transverse colon (like appendix, cecum, hepatic flexure, ascending colon, transverse colon), descending colon\u0026ndash;sigmoid (like splenic flexure, descending colon, sigmoid colon), rectum, multiple or unknown[\u003ca href=\"#_ENREF_11\"\u003e11\u003c/a\u003e]. As for the year of diagnosis, it was classified as 2004-2007, 2008-2011, 2012-2015, in accordance with previous studies[\u003ca href=\"#_ENREF_12\"\u003e12\u003c/a\u003e, \u003ca href=\"#_ENREF_13\"\u003e13\u003c/a\u003e]. Additionally, and tumor size[\u003ca href=\"#_ENREF_14\"\u003e14\u003c/a\u003e, \u003ca href=\"#_ENREF_15\"\u003e15\u003c/a\u003e]were also grouped in line with previous reports. Cancer stage was classified by the AJCC classification system (6th edition) adapting to SEER-derived patients diagnosed between 2004 and 2015[\u003ca href=\"#_ENREF_16\"\u003e16\u003c/a\u003e]. In this study, we set cancer‐specific survival (CSS) as the endpoint, which referred to the duration between diagnosis and death because of colorectal SRCC.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003ePropensity score matching (PSM)\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eSelection bias was inevitable in the observational studies; as a result, confounding factors may be unequally distributed between the two groups. PSM refers to the process to assign conditional probabilities to the specific treatment based on diverse observed covariates[\u003ca href=\"#_ENREF_17\"\u003e17\u003c/a\u003e]. For reducing the selection bias and avoiding the unequal confounding factor distribution, we adopted PSM in the present study[\u003ca href=\"#_ENREF_18\"\u003e18\u003c/a\u003e]. In addition, the logistic regression model was utilized to predict the propensity score for each case using the SPSS plug-in PSM, including each survival-affecting covariate. Thereafter, PSM at the 1:1 nearest neighbor matching was carried out between the elderly and younger groups for all subgroups, and the caliper was set at 0.01 for the sake of accepting the matched pair.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eStatistical analysis\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAll the categorical were expressed in the manner of number and percentage, while continuous variables were expressed as mean \u0026plusmn;SD. Fisher\u0026rsquo;s exact test and Pearson\u0026rsquo;s chi-square test were used to compare clinicopathological features pre- and post-PSM. Meanwhile, the Kaplan\u0026ndash;Meier method was utilized to estimate patients\u0026rsquo; survival. Differences in patients\u0026rsquo; survival between different groups were evaluated by log-rank test. Cox proportional hazards regression was adopted for assessing the relationships of different variables with survival. Later, significant variables obtained from univariate analysis (\u003cem\u003eP \u003c/em\u003e\u0026lt; 0.05) or those identified to be prognostic factors before were enrolled in multivariate analysis. SPSS23.0 (SPSS Inc., Chicago, USA) was utilized for statistical analysis. A two-sided \u003cem\u003eP\u003c/em\u003e\u0026lt; 0.05 was considered as statistically significant.\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003e\u003cstrong\u003e\u003cem\u003ePatient selection procedure and age distribution\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eA total of 3305 patients met the inclusion criteria for analyzing characteristics. Figure 1 presents the patients selection procedure. Median age at diagnosis of all patients was 63 years (12-103 years). The age of patients is almost normal distribution, and the age group of 50-70 accounted for 43.4%. Figure 2 shows the age distribution. Besides, in line with previous[\u003ca href=\"#_ENREF_19\"\u003e19\u003c/a\u003e, \u003ca href=\"#_ENREF_20\"\u003e20\u003c/a\u003e], the enrolled patients were classified as two age groups, including the older (\u0026sup3;65 years, n=1564) and younger (˂65 years, n=1741) groups.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003ePatient features between two groups\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eTable 1 presents the patient demographic, tumor feature and treatment data. Differences in sex, race, insurance status, marital status, tumor size, grade, primary site, AJCC stage, LND number, chemotherapy and radiotherapy were statistically significant between the two groups. There were more female(\u003cem\u003eP\u003c/em\u003e\u0026lt;0.001),unmarried(\u003cem\u003eP\u003c/em\u003e\u0026lt;0.001), white (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.001), medicaid/insured(\u003cem\u003eP\u003c/em\u003e=0.023), earlier AJCC stage, tumor size \u0026le;5cm, grade III/IV(\u003cem\u003eP\u003c/em\u003e\u0026lt;0.001) and cecum\u0026ndash;transverse colon(\u003cem\u003eP\u003c/em\u003e\u0026lt;0.001) cancer patients in the elderly group; whereas a lower proportion of these patients received chemotherapy(\u003cem\u003eP\u003c/em\u003e\u0026lt;0.001) and radiotherapy(\u003cem\u003eP\u003c/em\u003e\u0026lt;0.001) in comparison with those in the younger group. Meanwhile, difference in received surgery was not significant between the two groups (\u003cem\u003eP \u003c/em\u003e=0.065).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003ePSM and CSS post-PSM\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003ePSM incorporated factors such as age, sex, race, insurance status, marital status, tumor size, grade, primary site, LND number, AJCC stage, chemotherapy, surgery and radiotherapy. After 1:1 PSM analysis, both groups contained 1032 cases, respectively. None of the variables showed significant difference after PSM (Table 2). In addition, according to Kaplan\u0026ndash;Meier analysis, the elderly patients had markedly poorer survival compared with the younger patients after PSM( \u003cem\u003eP\u003c/em\u003e =0.0091) (Figure 3).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eSurvival and prognostic factors for the elderly group patients \u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eFor the 1564 elderly cases, the survival time ranged from 0 to 155 (median, 13.0) months. The CSS rates at 1, 3 and 5 years were 57.25%, 37.66% and 33.64%. As revealed by univariate analysis, sex, tumor size, primary site, AJCC stage, grade, LND number, surgery and chemotherapy were identified as the predicting factors for CSS (all \u003cem\u003eP\u003c/em\u003e˂0.05). According to multivariate analysis, tumor size \u0026le;5cm, primary site at cecum\u0026ndash;transverse colon, earlier AJCC stage and grade I/II were identified to be the favorable prognostic factors. Moreover, patients who received surgery or chemotherapy were associated with superior prognosis compared to those who did not [(HR:0.674, 95% CI: 0.498\u0026ndash;0.912, \u003cem\u003eP\u003c/em\u003e =0.010) and (HR:0.488, 95% CI: 0.424\u0026ndash;0.562, \u003cem\u003eP\u003c/em\u003e\u0026lt;0.001)] (Table 3).\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eThe present population-based, retrospective study was carried out to illustrate age distribution in colorectal SRCC and evaluate the significance of age in prognosis prediction. As far as we know, this study is the first large scale population-based study that utilizes PSM for assessing the significance of age in predicting colorectal SRCC prognosis. As a result, the age of colorectal SRCCs patients was almost distributed normally. Difference in survival was significant between patients of the two age groups. Moreover, tumor size, primary site, AJCC stage, grade, chemotherapy and surgery were identified to be the independent prognostic factors for the elderly patients.\u003c/p\u003e\n\u003cp\u003eColorectal SRCC, an uncommon CRC histological subtype, is classified by the WHO classification of tumors to be the colorectal adenocarcinoma variant, where over 50% cancer cells have obvious intracytoplasmic mucin[\u003ca href=\"#_ENREF_21\"\u003e21\u003c/a\u003e]. Such cancer is featured by different clinical presentations and prognostic outcomes[\u003ca href=\"#_ENREF_22\"\u003e22\u003c/a\u003e]. SRCC shows dismal prognostic outcome and high malignancy grade relative to additional CRC subtypes[\u003ca href=\"#_ENREF_23\"\u003e23\u003c/a\u003e, \u003ca href=\"#_ENREF_24\"\u003e24\u003c/a\u003e].\u003c/p\u003e\n\u003cp\u003eDue to the low prevalence of colorectal SRCC, little information is available regarding the role of age in predicting the colorectal SRCC prognosis.As discovered by Ping He, the elderly (\u0026sup3; 65 years old) showed dismal prognosis compared with the younger patients(˂ 65 years old)[\u003ca href=\"#_ENREF_19\"\u003e19\u003c/a\u003e], which is conformed to our findings.\u003c/p\u003e\n\u003cp\u003eIn addition, our study suggested that chemotherapy and surgery were the factors for the favorable prognosis among the elderly patients, indicating that the aggressive and effective treatment markedly decreased the colorectal SRCC-associated mortality among the elderly patients. Surgery exerts an important part in treating locoregional tumors[\u003ca href=\"#_ENREF_25\"\u003e25\u003c/a\u003e]. The value of chemotherapy has also been affirmed by many studies[\u003ca href=\"#_ENREF_14\"\u003e14\u003c/a\u003e, \u003ca href=\"#_ENREF_19\"\u003e19\u003c/a\u003e, \u003ca href=\"#_ENREF_26\"\u003e26\u003c/a\u003e]. Our results suggested that the proportions of the patients who received surgery were similar between the two age groups, while that of patients who received chemotherapy significantly decreased in the elderly group (39.0% vs. 74.8%).Such finding is commonly found among the elderly patients who receive anticancer treatment in other tumors[\u003ca href=\"#_ENREF_27\"\u003e27-29\u003c/a\u003e]. Therefore, we should strengthen the treatment of elderly patients.\u003c/p\u003e\n\u003cp\u003eSo far, the present study is the first large-scale retrospective analysis on the role of age in predicting colorectal SRCC prognosis. Our study assists the clinical workers in further understanding the clinicopathological characteristics and treatment for the elderly colorectal SRCC patients (\u0026sup3;65 years old). Nonetheless, certain limitations should be noted in the present study. First of all, selection bias was inevitable in the observational study. The application of PSM analysis could reduced the bias resulting from the unequal distribution of covariates measured, but bias induced by the unmeasured variables were inevitable. Secondly, we enrolled altogether 14 variables, but some variables still could not enrolled in the SEER database, like vascular invasion, status of surgical margin or the molecular-genetic profiles. Thirdly, detailed information about chemotherapy was not available. Therefore, we can not further explore which chemotherapy regimen is safe and effective for elderly patients. Our future work will focus on solving the above limitations.\u003c/p\u003e"},{"header":"Conclusion","content":"\u003cp\u003eIn conclusion, the clinicopathological features were significantly different between younger and older group, and the prognosis of colorectal SRCC in aged \u0026sup3;65 years patients was significantly worse than that in younger patients. Primary site, grade, tumor size, AJCC stage, surgery and chemotherapy were independent risk factors for the prognosis of elderly patients. Nevertheless, more studies are warranted to determine whether more intense treatment is necessary for colorectal SRCC patients if appropriate.\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eEthics approval\u003cbr /\u003e \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eApproval from the ethical board for this study was not required because of the public nature of all the data.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNo funding.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConflict of interest\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAll authors declare that they have no conflicts of interest.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAcknowledgements \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eWe thank the staff members of the National Cancer Institute and their colleagues across the United States and at Information Management Services, Inc., who have been involved with the Surveillance, Epidemiology, and End Results (SEER) Program.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthor contributions\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eJian-dong Diao conceived the study. Di Zhou searched the database and literature. Di Zhou, Yong-jing Yang, Chun-cao Niu and Yong-jiang Yu discussed and analyzed the data. Di Zhou wrote the manuscript. Jian-dong Diao revised the manuscript. All authors reviewed the manuscript.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eEl-Shami K, Oeffinger KC, Erb NL, Willis A, Bretsch JK, Pratt-Chapman ML, Cannady RS, Wong SL, Rose J, Barbour AL, Stein KD, Sharpe KB, Brooks DD, et al. American Cancer Society Colorectal Cancer Survivorship Care Guidelines. CA Cancer J Clin. 2015; 65: 428-55.\u003c/li\u003e\n\u003cli\u003eLaufman H, Saphir O. Primary linitis plastica type of carcinoma of the colon. AMA Arch Surg. 1951; 62: 79-91.\u003c/li\u003e\n\u003cli\u003eGopalan V, Smith RA, Ho YH, Lam AK. Signet-ring cell carcinoma of colorectum--current perspectives and molecular biology. Int J Colorectal Dis. 2011; 26: 127-33.\u003c/li\u003e\n\u003cli\u003eHugen N, van de Velde CJH, de Wilt JHW, Nagtegaal ID. Metastatic pattern in colorectal cancer is strongly influenced by histological subtype. Ann Oncol. 2014; 25: 651-7.\u003c/li\u003e\n\u003cli\u003eGallagher EG, Zeigler MG. Rectal carcinoma in patients in the second and third decades of life. Am J Surg. 1972; 124: 655-9.\u003c/li\u003e\n\u003cli\u003eO'Connell JB, Maggard MA, Liu JH, Etzioni DA, Ko CY. Are survival rates different for young and older patients with rectal cancer? Dis Colon Rectum. 2004; 47: 2064-9.\u003c/li\u003e\n\u003cli\u003eIsbister WH, Fraser J. Large-bowel cancer in the young: a national survival study. Dis Colon Rectum. 1990; 33: 363-6.\u003c/li\u003e\n\u003cli\u003eMitry E, Benhamiche AM, Jouve JL, Clinard F, Finn-Faivre C, Faivre J. Colorectal adenocarcinoma in patients under 45 years of age: comparison with older patients in a well-defined French population. Dis Colon Rectum. 2001; 44: 380-7.\u003c/li\u003e\n\u003cli\u003eYu JB, Gross CP, Wilson LD, Smith BD. NCI SEER public-use data: applications and limitations in oncology research. Oncology (Williston Park). 2009; 23: 288-95.\u003c/li\u003e\n\u003cli\u003eCahill KS, Claus EB. Treatment and survival of patients with nonmalignant intracranial meningioma: results from the Surveillance, Epidemiology, and End Results Program of the National Cancer Institute. Clinical article. J Neurosurg. 2011; 115: 259-67.\u003c/li\u003e\n\u003cli\u003eNitsche U, Friess H, Agha A, Angele M, Eckel R, Heitland W, Jauch KW, Krenz D, Nussler NC, Rau HG, Ruppert R, Schubert-Fritschle G, Wilhelm D, et al. Prognosis of mucinous and signet-ring cell colorectal cancer in a population-based cohort. J Cancer Res Clin Oncol. 2016; 142: 2357-66.\u003c/li\u003e\n\u003cli\u003eLv X, Yu H, Gao P, Song Y, Sun J, Chen X, Wang Y, Wang Z. A nomogram for predicting bowel obstruction in preoperative colorectal cancer patients with clinical characteristics. World J Surg Oncol. 2019; 17: 21.\u003c/li\u003e\n\u003cli\u003eWu SG, Chen XT, Zhang WW, Sun JY, Li FY, He ZY, Pei XQ, Lin Q. Survival in signet ring cell carcinoma varies based on primary tumor location: a Surveillance, Epidemiology, and End Results database analysis. Expert Rev Gastroenterol Hepatol. 2018; 12: 209-14.\u003c/li\u003e\n\u003cli\u003eShi T, Huang M, Han D, Tang X, Chen Y, Li Z, Liu C, Xiang D, Wang T, Chen Y, Wang R, Lei Z, Chu X. Chemotherapy is associated with increased survival from colorectal signet ring cell carcinoma with distant metastasis: A Surveillance, Epidemiology, and End Results database analysis. Cancer Med. 2019; 8: 1930-40.\u003c/li\u003e\n\u003cli\u003eWei F, Lyu H, Wang S, Chu Y, Chen F. Postoperative Radiotherapy Improves Survival in Gastric Signet-Ring Cell Carcinoma: a SEER Database Analysis. J Gastric Cancer. 2019; 19: 393-407.\u003c/li\u003e\n\u003cli\u003eShi M, Zhou B, Yang SP. Nomograms for predicting overall survival and cancer-specific survival in young patients with pancreatic cancer in the US based on the SEER database. PeerJ. 2020; 8: e8958.\u003c/li\u003e\n\u003cli\u003eLittle RJ, Rubin DB. Causal effects in clinical and epidemiological studies via potential outcomes: concepts and analytical approaches. Annu Rev Public Health. 2000; 21: 121-45.\u003c/li\u003e\n\u003cli\u003ePattanayak CW, Rubin DB, Zell ER. [Propensity score methods for creating covariate balance in observational studies]. Rev Esp Cardiol. 2011; 64: 897-903.\u003c/li\u003e\n\u003cli\u003eYang LL, Wang M, He P. Clinicopathological characteristics and survival in colorectal signet ring cell carcinoma: a population-based study. Sci Rep. 2020; 10: 10460.\u003c/li\u003e\n\u003cli\u003eKim SE, Paik HY, Yoon H, Lee JE, Kim N, Sung MK. Sex- and gender-specific disparities in colorectal cancer risk. World J Gastroenterol. 2015; 21: 5167-75.\u003c/li\u003e\n\u003cli\u003eTajiri K, Sudou T, Fujita F, Hisaka T, Kinugasa T, Akagi Y. Clinicopathological and Corresponding Genetic Features of Colorectal Signet Ring Cell Carcinoma. Anticancer Res. 2017; 37: 3817-23.\u003c/li\u003e\n\u003cli\u003eNitsche U, Zimmermann A, Spath C, Muller T, Maak M, Schuster T, Slotta-Huspenina J, Kaser SA, Michalski CW, Janssen KP, Friess H, Rosenberg R, Bader FG. Mucinous and signet-ring cell colorectal cancers differ from classical adenocarcinomas in tumor biology and prognosis. Ann Surg. 2013; 258: 775-82; discussion 82-3.\u003c/li\u003e\n\u003cli\u003eHartman DJ, Nikiforova MN, Chang DT, Chu E, Bahary N, Brand RE, Zureikat AH, Zeh HJ, Choudry H, Pai RK. Signet ring cell colorectal carcinoma: a distinct subset of mucin-poor microsatellite-stable signet ring cell carcinoma associated with dismal prognosis. Am J Surg Pathol. 2013; 37: 969-77.\u003c/li\u003e\n\u003cli\u003eLing CR, Wang R, Wang MJ, Ping J, Zhuang W. Prognosis and value of preoperative radiotherapy in locally advanced rectal signet-ring cell carcinoma. Sci Rep. 2017; 7: 45334.\u003c/li\u003e\n\u003cli\u003eArifi S, Elmesbahi O, Amarti Riffi A. Primary signet ring cell carcinoma of the colon and rectum. Bull Cancer. 2015; 102: 880-8.\u003c/li\u003e\n\u003cli\u003eHugen N, Verhoeven RH, Lemmens VE, van Aart CJ, Elferink MA, Radema SA, Nagtegaal ID, de Wilt JH. Colorectal signet-ring cell carcinoma: benefit from adjuvant chemotherapy but a poor prognostic factor. Int J Cancer. 2015; 136: 333-9.\u003c/li\u003e\n\u003cli\u003eFu J, Ruan H, Zheng H, Cai C, Zhou S, Wang Q, Chen W, Fu W, Du J. Impact of old age on resectable colorectal cancer outcomes. PeerJ. 2019; 7: e6350.\u003c/li\u003e\n\u003cli\u003eKrok-Schoen JL, Adams IK, Baltic RD, Fisher JL. Ethnic disparities in cancer incidence and survival among the oldest old in the United States. Ethn Health. 2020; 25: 79-92.\u003c/li\u003e\n\u003cli\u003eCao L, Li ZW, Wang M, Zhang TT, Bao B, Liu YP. Clinicopathological characteristics, treatment and survival of pulmonary large cell neuroendocrine carcinoma: a SEER population-based study. PeerJ. 2019; 7: e6539.\u003c/li\u003e\n\u003c/ol\u003e"},{"header":"Tables","content":"\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003eTable 1.\u0026nbsp;\u003c/span\u003e\u003cspan style=\"font-family: 'AdvTT96740c24',serif; color: black; font-weight: normal; font-style: normal;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif;\"\u003ePatient Demographic, Clinical, and Tumor Characteristics before PSM\u003c/span\u003e\u003c/span\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e.\u003c/span\u003e\u003c/p\u003e\n\u003cdiv style=\"margin: 0in; text-align: justify; font-size: 14px; font-family: 'Calibri',sans-serif;\" align=\"center\"\u003e\n\u003ctable style=\"width: 4.9e+2pt; border: none; border-collapse: collapse;\"\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; border-top: solid black 2.25pt; border-left: none; border-bottom: solid black 2.25pt; border-right: none; background: white; padding: 0in 0in 0in 0in; height: 16.35pt;\" rowspan=\"2\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif; margin-bottom: 10.0pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 15px; color: black;\"\u003eCharacteristic\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; border: none; border-top: solid black 2.25pt; background: white; padding: 0in 0in 0in 0in; height: 16.35pt;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif; margin-bottom: 10.0pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 15px; color: black;\"\u003e\u0026nbsp; \u0026nbsp;A\u003c/span\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 15px; color: black;\"\u003ell patients\u003c/span\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 15px; color: black;\"\u003e\u0026nbsp; \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; border: none; border-top: solid black 2.25pt; background: white; padding: 0in 0in 0in 0in; height: 16.35pt;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif; margin-bottom: 10.0pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 15px; color: black;\"\u003e\u0026nbsp; \u0026nbsp; \u0026lt;65\u003c/span\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 15px; color: black;\"\u003e\u0026nbsp;years\u003c/span\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 15px; color: black;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; border: none; border-top: solid black 2.25pt; background: white; padding: 0in 0in 0in 0in; height: 16.35pt;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif; margin-bottom: 10.0pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 15px; color: black;\"\u003e\u0026nbsp; \u0026nbsp; \u0026ge;65\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 15px; color: black;\"\u003eyears\u003c/span\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 15px; color: black;\"\u003e\u0026nbsp; \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; border-top: solid black 2.25pt; border-left: none; border-bottom: solid black 2.25pt; border-right: none; background: white; padding: 0in 0in 0in 0in; height: 16.35pt;\" rowspan=\"2\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif; margin-bottom: 10.0pt;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif; margin-bottom: 10.0pt;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"font-size: 15px; color: black;\"\u003eP\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 15px; color: black;\"\u003e-value\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 86.6pt; border: none; border-bottom: solid black 2.25pt; background: white; padding: 0in 0in 0in 0in; height: 14.5pt;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif; margin-bottom: 10.0pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 15px; color: black;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;N=3305 \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; border: none; border-bottom: solid black 2.25pt; background: white; padding: 0in 0in 0in 0in; height: 14.5pt;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif; margin-bottom: 10.0pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 15px; color: black;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;N=1741 \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; border: none; border-bottom: solid black 2.25pt; background: white; padding: 0in 0in 0in 0in; height: 14.5pt;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif; margin-bottom: 10.0pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 15px; color: black;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;N=1564 \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 20.7pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003eSex\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 20.7pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 20.7pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; 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background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; female\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e1620 (49.0%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e753 (43.3%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: black;\"\u003e867 (55.4%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; 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font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: black;\"\u003e697 (44.6%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 20.55pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003eRace\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 20.55pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 20.55pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 20.55pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: red;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; background: white; padding: 0in 0in 0in 0in; height: 20.55pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp;\u0026lt;0.001 \u0026nbsp; \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; black\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e313 (9.47%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e204 (11.7%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e109 (6.97%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; other\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e282 (8.53%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e184 (10.6%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp;98 (6.27%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; white\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e2710 (82.0%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e1353 (77.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e1357 (86.8%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.6pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003eMarital\u003c/span\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp;\u003c/span\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003estatus\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.6pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.6pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.6pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; background: white; padding: 0in 0in 0in 0in; height: 22.6pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp;\u0026lt;0.001 \u0026nbsp; \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; married\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e1782 (53.9%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e1012 (58.1%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e770 (49.2%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;unmarried\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e1523 (46.1%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e729 (41.9%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e794 (50.8%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 20.6pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003eInsurance\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 20.6pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 20.6pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 20.6pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; background: white; padding: 0in 0in 0in 0in; height: 20.6pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;0.023 \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; any medicaid/insured\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e2268 (68.6%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e1164 (66.9%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e1104 (70.6%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;uninsured/unknown\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e1037 (31.4%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e577 (33.1%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e460 (29.4%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.7pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003ePrimary\u003c/span\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp;\u003c/span\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003esite\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.7pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.7pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.7pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; background: white; padding: 0in 0in 0in 0in; height: 22.7pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp;\u0026lt;0.001 \u0026nbsp; \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;cecum\u0026ndash;transverse colon\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e2002 (60.6%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e919 (52.8%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e1083 (69.2%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;descending colon\u0026ndash;sigmoid\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e517 (15.6%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e323 (18.6%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e194 (12.4%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;multiple\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp;50 (1.51%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp;25 (1.44%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp;25 (1.60%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; rectum\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e644 (19.5%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e425 (24.4%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e219 (14.0%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; unknown\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp;92 (2.78%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp;49 (2.81%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp;43 (2.75%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 20.7pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003eGrade\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 20.7pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 20.7pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 20.7pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; background: white; padding: 0in 0in 0in 0in; height: 20.7pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;0.001 \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; grade I/II\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e177 (5.36%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp;90 (5.17%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp;87 (5.56%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; grade III/IV\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e2537 (76.8%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e1298 (74.6%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e1239 (79.2%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; unknown\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e591 (17.9%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e353 (20.3%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e238 (15.2%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.75pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003eT\u003c/span\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003eumor\u003c/span\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp;\u003c/span\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003esize\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.75pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.75pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.75pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; background: white; padding: 0in 0in 0in 0in; height: 22.75pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp;\u0026lt;0.001 \u0026nbsp; \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026gt;5cm\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e1279 (38.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e638 (36.6%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e641 (41.0%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026le;5cm\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e1226 (37.1%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e612 (35.2%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e614 (39.3%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; unknown\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e800 (24.2%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e491 (28.2%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e309 (19.8%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 20.7pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003eAJCC\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 20.7pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 20.7pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 20.7pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; background: white; padding: 0in 0in 0in 0in; height: 20.7pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp;\u0026lt;0.001 \u0026nbsp; \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; I\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e158 (4.78%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp;69 (3.96%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp;89 (5.69%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; II\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e465 (14.1%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e171 (9.82%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e294 (18.8%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; III\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e1227 (37.1%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e615 (35.3%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e612 (39.1%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; IV\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e1455 (44.0%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e886 (50.9%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e569 (36.4%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003eSurgery\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;0.065 \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; no\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e676 (20.5%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e378 (21.7%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e298 (19.1%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; yes\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e2629 (79.5%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e1363 (78.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e1266 (80.9%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003eLymph node dissection\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;0.002 \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; 1 to 3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp;87 (2.63%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp;46 (2.64%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp;41 (2.62%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026ge;4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e2325 (70.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e1180 (67.8%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e1145 (73.2%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; None or Biopsy\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e893 (27.0%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e515 (29.6%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e378 (24.2%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003eChemotherapy\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp;\u0026lt;0.001 \u0026nbsp; \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;no/unknown\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e1393 (42.1%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e439 (25.2%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e954 (61.0%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; yes\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e1912 (57.9%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e1302 (74.8%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e610 (39.0%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.7pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003eRadiotherapy\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.7pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.7pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.7pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; background: white; padding: 0in 0in 0in 0in; height: 22.7pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp;\u0026lt;0.001 \u0026nbsp; \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;no/unknown\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e2868 (86.8%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e1427 (82.0%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e1441 (92.1%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; yes\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e437 (13.2%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e314 (18.0%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e123 (7.86%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003eYear\u003c/span\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp;o\u003c/span\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003ef\u003c/span\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp;\u003c/span\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003ediagnosis\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;0.567 \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;2004-2007\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e1120 (33.9%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e580 (33.3%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e540 (34.5%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;2008-2011\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e1069 (32.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e577 (33.1%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e492 (31.5%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; border: none; border-bottom: solid black 2.25pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;2012-2015\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; border: none; border-bottom: solid black 2.25pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e1116 (33.8%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; border: none; border-bottom: solid black 2.25pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e584 (33.5%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; border: none; border-bottom: solid black 2.25pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e532 (34.0%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.65pt; border: none; border-bottom: solid black 2.25pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"margin: 2.0pt 5.0pt 2.0pt 5.0pt; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003c/div\u003e\n\u003cp style=\"margin: 0in; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif; margin-bottom: 10.0pt;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003eTable\u0026nbsp;\u003c/span\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e2\u003c/span\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e. Baseline characteristics\u0026nbsp;\u003c/span\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003eafter\u003c/span\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp;propensity score matching.\u003c/span\u003e\u003c/p\u003e\n\u003cdiv style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 0in 0in 10.0pt 0in;\" align=\"center\"\u003e\n\u003ctable style=\"width: 4.7e+2pt; border: none; border-collapse: collapse;\"\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; border-top: solid black 2.25pt; border-left: none; border-bottom: solid black 2.25pt; border-right: none; background: white; padding: 0in 0in 0in 0in; height: 16.35pt;\" rowspan=\"2\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 0in;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: black;\"\u003eCharacteristic\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; border: none; border-top: solid black 2.25pt; background: white; padding: 0in 0in 0in 0in; height: 16.35pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 0in;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: black;\"\u003e\u0026nbsp; All patients \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; border: none; border-top: solid black 2.25pt; background: white; padding: 0in 0in 0in 0in; height: 16.35pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 0in;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: black;\"\u003e\u0026nbsp; \u0026nbsp; \u0026lt;65 years \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; border: none; border-top: solid black 2.25pt; background: white; padding: 0in 0in 0in 0in; height: 16.35pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 0in;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: black;\"\u003e\u0026nbsp; \u0026nbsp; \u0026ge;65 \u0026nbsp;years \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; border-top: solid black 2.25pt; border-left: none; border-bottom: solid black 2.25pt; border-right: none; background: white; padding: 0in 0in 0in 0in; height: 16.35pt;\" rowspan=\"2\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 0in;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 0in;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: black;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u003cem\u003e\u0026nbsp;P\u003c/em\u003e-value \u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 86.6pt; border: none; border-bottom: solid black 2.25pt; background: white; padding: 0in 0in 0in 0in; height: 14.5pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 0in;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: black;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;N=2064 \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; border: none; border-bottom: solid black 2.25pt; background: white; padding: 0in 0in 0in 0in; height: 14.5pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 0in;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: black;\"\u003e\u0026nbsp; N=1032 \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; border: none; border-bottom: solid black 2.25pt; background: white; padding: 0in 0in 0in 0in; height: 14.5pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 0in;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: black;\"\u003e\u0026nbsp; N=1032 \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 20.7pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003eSex:\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 20.7pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 20.7pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 20.7pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; background: white; padding: 0in 0in 0in 0in; height: 20.7pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; 0.792 \u0026nbsp; \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; female\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e997 (48.3%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e495 (48.0%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e502 (48.6%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; male\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e1067 (51.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e537 (52.0%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e530 (51.4%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 20.55pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003eRace:\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 20.55pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 20.55pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 20.55pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; background: white; padding: 0in 0in 0in 0in; height: 20.55pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; 0.985 \u0026nbsp; \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; black\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e189 (9.16%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e95 (9.21%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e94 (9.11%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; other\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e168 (8.14%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e83 (8.04%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e85 (8.24%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; white\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e1707 (82.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e854 (82.8%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e853 (82.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.6pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003eMarital_status:\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.6pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.6pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.6pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; background: white; padding: 0in 0in 0in 0in; height: 22.6pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; 0.566 \u0026nbsp; \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; married\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e1096 (53.1%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e555 (53.8%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e541 (52.4%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; unmarried\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e968 (46.9%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e477 (46.2%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e491 (47.6%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 20.55pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003eInsurance:\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 20.55pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 20.55pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 20.55pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; background: white; padding: 0in 0in 0in 0in; height: 20.55pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; 0.771 \u0026nbsp; \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; any medicaid/insured\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e1465 (71.0%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e729 (70.6%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e736 (71.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; uninsured/unknown\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e599 (29.0%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e303 (29.4%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e296 (28.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.7pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003ePrimary_site:\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.7pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.7pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.7pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; background: white; padding: 0in 0in 0in 0in; height: 22.7pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; 0.705 \u0026nbsp; \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; cecum\u0026ndash;transverse colon\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e1257 (60.9%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e639 (61.9%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e618 (59.9%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; descending colon\u0026ndash;sigmoid\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e311 (15.1%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e151 (14.6%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e160 (15.5%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; multiple\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp;41 (1.99%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e18 (1.74%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e23 (2.23%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; rectum\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e387 (18.8%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e194 (18.8%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e193 (18.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; 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font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e38 (3.68%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 20.7pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003eGrade:\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 20.7pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 20.7pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 20.7pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; background: white; padding: 0in 0in 0in 0in; height: 20.7pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; 0.691 \u0026nbsp; \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; grade I/II\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e115 (5.57%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e54 (5.23%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e61 (5.91%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; 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unknown\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e380 (18.4%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e186 (18.0%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; 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font-family: 'Calibri',sans-serif; color: #111111;\"\u003eumor\u003c/span\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp;\u003c/span\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003esize:\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.75pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.75pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.75pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; background: white; padding: 0in 0in 0in 0in; height: 22.75pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; 0.998 \u0026nbsp; \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026gt;5cm\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e780 (37.8%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e390 (37.8%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e390 (37.8%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026le;5cm\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e787 (38.1%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e394 (38.2%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e393 (38.1%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; unknown\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e497 (24.1%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e248 (24.0%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e249 (24.1%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 20.7pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003eAJCC:\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 20.7pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 20.7pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 20.7pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; background: white; padding: 0in 0in 0in 0in; height: 20.7pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; 0.732 \u0026nbsp; \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; I\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e116 (5.62%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e53 (5.14%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e63 (6.10%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; II\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e262 (12.7%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e130 (12.6%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e132 (12.8%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; 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text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e400 (38.8%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; IV\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e892 (43.2%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e455 (44.1%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e437 (42.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003eSurgery:\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; 0.392 \u0026nbsp; \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; no/unknown\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e445 (21.6%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e214 (20.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e231 (22.4%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; 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margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e801 (77.6%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003eReg_LN_Sur:\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; 0.166 \u0026nbsp; \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; 1 to 3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp;57 (2.76%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e23 (2.23%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e34 (3.29%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026ge;4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e1420 (68.8%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e726 (70.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e694 (67.2%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; None or Biopsy\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e587 (28.4%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e283 (27.4%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e304 (29.5%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003eChemotherapy:\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; 0.349 \u0026nbsp; \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; no/unknown\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e866 (42.0%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e422 (40.9%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e444 (43.0%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; yes\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e1198 (58.0%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e610 (59.1%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e588 (57.0%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.7pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003eRadiotherapy:\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.7pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.7pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.7pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; background: white; padding: 0in 0in 0in 0in; height: 22.7pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; 0.836 \u0026nbsp; \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; no/unknown\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e1826 (88.5%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e911 (88.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e915 (88.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; yes\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e238 (11.5%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e121 (11.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e117 (11.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003eYear_of_diagnosis:\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; 0.774 \u0026nbsp; \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; 2004-2007\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e660 (32.0%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e323 (31.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e337 (32.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; 2008-2011\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e716 (34.7%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e359 (34.8%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e357 (34.6%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.4pt; border: none; border-bottom: solid black 2.25pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; 2012-2015\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.6pt; border: none; border-bottom: solid black 2.25pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e688 (33.3%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; border: none; border-bottom: solid black 2.25pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e350 (33.9%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.45pt; border: none; border-bottom: solid black 2.25pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e338 (32.8%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 60.3pt; border: none; border-bottom: solid black 2.25pt; background: white; padding: 0in 0in 0in 0in; height: 22.85pt;\"\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; text-align: center; margin: 2.0pt 5.0pt 2.0pt 5.0pt;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif; color: #111111;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003c/div\u003e\n\u003cp style=\"font-size: 16px; font-family: 'Cambria',serif; margin: 0in 0in 10.0pt 0in;\"\u003e\u003cspan style=\"font-size: 15px; font-family: 'Calibri',sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in; text-align: justify; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 15px;\"\u003eTable 3\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"font-size: 15px;\"\u003eUnivariate and multivariate analyses of \u003cspan style=\"font-family: 'GillSansMT',serif; color: black; font-weight: normal; font-style: normal;\"\u003e\u003cspan style=\"font-family: 'Calibri',sans-serif;\"\u003ecancer-specific s\u003c/span\u003e\u003c/span\u003eurvival (CSS) for patients with colorectal SRCC aged \u0026ge; 65 .\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"float: left; width: 71%; border: none; border-collapse: collapse; margin-left: 6.75pt; margin-right: 6.75pt;\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 29.86%; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.65pt;\" rowspan=\"2\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003eCharacteristic\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 28.06%; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.65pt;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003eUnivariate \u0026nbsp;analysis\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.08%; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.65pt;\" colspan=\"2\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003eMultivariate analysis\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 28.06%; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 15px;\"\u003eP\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"font-size: 15px;\"\u003e-value\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 25.72%; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003eHR(95%CI)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 16.36%; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 15px;\"\u003eP\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"font-size: 15px;\"\u003e-value\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 29.86%; border: none; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003eYear at diagnosis\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 28.06%; border: none; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e0.761\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 25.72%; border: none; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 16.36%; border: none; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003eNI\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 29.86%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif; text-indent: 16.5pt;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e2004-2007\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 28.06%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 25.72%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 16.36%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 29.86%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif; text-indent: 16.5pt;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e2008-2011\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 28.06%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 25.72%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 16.36%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 29.86%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif; text-indent: 16.5pt;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e2012-2015\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 28.06%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 25.72%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 16.36%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 29.86%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003eSex\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 28.06%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e0.049\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 25.72%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: justify; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 16.36%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e0.317\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 29.86%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif; text-indent: 16.5pt;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003eFemale\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 28.06%; 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padding: 0in 5.4pt; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 25.72%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e1.069(0.938,1.219)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 16.36%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 29.86%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003eRace\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 28.06%; 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font-family: 'Calibri',sans-serif; text-indent: 16.5pt;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003eblack\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 28.06%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 25.72%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 16.36%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 29.86%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif; text-indent: 16.5pt;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003ewhite\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 28.06%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 25.72%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 16.36%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 29.86%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif; text-indent: 16.5pt;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003eother\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 28.06%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 25.72%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 16.36%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 29.86%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003eMarital status\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 28.06%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e0.374\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 25.72%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 16.36%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003eNI\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 29.86%; 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padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e1.456(1.180,1.796)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 16.36%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 29.86%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003eAJCC stage\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 28.06%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 25.72%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 16.36%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 29.86%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif; text-indent: 16.5pt;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003eI\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 28.06%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 25.72%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003eReference\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 16.36%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 29.86%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif; text-indent: 16.5pt;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003eII\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 28.06%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 25.72%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e1.419(0.889,2.267)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 16.36%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e0.143\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 29.86%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif; text-indent: 16.5pt;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003eIII\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 28.06%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 25.72%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e4.765(3.088,7.354)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 16.36%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 29.86%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif; text-indent: 16.5pt;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003eIV\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 28.06%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 25.72%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e11.678(7.543,18.079)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 16.36%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 29.86%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003eSurgery\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 28.06%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 25.72%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 16.36%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e0.010\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 29.86%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif; text-indent: 16.5pt;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003eno surgery\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 28.06%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 25.72%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003eReference\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 16.36%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 29.86%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif; text-indent: 16.5pt;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003eyes\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 28.06%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 25.72%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e0.674(0.498,0.912)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 16.36%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 29.86%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: left; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003eDissected lymph node\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 28.06%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 25.72%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; font-size: 14px; font-family: 'Calibri',sans-serif;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 16.36%; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"margin: 0in; text-align: center; 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text-align: justify; font-size: 14px; font-family: 'Calibri',sans-serif; text-indent: .15in;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp style=\"margin: 0in; text-align: justify; font-size: 14px; font-family: 'Calibri',sans-serif; text-indent: .15in;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp style=\"margin: 0in; text-align: justify; font-size: 14px; font-family: 'Calibri',sans-serif; text-indent: .15in;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp style=\"margin: 0in; text-align: justify; font-size: 14px; font-family: 'Calibri',sans-serif; text-indent: .15in;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp style=\"margin: 0in; text-align: justify; font-size: 14px; font-family: 'Calibri',sans-serif; text-indent: .15in;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp style=\"margin: 0in; text-align: justify; font-size: 14px; font-family: 'Calibri',sans-serif; text-indent: .15in;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp style=\"margin: 0in; text-align: justify; font-size: 14px; font-family: 'Calibri',sans-serif; text-indent: .15in;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp style=\"margin: 0in; text-align: justify; font-size: 14px; font-family: 'Calibri',sans-serif; text-indent: .15in;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 15px;\"\u003eAbbreviation:\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u0026nbsp;NI, not included in the multivariate survival analysis;\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in; text-align: justify; font-size: 14px; font-family: 'Calibri',sans-serif; text-indent: .15in;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp style=\"margin: 0in; text-align: justify; font-size: 14px; font-family: 'Calibri',sans-serif; text-indent: .15in;\"\u003e\u0026nbsp;\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Signet ring cell carcinoma, colorectal, eldly, prognosis, SEER database.","lastPublishedDoi":"10.21203/rs.3.rs-200148/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-200148/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eObjective:\u003c/strong\u003e To evaluate the prognostic value of age on colorectal signet ring cell carcinoma (SRCC) and identify the prognosis factors of patients aged ≥ 65 years.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eMethods\u003c/strong\u003e: Patients were recruited from the Surveillance, Epidemiology, and End Results (SEER) database. We ensured that all characteristics were well balanced through adopting the propensity score matching (PSM) method. In addition, the prognostic factors were evaluated by the Cox proportional hazardous model.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eResults\u003c/strong\u003e: Altogether 3305 cases were enrolled, including 1564 in elderly group (aged ³65 years). As a result, more patients were female, unmarried, white, earlier AJCC stage, tumor size ≤5cm, grade III/IV and located in cecum–transverse colon in the elderly group; whereas significant fewer patients received chemotherapy and radiotherapy. After 1:1 PSM analysis, each group contained 1032 cases. As discovered by Kaplan-Meier analysis, the elderly group was associated with remarkably dismal survival compared with the younger group after PSM analysis (\u003cem\u003eP\u003c/em\u003e=0.0091).Moreover, grade, primary site, AJCC stage, tumor size, surgery and chemotherapy were identified as the independent prognostic factors for the elderly patients.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eConclusion\u003c/strong\u003e: The prognosis of colorectal SRCC aged ≥ 65 years was worse than the younger patients. We may need strengthen the chemotherapy of the eldly colorectal SRCC.\u003c/p\u003e","manuscriptTitle":"Characteristics and prognosis of colorectal signet ring cell carcinoma in patients aged ≥ 65 years ","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2021-02-17 22:36:42","doi":"10.21203/rs.3.rs-200148/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"a99e8673-e229-4954-a84a-e7a8adb3f9b3","owner":[],"postedDate":"February 17th, 2021","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":2465884,"name":"Cancer Biology"},{"id":2465885,"name":"Oncology"}],"tags":[],"updatedAt":"2021-07-06T11:44:10+00:00","versionOfRecord":[],"versionCreatedAt":"2021-02-17 22:36:42","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-200148","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-200148","identity":"rs-200148","version":["v1"]},"buildId":"7rjqhiLT3MXkJMwkYKINL","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}